LV11785B - Metodes t šūnu tolerances izraisīšanai pret audu vai orgāna transplantātu - Google Patents
Metodes t šūnu tolerances izraisīšanai pret audu vai orgāna transplantātu Download PDFInfo
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- LV11785B LV11785B LVP-96-440A LV960440A LV11785B LV 11785 B LV11785 B LV 11785B LV 960440 A LV960440 A LV 960440A LV 11785 B LV11785 B LV 11785B
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Claims (51)
- LV 11785 IZGUDROJUMA FORMULA 1 a) Allogēnas vai ksenogēnas šūnas, kas ekspresē vismaz vienu donora antigēnu un kurai uz šūnas virsmas ir ligands, kas mijiedarbojas ar receptoru uz recipienta T šūnas virsmas, kura ir starpnieks kontaktatkarīgajā helpera efektorajā funkcijā, un b) T šūnas virsmas receptora antagonista, kas inhibē liganda mijiedarbību ar receptoru, izmantošanas metode medikamenta ražošanai audu vai orgāna recipienta T šūnu tolerances izraisīšanai pret donora audiem vai orgānu.
- 2. Metode saskaņā ar 1. punktu, kur receptors uz recipienta T šūnas virsmas ir gp39.
- 3. Metode saskaņā ar 2. punktu, kur antagonists ir anti-gp39 antiviela.
- 4. Metode saskaņā ar 3. punktu, klir anti-gp39 antiviela ir monoklonāla antiviela.
- 5. Metode saskaņā ar 3. punktu, kur anti-gp39 antiviela ir anti-cilvēka gp39 antiviela.
- 6. Metode saskaņā ar 4. punktu, kur monoklonālā antiviela ir MR1.
- 7. Metode saskaņā ar 4. punktu, kur monoklonālā antiviela ir himēra monoklonāla antiviela.
- 8. Metode saskaņā ar 4. punktu, kur monoklonālā antiviela ir humanizēta monoklonāla antiviela.
- 9. Metode saskaņā ar 1. punktu, kur allogēnā vai ksenogēnā šūna ir limfātiska šūna.
- 10. Metode saskaņā ar 9. punktu, kur limfātiskā šūna ir B šūna. 2
- 11. Metode saskaņā ar 10. punktu, kur B šūna ir miera stāvoklī esoša B šūna.
- 12. Metode saskaņā ar 1. punktu, kur audi vai orgāns satur pankreatiskās saliņas.
- 13. Metode saskaņā ar 1. punktu, kur audi vai orgāns ir izvēlēti no grupas, kurā ietilpst aknas, nieres, sirds, plaušas, āda, muskuļi, neironu audi, kuņģis un zarnas.
- 14. Metode a) allogēnas vai ksenogēnas šūnas, kas ekspresē vismaz vienu donora antigēnu; un b) liganda, kas piesaista gp39 izmantošanai medikamenta ražošanai audu vai orgāna recipienta T šūnu tolerances izraisīšanai pret donora audiem vai orgānu.
- 15. Metode saskaņā ar 14. punktu, kur ligands, kas piesaista gp39, ir anti-gp39 antiviela.
- 16. Metode saskaņā ar 15. punktu, kur anti-gp39 antiviela ir anti-cilvēka gp39 antiviela.
- 17. Metode saskaņā ar 15. punktu, kur anti-gp39 antiviela ir MR1.
- 18. Metode saskaņā ar 15. punktu, kur anti-gp39 antiviela ir monoklonāla antiviela.
- 19. Metode saskaņā ar 18. punktu, kur monoklonālā antiviela ir himēra monoklonāla antiviela.
- 20. Metode saskaņā ar 18. punktu, kur monoklonālā antiviela ir humanizēta monoklonāla antiviela.
- 21. Metode saskaņā ar 15. punktu, kur ligands, kas piesaista gp39, ir šķīstošs gp39 ligands. 3 3 LV 11785
- 22. Metode saskaņā ar 21. punktu, kur šķīstošais gp39 ligands ir CD40 sapludinātais proteīns.
- 23. Metode saskaņā ar 14. punktu, kur allogēnā vai ksenogēnā šūna ir limfātiska šūna.
- 24. Metode saskaņā ar 23. punktu, kur limfātiskā šūna ir B šūna.
- 25. Metode saskaņā ar 24. punktu, kur B šūna ir miera stāvoklī esoša B šūna.
