LV10433B - Hexahydroazepine derivatives, a process for their preparation and pharmaceutical compositions containing them - Google Patents

Hexahydroazepine derivatives, a process for their preparation and pharmaceutical compositions containing them Download PDF

Info

Publication number
LV10433B
LV10433B LVP-93-141A LV930141A LV10433B LV 10433 B LV10433 B LV 10433B LV 930141 A LV930141 A LV 930141A LV 10433 B LV10433 B LV 10433B
Authority
LV
Latvia
Prior art keywords
formula
compound
group
give
necessary
Prior art date
Application number
LVP-93-141A
Other languages
English (en)
Latvian (lv)
Other versions
LV10433A (lv
Inventor
Lavastre Serge
Maignan Jean-Pierre
Paul Raymond
Poncelet Martine
Santucci Vincent
Original Assignee
Sanofi Elf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Elf filed Critical Sanofi Elf
Publication of LV10433A publication Critical patent/LV10433A/xx
Publication of LV10433B publication Critical patent/LV10433B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/04Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/067Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Control Of Transmission Device (AREA)
  • Data Exchanges In Wide-Area Networks (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LVP-93-141A 1990-06-14 1993-02-25 Hexahydroazepine derivatives, a process for their preparation and pharmaceutical compositions containing them LV10433B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR909007434A FR2663328B1 (fr) 1990-06-14 1990-06-14 Derives d'hexahydroazepines, un procede pour leur preparation et compositions pharmaceutiques les contenant.

Publications (2)

Publication Number Publication Date
LV10433A LV10433A (lv) 1995-02-20
LV10433B true LV10433B (en) 1995-08-20

Family

ID=9397608

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-93-141A LV10433B (en) 1990-06-14 1993-02-25 Hexahydroazepine derivatives, a process for their preparation and pharmaceutical compositions containing them

Country Status (30)

Country Link
US (2) US5231092A (pl)
EP (1) EP0461986B1 (pl)
JP (1) JP2620422B2 (pl)
KR (1) KR100213531B1 (pl)
AT (1) ATE132861T1 (pl)
AU (1) AU647481B2 (pl)
BR (1) BR1100207A (pl)
CA (1) CA2044484C (pl)
CZ (1) CZ285696B6 (pl)
DE (1) DE69116237T2 (pl)
DK (1) DK0461986T3 (pl)
ES (1) ES2084792T3 (pl)
FI (1) FI101301B (pl)
FR (1) FR2663328B1 (pl)
GR (1) GR3019197T3 (pl)
HK (1) HK1000598A1 (pl)
HU (2) HU222490B1 (pl)
IE (1) IE74709B1 (pl)
IL (1) IL98479A (pl)
LT (1) LT3550B (pl)
LV (1) LV10433B (pl)
MX (1) MX9203360A (pl)
MY (1) MY135774A (pl)
NO (1) NO180195C (pl)
NZ (1) NZ238516A (pl)
PL (1) PL165842B1 (pl)
PT (1) PT97944B1 (pl)
RU (2) RU2070194C1 (pl)
UA (1) UA27222C2 (pl)
ZA (1) ZA914572B (pl)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2751645B1 (fr) * 1996-07-29 1998-12-24 Sanofi Sa Amines pour la fabrication de medicaments destines a empecher la proliferation de cellules tumorales
US6005102A (en) 1997-10-15 1999-12-21 American Home Products Corporation Aryloxy-alkyl-dialkylamines
FR2794742B1 (fr) 1999-06-11 2005-06-03 Sanofi Synthelabo Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant
FR2795724B1 (fr) * 1999-07-02 2002-12-13 Sanofi Synthelabo Nouveaux derives du benzene, un procede pour leur preparation et les compositions pharmaceutiques les contenant
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
AU2007249399A1 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
PT2471780E (pt) 2007-05-30 2015-02-24 Ind Swift Lab Ltd Sais oxalato de ivabradina cristalinos e seus polimorfos
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
JP2023541960A (ja) 2020-09-17 2023-10-04 メレティオス セラピューティクス ウイルス感染を治療するための化合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2881165A (en) * 1956-06-29 1959-04-07 Nl Combinatie Chem Ind alpha-alpha-diphenyl-gamma-hexamethyleneiminobutyramide
DE1545561A1 (de) * 1965-08-23 1969-12-11 Acraf Verfahren zur Herstellung von pharmakologisch aktiven N,N-disubstituierten 1-Aryl-3-aminopropinen
GB1475314A (en) * 1973-11-02 1977-06-01 Cm Ind Phenyl-propylamine derivatives
US4104383A (en) * 1973-11-02 1978-08-01 C M Industries Derivatives of phenylpropenylamine
DE3019497A1 (de) * 1980-05-22 1981-11-26 Bayer Ag, 5090 Leverkusen Aminopropiophenon-derivate, verfahren zu ihrer herstellung und ihre verwendung als fungizide
AU4261285A (en) * 1984-06-01 1985-12-05 Tokyo Tanabe Company Limited 1-propanone derivatives
DE3508398A1 (de) * 1985-03-08 1986-11-06 Hoechst Ag, 6230 Frankfurt Fungizide mittel auf der basis von 3-(hetero)-arylpropylaminen sowie neue (hetero)-aryl-propylamine und verfahren zu ihrer herstellung
US4709094A (en) 1986-07-10 1987-11-24 State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon Sigma brain receptor ligands and their use

