LU87331A1 - Orale magnesium und kalium enthaltende praeparate und deren verwendung - Google Patents
Orale magnesium und kalium enthaltende praeparate und deren verwendung Download PDFInfo
- Publication number
- LU87331A1 LU87331A1 LU87331A LU87331A LU87331A1 LU 87331 A1 LU87331 A1 LU 87331A1 LU 87331 A LU87331 A LU 87331A LU 87331 A LU87331 A LU 87331A LU 87331 A1 LU87331 A1 LU 87331A1
- Authority
- LU
- Luxembourg
- Prior art keywords
- potassium
- magnesium
- pharmaceutical preparations
- bioavailable
- preparations according
- Prior art date
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- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 title claims description 82
- 239000011777 magnesium Substances 0.000 title claims description 65
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title claims description 63
- 229910052749 magnesium Inorganic materials 0.000 title claims description 63
- 239000011591 potassium Substances 0.000 claims description 81
- 229910052700 potassium Inorganic materials 0.000 claims description 81
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 36
- 239000001103 potassium chloride Substances 0.000 claims description 18
- 235000011164 potassium chloride Nutrition 0.000 claims description 18
- 238000013270 controlled release Methods 0.000 claims description 14
- 208000008167 Magnesium Deficiency Diseases 0.000 claims description 13
- 150000003839 salts Chemical class 0.000 claims description 13
- 208000019025 Hypokalemia Diseases 0.000 claims description 10
- 210000001035 gastrointestinal tract Anatomy 0.000 claims description 10
- 208000007645 potassium deficiency Diseases 0.000 claims description 10
- 239000007787 solid Substances 0.000 claims description 10
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- 210000004165 myocardium Anatomy 0.000 claims description 9
- 210000002027 skeletal muscle Anatomy 0.000 claims description 9
- 238000011282 treatment Methods 0.000 claims description 7
- 206010070840 Gastrointestinal tract irritation Diseases 0.000 claims description 5
- 238000011321 prophylaxis Methods 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 3
- 239000013543 active substance Substances 0.000 claims description 3
- 235000005911 diet Nutrition 0.000 claims description 3
- 239000008183 oral pharmaceutical preparation Substances 0.000 claims description 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 18
- 230000000378 dietary effect Effects 0.000 claims 2
- 229960003975 potassium Drugs 0.000 description 59
- 229940091250 magnesium supplement Drugs 0.000 description 44
- 239000003826 tablet Substances 0.000 description 28
- 239000000203 mixture Substances 0.000 description 19
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 14
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 14
- 159000000003 magnesium salts Chemical class 0.000 description 12
- 238000002360 preparation method Methods 0.000 description 12
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- 239000013078 crystal Substances 0.000 description 9
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 8
- 229940050906 magnesium chloride hexahydrate Drugs 0.000 description 8
- DHRRIBDTHFBPNG-UHFFFAOYSA-L magnesium dichloride hexahydrate Chemical compound O.O.O.O.O.O.[Mg+2].[Cl-].[Cl-] DHRRIBDTHFBPNG-UHFFFAOYSA-L 0.000 description 8
- 239000008188 pellet Substances 0.000 description 8
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- -1 alkyl ketones Chemical class 0.000 description 5
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- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 4
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- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000030136 gastric emptying Effects 0.000 description 1
- 208000030304 gastrointestinal bleeding Diseases 0.000 description 1
- 229960002518 gentamicin Drugs 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 210000002837 heart atrium Anatomy 0.000 description 1
- 210000002064 heart cell Anatomy 0.000 description 1
- 210000001308 heart ventricle Anatomy 0.000 description 1
- 150000004687 hexahydrates Chemical class 0.000 description 1
- 150000004677 hydrates Chemical class 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000002642 intravenous therapy Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 239000007942 layered tablet Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002171 loop diuretic Substances 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 230000000527 lymphocytic effect Effects 0.000 description 1
- 229960001983 magnesium aspartate Drugs 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 229960001708 magnesium carbonate Drugs 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 229960000869 magnesium oxide Drugs 0.000 description 1
- GVALZJMUIHGIMD-UHFFFAOYSA-H magnesium phosphate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GVALZJMUIHGIMD-UHFFFAOYSA-H 0.000 description 1
- 239000004137 magnesium phosphate Substances 0.000 description 1
- 229960002261 magnesium phosphate Drugs 0.000 description 1
- 229910000157 magnesium phosphate Inorganic materials 0.000 description 1
- 235000010994 magnesium phosphates Nutrition 0.000 description 1
