LU86444A1 - Nouvelle compostion d'activateur tissulaire du plasminogene - Google Patents

Nouvelle compostion d'activateur tissulaire du plasminogene Download PDF

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Publication number
LU86444A1
LU86444A1 LU86444A LU86444A LU86444A1 LU 86444 A1 LU86444 A1 LU 86444A1 LU 86444 A LU86444 A LU 86444A LU 86444 A LU86444 A LU 86444A LU 86444 A1 LU86444 A1 LU 86444A1
Authority
LU
Luxembourg
Prior art keywords
pharmaceutical composition
per
aqueous solution
concentration
lyophilized pharmaceutical
Prior art date
Application number
LU86444A
Other languages
English (en)
French (fr)
Inventor
Michael Denis Johnston
Henry Berger
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858513358A external-priority patent/GB8513358D0/en
Priority claimed from GB858521705A external-priority patent/GB8521705D0/en
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of LU86444A1 publication Critical patent/LU86444A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
LU86444A 1985-05-28 1986-05-27 Nouvelle compostion d'activateur tissulaire du plasminogene LU86444A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB858513358A GB8513358D0 (en) 1985-05-28 1985-05-28 Formulation
GB8513358 1985-08-31
GB8521705 1985-08-31
GB858521705A GB8521705D0 (en) 1985-08-31 1985-08-31 Formulation

Publications (1)

Publication Number Publication Date
LU86444A1 true LU86444A1 (fr) 1986-12-05

Family

ID=26289290

Family Applications (1)

Application Number Title Priority Date Filing Date
LU86444A LU86444A1 (fr) 1985-05-28 1986-05-27 Nouvelle compostion d'activateur tissulaire du plasminogene

Country Status (22)

Country Link
US (2) US4929444A (da)
JP (1) JPH0759517B2 (da)
AU (1) AU567236B2 (da)
BE (1) BE904830A (da)
CA (1) CA1300008C (da)
CH (1) CH665356A5 (da)
DE (1) DE3617752A1 (da)
DK (1) DK163173C (da)
ES (2) ES8800601A1 (da)
FI (1) FI85335C (da)
FR (1) FR2583984B1 (da)
GB (1) GB2176702B (da)
GR (1) GR861366B (da)
HU (1) HU195733B (da)
IL (1) IL78938A (da)
IT (1) IT1191926B (da)
LU (1) LU86444A1 (da)
NL (1) NL8601355A (da)
NO (1) NO171345C (da)
NZ (1) NZ216307A (da)
PT (1) PT82646B (da)
SE (1) SE462016B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE462893B (sv) * 1985-05-28 1990-09-17 Wellcome Found Vattenhaltig parenteral loesning av vaevnadsplasminogenaktivator och saett foer framstaellning av den
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
US5034225A (en) * 1985-12-17 1991-07-23 Genentech Inc. Stabilized human tissue plasminogen activator compositions
US4777043A (en) * 1985-12-17 1988-10-11 Genentech, Inc. Stabilized human tissue plasminogen activator compositions
SE8701921L (sv) * 1986-05-12 1987-11-13 Wellcome Found Ny farmaceutisk anvendning
US4976959A (en) * 1986-05-12 1990-12-11 Burroughs Wellcome Co. T-PA and SOD in limiting tissue damage
GB8619098D0 (en) * 1986-08-05 1986-09-17 Wellcome Found Combination
US5270198A (en) * 1988-05-20 1993-12-14 Genentech, Inc. DNA molecules encoding variants of tissue plasminogen activators, vectors, and host cells
US5342616A (en) * 1988-06-20 1994-08-30 The Wellcome Foundation Limited Method of administering tissue plasminogen activator
US5262170A (en) * 1988-09-02 1993-11-16 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties and substituted at amino acid positions 296-299, DNA molecules encoding them, vectors, and host cells
US5714145A (en) * 1988-09-02 1998-02-03 Genentech, Inc. Tissue plasminogen activator having zymogenic or fibrin specific properties
DE3835350A1 (de) * 1988-10-17 1990-04-19 Boehringer Mannheim Gmbh Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern
US4980165A (en) * 1989-01-27 1990-12-25 Genetics Institute, Inc. Pharmaceutical formulations of plasminogen activator proteins
DE3942142A1 (de) * 1989-12-20 1991-06-27 Boehringer Mannheim Gmbh Stabilisierung von glykosyliertem t-pa
WO1992011866A1 (en) * 1991-01-14 1992-07-23 Duke University LAMININ SEQUENCE AS tPA ACTIVATOR
EP0643772B1 (en) * 1992-06-03 1997-07-23 Genentech, Inc. Tissue plasminogen activator glycosylation variants with improved therapeutic properties
ATE248912T1 (de) * 1995-10-23 2003-09-15 Childrens Medical Center Therapeutische antiangiogenische zusammensetzungen und verfahren
US6346510B1 (en) 1995-10-23 2002-02-12 The Children's Medical Center Corporation Therapeutic antiangiogenic endostatin compositions
KR100477280B1 (ko) * 1995-12-13 2005-07-18 아보트 러보러터리즈 맥관형성에의한질환치료제
EP0827751B1 (en) * 1996-09-06 2003-02-26 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Medicinal composition containing tissue plasminogen activator and nicotinamide
JP2005502710A (ja) * 2001-09-07 2005-01-27 グローバル バイオテック インコーポレイテッド ヒト組織ウロキナーゼ型プラスミノーゲン活性化因子製剤
US20040091465A1 (en) * 2002-06-26 2004-05-13 Zachary Yim Therapeutic antiangiogenic compositions and methods
CA2528577C (en) * 2003-06-20 2012-08-07 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US7491263B2 (en) * 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
ES2443653T3 (es) * 2005-04-20 2014-02-20 Fred Hutchinson Cancer Research Center Procedimientos, composiciones y artículos de fabricación para mejorar la supervivencia de células, tejidos, órganos y organismos

