MA26985A1 - Derives d'amides de thiazolyl-,oxazolyl-pyrrolyl-et imidazolyl-acides utiles comme inhibiteurs d'isozymes pde4 - Google Patents
Derives d'amides de thiazolyl-,oxazolyl-pyrrolyl-et imidazolyl-acides utiles comme inhibiteurs d'isozymes pde4Info
- Publication number
- MA26985A1 MA26985A1 MA27243A MA27243A MA26985A1 MA 26985 A1 MA26985 A1 MA 26985A1 MA 27243 A MA27243 A MA 27243A MA 27243 A MA27243 A MA 27243A MA 26985 A1 MA26985 A1 MA 26985A1
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- group
- inhibitors
- alkyl
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Abstract
DEPOSANT Société dite : PFIZER PRODUCTS INC. REVENDICATION DE PRIORITES US 31 Janvier 2001 60/265,486 Voir en annexe le titre de l'invention et le texte de l'abrégé Dérivés d'amides de thiazolyl-, oxazolyl-, pyrrolyl- et imidazolyl-acides utiles comme inhibiteurs d'isozymes PDE4 Composés utiles comme inhibiteurs de PDE4 dans le traitement de maladies, régulées par l'activation et la dégranulation des cellules éosinophiles, notamment l'asthme, la bronchite chronique, et une maladie pulmonaire obstructive chronique, de formule (I), dans laquelle j est égal à 0 ou 1 ; k est égal à 0 ou 1 ; m est égal à 0, 1, 2 ou 3 ; n est égal à 1 ou 2 ; W1 représente un groupe -O- ; ou -S(=O)t-, dans lequel t est égal à 0, 1 ou 2 ; ou -N(R3)- ; W2 représente un groupe -O-CRARB-ou est absent ; Y représente un groupe =C(R1a) ou - [N(flèche) (O) k] -, dans lequel k est égal à 0 ou 1 ; RA et RB représentent des groupes -H ; -F ; -CF3 ; -(alkyle en C1 à C4) ; - (cycloalkyle en C3 à C7), phényle ; ou benzyle substitué avec 0 à 3 substituants R10 ; ou bien RA et RB sont pris conjointement, mais seulement dans le cas oé m est égal à 1, pour former un groupement spiro ; Rc et RD répondent aux définitions de RA et RB, sauf qu'un d'entre eux doit représenter -H ; R1 et R2 représentent des groupes -H ; -F ; -Cl ; -CN ; -NO2 ; -(alkyle en C1 à C4) ; -(alcynyle en C2 à C4) ; - (fluoralkyle en C1 à C3) ; -OR16 ; ou -C (=O) NR22aR22b ; R3 représente -H ; un groupe -(alkyle en C1 à C3) ; phényle ; benzyle ; ou -OR16; R4, R5 et R6, en plus d'autres définitions, peuvent être pris conjointement pour former la formule (II) ; G1 représente un système de noyau carboné saturé ou insaturé ; dans lequel, facultativement, un atome de carbone peut être remplacé par un hétéroatome choisi entre N, O et S ; G2 représente un système de noyau carboné saturé ou insaturé ; dans lequel un atome de carbone peut être remplacé par un hétéroatome choisi entre N, O et S ; et E est choisi parmi les groupes de formule (III).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26548601P | 2001-01-31 | 2001-01-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA26985A1 true MA26985A1 (fr) | 2004-12-20 |
Family
ID=23010641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA27243A MA26985A1 (fr) | 2001-01-31 | 2003-07-21 | Derives d'amides de thiazolyl-,oxazolyl-pyrrolyl-et imidazolyl-acides utiles comme inhibiteurs d'isozymes pde4 |
Country Status (24)
Country | Link |
---|---|
US (3) | US6559168B2 (fr) |
EP (1) | EP1355907A1 (fr) |
JP (1) | JP2004518691A (fr) |
KR (1) | KR20030072614A (fr) |
CN (1) | CN1489588A (fr) |
BG (1) | BG108039A (fr) |
BR (1) | BR0116850A (fr) |
CA (1) | CA2436551A1 (fr) |
CR (1) | CR7038A (fr) |
CZ (1) | CZ20031903A3 (fr) |
EA (1) | EA200300622A1 (fr) |
EC (1) | ECSP034683A (fr) |
EE (1) | EE200300362A (fr) |
HU (1) | HUP0401305A2 (fr) |
IL (1) | IL156412A0 (fr) |
IS (1) | IS6844A (fr) |
MA (1) | MA26985A1 (fr) |
MX (1) | MXPA03006886A (fr) |
NO (1) | NO20033398L (fr) |
OA (1) | OA12542A (fr) |
PL (1) | PL365443A1 (fr) |
TN (1) | TNSN03050A1 (fr) |
WO (1) | WO2002060898A1 (fr) |
ZA (1) | ZA200305769B (fr) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1371650A4 (fr) * | 2001-03-23 | 2005-05-04 | Nippon Chemiphar Co | Activateur de recepteur active par les proliferateurs du peroxysome |
US20030055026A1 (en) | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
MXPA03010679A (es) * | 2001-05-23 | 2004-03-02 | Tanabe Seiyaku Co | Una composicion para acelerar la cicatrizacion de fractura osea. |
US20040180900A1 (en) * | 2001-05-23 | 2004-09-16 | Masaharu Takigawa | Therapeutic composition for repairing chondropathy |
EP1424078A4 (fr) * | 2001-09-04 | 2009-03-25 | Ono Pharmaceutical Co | Medicaments contre les maladies respiratoires renfermant un agent de regulation du recepteur de la sphingosine-1-phosphate |
