LV10251B - Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d|indole - Google Patents

Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d|indole

Info

Publication number
LV10251B
LV10251B LVP-93-509A LV930509A LV10251B LV 10251 B LV10251 B LV 10251B LV 930509 A LV930509 A LV 930509A LV 10251 B LV10251 B LV 10251B
Authority
LV
Latvia
Prior art keywords
tetrahydrobenz
propyl
amino
preparation
indole
Prior art date
Application number
LVP-93-509A
Other languages
English (en)
Other versions
LV10251A (lv
Inventor
Thomas Joseph Kress
David Lee Varie
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of LV10251A publication Critical patent/LV10251A/xx
Publication of LV10251B publication Critical patent/LV10251B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
LVP-93-509A 1990-02-26 1993-06-08 Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d|indole LV10251B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US48518590A 1990-02-26 1990-02-26

Publications (2)

Publication Number Publication Date
LV10251A LV10251A (lv) 1994-10-20
LV10251B true LV10251B (en) 1995-04-20

Family

ID=23927224

Family Applications (1)

Application Number Title Priority Date Filing Date
LVP-93-509A LV10251B (en) 1990-02-26 1993-06-08 Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d|indole

Country Status (28)

Country Link
US (1) US5397799A (Direct)
EP (1) EP0444852B1 (Direct)
JP (1) JP3157007B2 (Direct)
KR (1) KR100208114B1 (Direct)
CN (1) CN1027503C (Direct)
AT (1) ATE126506T1 (Direct)
AU (1) AU629453B2 (Direct)
BR (1) BR9100767A (Direct)
CA (1) CA2037099C (Direct)
CY (1) CY1887A (Direct)
DE (1) DE69112099T2 (Direct)
DK (1) DK0444852T3 (Direct)
ES (1) ES2077796T3 (Direct)
FI (1) FI95464C (Direct)
GR (1) GR3017940T3 (Direct)
HK (1) HK175495A (Direct)
HU (1) HU217118B (Direct)
IE (1) IE67801B1 (Direct)
IL (1) IL97306A (Direct)
LV (1) LV10251B (Direct)
NO (1) NO174149C (Direct)
NZ (1) NZ237181A (Direct)
PT (1) PT96852B (Direct)
RU (2) RU2034837C1 (Direct)
SG (1) SG69975A1 (Direct)
TW (1) TW219933B (Direct)
YU (1) YU47594B (Direct)
ZA (1) ZA911258B (Direct)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL97309A (en) * 1990-02-26 1996-11-14 Lilly Co Eli Intermediates for hexahydrobenz Úcd¾ indoles and process for the preparation of pure enantiomers thereof
US5302612A (en) * 1990-02-26 1994-04-12 Eli Lilly And Company 6-substituted-hexahydrobenz[cd]indoles
IL97308A (en) * 1990-02-26 1996-10-31 Lilly Co Eli 6-Substituted-hexahydrobenz (cd) indoles process for their preparation and pharmaceutical compositions containing them
US5627199A (en) * 1991-03-28 1997-05-06 Eli Lilly And Company 6-heterocyclic-4-amino-1,2,2A,3,4,5-hexahydrobenz [CD] indoles
US5364856A (en) * 1991-03-28 1994-11-15 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
TW248556B (Direct) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
UA53205C2 (en) * 2002-04-03 2006-06-15 Pharmatech Close Joint Stock C Antidepressant formulation and method for its manufacture
US7588924B2 (en) 2006-03-07 2009-09-15 Procter & Gamble Company Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
CN101506149B (zh) 2006-06-26 2012-11-14 华纳奇考特有限责任公司 脯氨酰羟化酶抑制剂及使用方法
MY163511A (en) 2009-11-06 2017-09-15 Aerpio Therapeutics Inc Prolyl hydroxylase inhibitors
NO2686520T3 (Direct) 2011-06-06 2018-03-17
US8865748B2 (en) 2011-06-06 2014-10-21 Akebia Therapeutics Inc. Compounds and compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
PE20160194A1 (es) 2013-06-13 2016-04-20 Akebia Therapeutics Inc Composiciones y metodos para tratar anemia
CN105916502A (zh) 2013-11-15 2016-08-31 阿克比治疗有限公司 {[5-(3-氯苯基)-3-羟基吡啶-2-羰基]氨基}乙酸的固体形式，其组合物和用途
EP3247355A4 (en) 2015-01-23 2018-06-13 Akebia Therapeutics, Inc. Solid forms of 2-(5-(3-fluorophenyl)-3-hydroxypicolinamido)acetic acid, compositions, and uses thereof
MX374909B (es) 2015-04-01 2025-03-06 Akebia Therapeutics Inc El uso del inhibidor de propil hidrolasa del factor inducible de hipoxia (hif) para el tratamiento o prevención de la anemia.
TWI822776B (zh) 2018-05-09 2023-11-21 美商阿克比治療有限公司 用於製備2-[[5-(3-氯苯基)-3-羥基吡啶-2-羰基]胺基]乙酸之方法
US11524939B2 (en) 2019-11-13 2022-12-13 Akebia Therapeutics, Inc. Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110339A (en) * 1977-11-25 1978-08-29 Eli Lilly And Company 4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4576959A (en) * 1984-02-06 1986-03-18 Eli Lilly And Company 6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
US4745126A (en) * 1987-03-12 1988-05-17 Eli Lilly And Company Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) * 1988-03-18 1989-09-28 Bayer Ag 1,3,4,5-tetrahydrobenz-(c,d)-indole
US5204340A (en) * 1989-04-11 1993-04-20 Eli Lilly And Company Tetrahydrobenz(c,d)indole serotonin agonists
US5229409A (en) * 1990-08-15 1993-07-20 Eli Lilly And Company 6-substituted-tetrahydrobenz[cd]indoles

