LV11106A - Radioiezimeti trombocitu GPIIb/IIIa receptora antagonisti ka attelu veidojoss lidzeklis - Google Patents
Radioiezimeti trombocitu GPIIb/IIIa receptora antagonisti ka attelu veidojoss lidzeklisInfo
- Publication number
- LV11106A LV11106A LV950296A LV950296A LV11106A LV 11106 A LV11106 A LV 11106A LV 950296 A LV950296 A LV 950296A LV 950296 A LV950296 A LV 950296A LV 11106 A LV11106 A LV 11106A
- Authority
- LV
- Latvia
- Prior art keywords
- radiymetics
- image
- receptor antagonists
- forming agent
- iiia receptor
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/008—Peptides; Proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4033693A | 1993-03-30 | 1993-03-30 | |
US08/218,861 US5879657A (en) | 1993-03-30 | 1994-03-28 | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
PCT/US1994/003256 WO1994022494A1 (en) | 1993-03-30 | 1994-03-29 | RADIOLABELED PLATELET GPIIb/IIIa RECEPTOR ANTAGONISTS AS IMAGING AGENTS FOR THE DIAGNOSIS OF THROMBOEMBOLIC DISORDERS |
Publications (2)
Publication Number | Publication Date |
---|---|
LV11106A true LV11106A (lv) | 1996-04-20 |
LV11106B LV11106B (en) | 1997-04-20 |
Family
ID=21910453
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LVP-95-296A LV11106B (en) | 1993-03-30 | 1995-10-27 | Radiolabeled platelet gpiib/iiia receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
Country Status (26)
Country | Link |
---|---|
US (2) | US5879657A (lv) |
EP (2) | EP0692982B1 (lv) |
JP (1) | JP3042887B2 (lv) |
KR (1) | KR960701666A (lv) |
CN (1) | CN1122577A (lv) |
AT (1) | ATE194293T1 (lv) |
AU (2) | AU6524894A (lv) |
BG (1) | BG100036A (lv) |
BR (2) | BR9406055A (lv) |
CA (1) | CA2159445A1 (lv) |
DE (1) | DE69425138T2 (lv) |
DK (1) | DK0692982T3 (lv) |
ES (1) | ES2149266T3 (lv) |
FI (1) | FI954655A (lv) |
GR (1) | GR3034272T3 (lv) |
HU (1) | HUT72889A (lv) |
LV (1) | LV11106B (lv) |
NO (1) | NO307568B1 (lv) |
NZ (1) | NZ263970A (lv) |
PL (1) | PL178252B1 (lv) |
PT (1) | PT692982E (lv) |
RU (1) | RU2145608C1 (lv) |
TW (1) | TW445267B (lv) |
UA (1) | UA32577C2 (lv) |
WO (1) | WO1994022494A1 (lv) |
ZA (1) | ZA942262B (lv) |
Families Citing this family (54)
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DK0570493T3 (da) * | 1991-02-08 | 2000-06-26 | Diatide Inc | Technetium-99m-mærkede polypeptider til billeddannelse. |
US5645815A (en) | 1991-02-08 | 1997-07-08 | Diatide, Inc. | Radiolabled compounds for thrombus imaging |
US5736122A (en) * | 1991-02-08 | 1998-04-07 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
US5968476A (en) * | 1992-05-21 | 1999-10-19 | Diatide, Inc. | Technetium-99m labeled peptides for thrombus imaging |
US6083481A (en) * | 1992-05-21 | 2000-07-04 | Diatide, Inc. | Thrombus imaging agents |
US5750088A (en) * | 1993-03-30 | 1998-05-12 | The Dupont Merck Pharmaceutical Company | Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals |
US5744120A (en) * | 1993-03-30 | 1998-04-28 | The Dupont Merick Pharmaceutical Company | Ternary radiopharmaceutical complexes |
US5879657A (en) * | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
WO1994023758A1 (en) * | 1993-04-08 | 1994-10-27 | Diatech, Inc. | Radiolabeled compounds for thrombus imaging |
ES2157422T3 (es) * | 1995-02-07 | 2001-08-16 | Brusilow Entpr Llc | Trigliceridos y esteres etilicos de acido fenilalcanoico y acido fenilalquenoico utiles en el tratamiento de diversos trastornos. |
US5879659A (en) * | 1996-03-13 | 1999-03-09 | Dupont Pharmaceuticals Company | Ternary radiopharmaceutical complexes |