- 26. Metode saskaņā ar 14. punktu, kur audi vai orgāns satur pankreatiskās saliņas.
- 27. Metode saskaņā ar 14. punktu, kur audi vai orgāns ir izvēlēti no grupas, kurā ietilpst aknas, nieres, sirds, plaušas, āda, muskuļi, neironu audi, kuņģis un zarnas.
- 28. Metode medikamenta ražošanai diabēta ārstēšanai, kurā tiek izmantotas sekojošas sastāvdaļas: a) allogēna vai ksenogēnā šūna, kas ekspresē vismaz vienu donora antigēnu, b) ligands, kas piesaista gp39, un c) donora pankreatisko saliņu šūnas.
- 29. Metode saskaņā ar 28. punktu, kur ligands, kas piesaista gp39, ir monoklonāla antiviela.
- 30. Metode saskaņā ar 29. punktu, kur monoklonālā antiviela piesaista cilvēka gp39.
- 31. Metode saskaņā ar 29. punktu, kur monoklonālā antiviela ir himēra antiviela.
- 32. Metode saskaņā ar 29. punktu, kur monoklonālā antiviela ir humanizēta antiviela. 4
- 33. Metode saskaņa ar 28. punktu, kur ligands, kas piesaista gp39, ir šķīstošs.
- 34. Metode saskaņā ar 33. punktu, kur šķīstošais ligands ir CD40 sapludinātais proteīns.
- 35. Metode saskaņā ar 28. punktu, kur allogēnā vai ksenogēnā šūna ir limfātiska šūna.
- 36. Metode saskaņā ar 35. punktu, kur limfātiskā šūna ir B šūna.
- 37. Metode saskaņā ar 36. punktu, kur B šūna ir miera stāvoklī esoša B šūna.
- 38. Metode medikamenta ražošanai audu vai orgāna recipienta T šūnu tolerances izraisīšanai pret donora audiem vai orgānu, kurā tiek izmantotas: a) donora allogēna šūna un b) anti-gp39 antiviela.
- 39. Metode saskaņā ar 38. punktu, kur anti-gp39 antiviela ir monoklonāla antiviela.
- 40. Metode saskaņā ar 39. punktu, kur monoklonālā antiviela ir anti-cilvēka gp39 antiviela.
- 41. Metode saskaņā ar 39. punktu, kur monoklonālā antiviela ir MR1.
- 42. Metode saskaņā ar 39. punktu, kur monoklonālā antiviela ir himēra monoklonāla antiviela.
- 43. Metode saskaņā ar 39. punktu, kur monoklonālā antiviela ir humanizēta monoklonāla antiviela.
- 44. Metode saskaņā ar 38. punktu, kur donora allogēnā šūna ir limfātiska šūna. 5 5 LV 11785
- 45. Metode saskaņā ar 44. punktu, kur limfātiskā šūna ir B šūna.
- 46. Metode medikamenta ražošanai audu vai orgāna recipienta T šūnu tolerances izraisīšanai pret donora audiem vai orgānu, kurā tiek 5 izmantots ligands, kas piesaista gp39.
- 47. Metode saskaņā ar 46. punktu, kur ligands ir anti-gp39 antiviela.
- 48. Metode saskaņā ar 47. punktu, kur antiviela ir monoklonāla 10 antiviela.
- 49. Metode saskaņā ar 48. punktu, kur monoklonālā antiviela ir himēra monoklonāla antiviela.
- 50. Metode saskaņā ar 47. punktu, kur monoklonālā antiviela ir humanizēta monoklonāla antiviela.
