MA26985A1 - Derives d'amides de thiazolyl-,oxazolyl-pyrrolyl-et imidazolyl-acides utiles comme inhibiteurs d'isozymes pde4 - Google Patents
Derives d'amides de thiazolyl-,oxazolyl-pyrrolyl-et imidazolyl-acides utiles comme inhibiteurs d'isozymes pde4Info
- Publication number
- MA26985A1 MA26985A1 MA27243A MA27243A MA26985A1 MA 26985 A1 MA26985 A1 MA 26985A1 MA 27243 A MA27243 A MA 27243A MA 27243 A MA27243 A MA 27243A MA 26985 A1 MA26985 A1 MA 26985A1
- Authority
- MA
- Morocco
- Prior art keywords
- group
- inhibitors
- alkyl
- represent
- groups
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Virology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- AIDS & HIV (AREA)
- Vascular Medicine (AREA)
Abstract
DEPOSANT Société dite : PFIZER PRODUCTS INC. REVENDICATION DE PRIORITES US 31 Janvier 2001 60/265,486 Voir en annexe le titre de l'invention et le texte de l'abrégé Dérivés d'amides de thiazolyl-, oxazolyl-, pyrrolyl- et imidazolyl-acides utiles comme inhibiteurs d'isozymes PDE4 Composés utiles comme inhibiteurs de PDE4 dans le traitement de maladies, régulées par l'activation et la dégranulation des cellules éosinophiles, notamment l'asthme, la bronchite chronique, et une maladie pulmonaire obstructive chronique, de formule (I), dans laquelle j est égal à 0 ou 1 ; k est égal à 0 ou 1 ; m est égal à 0, 1, 2 ou 3 ; n est égal à 1 ou 2 ; W1 représente un groupe -O- ; ou -S(=O)t-, dans lequel t est égal à 0, 1 ou 2 ; ou -N(R3)- ; W2 représente un groupe -O-CRARB-ou est absent ; Y représente un groupe =C(R1a) ou - [N(flèche) (O) k] -, dans lequel k est égal à 0 ou 1 ; RA et RB représentent des groupes -H ; -F ; -CF3 ; -(alkyle en C1 à C4) ; - (cycloalkyle en C3 à C7), phényle ; ou benzyle substitué avec 0 à 3 substituants R10 ; ou bien RA et RB sont pris conjointement, mais seulement dans le cas oé m est égal à 1, pour former un groupement spiro ; Rc et RD répondent aux définitions de RA et RB, sauf qu'un d'entre eux doit représenter -H ; R1 et R2 représentent des groupes -H ; -F ; -Cl ; -CN ; -NO2 ; -(alkyle en C1 à C4) ; -(alcynyle en C2 à C4) ; - (fluoralkyle en C1 à C3) ; -OR16 ; ou -C (=O) NR22aR22b ; R3 représente -H ; un groupe -(alkyle en C1 à C3) ; phényle ; benzyle ; ou -OR16; R4, R5 et R6, en plus d'autres définitions, peuvent être pris conjointement pour former la formule (II) ; G1 représente un système de noyau carboné saturé ou insaturé ; dans lequel, facultativement, un atome de carbone peut être remplacé par un hétéroatome choisi entre N, O et S ; G2 représente un système de noyau carboné saturé ou insaturé ; dans lequel un atome de carbone peut être remplacé par un hétéroatome choisi entre N, O et S ; et E est choisi parmi les groupes de formule (III).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26548601P | 2001-01-31 | 2001-01-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA26985A1 true MA26985A1 (fr) | 2004-12-20 |
Family
ID=23010641
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA27243A MA26985A1 (fr) | 2001-01-31 | 2003-07-21 | Derives d'amides de thiazolyl-,oxazolyl-pyrrolyl-et imidazolyl-acides utiles comme inhibiteurs d'isozymes pde4 |
Country Status (24)
Country | Link |
---|---|
US (3) | US6559168B2 (fr) |
EP (1) | EP1355907A1 (fr) |
JP (1) | JP2004518691A (fr) |
KR (1) | KR20030072614A (fr) |
CN (1) | CN1489588A (fr) |