Also Published As

Publication number Publication date
HU9101983D0 (en) 1991-12-30
IE911963A1 (en) 1991-12-18
AU647481B2 (en) 1994-03-24
UA27222C2 (uk) 2000-08-15
PT97944A (pt) 1992-03-31
ES2084792T3 (es) 1996-05-16
NO180195C (no) 1997-03-05
RU2133741C1 (ru) 1999-07-27
IE74709B1 (en) 1997-07-30
CZ181891A3 (en) 1994-01-19
FR2663328B1 (fr) 1994-08-05
MY135774A (en) 2008-06-30
KR920000728A (ko) 1992-01-29
GR3019197T3 (en) 1996-06-30
LV10433A (lv) 1995-02-20
FI912899A0 (fi) 1991-06-14
CZ285696B6 (cs) 1999-10-13
DE69116237T2 (de) 1996-07-25
MX9203360A (es) 1992-07-01
JPH04321676A (ja) 1992-11-11
AU7843491A (en) 1991-12-19
FR2663328A1 (fr) 1991-12-20
NO912283D0 (no) 1991-06-13
US5296596A (en) 1994-03-22
ZA914572B (en) 1992-03-25
IL98479A (en) 1995-11-27
JP2620422B2 (ja) 1997-06-11
EP0461986B1 (fr) 1996-01-10
HU222490B1 (hu) 2003-07-28
HK1000598A1 (en) 1998-04-09
US5231092A (en) 1993-07-27
FI101301B1 (fi) 1998-05-29
NO180195B (no) 1996-11-25
HUT61736A (en) 1993-03-01
RU2070194C1 (ru) 1996-12-10
BR1100207A (pt) 1999-10-05
PL290675A1 (en) 1992-03-23
IL98479A0 (en) 1992-07-15
CA2044484C (en) 1998-05-26
FI912899A (fi) 1991-12-15
RU94038042A (ru) 1996-09-10
FI101301B (fi) 1998-05-29
EP0461986A1 (fr) 1991-12-18
NO912283L (no) 1991-12-16
DE69116237D1 (de) 1996-02-22
NZ238516A (en) 1993-09-27
PT97944B (pt) 1998-11-30
HU211616A9 (en) 1995-12-28
PT97944B1 (pt) 1999-05-31
PL165842B1 (pl) 1995-02-28
LT3550B (en) 1995-11-27
KR100213531B1 (ko) 1999-08-02
ATE132861T1 (de) 1996-01-15
CA2044484A1 (en) 1991-12-15
DK0461986T3 (da) 1996-05-28
LTIP704A (en) 1995-01-31

Similar Documents

Publication Publication Date Title
FI113172B (fi) Bifenyylijohdannaiset, menetelmät niiden valmistamiseksi ja niiden käyttö sekä uudet välituotteet
US8110567B2 (en) Phenyl-piperazine derivatives as serotonin reuptake inhibitors
JP3205343B2 (ja) ジアリールジアミン誘導体およびそれらのデルタオピオイド(アント)−アゴニストとしての使用
AU626949B2 (en) 2-amino-4 or 5-methoxycyclohexyl amides useful as analgesics
US5607961A (en) Antidepressant 3-(aminocycloalkenyl)-indole-5-nitrile derivatives
US5296596A (en) Hexahydroazepine derivatives, a process for their preparation
JPH0819065B2 (ja) ベンゾ融合シクロアルカンおよびオキサ‐およびチア‐シクロアルカントランス‐1,2‐ジアミン誘導体
JP2007537278A (ja) カルボキサミド系オピオイド化合物
HU227973B1 (hu) Indazolamidok és az ezeket tartalmazó gyógyszerek
MX2007009816A (es) Sales de tartrato y de malato de trans-1-((1r,3s)-6-cloro-3- fenilindan-1-i1)-3,3-dimetilpiperazina.
NZ202728A (en) 2-(phenylmethylene)-cycloalkylamine and-azetidine derivatives
JPS63156763A (ja) 塩基性置換フェニルアセトニトリル及びカルシウム拮抗作用を有する心血管系疾患の治療剤
HU211155A9 (en) Benzene derivatives, process for preparing them and pharmaceutical compositions containing them
KR20070107043A (ko) 트랜스-1-((1r,3s)-6-클로로-3-페닐인단-1-일)-3,3-디메틸피페라진의 타르트레이트 및 말레이트 염
HU224310B1 (hu) 1,2-Dihidrociklobutabenzol-származékok, és az ezeket tartalmazó gyógyászati készítmények
JPH05194465A (ja) 鎮痛剤として有用な2−アミノ−モノ−メトキシシクロヘキシルアミド類