LV10959B - Novel 16,17-acetalsubstitute derivatives of pregnane-21-acid, method for their preparation, medicinal preparations of thereof - Google Patents
Novel 16,17-acetalsubstitute derivatives of pregnane-21-acid, method for their preparation, medicinal preparations of thereof Download PDFInfo
- Publication number
- LV10959B LV10959B LVP-93-1046A LV931046A LV10959B LV 10959 B LV10959 B LV 10959B LV 931046 A LV931046 A LV 931046A LV 10959 B LV10959 B LV 10959B
- Authority
- LV
- Latvia
- Prior art keywords
- formula
- mji
- hjih
- compound
- compound according
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract 5
- 238000002360 preparation method Methods 0.000 title claims abstract 4
- 239000002253 acid Substances 0.000 title claims 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 18
- 230000000172 allergic effect Effects 0.000 claims abstract 4
- 208000010668 atopic eczema Diseases 0.000 claims abstract 4
- 230000002757 inflammatory effect Effects 0.000 claims abstract 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims abstract 3
- 239000000203 mixture Substances 0.000 claims description 9
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 claims 1
- 125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 150000008049 diazo compounds Chemical class 0.000 claims 1
- 239000002552 dosage form Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000032050 esterification Effects 0.000 claims 1
- 238000005886 esterification reaction Methods 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 230000001590 oxidative effect Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 101150115538 nero gene Proteins 0.000 description 6
- 101100397240 Arabidopsis thaliana ISPD gene Proteins 0.000 description 5
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 101150096418 Mepe gene Proteins 0.000 description 2
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
- 241000191291 Abies alba Species 0.000 description 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 1
- 241001669680 Dormitator maculatus Species 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 101100366940 Mus musculus Stom gene Proteins 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(I) nitrate Inorganic materials [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 235000011149 sulphuric acid Nutrition 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE8506015A SE8506015D0 (sv) | 1985-12-19 | 1985-12-19 | Novel 16,17-acetalsubstituted pregnane 21-oic acid derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| LV10959A LV10959A (lv) | 1995-12-20 |
| LV10959B true LV10959B (en) | 1996-06-20 |
Family
ID=20362521
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LVP-93-1046A LV10959B (en) | 1985-12-19 | 1993-08-27 | Novel 16,17-acetalsubstitute derivatives of pregnane-21-acid, method for their preparation, medicinal preparations of thereof |
Country Status (31)
| Country | Link |
|---|---|
| EP (1) | EP0232690B1 (cs) |
| JP (1) | JPH0780900B2 (cs) |
| KR (1) | KR940004067B1 (cs) |
| CN (1) | CN1016508B (cs) |
| AR (1) | AR242797A1 (cs) |
| AT (1) | ATE57935T1 (cs) |
| AU (1) | AU591950B2 (cs) |
| CA (1) | CA1318664C (cs) |
| CS (1) | CS266597B2 (cs) |
| DD (1) | DD256703A5 (cs) |
| DE (1) | DE3675378D1 (cs) |
| DK (1) | DK168601B1 (cs) |
| ES (1) | ES2018656B3 (cs) |
| FI (1) | FI84488C (cs) |
| GR (1) | GR3001052T3 (cs) |
| HU (1) | HU196831B (cs) |
| IE (1) | IE59241B1 (cs) |
| IL (1) | IL80679A (cs) |
| IS (1) | IS1559B (cs) |
| JO (1) | JO1499B1 (cs) |
| LT (1) | LT3912B (cs) |
| LV (1) | LV10959B (cs) |
| MY (1) | MY100750A (cs) |
| NO (1) | NO164243C (cs) |
| NZ (1) | NZ218614A (cs) |
| PH (1) | PH23237A (cs) |
| PL (1) | PL151627B1 (cs) |
| PT (1) | PT83984B (cs) |
| RU (1) | RU1839673C (cs) |
| SE (1) | SE8506015D0 (cs) |
| ZA (1) | ZA868750B (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU203769B (en) * | 1989-03-09 | 1991-09-30 | Richter Gedeon Vegyeszet | Process for producing new steroide derivatives and pharmaceutical compositions containing them |