BG (1) | BG108039A (fr) |
BR (1) | BR0116850A (fr) |
CA (1) | CA2436551A1 (fr) |
CR (1) | CR7038A (fr) |
CZ (1) | CZ20031903A3 (fr) |
EA (1) | EA200300622A1 (fr) |
EC (1) | ECSP034683A (fr) |
EE (1) | EE200300362A (fr) |
HU (1) | HUP0401305A2 (fr) |
IL (1) | IL156412A0 (fr) |
IS (1) | IS6844A (fr) |
MA (1) | MA26985A1 (fr) |
MX (1) | MXPA03006886A (fr) |
NO (1) | NO20033398L (fr) |
OA (1) | OA12542A (fr) |
PL (1) | PL365443A1 (fr) |
TN (1) | TNSN03050A1 (fr) |
WO (1) | WO2002060898A1 (fr) |
ZA (1) | ZA200305769B (fr) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1371650A4 (fr) * | 2001-03-23 | 2005-05-04 | Nippon Chemiphar Co | Activateur de recepteur active par les proliferateurs du peroxysome |
US20030055026A1 (en) | 2001-04-17 | 2003-03-20 | Dey L.P. | Formoterol/steroid bronchodilating compositions and methods of use thereof |
MXPA03010672A (es) * | 2001-05-23 | 2004-03-02 | Tanabe Seiyaku Co | Composicion para el tratamiento regenerativo de enfermedades del cartilago. |
MXPA03010679A (es) * | 2001-05-23 | 2004-03-02 | Tanabe Seiyaku Co | Una composicion para acelerar la cicatrizacion de fractura osea. |
WO2003020313A1 (fr) * | 2001-09-04 | 2003-03-13 | Ono Pharmaceutical Co., Ltd. | Medicaments contre les maladies respiratoires renfermant un agent de regulation du recepteur de la sphingosine-1-phosphate |
CN100506807C (zh) * | 2001-12-21 | 2009-07-01 | 诺沃挪第克公司 | 作为gk活化剂的酰胺衍生物 |
ATE521599T1 (de) * | 2001-12-21 | 2011-09-15 | X Ceptor Therapeutics Inc | Heterocyclische modulatoren von nukleären rezeptoren |
GB0201677D0 (en) * | 2002-01-25 | 2002-03-13 | Glaxo Group Ltd | Medicament dispenser |
DE60231063D1 (de) * | 2002-02-01 | 2009-03-19 | Anges Mg Inc | N zur behandlung von aneurysmen |
US20050158371A1 (en) * | 2002-02-12 | 2005-07-21 | Sumitomo Pharmaceuticals Co., Ltd. | Novel external agent |
EP2471533A1 (fr) * | 2002-06-27 | 2012-07-04 | Novo Nordisk A/S | Dérivés d'aryle carbonyle en tant qu'agents thérapeutiques |
GB0217196D0 (en) * | 2002-07-25 | 2002-09-04 | Glaxo Group Ltd | Medicament dispenser |
FI114917B (fi) * | 2002-08-29 | 2005-01-31 | Hormos Nutraceutical Oy Ltd | Lignaanikomplekseja |
US20060079540A1 (en) * | 2002-11-27 | 2006-04-13 | Altana Pharma Ag | Pde4 and pde3/4 inhibitors for use in the treatment of cachexia |
EP1424101A3 (fr) * | 2002-11-29 | 2004-08-18 | NOZAKI, Masako | Utilisation d'un antagoniste du leucotriène c4/d4 pour la préparation d'un médicament pour le traitement ou la prévention d'une inflammation ou septicémie du cerveau |
US7148248B2 (en) * | 2002-11-29 | 2006-12-12 | Masako Nozaki | Method of treating or inhibiting the development of brain inflammation and sepsis |
US20040225077A1 (en) | 2002-12-30 | 2004-11-11 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
GB0302094D0 (en) | 2003-01-29 | 2003-02-26 | Pharmagene Lab Ltd | EP4 receptor antagonists |
US20050079548A1 (en) * | 2003-07-07 | 2005-04-14 | Plexxikon, Inc. | Ligand development using PDE4B crystal structures |
US7132435B2 (en) * | 2003-07-25 | 2006-11-07 | Pfizer Inc. | Compounds |
US20050020587A1 (en) * | 2003-07-25 | 2005-01-27 | Pfizer Inc | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0317484D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
GB0317498D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Compounds |
