LV12273B - NEW METHOD 7- (REPLACED) -9 - [(REPLACED GLYCYL) AMIDO] -6-DIMETHYL-6-DEOXYDETRACYLS MANUFACTURE - Google Patents

NEW METHOD 7- (REPLACED) -9 - [(REPLACED GLYCYL) AMIDO] -6-DIMETHYL-6-DEOXYDETRACYLS MANUFACTURE Download PDF

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Publication number
LV12273B
LV12273B LVP-99-19A LV990019A LV12273B LV 12273 B LV12273 B LV 12273B LV 990019 A LV990019 A LV 990019A LV 12273 B LV12273 B LV 12273B
Authority
LV
Latvia
Prior art keywords
amino
methylpropyl
butyl
substituted
methyl
Prior art date
Application number
LVP-99-19A
Other languages
English (en)
Latvian (lv)
Other versions
LV12273A (lv
Inventor
Phaik-Eng Sum
Ving J. Lee
Original Assignee
American Cyanamid Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Company filed Critical American Cyanamid Company
Publication of LV12273A publication Critical patent/LV12273A/xx
Publication of LV12273B publication Critical patent/LV12273B/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
LVP-99-19A 1992-08-13 1999-02-08 NEW METHOD 7- (REPLACED) -9 - [(REPLACED GLYCYL) AMIDO] -6-DIMETHYL-6-DEOXYDETRACYLS MANUFACTURE LV12273B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/928,588 US5284963A (en) 1992-08-13 1992-08-13 Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines

Publications (2)

Publication Number Publication Date
LV12273A LV12273A (lv) 1999-05-20
LV12273B true LV12273B (en) 1999-11-20

Family

ID=25456483

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-99-19A LV12273B (en) 1992-08-13 1999-02-08 NEW METHOD 7- (REPLACED) -9 - [(REPLACED GLYCYL) AMIDO] -6-DIMETHYL-6-DEOXYDETRACYLS MANUFACTURE

Country Status (27)

Country Link
US (1) US5284963A (zh)
EP (1) EP0582790B1 (zh)
JP (1) JP3590643B2 (zh)
KR (1) KR100250603B1 (zh)
CN (1) CN1037680C (zh)
AT (1) ATE174903T1 (zh)
AU (1) AU674689B2 (zh)
CA (1) CA2103837C (zh)
CZ (1) CZ286261B6 (zh)
DE (1) DE69322708T2 (zh)
DK (1) DK0582790T3 (zh)
ES (1) ES2125927T3 (zh)
FI (1) FI115722B (zh)
GR (1) GR3029764T3 (zh)
HU (1) HU222886B1 (zh)
IL (3) IL106674A (zh)
LV (1) LV12273B (zh)
MX (1) MX9304649A (zh)
NO (1) NO303574B1 (zh)
NZ (1) NZ248358A (zh)
PH (1) PH30150A (zh)
PL (2) PL173923B1 (zh)
RU (1) RU2111958C1 (zh)
SG (1) SG68556A1 (zh)
SK (1) SK281698B6 (zh)
TW (1) TW221285B (zh)
ZA (1) ZA935891B (zh)

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USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5248797A (en) * 1992-08-13 1993-09-28 American Cyanamid Company Method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
ES2260051T3 (es) * 1999-09-14 2006-11-01 Trustees Of Tufts College Metodo para preparar tetraciclinas substituidas con quimicas basadas en metales de transicion.
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US7094806B2 (en) * 2000-07-07 2006-08-22 Trustees Of Tufts College 7, 8 and 9-substituted tetracycline compounds
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Also Published As

Publication number Publication date
HU9302331D0 (en) 1993-10-28
TW221285B (zh) 1994-02-21
HU222886B1 (hu) 2003-12-29
FI933566A0 (fi) 1993-08-12
CA2103837A1 (en) 1994-02-14
IL106674A0 (en) 1993-12-08
PL300064A1 (en) 1994-02-21
KR940003923A (ko) 1994-03-14
EP0582790A1 (en) 1994-02-16
PH30150A (en) 1997-01-21
CZ157793A3 (en) 1994-03-16
GR3029764T3 (en) 1999-06-30
SK84993A3 (en) 1994-06-08
NO932870L (no) 1994-02-14
DE69322708T2 (de) 1999-04-29
NO303574B1 (no) 1998-08-03
RU2111958C1 (ru) 1998-05-27
HUT64941A (en) 1994-03-28
ZA935891B (en) 1994-03-09
SG68556A1 (en) 1999-11-16
DE69322708D1 (de) 1999-02-04
NZ248358A (en) 1996-04-26
CA2103837C (en) 2004-10-05
IL119551A0 (en) 1997-02-18
FI933566A (fi) 1994-02-14
PL173923B1 (pl) 1998-05-29
JPH06184075A (ja) 1994-07-05
US5284963A (en) 1994-02-08
CN1083047A (zh) 1994-03-02
PL173606B1 (pl) 1998-03-31
KR100250603B1 (ko) 2000-04-01
AU674689B2 (en) 1997-01-09
IL106674A (en) 1998-07-15
ATE174903T1 (de) 1999-01-15
AU4460393A (en) 1994-02-17
JP3590643B2 (ja) 2004-11-17
IL119551A (en) 2003-02-12
FI115722B (fi) 2005-06-30
DK0582790T3 (da) 1999-08-23
LV12273A (lv) 1999-05-20
SK281698B6 (sk) 2001-07-10
CN1037680C (zh) 1998-03-11
MX9304649A (es) 1994-02-28
EP0582790B1 (en) 1998-12-23
NO932870D0 (no) 1993-08-12
ES2125927T3 (es) 1999-03-16
CZ286261B6 (cs) 2000-02-16

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