| SE8903914D0 (sv) | 1989-11-22 | 1989-11-22 | Draco Ab | Oral composition for the treatment of inflammatory bowel diseases |
| US5643602A (en) * | 1989-11-22 | 1997-07-01 | Astra Aktiebolag | Oral composition for the treatment of inflammatory bowel disease |
| US6166024A (en) * | 1995-03-30 | 2000-12-26 | Mayo Foundation For Medical Education And Research | Use of topical azathioprine and thioguanine to treat colorectal adenomas |
| CA2902911C (en) | 2014-10-31 | 2017-06-27 | Purdue Pharma | Methods and compositions particularly for treatment of attention deficit disorder |
| US10722473B2 (en) | 2018-11-19 | 2020-07-28 | Purdue Pharma L.P. | Methods and compositions particularly for treatment of attention deficit disorder |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2150268C3 (de) * | 1971-10-04 | 1980-11-06 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Pregnansäure-Derivate, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel |
| DE2204360C2 (de) * | 1972-01-27 | 1982-11-04 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue Pregnansäure-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
| DD95565B1 (de) * | 1971-10-04 | 1986-10-29 | Schering Ag | Verfahren zur herstellung neuer pregnansaeurederivate |
| SE378109B (cs) * | 1972-05-19 | 1975-08-18 | Bofors Ab | |
| DE2264003C2 (de) * | 1972-12-22 | 1982-11-04 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue Pregnansäure-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate |
| DK135380C (da) * | 1972-12-22 | 1977-10-03 | Schering Ag | Analogifremgangsmade til fremstilling af pregnan-21-syrederivater |
| SE8403905D0 (sv) * | 1984-07-30 | 1984-07-30 | Draco Ab | Liposomes and steroid esters |
-
1985
- 1985-12-19 SE SE8506015A patent/SE8506015D0/xx unknown
-
1986
- 1986-11-18 ZA ZA868750A patent/ZA868750B/xx unknown
- 1986-11-18 IL IL80679A patent/IL80679A/xx not_active IP Right Cessation
- 1986-12-11 NO NO865004A patent/NO164243C/no unknown
- 1986-12-11 IE IE324586A patent/IE59241B1/en not_active IP Right Cessation
- 1986-12-12 AU AU66448/86A patent/AU591950B2/en not_active Ceased
- 1986-12-12 AT AT86850436T patent/ATE57935T1/de not_active IP Right Cessation
- 1986-12-12 EP EP86850436A patent/EP0232690B1/en not_active Expired - Lifetime
- 1986-12-12 DE DE8686850436T patent/DE3675378D1/de not_active Expired - Lifetime
- 1986-12-12 ES ES86850436T patent/ES2018656B3/es not_active Expired - Lifetime
- 1986-12-12 NZ NZ218614A patent/NZ218614A/xx unknown
- 1986-12-15 PH PH34590A patent/PH23237A/en unknown
- 1986-12-15 JO JO19861499A patent/JO1499B1/en active
- 1986-12-16 FI FI865128A patent/FI84488C/fi not_active IP Right Cessation
- 1986-12-16 DK DK605186A patent/DK168601B1/da not_active IP Right Cessation
- 1986-12-17 MY MYPI86000221A patent/MY100750A/en unknown
- 1986-12-17 PL PL1986263041A patent/PL151627B1/pl unknown
- 1986-12-18 KR KR1019860010870A patent/KR940004067B1/ko not_active Expired - Fee Related
- 1986-12-18 HU HU865302A patent/HU196831B/hu not_active IP Right Cessation
- 1986-12-18 AR AR86306261A patent/AR242797A1/es active
- 1986-12-18 JP JP61300242A patent/JPH0780900B2/ja not_active Expired - Lifetime
- 1986-12-18 CA CA000525677A patent/CA1318664C/en not_active Expired - Fee Related
- 1986-12-18 DD DD86297902A patent/DD256703A5/de unknown
- 1986-12-18 RU SU864028689A patent/RU1839673C/ru active
- 1986-12-19 IS IS3179A patent/IS1559B/is unknown
- 1986-12-19 CS CS869604A patent/CS266597B2/cs unknown
- 1986-12-19 CN CN86108634A patent/CN1016508B/zh not_active Expired
- 1986-12-19 PT PT83984A patent/PT83984B/pt not_active IP Right Cessation
-
1990
- 1990-11-06 GR GR90400871T patent/GR3001052T3/el unknown
-
1993
- 1993-08-27 LV LVP-93-1046A patent/LV10959B/lv unknown
- 1993-12-28 LT LTIP1682A patent/LT3912B/lt not_active IP Right Cessation
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