US7153870B2 (en) | 2003-07-25 | 2006-12-26 | Pfizer Inc. | Nicotinamide derivatives useful as PDE4 inhibitors |
GB0317482D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
GB0317516D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
US20050187278A1 (en) * | 2003-08-28 | 2005-08-25 | Pharmacia Corporation | Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors |
AU2004269923B2 (en) * | 2003-09-05 | 2010-05-13 | Takeda Gmbh | Use of PDE4 inhibitors for the treatment of diabetes mellitus |
US7534894B2 (en) * | 2003-09-25 | 2009-05-19 | Wyeth | Biphenyloxy-acids |
GB0324269D0 (en) | 2003-10-16 | 2003-11-19 | Pharmagene Lab Ltd | EP4 receptor antagonists |
PT1723128E (pt) * | 2004-01-06 | 2013-02-27 | Novo Nordisk As | Heteroaril-ureias e o seu uso como activadores da glicoquinase |
US20090042951A1 (en) * | 2004-02-20 | 2009-02-12 | Robert Danziger | Blood Pressure Reduction in Salt-Sensitive Hypertension |
WO2005102388A1 (fr) * | 2004-04-26 | 2005-11-03 | Ono Pharmaceutical Co., Ltd. | Nouvelle maladie médiée par blt2, et agent et composé de liaison à blt2 |
CA2565965A1 (fr) * | 2004-05-06 | 2006-07-27 | Plexxikon, Inc. | Inhibiteurs de pde4b |
KR101242310B1 (ko) * | 2004-05-17 | 2013-03-12 | 오츠카 세이야쿠 가부시키가이샤 | 티아졸 화합물 및 그의 용도 |
US20060004185A1 (en) * | 2004-07-01 | 2006-01-05 | Leese Richard A | Peptide antibiotics and peptide intermediates for their prepartion |
CA2583428A1 (fr) * | 2004-09-03 | 2006-03-09 | Plexxikon, Inc. | Inhibiteurs de la phosphodiesterase 4b (pde4b) |
US7704522B2 (en) * | 2004-09-08 | 2010-04-27 | Clyde Morgan | Topical medicament |
WO2006094942A1 (fr) * | 2005-03-08 | 2006-09-14 | Nycomed Gmbh | Roflumilast pour le traitement du diabète sucré |
NZ560269A (en) * | 2005-03-08 | 2010-12-24 | Nycomed Gmbh | Roflumilast for the treatment of diabetes mellitus |
PL2366393T3 (pl) * | 2005-04-19 | 2014-01-31 | Takeda Gmbh | Roflumilast do leczenia nadciśnienia płucnego |
EP1904438B1 (fr) * | 2005-07-08 | 2012-02-29 | Novo Nordisk A/S | Dicycloalkylcarbamoylurées en tant qu' activateurs de glucokinase |
WO2007006814A1 (fr) * | 2005-07-14 | 2007-01-18 | Novo Nordisk A/S | Activateurs de l'uree glucokinase |
EP2258358A3 (fr) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenèse avec un inhibiteur de l'acetylcholinestérase |
EP2275095A3 (fr) | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenese par modulation des recepteurs muscariniques |
CN1954882A (zh) * | 2005-10-14 | 2007-05-02 | 李海 | 长效人重组可溶性肿瘤坏死因子α受体在制备防治肝衰竭药物中的用途 |
CA2625153A1 (fr) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation de la neurogenese par inhibition de la pde |
TWI385169B (zh) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
JP2009513672A (ja) | 2005-10-31 | 2009-04-02 | ブレインセルス,インコーポレイティド | 神経発生のgaba受容体媒介調節 |
KR20080065704A (ko) | 2005-11-09 | 2008-07-14 | 콤비네이토릭스, 인코포레이티드 | 의학적 이상의 치료 방법들, 조성물들, 및 키트들 |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
CA2651862A1 (fr) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenese induite par le recepteur 5ht |
EP2021000A2 (fr) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenèse par modulation de l'angiotensine |
JP5259592B2 (ja) * | 2006-08-11 | 2013-08-07 | メルク カナダ インコーポレイテッド | Ep4受容体リガンドとしてのチオフェンカルボキサミド誘導体 |
AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