Also Published As

Publication number Publication date
AU629453B2 (en) 1992-10-01
JPH04217662A (ja) 1992-08-07
RU2083561C1 (ru) 1997-07-10
TW219933B (Direct) 1994-02-01
IL97306A0 (en) 1992-05-25
HU217118B (hu) 1999-11-29
HUT56542A (en) 1991-09-30
LV10251A (lv) 1994-10-20
EP0444852A3 (en) 1992-02-19
CA2037099C (en) 2001-09-11
DK0444852T3 (da) 1995-12-11
IL97306A (en) 1996-10-16
FI910895L (fi) 1991-08-27
PT96852B (pt) 1998-07-31
EP0444852B1 (en) 1995-08-16
KR100208114B1 (ko) 1999-07-15
IE67801B1 (en) 1996-05-01
PT96852A (pt) 1991-10-31
CN1027503C (zh) 1995-01-25
NO910735D0 (no) 1991-02-25
RU2034837C1 (ru) 1995-05-10
CN1054589A (zh) 1991-09-18
KR910021375A (ko) 1991-12-20
EP0444852A2 (en) 1991-09-04
AU7197191A (en) 1991-08-29
ES2077796T3 (es) 1995-12-01
FI95464B (fi) 1995-10-31
FI95464C (fi) 1996-02-12
NO174149C (no) 1994-03-23
DE69112099T2 (de) 1996-02-08
NO910735L (no) 1991-08-27
NO174149B (no) 1993-12-13
DE69112099D1 (de) 1995-09-21
CY1887A (en) 1996-04-05
YU32791A (sh) 1994-01-20
BR9100767A (pt) 1991-10-29
GR3017940T3 (en) 1996-02-29
NZ237181A (en) 1992-06-25
US5397799A (en) 1995-03-14
CA2037099A1 (en) 1991-08-27
JP3157007B2 (ja) 2001-04-16
YU47594B (sh) 1995-10-24
HK175495A (en) 1995-11-24
FI910895A0 (fi) 1991-02-25
IE910625A1 (en) 1991-08-28
SG69975A1 (en) 2000-01-25
ZA911258B (en) 1992-10-28
ATE126506T1 (de) 1995-09-15

Similar Documents

Publication Publication Date Title
LV10251B (en) Method of preparation of hypuric acid salts of 4-(di-n-propyl)amino-6-aminocarbonil-1,3,4,5-tetrahydrobenz£c,d|indole
IE782325L (en) TETRAHYDROBENZ £cd| INDOLES
AU2378988A (en) 4-(N-3-pyridylmethyl)-amino-1,2,4-triazinones
AU6666990A (en) Indole derivatives
AU3430689A (en) Prevention of lens-related tissue growth in the eye
ZA92451B (en) Indole derivatives
AU7941691A (en) Antimigraine alkoxypyrimidine derivatives
EP0485218A3 (en) Process for preparing (1'r,3s)-3-(1'-hydroxy-ethyl)-azetidin-2-one and derivatives thereof
RU92004575A (ru) Кристаллическая соль 4-(ди-н-пропил) амино-6-аминокарбонил-1,3,4,5-тетрагидробенз (cd) индола и ее 4p и 4s-изомеры
AU8949091A (en) Method and apparatus for surgically profiling the cornea using vacuum
AU597017B2 (en) 3-(2-aminoethyl) indoles derivatives
EP0462837A3 (en) Preparation of indole derivatives
PH23992A (en) Optically active 2,3-dihydrobenzoxazine derivatives and process for preparing the same
AU7668987A (en) Lid for improved dendritic web growth
AU590603B2 (en) A method of preparing indoles or indole derivatives, coupled via position 4, 5, 6, or 7, the indoles or indole derivatives concerned, as well as the use thereof
AU609159B2 (en) Method of sterilizing anthers utilizing carboxylic acid derivatives
AU589745B2 (en) 2', 3', 4', 10'-tetrahydro-10'-substituted-10'-hydroxy-spiro ((cycloalkane or heterocyclic)-pyrimido(1,2a)indoles
ZA885123B (en) Pest-combating agents based on derivatives of 2,3-diaminomaleonitrile
AU2803689A (en) Certain 3-substituted 2- alkyl indole derivatives
EP0275104A3 (en) Process for preparing 2,3-dihydro-1h-imidazolylalkoxyindene derivatives and pharmaceutically acceptable salts
AU1418888A (en) Method for producing 2,4-dihydroxyquinoline derivatives
AU609158B2 (en) Method of sterilizing anthers utilizing substituted maleamino acids
AU7983787A (en) Wheelchair having seated & upright modes
GB9024172D0 (en) Method of generating an'i.c.inserted'signal automatically for an i.c.socket
HU205109B (en) Process for producing new, optically active octahydroindolo /2,3-a/ quinolizine-half acid-half ester derivatives and hexahydroindolo/2,3-a/quinolizinium salts