CZ2004747A3 (cs) * | 2001-12-21 | 2004-11-10 | Novo Nordisk A/S | Deriváty amidů jako GK aktivátory |
EP1465882B1 (fr) * | 2001-12-21 | 2011-08-24 | X-Ceptor Therapeutics, Inc. | Modulateurs heterocycliques de recepteurs nucleaires |
GB0201677D0 (en) | 2002-01-25 | 2002-03-13 | Glaxo Group Ltd | Medicament dispenser |
WO2003063911A1 (fr) * | 2002-02-01 | 2003-08-07 | Anges Mg, Inc. | Compositions pharmaceutiques contenant un leurre et procede d'utilisation |
US20050158371A1 (en) * | 2002-02-12 | 2005-07-21 | Sumitomo Pharmaceuticals Co., Ltd. | Novel external agent |
KR101116627B1 (ko) * | 2002-06-27 | 2012-10-09 | 노보 노르디스크 에이/에스 | 치료제로서 아릴 카르보닐 유도체 |
GB0217196D0 (en) * | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicament dispenser |
FI114917B (fi) * | 2002-08-29 | 2005-01-31 | Hormos Nutraceutical Oy Ltd | Lignaanikomplekseja |
WO2004047817A1 (fr) * | 2002-11-27 | 2004-06-10 | Altana Pharma Ag | Inhibiteurs de pde4 et pde3/4 que l'on utilise dans le traitement de la cachexie |
EP1424101A3 (fr) * | 2002-11-29 | 2004-08-18 | NOZAKI, Masako | Utilisation d'un antagoniste du leucotriène c4/d4 pour la préparation d'un médicament pour le traitement ou la prévention d'une inflammation ou septicémie du cerveau |
US7148248B2 (en) * | 2002-11-29 | 2006-12-12 | Masako Nozaki | Method of treating or inhibiting the development of brain inflammation and sepsis |
JP2006516548A (ja) | 2002-12-30 | 2006-07-06 | アンジオテック インターナショナル アクツィエン ゲゼルシャフト | 迅速ゲル化ポリマー組成物からの薬物送達法 |
GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
US20050079548A1 (en) * | 2003-07-07 | 2005-04-14 | Plexxikon, Inc. | Ligand development using PDE4B crystal structures |
GB0317482D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
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-
2001
- 2001-12-24 HU HU0401305A patent/HUP0401305A2/hu unknown
- 2001-12-24 CZ CZ20031903A patent/CZ20031903A3/cs unknown
- 2001-12-24 OA OA1200300177A patent/OA12542A/en unknown
- 2001-12-24 PL PL01365443A patent/PL365443A1/xx not_active Application Discontinuation
- 2001-12-24 KR KR10-2003-7010071A patent/KR20030072614A/ko not_active Application Discontinuation
- 2001-12-24 EP EP01273600A patent/EP1355907A1/fr not_active Withdrawn
- 2001-12-24 JP JP2002561466A patent/JP2004518691A/ja active Pending
- 2001-12-24 IL IL15641201A patent/IL156412A0/xx unknown
- 2001-12-24 CA CA002436551A patent/CA2436551A1/fr not_active Abandoned
- 2001-12-24 CN CNA018224431A patent/CN1489588A/zh active Pending
- 2001-12-24 EA EA200300622A patent/EA200300622A1/ru unknown
- 2001-12-24 EE EEP200300362A patent/EE200300362A/xx unknown
- 2001-12-24 MX MXPA03006886A patent/MXPA03006886A/es active IP Right Grant
- 2001-12-24 WO PCT/IB2001/002728 patent/WO2002060898A1/fr not_active Application Discontinuation
- 2001-12-24 BR BR0116850-9A patent/BR0116850A/pt not_active IP Right Cessation
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2002
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- 2003-07-04 EC EC2003004683A patent/ECSP034683A/es unknown
- 2003-07-08 TN TNPCT/IB2001/002728A patent/TNSN03050A1/fr unknown
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- 2003-07-25 ZA ZA200305769A patent/ZA200305769B/en unknown
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- 2003-07-29 CR CR7038A patent/CR7038A/es not_active Application Discontinuation
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BG108039A (en) | 2004-07-30 |
CN1489588A (zh) | 2004-04-14 |
US20030186974A1 (en) | 2003-10-02 |
US6559168B2 (en) | 2003-05-06 |
BR0116850A (pt) | 2004-02-25 |
AU2002222429A2 (fr) | 2002-08-12 |
US6894041B2 (en) | 2005-05-17 |
EE200300362A (et) | 2003-12-15 |
IL156412A0 (en) | 2004-01-04 |
NO20033398L (no) | 2003-09-29 |
ZA200305769B (en) | 2004-10-25 |
EA200300622A1 (ru) | 2003-12-25 |
TNSN03050A1 (fr) | 2005-12-23 |
OA12542A (en) | 2006-06-05 |
US20030130254A1 (en) | 2003-07-10 |
EP1355907A1 (fr) | 2003-10-29 |
NO20033398D0 (no) | 2003-07-30 |
US6869945B2 (en) | 2005-03-22 |
CR7038A (es) | 2004-04-22 |
JP2004518691A (ja) | 2004-06-24 |
CZ20031903A3 (cs) | 2004-07-14 |
CA2436551A1 (fr) | 2002-08-08 |
PL365443A1 (en) | 2005-01-10 |
MXPA03006886A (es) | 2003-11-13 |
IS6844A (is) | 2003-06-16 |
ECSP034683A (es) | 2003-08-29 |
HUP0401305A2 (hu) | 2004-10-28 |
US20020123520A1 (en) | 2002-09-05 |
WO2002060898A1 (fr) | 2002-08-08 |
KR20030072614A (ko) | 2003-09-15 |
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