AR051970A1 - Pirazolo [3,4-b] piridinas e indazoles terapeuticos - Google Patents
Pirazolo [3,4-b] piridinas e indazoles terapeuticosInfo
- Publication number
- AR051970A1 AR051970A1 ARP050104934A ARP050104934A AR051970A1 AR 051970 A1 AR051970 A1 AR 051970A1 AR P050104934 A ARP050104934 A AR P050104934A AR P050104934 A ARP050104934 A AR P050104934A AR 051970 A1 AR051970 A1 AR 051970A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- pyridinyl
- piperidinyl
- halo
- methoxy
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/12—Antiepileptics; Anticonvulsants for grand-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Son utiles como agente en el tratamiento de trastornos y enfermedades del sistema nervioso central incluyendo el trastorno de déficit de atencion con hiperactividad, dolor neuropático, incontinencia urinaria, ansiedad, depresion, y esquizofrenia y fibromialgia. También se proporcionan composiciones farmacéuticas que comprenden uno o más compuestos de la formula (1). Reivindicacion 1: Un compuesto caracterizado por ser de formula (1), o una de sus sales farmacéuticamente aceptables; en el que: X es N o C(R4); R2 es 2-piridinilo o fenilo, pudiendo estar dicho 2-piridinilo o dicho fenilo opcionalmente sustituido con uno a tres sustituyentes seleccionados independientemente del grupo que consiste en: hidrogeno, halo, metilo, etilo, CF3, metoxi, CH2F, CHF2, y CH2OH; L está ausente o es metileno; R3 se selecciona del grupo que consiste en: 3-pirrolidinilo, 4-piperidinilo, 3-piperidinilo, y 2-morfolinilo; y R4, R5; R6, y R7 son H; o tres de R4, R5, R6, y R7 son H y uno de R4, R5,, R6, y R7 se selecciona del grupo que consiste en: halo, metoxi, y un alquilo C1-3.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63138604P | 2004-11-29 | 2004-11-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR051970A1 true AR051970A1 (es) | 2007-02-21 |
Family
ID=36218221
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050104934A AR051970A1 (es) | 2004-11-29 | 2005-11-25 | Pirazolo [3,4-b] piridinas e indazoles terapeuticos |
Country Status (29)
Country | Link |
---|---|
US (3) | US7423054B2 (es) |
EP (1) | EP1828182B1 (es) |
JP (1) | JP4130219B2 (es) |
KR (1) | KR20070094747A (es) |
CN (1) | CN101111494A (es) |
AP (1) | AP2007004024A0 (es) |
AR (1) | AR051970A1 (es) |
AT (1) | ATE460415T1 (es) |
AU (1) | AU2005308523B2 (es) |
BR (1) | BRPI0518693A2 (es) |
CA (1) | CA2588812A1 (es) |
CR (1) | CR9155A (es) |
DE (1) | DE602005019913D1 (es) |
DK (1) | DK1828182T3 (es) |
EA (1) | EA012245B1 (es) |
ES (1) | ES2339794T3 (es) |
GT (1) | GT200500348A (es) |
IL (1) | IL183485A0 (es) |
MA (1) | MA29215B1 (es) |
MX (1) | MX2007006408A (es) |
NL (2) | NL1030540C2 (es) |
NO (1) | NO20072972L (es) |
PA (1) | PA8653901A1 (es) |
PE (1) | PE20061062A1 (es) |
TN (1) | TNSN07207A1 (es) |
TW (1) | TWI304063B (es) |
UY (1) | UY29228A1 (es) |
WO (1) | WO2006056873A2 (es) |
ZA (1) | ZA200704408B (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ332762A (en) | 1996-07-24 | 2000-09-29 | Warner Lambert Co | Isobutylgaba and its derivatives for the treatment of pain |
KR20070094747A (ko) * | 2004-11-29 | 2007-09-21 | 워너-램버트 캄파니 엘엘씨 | 치료용 피라졸로[3,4-b]피리딘 및 인다졸 |