EP2118083A1 (fr) * | 2007-01-09 | 2009-11-18 | Novo Nordisk A/S | Activateurs de la glucokinase à base d'urée |
WO2008084044A1 (fr) | 2007-01-11 | 2008-07-17 | Novo Nordisk A/S | Activateurs de l'urée glucokinase |
CA2676357A1 (fr) | 2007-01-24 | 2008-07-31 | Glaxo Group Limited | Nouvelles compositions pharmaceutiques |
KR20100090289A (ko) * | 2007-11-21 | 2010-08-13 | 디코드 제네틱스 이에이치에프 | 염증, 심혈관 및 중추신경계 질환의 치료를 위한 치환된 벤조아졸 pde4 억제제 |
US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
KR20110005828A (ko) * | 2008-03-28 | 2011-01-19 | 콘서트 파마슈티컬즈, 인크. | 퀴나졸린 유도체 및 치료방법 |
US10517839B2 (en) * | 2008-06-09 | 2019-12-31 | Cornell University | Mast cell inhibition in diseases of the retina and vitreous |
TW201035111A (en) | 2008-12-23 | 2010-10-01 | Biosource Pharm Inc | Antibiotic compositions for the treatment of gram negative infections |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
ES2469849T3 (es) | 2009-06-18 | 2014-06-20 | Concert Pharmaceuticals Inc. | Derivados deuterados de isoindolin-1,3-diona como inhibidores de PDE4 y TNF-alfa |
US8415307B1 (en) | 2010-06-23 | 2013-04-09 | Biosource Pharm, Inc. | Antibiotic compositions for the treatment of gram negative infections |
WO2013106547A1 (fr) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Composés promoteurs de réplication des cellules bêta et leurs procédés d'utilisation |
TWI617553B (zh) * | 2013-03-13 | 2018-03-11 | 美國禮來大藥廠 | 吖丁啶基氧苯基吡咯啶化合物 |
MY168609A (en) | 2013-06-12 | 2018-11-14 | Kaken Pharma Co Ltd | 4-alkynyl imidazole derivative and medicine comprising same as active ingredient |
TW201625591A (zh) * | 2014-09-12 | 2016-07-16 | 美國禮來大藥廠 | 吖丁啶基氧苯基吡咯啶化合物 |
CN108794620A (zh) * | 2017-05-04 | 2018-11-13 | 南开大学 | 茶碱的偶联物及其制备方法与应用 |
US11866482B2 (en) | 2018-02-07 | 2024-01-09 | Duke University | System and method for homogenous GPCR phosphorylation and identification of beta-2 adrenergic receptor positive allosteric modulators |
AU2019287437A1 (en) | 2018-06-12 | 2020-09-10 | Vtv Therapeutics Llc | Therapeutic uses of glucokinase activators in combination with insulin or insulin analogs |
US11116737B1 (en) | 2020-04-10 | 2021-09-14 | University Of Georgia Research Foundation, Inc. | Methods of using probenecid for treatment of coronavirus infections |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2140772A5 (en) | 1971-06-07 | 1973-01-19 | Aries Robert | Phenoxynicotinoylaminophenols - analgesics tranquillisers antipyretics, anti-inflammatories and antirheumatics |
US4270946A (en) * | 1979-10-01 | 1981-06-02 | Stauffer Chemical Company | N-Aryl,2-phenoxy nicotinamide compounds and the herbicidal use thereof |
US4692185A (en) * | 1986-01-13 | 1987-09-08 | Stauffer Chemical Company | N-(ortho-substituted) benzyl, 3-trifluoromethylphenoxy nicotinamides as herbicides |
US4861891A (en) | 1988-08-31 | 1989-08-29 | Pfizer Inc. | Antidepressant N-substituted nicotinamide compounds |
EP0500989B1 (fr) | 1991-02-27 | 1998-12-09 | Lacer, S.A. | Agents antihypertensifs dipeptidiques N-(pyridyl-alpha-substituée) carbonyle |
DE4200323A1 (de) | 1992-01-09 | 1993-07-15 | Bayer Ag | Herbizide und pflanzennematizide mittel auf basis von mercaptonicotinsaeurederivaten |
HU225869B1 (en) | 1992-04-02 | 2007-11-28 | Smithkline Beecham Corp | Compounds with antiallergic and antiinflammatory activity and pharmaceutical compns. contg. them |
