MA29215B1 - Pyrazolo[3,4-b] pyridines et indazoles therapeutiques - Google Patents
Pyrazolo[3,4-b] pyridines et indazoles therapeutiquesInfo
- Publication number
- MA29215B1 MA29215B1 MA29948A MA29948A MA29215B1 MA 29215 B1 MA29215 B1 MA 29215B1 MA 29948 A MA29948 A MA 29948A MA 29948 A MA29948 A MA 29948A MA 29215 B1 MA29215 B1 MA 29215B1
- Authority
- MA
- Morocco
- Prior art keywords
- indazoles
- pyrazolo
- pyridines
- therapeutic
- formula
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA PRÉSENTE INVENTION CONCERNE DES COMPOSÉS DE FORMULE (I), DANS LAQUELLE R2, R3, R4, R5, R6, R7, X, ET L REPRÉSENTENT UNE DES VALEURS DÉFINIES DANS LA SPÉCIFICATION, ET DES SELS ACCEPTABLES PHARMACEUTIQUEMENT ASSOCIÉS, QUI SONT UTILISÉS EN TANT QU'AGENTS DANS LE TRAITEMENT DE TROUBLES DU SYSTÈME NERVEUX CENTRAL ET D'AUTRES TROUBLES, Y COMPRIS, LE TROUBLE D'HYPERACTIVITÉ AVEC DÉFICIT DE L'ATTENTION, UNE DOULEUR NEUROPATHIQUE, L'INCONTINENCE URINAIRE, L'ANXIÉTÉ, LA DÉPRESSION, LA SCHIZOPHRÉNIE ET LA FIBROMYALGIE. CETTE INVENTION A AUSSI POUR OBJET DES COMPOSITIONS PHARMACEUTIQUES RENFERMANT AU MOINS UN COMPOSÉ DE LA FORMULE (I).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63138604P | 2004-11-29 | 2004-11-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA29215B1 true MA29215B1 (fr) | 2008-02-01 |
Family
ID=36218221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA29948A MA29215B1 (fr) | 2004-11-29 | 2007-05-29 | Pyrazolo[3,4-b] pyridines et indazoles therapeutiques |
Country Status (29)
Country | Link |
---|---|
US (3) | US7423054B2 (fr) |
EP (1) | EP1828182B1 (fr) |
JP (1) | JP4130219B2 (fr) |
KR (1) | KR20070094747A (fr) |
CN (1) | CN101111494A (fr) |
AP (1) | AP2007004024A0 (fr) |
AR (1) | AR051970A1 (fr) |
AT (1) | ATE460415T1 (fr) |
AU (1) | AU2005308523B2 (fr) |
BR (1) | BRPI0518693A2 (fr) |
CA (1) | CA2588812A1 (fr) |
CR (1) | CR9155A (fr) |
DE (1) | DE602005019913D1 (fr) |
DK (1) | DK1828182T3 (fr) |
EA (1) | EA012245B1 (fr) |
ES (1) | ES2339794T3 (fr) |
GT (1) | GT200500348A (fr) |
IL (1) | IL183485A0 (fr) |
MA (1) | MA29215B1 (fr) |
MX (1) | MX2007006408A (fr) |
NL (2) | NL1030540C2 (fr) |
NO (1) | NO20072972L (fr) |
PA (1) | PA8653901A1 (fr) |
PE (1) | PE20061062A1 (fr) |
TN (1) | TNSN07207A1 (fr) |
TW (1) | TWI304063B (fr) |
UY (1) | UY29228A1 (fr) |
WO (1) | WO2006056873A2 (fr) |
ZA (1) | ZA200704408B (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ332762A (en) | 1996-07-24 | 2000-09-29 | Warner Lambert Co | Isobutylgaba and its derivatives for the treatment of pain |
KR20070094747A (ko) * | 2004-11-29 | 2007-09-21 | 워너-램버트 캄파니 엘엘씨 | 치료용 피라졸로[3,4-b]피리딘 및 인다졸 |
JP2010043063A (ja) | 2008-05-09 | 2010-02-25 | Agency For Science Technology & Research | 川崎病の診断及び治療 |
US9938269B2 (en) | 2011-06-30 | 2018-04-10 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
WO2014078568A1 (fr) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Méthodes et compositions pour le traitement de la schizophrénie |
EP2929883A1 (fr) * | 2014-04-08 | 2015-10-14 | Institut Pasteur | Dérivés du pyrazole en tant qu'inhibiteurs de la dihydrooratate déhydrogénase (DHODH) |
CN107082763A (zh) * | 2016-02-15 | 2017-08-22 | 中山大学 | 一种合成吲唑酮类化合物的方法 |
WO2022254395A1 (fr) * | 2021-06-04 | 2022-12-08 | Pi Industries Ltd. | Nouveau procédé de préparation de diamides anthraniliques |
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HUP0400343A2 (hu) * | 2001-03-29 | 2004-09-28 | Bristol-Myers Squibb Co. | Ciklopropil-indol-származékok mint szelektív szerotonin-újrafelvétel inhibitorok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
WO2003035005A2 (fr) * | 2001-10-26 | 2003-05-01 | University Of Connecticut | Heteroindanes: nouvelle classe de ligands cannabimimetiques efficaces |
