EA200700963A1 - ТЕРАПЕВТИЧЕСКИЕ ПИРАЗОЛО[3,4-b]ПИРИДИНЫ И ИНДАЗОЛЫ - Google Patents

ТЕРАПЕВТИЧЕСКИЕ ПИРАЗОЛО[3,4-b]ПИРИДИНЫ И ИНДАЗОЛЫ

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Publication number
EA200700963A1
EA200700963A1 EA200700963A EA200700963A EA200700963A1 EA 200700963 A1 EA200700963 A1 EA 200700963A1 EA 200700963 A EA200700963 A EA 200700963A EA 200700963 A EA200700963 A EA 200700963A EA 200700963 A1 EA200700963 A1 EA 200700963A1
Authority
EA
Eurasian Patent Office
Prior art keywords
indazoles
pyrazolo
pyridine
therapeutic
formula
Prior art date
Application number
EA200700963A
Other languages
English (en)
Other versions
EA012245B1 (ru
Inventor
Роберт М. Щелкун
По-Вай Юен
Original Assignee
УОРНЕР-ЛАМБЕРТ КОМПАНИ ЭлЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by УОРНЕР-ЛАМБЕРТ КОМПАНИ ЭлЭлСи filed Critical УОРНЕР-ЛАМБЕРТ КОМПАНИ ЭлЭлСи
Publication of EA200700963A1 publication Critical patent/EA200700963A1/ru
Publication of EA012245B1 publication Critical patent/EA012245B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В настоящем изобретении предложены соединения формулы (I), где R, R, R, R, R, R, Х и L имеют любые значения, определенные в описании, и их фармацевтически приемлемые соли, полезные в качестве агентов при лечении расстройств и состояний центральной нервной системы, включая синдром дефицита внимания и гиперактивности, невропатическую боль, недержание мочи, тревогу, депрессию, шизофрению и фибромиалгию. Также предложены фармацевтические композиции, содержащие одно или более чем одно из соединений формулы (I).
EA200700963A 2004-11-29 2005-11-17 Терапевтические пиразоло[3,4-b]пиридины и индазолы EA012245B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63138604P 2004-11-29 2004-11-29
PCT/IB2005/003549 WO2006056873A2 (en) 2004-11-29 2005-11-17 Therapeutic pyrazolo[3,4-b] pyridines and indazoles

Publications (2)

Publication Number Publication Date
EA200700963A1 true EA200700963A1 (ru) 2008-02-28
EA012245B1 EA012245B1 (ru) 2009-08-28

Family

ID=36218221

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700963A EA012245B1 (ru) 2004-11-29 2005-11-17 Терапевтические пиразоло[3,4-b]пиридины и индазолы

Country Status (29)

Country Link
US (3) US7423054B2 (ru)
EP (1) EP1828182B1 (ru)
JP (1) JP4130219B2 (ru)
KR (1) KR20070094747A (ru)
CN (1) CN101111494A (ru)
AP (1) AP2007004024A0 (ru)
AR (1) AR051970A1 (ru)
AT (1) ATE460415T1 (ru)
AU (1) AU2005308523B2 (ru)
BR (1) BRPI0518693A2 (ru)
CA (1) CA2588812A1 (ru)
CR (1) CR9155A (ru)
DE (1) DE602005019913D1 (ru)
DK (1) DK1828182T3 (ru)
EA (1) EA012245B1 (ru)
ES (1) ES2339794T3 (ru)
GT (1) GT200500348A (ru)
IL (1) IL183485A0 (ru)
MA (1) MA29215B1 (ru)
MX (1) MX2007006408A (ru)
NL (2) NL1030540C2 (ru)
NO (1) NO20072972L (ru)
PA (1) PA8653901A1 (ru)
PE (1) PE20061062A1 (ru)
TN (1) TNSN07207A1 (ru)
TW (1) TWI304063B (ru)
UY (1) UY29228A1 (ru)
WO (1) WO2006056873A2 (ru)
ZA (1) ZA200704408B (ru)

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JP2010043063A (ja) 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
US9938269B2 (en) 2011-06-30 2018-04-10 Abbvie Inc. Inhibitor compounds of phosphodiesterase type 10A
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CN107082763A (zh) * 2016-02-15 2017-08-22 中山大学 一种合成吲唑酮类化合物的方法
WO2022254395A1 (en) * 2021-06-04 2022-12-08 Pi Industries Ltd. A novel process for the preparation of anthranilic diamides

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CA2588812A1 (en) 2006-06-01
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ATE460415T1 (de) 2010-03-15
AR051970A1 (es) 2007-02-21
JP2008528444A (ja) 2008-07-31
GT200500348A (es) 2006-06-13
WO2006056873A3 (en) 2006-12-28
UY29228A1 (es) 2006-06-30
US7423054B2 (en) 2008-09-09
PA8653901A1 (es) 2006-09-22
US7485636B2 (en) 2009-02-03
US20060217376A1 (en) 2006-09-28
NO20072972L (no) 2007-08-23
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TW200631582A (en) 2006-09-16
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