ES2229221T3 (es) | 1993-06-18 | 2005-04-16 | Smithkline Beecham Corporation | Procedimiento de identificacion de un inhibidor de pde iv. |
JP3406689B2 (ja) | 1994-03-15 | 2003-05-12 | 株式会社大塚製薬工場 | ナフチリジン及びピリドピラジン誘導体 |
US5618027A (en) * | 1994-07-20 | 1997-04-08 | Nevrekar; Venkatesh R. | Gate valve |
EP0796096A4 (fr) | 1994-12-23 | 1998-04-29 | Smithkline Beecham Corp | Monomeres 4,4-(disubstitues)cyclohexan-1-carboxylate et composes correspondants |
TW429148B (en) * | 1995-10-27 | 2001-04-11 | Pfizer | Pharmaceutical agents for the treatment of acute and chronic inflammatory diseases |
GB9622386D0 (en) | 1996-10-28 | 1997-01-08 | Sandoz Ltd | Organic compounds |
US5922557A (en) | 1997-01-09 | 1999-07-13 | Merck & Co., Inc. | System for stably expressing a high-affinity camp phosphodiesterase and use thereof |
TR199902432T2 (xx) | 1997-04-04 | 2000-01-21 | Prizer Products Inc. | Nikotinamid t�revleri. |
GB9715584D0 (en) * | 1997-07-23 | 1997-10-01 | Eisai Co Ltd | Compounds |
UA67753C2 (uk) | 1997-10-10 | 2004-07-15 | Смітклайн Бічам Корпорейшн | Спосіб отримання заміщених 4-феніл-4-ціанциклогексанових кислот |
AR015966A1 (es) | 1997-10-17 | 2001-05-30 | Smithkline Beecham Corp | Uso de un compuesto inhibidor de pde4 para la preparacion de un medicamento util para el tratamiento de prurito |
MA24682A1 (fr) | 1997-10-23 | 1999-07-01 | Smithkline Beecham Corp | Formes polymorphes nouvelles de cipamfylline, procede pour leur preparation et compositions les contenant |
JP3917863B2 (ja) * | 2000-01-31 | 2007-05-23 | ファイザー・プロダクツ・インク | Pde4アイソザイムの選択的阻害薬として有用なニコチンアミドベンゾ縮合複素環誘導体 |
US6740655B2 (en) * | 2000-01-31 | 2004-05-25 | Pfizer Inc | Pyrimidine carboxamides useful as inhibitors of PDE4 isozymes |
-
2001
- 2001-12-24 HU HU0401305A patent/HUP0401305A2/hu unknown
- 2001-12-24 EA EA200300622A patent/EA200300622A1/ru unknown
- 2001-12-24 OA OA1200300177A patent/OA12542A/en unknown
- 2001-12-24 KR KR10-2003-7010071A patent/KR20030072614A/ko not_active Application Discontinuation
- 2001-12-24 CA CA002436551A patent/CA2436551A1/fr not_active Abandoned
- 2001-12-24 MX MXPA03006886A patent/MXPA03006886A/es active IP Right Grant
- 2001-12-24 WO PCT/IB2001/002728 patent/WO2002060898A1/fr not_active Application Discontinuation
- 2001-12-24 EP EP01273600A patent/EP1355907A1/fr not_active Withdrawn
- 2001-12-24 CZ CZ20031903A patent/CZ20031903A3/cs unknown
- 2001-12-24 BR BR0116850-9A patent/BR0116850A/pt not_active IP Right Cessation
- 2001-12-24 EE EEP200300362A patent/EE200300362A/xx unknown
- 2001-12-24 PL PL01365443A patent/PL365443A1/xx not_active Application Discontinuation
- 2001-12-24 IL IL15641201A patent/IL156412A0/xx unknown
- 2001-12-24 CN CNA018224431A patent/CN1489588A/zh active Pending
- 2001-12-24 JP JP2002561466A patent/JP2004518691A/ja active Pending
-
2002
- 2002-01-31 US US10/062,145 patent/US6559168B2/en not_active Expired - Fee Related
- 2002-11-20 US US10/300,950 patent/US6869945B2/en not_active Expired - Fee Related
- 2002-11-20 US US10/300,959 patent/US6894041B2/en not_active Expired - Fee Related
-
2003
- 2003-06-16 IS IS6844A patent/IS6844A/is unknown
- 2003-07-04 EC EC2003004683A patent/ECSP034683A/es unknown
- 2003-07-08 TN TNPCT/IB2001/002728A patent/TNSN03050A1/fr unknown
- 2003-07-21 MA MA27243A patent/MA26985A1/fr unknown
- 2003-07-25 ZA ZA200305769A patent/ZA200305769B/en unknown