US20040034101A1 (en) * | 2001-11-05 | 2004-02-19 | Cypress Bioscience, Inc. | Treatment and prevention of depression secondary to pain (DSP) |
JP2003146879A (ja) | 2001-11-08 | 2003-05-21 | Dai Ichi Seiyaku Co Ltd | 精神分裂病治療及び/又は予防薬 |
JP2003146973A (ja) | 2001-11-08 | 2003-05-21 | Dai Ichi Seiyaku Co Ltd | うつ病、うつ状態又は不安障害の治療及び/又は予防薬 |
WO2003076408A2 (fr) * | 2002-03-08 | 2003-09-18 | Abbott Laboratories | Derives d'indazole qui sont des activateurs de guanylate cyclase soluble |
US7057042B2 (en) * | 2002-05-29 | 2006-06-06 | Abbott Laboratories | Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction |
WO2003101994A1 (fr) | 2002-05-29 | 2003-12-11 | Abbott Laboratories | Composes aromatiques bicycliques condenses utiles dans le traitement de dysfonctionnement sexuel |
AR043633A1 (es) * | 2003-03-20 | 2005-08-03 | Schering Corp | Ligandos de receptores de canabinoides |
US20060019967A1 (en) * | 2004-07-21 | 2006-01-26 | Su-Ying Wu | SARS CoV main protease inhibitors |
KR20070094747A (ko) * | 2004-11-29 | 2007-09-21 | 워너-램버트 캄파니 엘엘씨 | 치료용 피라졸로[3,4-b]피리딘 및 인다졸 |
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2005
- 2005-11-17 KR KR1020077014752A patent/KR20070094747A/ko active IP Right Grant
- 2005-11-17 AT AT05806091T patent/ATE460415T1/de not_active IP Right Cessation
- 2005-11-17 MX MX2007006408A patent/MX2007006408A/es active IP Right Grant
- 2005-11-17 BR BRPI0518693-5A patent/BRPI0518693A2/pt not_active IP Right Cessation
- 2005-11-17 WO PCT/IB2005/003549 patent/WO2006056873A2/fr active Application Filing
- 2005-11-17 DE DE602005019913T patent/DE602005019913D1/de active Active
- 2005-11-17 CA CA002588812A patent/CA2588812A1/fr not_active Abandoned
- 2005-11-17 EA EA200700963A patent/EA012245B1/ru not_active IP Right Cessation
- 2005-11-17 DK DK05806091.4T patent/DK1828182T3/da active
- 2005-11-17 EP EP05806091A patent/EP1828182B1/fr active Active
- 2005-11-17 CN CNA2005800474774A patent/CN101111494A/zh active Pending
- 2005-11-17 ES ES05806091T patent/ES2339794T3/es active Active
- 2005-11-17 AP AP2007004024A patent/AP2007004024A0/xx unknown
- 2005-11-17 AU AU2005308523A patent/AU2005308523B2/en not_active Ceased
- 2005-11-17 JP JP2007542168A patent/JP4130219B2/ja not_active Expired - Fee Related
- 2005-11-25 AR ARP050104934A patent/AR051970A1/es not_active Application Discontinuation
- 2005-11-25 UY UY29228A patent/UY29228A1/es not_active Application Discontinuation
- 2005-11-25 PE PE2005001373A patent/PE20061062A1/es not_active Application Discontinuation
- 2005-11-25 TW TW094141562A patent/TWI304063B/zh active
- 2005-11-28 NL NL1030540A patent/NL1030540C2/nl not_active IP Right Cessation
- 2005-11-28 US US11/287,759 patent/US7423054B2/en not_active Expired - Fee Related
- 2005-11-29 GT GT200500348A patent/GT200500348A/es unknown
- 2005-11-29 PA PA20058653901A patent/PA8653901A1/es unknown
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2006
- 2006-06-02 US US11/446,277 patent/US7485636B2/en not_active Expired - Fee Related
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2007
- 2007-02-15 NL NL1033403A patent/NL1033403C2/nl not_active IP Right Cessation
- 2007-05-25 TN TNP2007000207A patent/TNSN07207A1/fr unknown
- 2007-05-28 IL IL183485A patent/IL183485A0/en unknown
- 2007-05-29 CR CR9155A patent/CR9155A/es not_active Application Discontinuation
- 2007-05-29 MA MA29948A patent/MA29215B1/fr unknown
- 2007-05-29 ZA ZA200704408A patent/ZA200704408B/xx unknown
- 2007-06-11 NO NO20072972A patent/NO20072972L/no not_active Application Discontinuation
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2008
- 2008-08-04 US US12/185,419 patent/US20080293715A1/en not_active Abandoned
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