JP2010043063A (ja) | 2008-05-09 | 2010-02-25 | Agency For Science Technology & Research | 川崎病の診断及び治療 |
US9938269B2 (en) | 2011-06-30 | 2018-04-10 | Abbvie Inc. | Inhibitor compounds of phosphodiesterase type 10A |
WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
EP2929883A1 (en) * | 2014-04-08 | 2015-10-14 | Institut Pasteur | Pyrazole derivatives as dihydroorotate dehydrogenase (DHODH) inhibitors |
CN107082763A (zh) * | 2016-02-15 | 2017-08-22 | 中山大学 | 一种合成吲唑酮类化合物的方法 |
WO2022254395A1 (en) * | 2021-06-04 | 2022-12-08 | Pi Industries Ltd. | A novel process for the preparation of anthranilic diamides |
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HUP0400343A2 (hu) * | 2001-03-29 | 2004-09-28 | Bristol-Myers Squibb Co. | Ciklopropil-indol-származékok mint szelektív szerotonin-újrafelvétel inhibitorok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
WO2003035005A2 (en) * | 2001-10-26 | 2003-05-01 | University Of Connecticut | Heteroindanes: a new class of potent cannabimimetic ligands |
US20040034101A1 (en) * | 2001-11-05 | 2004-02-19 | Cypress Bioscience, Inc. | Treatment and prevention of depression secondary to pain (DSP) |
JP2003146879A (ja) | 2001-11-08 | 2003-05-21 | Dai Ichi Seiyaku Co Ltd | 精神分裂病治療及び/又は予防薬 |
JP2003146973A (ja) | 2001-11-08 | 2003-05-21 | Dai Ichi Seiyaku Co Ltd | うつ病、うつ状態又は不安障害の治療及び/又は予防薬 |
WO2003076408A2 (en) * | 2002-03-08 | 2003-09-18 | Abbott Laboratories | Indazole derivatives that are activators of soluble guanylate cyclase |
US7057042B2 (en) * | 2002-05-29 | 2006-06-06 | Abbott Laboratories | Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction |
WO2003101994A1 (en) | 2002-05-29 | 2003-12-11 | Abbott Laboratories | Fused bicyclic aromatic compounds that are useful in treating sexual dysfunction |
AR043633A1 (es) * | 2003-03-20 | 2005-08-03 | Schering Corp | Ligandos de receptores de canabinoides |
US20060019967A1 (en) * | 2004-07-21 | 2006-01-26 | Su-Ying Wu | SARS CoV main protease inhibitors |
KR20070094747A (ko) * | 2004-11-29 | 2007-09-21 | 워너-램버트 캄파니 엘엘씨 | 치료용 피라졸로[3,4-b]피리딘 및 인다졸 |
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2005
- 2005-11-17 KR KR1020077014752A patent/KR20070094747A/ko active IP Right Grant
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- 2005-11-17 WO PCT/IB2005/003549 patent/WO2006056873A2/en active Application Filing
- 2005-11-17 DE DE602005019913T patent/DE602005019913D1/de active Active
- 2005-11-17 CA CA002588812A patent/CA2588812A1/en not_active Abandoned
- 2005-11-17 EA EA200700963A patent/EA012245B1/ru not_active IP Right Cessation
- 2005-11-17 DK DK05806091.4T patent/DK1828182T3/da active
- 2005-11-17 EP EP05806091A patent/EP1828182B1/en active Active
- 2005-11-17 CN CNA2005800474774A patent/CN101111494A/zh active Pending
- 2005-11-17 ES ES05806091T patent/ES2339794T3/es active Active
- 2005-11-17 AP AP2007004024A patent/AP2007004024A0/xx unknown
- 2005-11-17 AU AU2005308523A patent/AU2005308523B2/en not_active Ceased
- 2005-11-17 JP JP2007542168A patent/JP4130219B2/ja not_active Expired - Fee Related
- 2005-11-25 AR ARP050104934A patent/AR051970A1/es not_active Application Discontinuation
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