- 2003-07-28 BG BG108039A patent/BG108039A/xx unknown
- 2003-07-29 CR CR7038A patent/CR7038A/es not_active Application Discontinuation
- 2003-07-30 NO NO20033398A patent/NO20033398L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO20033398L (no) | 2003-09-29 |
CN1489588A (zh) | 2004-04-14 |
NO20033398D0 (no) | 2003-07-30 |
BG108039A (en) | 2004-07-30 |
PL365443A1 (en) | 2005-01-10 |
US20030186974A1 (en) | 2003-10-02 |
US6869945B2 (en) | 2005-03-22 |
EA200300622A1 (ru) | 2003-12-25 |
AU2002222429A2 (fr) | 2002-08-12 |
CR7038A (es) | 2004-04-22 |
US6559168B2 (en) | 2003-05-06 |
IL156412A0 (en) | 2004-01-04 |
ZA200305769B (en) | 2004-10-25 |
MXPA03006886A (es) | 2003-11-13 |
IS6844A (is) | 2003-06-16 |
KR20030072614A (ko) | 2003-09-15 |
TNSN03050A1 (fr) | 2005-12-23 |
CA2436551A1 (fr) | 2002-08-08 |
WO2002060898A1 (fr) | 2002-08-08 |
US20030130254A1 (en) | 2003-07-10 |
EE200300362A (et) | 2003-12-15 |
HUP0401305A2 (hu) | 2004-10-28 |
OA12542A (en) | 2006-06-05 |
CZ20031903A3 (cs) | 2004-07-14 |
US6894041B2 (en) | 2005-05-17 |
BR0116850A (pt) | 2004-02-25 |
EP1355907A1 (fr) | 2003-10-29 |
JP2004518691A (ja) | 2004-06-24 |
ECSP034683A (es) | 2003-08-29 |
US20020123520A1 (en) | 2002-09-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA26985A1 (fr) | Derives d'amides de thiazolyl-,oxazolyl-pyrrolyl-et imidazolyl-acides utiles comme inhibiteurs d'isozymes pde4 | |
MA26983A1 (fr) | Derives biaryliques de nicotinamide utiles comme inhibiteurs d'iso-enzymes pde4 | |
MA26984A1 (fr) | Derives d'ethers utiles comme inhibiteurs d'isozymes pde4 | |
AU684887B2 (en) | Isoxazoline compounds as inhibitors of TNF release | |
ES2262137T3 (es) | Derivados de pirimidinamina farmacologicamente activos y procedimientos para su preparacion. | |
AU2019250163A1 (en) | Compositions and methods of modulating 15-PGDH activity | |
MA31865B1 (fr) | Dérivés isoxazolo-pyridine | |
JPWO2007142323A1 (ja) | 側鎖にスピロ環構造を有する新規インダゾール誘導体 | |
US9302984B2 (en) | Aryl-phenyl-sulfonamido-cycloalkyl compounds and their use | |
JP2017048212A (ja) | Bace阻害剤 | |
US5326770A (en) | Monoamine oxidase-B (MAO-B) inhibitory 5-substituted 2,4-thiazolidinediones useful in treating memory disorders of mammals | |
US20070066612A1 (en) | Substituted pyrimidine derivatives | |
CA2963681A1 (fr) | Induction de gata2 par des inhibiteurs de hdac1 et hdac2 | |
JP2005516986A (ja) | (オキシム)カルバモイル脂肪酸アミド加水分解酵素インヒビター | |
RU2269519C2 (ru) | Соединения фенилпиридазина и содержащие их лекарственные средства | |
TNSN04156A1 (fr) | Pyridinones substituees servant de modulateurs de la map-kinase p38 | |
FR2679903A1 (fr) | Derives de la n-sulfonyl indoline portant une fonction amidique, leur preparation, les compositions pharmaceutiques en contenant. | |
KR20100075436A (ko) | 칼륨 채널 조절제로서의 5-아미노-4,6-이치환된 인돌 및 5-아미노-4,6-이치환된 인돌린의 유도체 | |
JP2021531335A (ja) | ヒストンデアセチラーゼの二環式阻害剤 | |
AU2006322461A1 (en) | Pyrimidine derivatives and their use as KCNQ potassium channels openers | |
EA009372B1 (ru) | N-ациламинобензольные производные в качестве селективных ингибиторов моноаминооксидазы в | |
JPH06199786A (ja) | ジアミドフタリミドの置換誘導体 | |
RU2248971C2 (ru) | Производные пиримидин-2,4,6-трионов и фармацевтическая композиция, содержащая эти соединения | |
JP2001501221A (ja) | Nmda(n―メチル―d―アスパラギン酸)アンタゴニスト | |
KR20050117563A (ko) | 치환 아닐린 유도체 |