WO1997033627A2 (en) * | 1996-03-13 | 1997-09-18 | Du Pont Pharmaceuticals Company | New ternary radiopharmaceutical complexes |
AU3474997A (en) * | 1996-06-10 | 1998-01-07 | G.D. Searle & Co. | Radiopharmaceutical compositions capable of localizing at sites of thrombus |
ZA978758B (en) * | 1996-10-02 | 1999-03-30 | Du Pont Merck Pharma | Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents |
WO1998015295A2 (en) * | 1996-10-07 | 1998-04-16 | Dupont Pharmaceuticals Company | Radiopharmaceuticals for imaging infection and inflammation |
WO1999040882A2 (en) * | 1998-02-06 | 1999-08-19 | Trustees Of The University Of Pennsylvania | STEREOSELECTIVE Tc-99m LIGANDS |
AU6422299A (en) * | 1998-10-13 | 2000-05-01 | Du Pont Pharmaceuticals Company | Chelator incorporated arg-gly-asp (rgd) mimetic synthetic disintegrins as imaging agents |
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US6171578B1 (en) * | 1999-04-14 | 2001-01-09 | Diatide, Inc. | Benzodiazepine derivatives for imaging thrombi |
US6254852B1 (en) | 1999-07-16 | 2001-07-03 | Dupont Pharmaceuticals Company | Porous inorganic targeted ultrasound contrast agents |
US6685914B1 (en) * | 1999-09-13 | 2004-02-03 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants for metallopharmaceuticals |
US6518244B2 (en) | 2000-03-09 | 2003-02-11 | Intimax Corporation | Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof |
US7045286B2 (en) | 2000-07-25 | 2006-05-16 | The Trustees Of The University Of Pennsylvania | Methods of detecting molecules expressing selected epitopes via fluorescent dyes |
US6743592B1 (en) | 2000-07-25 | 2004-06-01 | The Trustees Of The University Of Pennsylvania | Methods, systems and kits for immuno-detection of epitopes expressed on molecules |
US7524628B2 (en) * | 2000-07-25 | 2009-04-28 | The Trustees Of The University Of Pennsylvania | Method for detecting molecules expressing a selected epitope via fluorescent dyes |
US7341831B2 (en) * | 2001-07-18 | 2008-03-11 | The Trustees Of The University Of Pennsylvania | Method for immuno-detection of epitopes |
EP1513543B1 (en) | 2002-05-23 | 2010-10-06 | The Trustees of The University of Pennsylvania | Fas peptide mimetics and uses thereof |
US7317104B2 (en) | 2003-06-13 | 2008-01-08 | Bristol-Myers Squibb Pharma Company | Chelants and macrocyclic metal complex radiopharmaceuticals thereof |
US7319149B2 (en) * | 2003-06-13 | 2008-01-15 | Bristol-Myers Squibb Pharma Company | Chelants and macrocyclic metal complex radiopharmaceuticals thereof |
CN101913973B (zh) | 2003-07-24 | 2013-11-20 | 皇后医学中心 | 烷基化剂的制备和用途 |
CN1867363B (zh) * | 2003-09-17 | 2010-05-12 | 得克萨斯大学体系董事会 | 用于使胰腺显像的组合物及其用途 |
CA2556834A1 (en) * | 2004-02-20 | 2005-09-09 | The Trustees Of The University Of Pennsylvania | Reagents, kits and methods for immunodetection of epitopes on molecules |
ATE536367T1 (de) * | 2004-02-20 | 2011-12-15 | Univ Pennsylvania | Bindende peptidomimetika und deren verwendungen |
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US8691761B2 (en) * | 2006-10-16 | 2014-04-08 | Jean E. F. Rivier | Somatostatin receptor 2 antagonists |
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US8603980B2 (en) | 2007-01-16 | 2013-12-10 | The Johns Hopkins University | Glutamate receptor antagonists and methods of use |
CA2699394C (en) | 2007-09-17 | 2020-03-24 | The Regents Of The University Of California | Internalizing human monoclonal antibodies targeting prostate cancer cells in situ |