- 51. Metode saskaņā ar 46. punktu, kur ligands ir šķīstošs CD40 sapludinātais proteīns.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/234,987 US5683693A (en) | 1994-04-25 | 1994-04-25 | Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40 |
| PCT/US1995/004832 WO1995028957A2 (en) | 1994-04-25 | 1995-04-25 | Methods for inducing t cell tolerance to a tissue or organ graft |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LV11785A LV11785A (lv) | 1997-06-20 |
| LV11785B true LV11785B (lv) | 1998-02-20 |
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|---|---|---|---|
| LVP-96-440A LV11785B (lv) | 1994-04-25 | 1996-11-25 | Metodes t šūnu tolerances izraisīšanai pret audu vai orgāna transplantātu |
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| US7070777B1 (en) * | 1991-11-15 | 2006-07-04 | The Trustees Of Columbia University In The City Of New York | Method for inhibiting inflammation with an antibody that binds the 5C8 protein |
| US5474771A (en) | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
| US6472510B1 (en) | 1992-02-14 | 2002-10-29 | Bristol-Myers Squibb Company | CD40 receptor ligands |
| ZA946765B (en) * | 1993-09-02 | 1996-02-15 | Dartmouth College | Methods of prolonged suppression of humoral immunity |
| DK0721469T3 (da) * | 1993-09-02 | 2000-05-01 | Dartmouth College | Anti-gp39-antistoffer og anvendelse deraf |
| US5683693A (en) | 1994-04-25 | 1997-11-04 | Trustees Of Dartmouth College | Method for inducing T cell unresponsiveness to a tissue or organ graft with anti-CD40 ligand antibody or soluble CD40 |
| US5876950A (en) * | 1995-01-26 | 1999-03-02 | Bristol-Myers Squibb Company | Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy |
| US6440418B1 (en) * | 1995-11-07 | 2002-08-27 | Idec Pharmaceuticals Corporation | Methods of treating autoimmune diseases with gp39-specific antibodies |
| US6001358A (en) * | 1995-11-07 | 1999-12-14 | Idec Pharmaceuticals Corporation | Humanized antibodies to human gp39, compositions containing thereof |
| US6340459B1 (en) | 1995-12-01 | 2002-01-22 | The Trustees Of Columbia University In The City Of New York | Therapeutic applications for the anti-T-BAM (CD40-L) monoclonal antibody 5C8 in the treatment of reperfusion injury in non-transplant recipients |
| CA2246352C (en) * | 1996-03-20 | 2011-11-08 | Bristol-Myers Squibb Company | Methods for inhibiting an immune response by blocking the gp39/cd40 and ctla4/cd28/b7 pathways and compositions for use therewith |
| WO1998030241A1 (en) * | 1997-01-10 | 1998-07-16 | Biogen, Inc. | Methods of therapeutic administration of anti-cd40l compounds |
| BR9810620A (pt) * | 1997-06-20 | 2000-10-03 | Biogen Inc | Terapia de bloqueio de cd154 para transplante de tecido da ilhota pancreática |
| EP1754490A3 (en) * | 1997-06-20 | 2010-01-20 | Biogen Idec MA Inc. | CD 154 blockage therapy for pancreatic islet tissue transplantation in primates |
| US20050031611A1 (en) * | 1998-05-08 | 2005-02-10 | Beth Israel Deaconess Medical Center | Transplant tolerance by costimulation blockade and T-cell activation-induced apoptosis |
| DK1100515T3 (da) * | 1998-07-30 | 2005-12-12 | Univ Minnesota | Ex vivo-behandling af allogene og xenogene T-celler med pg39-antagonister |
| US20020199218A1 (en) * | 1999-08-19 | 2002-12-26 | Daphne Goring | Proline-rich extensin-like receptor kinases |
| RU2162297C1 (ru) * | 1999-11-25 | 2001-01-27 | Камакин Владислав Владимирович | Способ индивидуального подбора оптимального питания человека |
| WO2001079555A2 (en) | 2000-04-14 | 2001-10-25 | Millennium Pharmaceuticals, Inc. | Roles of jak/stat family members in tolerance induction |
| AU2001261585B2 (en) | 2000-05-12 | 2006-08-31 | Beth Israel Deaconess Medical Center, Inc. | Compositions and methods for achieving immune suppression |
| AU2001275186A1 (en) * | 2000-06-02 | 2001-12-17 | Nicole Kirchhof | Immunotherapeutic method to prevent islet cell rejection |
| JP2003535592A (ja) * | 2000-06-06 | 2003-12-02 | アイデック ファーマスーティカルズ コーポレイション | ヒトｇｐ３９に対する非アゴニスト抗体、含有する組成物、およびその治療的使用 |
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| RU2580640C1 (ru) * | 2014-12-25 | 2016-04-10 | Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации | Способ профилактики гуморального отторжения при аво-несовместимой трансплантации печени детям раннего возраста |
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| EP0583799A1 (en) * | 1989-05-23 | 1994-02-23 | Otsuka Pharmaceutical Co., Ltd. | Monoclonal antibodies to ELAM-1 sialoglycoprotein antigen on the surface of activated endothelial cells |
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