- RXMQCXCANMAVIO-CEOVSRFSSA-L magnesium;(2s)-2-amino-4-hydroxy-4-oxobutanoate Chemical compound [H+].[H+].[Mg+2].[O-]C(=O)[C@@H](N)CC([O-])=O.[O-]C(=O)[C@@H](N)CC([O-])=O RXMQCXCANMAVIO-CEOVSRFSSA-L 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 235000000824 malnutrition Nutrition 0.000 description 1
- 230000001071 malnutrition Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 description 1
- 208000015380 nutritional deficiency disease Diseases 0.000 description 1
- QYSGYZVSCZSLHT-UHFFFAOYSA-N octafluoropropane Chemical compound FC(F)(F)C(F)(F)C(F)(F)F QYSGYZVSCZSLHT-UHFFFAOYSA-N 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000008506 pathogenesis Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 201000009395 primary hyperaldosteronism Diseases 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 201000010384 renal tubular acidosis Diseases 0.000 description 1
- 229940100486 rice starch Drugs 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 210000002363 skeletal muscle cell Anatomy 0.000 description 1
- 239000007962 solid dispersion Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 230000002966 stenotic effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 239000011975 tartaric acid Chemical class 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- WEAPVABOECTMGR-UHFFFAOYSA-N triethyl 2-acetyloxypropane-1,2,3-tricarboxylate Chemical compound CCOC(=O)CC(C(=O)OCC)(OC(C)=O)CC(=O)OCC WEAPVABOECTMGR-UHFFFAOYSA-N 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/14—Alkali metal chlorides; Alkaline earth metal chlorides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Inorganic Chemistry (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9575087A | 1987-09-11 | 1987-09-11 | |
| US9575087 | 1987-09-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LU87331A1 true LU87331A1 (fr) | 1989-10-26 |
Family
ID=22253423
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LU87331A LU87331A1 (fr) | 1987-09-11 | 1988-09-07 | Orale magnesium und kalium enthaltende praeparate und deren verwendung |
Country Status (12)
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0429679B1 (en) * | 1989-06-20 | 1997-03-19 | Otsuka Pharmaceutical Co., Ltd. | Potassium-supplementing preparation |
| US5132118A (en) * | 1990-05-11 | 1992-07-21 | Mills John A | Treatment of exercise-induced pulmonary hemorrhage in animals |
| FI911038A7 (fi) * | 1991-03-01 | 1992-09-02 | Slk Marketing Oy | Dryckpulver. |
| US5460972A (en) * | 1991-04-08 | 1995-10-24 | Research Foundation Of The State University Of New York | Ionized magnesium2+ concentrations in biological samples |
| FR2677546B1 (fr) * | 1991-06-12 | 1994-01-21 | Fabienne Joanny | Composition therapeutique pour liberation prolonge de magnesium. |
| DE4201504C2 (de) * | 1992-01-21 | 1997-04-30 | Protina Chemische Ges Mbh | Magnesiumpräparat |
| CN1090483C (zh) * | 1997-07-31 | 2002-09-11 | 谢理峰 | 钾镁缓释片及生产方法 |
| DE10158286B4 (de) * | 2000-11-20 | 2007-08-02 | Dehn, Michael C. | Wirkstoffspeicherndes Schichtmaterial |
| DE10126405A1 (de) * | 2001-05-22 | 2003-02-27 | Trommsdorff Gmbh & Co | Physiologisch verträgliche Kalium- und Magnesiumsalze enthaltendes pharmazeutisches Präparat sowie dessen Verwendung zur Prophylaxe und/oder Therapie von QT-Zeitverlängerungen |
| ATE485814T1 (de) * | 2005-08-19 | 2010-11-15 | Verla Pharm | Magnesium-mikrotabletten mit verzögerter freisetzung |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA73467B (en) * | 1972-02-25 | 1973-10-31 | Hoffmann La Roche | Mineral salts containing preparation |
| GB1422193A (en) * | 1974-07-26 | 1976-01-21 | Smith Kline French Lab | Pharmaceutical compositions |
-
1988
- 1988-09-01 CH CH3263/88A patent/CH677612A5/de not_active IP Right Cessation
- 1988-09-06 BE BE8801017A patent/BE1001842A3/fr not_active IP Right Cessation
- 1988-09-06 SE SE8803125A patent/SE8803125L/xx not_active Application Discontinuation
- 1988-09-07 LU LU87331A patent/LU87331A1/de unknown
- 1988-09-08 GB GB8821056A patent/GB2209668B/en not_active Expired - Lifetime
- 1988-09-08 DE DE3830563A patent/DE3830563A1/de not_active Withdrawn
- 1988-09-08 IT IT8848327A patent/IT1227010B/it active
- 1988-09-09 AU AU22043/88A patent/AU619481B2/en not_active Expired - Fee Related
- 1988-09-09 FR FR8811809A patent/FR2620334A1/fr not_active Withdrawn
- 1988-09-09 DK DK501288A patent/DK501288A/da not_active Application Discontinuation
- 1988-09-09 JP JP63224835A patent/JPH01100128A/ja active Pending
- 1988-09-09 NL NL8802224A patent/NL8802224A/nl not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IT8848327A0 (it) | 1988-09-08 |
| AU2204388A (en) | 1989-03-16 |
| DK501288A (da) | 1989-03-12 |
| FR2620334A1 (fr) | 1989-03-17 |
| DE3830563A1 (de) | 1989-03-30 |
| DK501288D0 (da) | 1988-09-09 |
| CH677612A5 (enrdf_load_stackoverflow) | 1991-06-14 |
| GB8821056D0 (en) | 1988-10-05 |
| SE8803125D0 (sv) | 1988-09-06 |
| IT1227010B (it) | 1991-03-05 |
| GB2209668B (en) | 1991-06-05 |
| AU619481B2 (en) | 1992-01-30 |
| JPH01100128A (ja) | 1989-04-18 |
| BE1001842A3 (fr) | 1990-03-20 |
| NL8802224A (nl) | 1989-04-03 |
| SE8803125L (sv) | 1989-03-12 |
| GB2209668A (en) | 1989-05-24 |
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