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CN105388287A (zh) | 2011-03-11 | 2016-03-09 | 内布拉斯加大学董事委员会 | 冠状动脉疾病的生物标志物 |
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CN104540507A (zh) | 2012-04-20 | 2015-04-22 | 海波龙治疗公司 | 苯乙酸前药的治疗性监测方法 |
JP2016506378A (ja) | 2012-11-21 | 2016-03-03 | ハイペリオン セラピューティクス,インコーポレイテッド | 肝性脳症の治療のための窒素除去薬の投与方法および評価方法 |
KR101639015B1 (ko) | 2013-07-30 | 2016-07-14 | 연세대학교 산학협력단 | 삭사틸린―Fc 융합 단백질 및 이의 용도 |
PT3383920T (pt) | 2015-11-30 | 2024-04-15 | Univ California | Entrega de carga útil específica para tumores e ativação imune utilizando um anticorpo humano que tem como alvo um antigénio altamente específico da superfície das células tumorais |
US9914692B2 (en) | 2016-05-25 | 2018-03-13 | Horizon Therapeutics, Llc | Procedure for the preparation of 4-phenyl butyrate and uses thereof |
US10668040B2 (en) | 2017-09-11 | 2020-06-02 | Horizon Therapeutics, Llc | Treatment of urea cycle disorders in neonates and infants |
CN116419747A (zh) | 2020-08-07 | 2023-07-11 | 福蒂斯治疗公司 | 靶向cd46的免疫偶联物及其使用方法 |
CN118165073B (zh) * | 2024-05-14 | 2024-07-19 | 中国药科大学 | 一种fap抑制剂及其制备方法和应用 |
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-
1994
- 1994-03-28 US US08/218,861 patent/US5879657A/en not_active Expired - Fee Related
- 1994-03-29 AU AU65248/94A patent/AU6524894A/en not_active Abandoned
- 1994-03-29 CN CN94192010A patent/CN1122577A/zh active Pending
- 1994-03-29 ES ES94912870T patent/ES2149266T3/es not_active Expired - Lifetime
- 1994-03-29 WO PCT/US1994/003256 patent/WO1994022494A1/en active IP Right Grant
- 1994-03-29 HU HU9502862A patent/HUT72889A/hu unknown
- 1994-03-29 DE DE69425138T patent/DE69425138T2/de not_active Expired - Fee Related
- 1994-03-29 PT PT94912870T patent/PT692982E/pt unknown
- 1994-03-29 AT AT94912870T patent/ATE194293T1/de not_active IP Right Cessation
- 1994-03-29 BR BR9406055A patent/BR9406055A/pt not_active Application Discontinuation
- 1994-03-29 JP JP6522205A patent/JP3042887B2/ja not_active Expired - Fee Related
- 1994-03-29 NZ NZ263970A patent/NZ263970A/en unknown
- 1994-03-29 DK DK94912870T patent/DK0692982T3/da active
- 1994-03-29 EP EP94912870A patent/EP0692982B1/en not_active Expired - Lifetime
- 1994-03-29 RU RU95118183A patent/RU2145608C1/ru active
- 1994-03-29 CA CA002159445A patent/CA2159445A1/en not_active Abandoned
- 1994-03-29 UA UA95094341A patent/UA32577C2/uk unknown
- 1994-03-29 PL PL94311037A patent/PL178252B1/pl unknown
- 1994-03-29 EP EP99116915A patent/EP0995761A3/en not_active Withdrawn
- 1994-03-29 BR BR9406820A patent/BR9406820A/pt not_active Application Discontinuation
- 1994-03-30 ZA ZA942262A patent/ZA942262B/xx unknown
- 1994-05-07 TW TW083104199A patent/TW445267B/zh active
-
1995
- 1995-09-29 KR KR1019950704228A patent/KR960701666A/ko not_active Application Discontinuation
- 1995-09-29 BG BG100036A patent/BG100036A/bg unknown
- 1995-09-29 FI FI954655A patent/FI954655A/fi not_active IP Right Cessation
- 1995-09-29 NO NO953886A patent/NO307568B1/no unknown
- 1995-10-27 LV LVP-95-296A patent/LV11106B/en unknown
- 1995-10-30 AU AU34525/95A patent/AU689643B2/en not_active Ceased
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1997
- 1997-12-29 US US08/999,400 patent/US6022523A/en not_active Expired - Fee Related
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2000
- 2000-08-30 GR GR20000401959T patent/GR3034272T3/el not_active IP Right Cessation
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