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998947A (en) * 1973-11-30 1976-12-21 Pierre Fabre S.A. Process for obtaining a plasminogen activator
FR2252842B1 (da) * 1973-12-03 1977-11-04 Fabre Sa Pierre
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
CH660742A5 (de) * 1982-10-29 1987-06-15 Mitsui Toatsu Chemicals Plasminogen-aktivator, verfahren zu seiner herstellung und diesen enthaltendes thrombolytisches agens.
AU554862B2 (en) * 1982-12-14 1986-09-04 Implico B.V. Plasminogen activator isolated by affinity chromatography
NZ206699A (en) * 1982-12-30 1989-08-29 Bio Response Inc Process for the production of serum independent cell lines
JPS59196824A (ja) * 1983-04-21 1984-11-08 Kowa Co 吸着防止剤
EP0156169B1 (en) * 1984-02-29 1991-12-18 Asahi Kasei Kogyo Kabushiki Kaisha An aqueous solution of a tissue plasminogen activator dissolved therein at an increased concentration and a method
DE3439980A1 (de) * 1984-11-02 1986-05-07 Behringwerke Ag, 3550 Marburg Verfahren zur reinigung sowie pasteurisierung von urokinase
EP0201153A3 (en) * 1985-02-09 1987-10-07 Beecham Group Plc Modified enzyme and process for its preparation
GB8513358D0 (en) * 1985-05-28 1985-07-03 Wellcome Found Formulation
ZW14486A1 (en) * 1985-07-29 1986-10-22 Smithkline Beckman Corp Pharmaceutical dosage unit
JPH0672105B2 (ja) * 1985-10-02 1994-09-14 持田製薬株式会社 血栓溶解剤及びその製法

Also Published As

Publication number Publication date
US4968617A (en) 1990-11-06
FI85335C (fi) 1992-04-10
GB2176702B (en) 1989-07-05
NO171345B (no) 1992-11-23
GR861366B (en) 1986-09-29
FI85335B (fi) 1991-12-31
NZ216307A (en) 1989-10-27
ES8802439A1 (es) 1988-06-01
FI862227A (fi) 1986-11-29
AU5796486A (en) 1986-12-04
NL8601355A (nl) 1986-12-16
IL78938A0 (en) 1986-09-30
CA1300008C (en) 1992-05-05
CH665356A5 (de) 1988-05-13
DK163173B (da) 1992-02-03
US4929444A (en) 1990-05-29
HUT41638A (en) 1987-05-28
DK163173C (da) 1992-06-22
SE8602405D0 (sv) 1986-05-27
ES557374A0 (es) 1988-06-01
PT82646B (pt) 1989-01-30
ES555353A0 (es) 1987-11-16
JPH0759517B2 (ja) 1995-06-28
GB2176702A (en) 1987-01-07
SE8602405L (sv) 1986-11-29
FR2583984B1 (fr) 1989-06-02
DK246786A (da) 1986-11-29
PT82646A (en) 1986-06-01
HU195733B (en) 1988-07-28
IT8648065A0 (it) 1986-05-27
DE3617752C2 (da) 1988-06-30
ES8800601A1 (es) 1987-11-16
SE462016B (sv) 1990-04-30
FI862227A0 (fi) 1986-05-27
NO862096L (no) 1986-12-01
FR2583984A1 (fr) 1987-01-02
BE904830A (fr) 1986-11-27
DE3617752A1 (de) 1986-12-04
IT1191926B (it) 1988-03-31
NO171345C (no) 1993-03-03
AU567236B2 (en) 1987-11-12
GB8612780D0 (en) 1986-07-02
DK246786D0 (da) 1986-05-27
IL78938A (en) 1993-02-21
JPH06183995A (ja) 1994-07-05

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