PL310896A1 - Cyclic compounds useful as platelet iib/iiia glycoprotein inhibitors - Google Patents

Cyclic compounds useful as platelet iib/iiia glycoprotein inhibitors

Info

Publication number
PL310896A1
PL310896A1 PL94310896A PL31089694A PL310896A1 PL 310896 A1 PL310896 A1 PL 310896A1 PL 94310896 A PL94310896 A PL 94310896A PL 31089694 A PL31089694 A PL 31089694A PL 310896 A1 PL310896 A1 PL 310896A1
Authority
PL
Poland
Prior art keywords
compounds useful
cyclic compounds
glycoprotein inhibitors
platelet iib
iiia glycoprotein
Prior art date
Application number
PL94310896A
Inventor
William Frank Degrado
Sharon Anne Jackson
Shaker Ahmed Mousa
Anju Parthasarathy
Michael Sworin
Maria Rafalski
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of PL310896A1 publication Critical patent/PL310896A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PL94310896A 1993-03-29 1994-03-28 Cyclic compounds useful as platelet iib/iiia glycoprotein inhibitors PL310896A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3844893A 1993-03-29 1993-03-29

Publications (1)

Publication Number Publication Date
PL310896A1 true PL310896A1 (en) 1996-01-08

Family

ID=21900014

Family Applications (1)

Application Number Title Priority Date Filing Date
PL94310896A PL310896A1 (en) 1993-03-29 1994-03-28 Cyclic compounds useful as platelet iib/iiia glycoprotein inhibitors

Country Status (10)

Country Link
EP (1) EP0691987A1 (en)
JP (1) JPH08508498A (en)
AU (1) AU6415894A (en)
CA (1) CA2159070A1 (en)
FI (1) FI954556A0 (en)
HU (1) HUT72896A (en)
NO (1) NO953832L (en)
NZ (1) NZ263456A (en)
PL (1) PL310896A1 (en)
WO (1) WO1994022910A1 (en)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0691986T3 (en) * 1993-03-29 1999-08-16 Du Pont Merck Pharma Novel Methods and Intermediate Compounds for the Preparation of Platelet Glycoprotein IIb / IIIa Inhibitors
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
JP4498471B2 (en) * 1996-11-27 2010-07-07 アヴェンティス ファーマシューティカルズ インコーポレイテッド Pharmaceutical composition comprising a compound having anti-Xa activity and a platelet aggregation antagonist compound
US6010911A (en) * 1997-04-30 2000-01-04 Medtronic, Inc. Apparatus for performing a heparin-independent high sensitivity platelet function evaluation technique
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
GB0623607D0 (en) 2006-11-27 2007-01-03 Haemostatix Ltd Tissue adhesive
CA2677045C (en) 2007-01-31 2016-10-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
US8592377B2 (en) 2007-03-28 2013-11-26 President And Fellows Of Harvard College Stitched polypeptides
US11673914B2 (en) 2009-11-10 2023-06-13 Allegro Pharmaceuticals, LLC Peptide therapies for reduction of macular thickening
KR101988362B1 (en) 2009-11-10 2019-06-12 알레그로 파마슈티칼스, 인코포레이티드. Compositions and methods for inhibiting cellular adhesion or directing diagnostic or therapeutic agents to rgd binding sites
CN108570097A (en) 2010-08-13 2018-09-25 爱勒让治疗公司 Peptidomimetic macrocyclic compound
CA2835214C (en) 2011-05-09 2023-08-01 Allegro Pharmaceuticals, Inc. Integrin receptor antagonists and their methods of use
US9096684B2 (en) 2011-10-18 2015-08-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
WO2013123266A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CN104812384B (en) 2012-11-01 2020-09-18 爱勒让治疗公司 Disubstituted amino acids and methods of making and using the same
CN112972378A (en) 2014-09-24 2021-06-18 艾瑞朗医疗公司 Peptidomimetic macrocycles and formulations thereof
EP3197478A4 (en) 2014-09-24 2018-05-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
KR20170129879A (en) 2015-03-20 2017-11-27 에일러론 테라퓨틱스 인코포레이티드 Peptidomimetic macrocycles and their uses
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2636066B1 (en) * 1988-09-02 1991-10-25 Centre Nat Rech Scient CYCLOPEPTIDE DERIVATIVES FOR USE AS SELECTIVE INHIBITORS AGAINST ACTIVE SERINE PROTEASES
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
AU6470590A (en) * 1989-10-23 1991-04-26 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
IL103252A (en) * 1991-09-30 1997-03-18 Du Pont Merck Pharma CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
NZ263456A (en) 1996-11-26
FI954556L (en) 1995-09-26
WO1994022910A1 (en) 1994-10-13
CA2159070A1 (en) 1994-10-13
JPH08508498A (en) 1996-09-10
HU9502832D0 (en) 1995-11-28
HUT72896A (en) 1996-06-28
FI954556A7 (en) 1995-09-26
EP0691987A1 (en) 1996-01-17
FI954556A0 (en) 1995-09-26
NO953832D0 (en) 1995-09-28
AU6415894A (en) 1994-10-24
NO953832L (en) 1995-11-28

Similar Documents

Publication Publication Date Title
PL310896A1 (en) Cyclic compounds useful as platelet iib/iiia glycoprotein inhibitors
FI943478A7 (en) Glycoprotein IIb/IIIa antagonists
FI941457L (en) Cyclic compounds useful as inhibitors of platelet glycoprotein IIb/IIIa
ZA93550B (en) Azabricyclic compounds as calcium channel antagonists
GB9420114D0 (en) Substituted cyclic derivatives as novel antidegenerative agents
EP0574494A4 (en) Indoles useful as platelet activating factor antagonists
EP0708765A4 (en) Substituted piperazinylcamphor derivatives as oxytocin antagonists
ITMI932056A1 (en) LOCK FOR CONTAINERS SUCH AS BAGS OR SIMILAR
SG44770A1 (en) Cyclic compounds
IL102127A0 (en) Packaging/containerization system
GB9216384D0 (en) Improvements relating to packaging
ZA927515B (en) Cyclic compounds useful as inhibitors of platelet glycoprotein IIb/IIIa
GB9302261D0 (en) Improvements relating to packaging
HUT70277A (en) New packaging/containerization system
HUT70279A (en) New packaging containerization system
GB2257958B (en) Improvements relating to packaging
GB2280658B (en) Improvements relating to containers
GB2275466B (en) Improvements relating to containers
GB9214278D0 (en) Improvements relating to packaging
ITAR920017A0 (en) COMPOSITE BOX FOR SEEDLING CONTAINERS
GB9324788D0 (en) Improvements relating to packaging
GB9321861D0 (en) Platelet derived growth factor analogues
GB9318547D0 (en) Improvements relating to packaging containers
GB9318882D0 (en) Improvements relating to containers
GB9305150D0 (en) Improvements relating to containers