LU85743A1 - Composes heterocycliques - Google Patents

Composes heterocycliques Download PDF

Info

Publication number
LU85743A1
LU85743A1 LU85743A LU85743A LU85743A1 LU 85743 A1 LU85743 A1 LU 85743A1 LU 85743 A LU85743 A LU 85743A LU 85743 A LU85743 A LU 85743A LU 85743 A1 LU85743 A1 LU 85743A1
Authority
LU
Luxembourg
Prior art keywords
methyl
compound
formula
group
hydrogen atom
Prior art date
Application number
LU85743A
Other languages
English (en)
French (fr)
Inventor
Ian Harold Coates
David Cedric Humber
James Angus Bell
George Blanch Ewan
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848401888A external-priority patent/GB8401888D0/en
Priority claimed from GB848425959A external-priority patent/GB8425959D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of LU85743A1 publication Critical patent/LU85743A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
LU85743A 1984-01-25 1985-01-25 Composes heterocycliques LU85743A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8401888 1984-01-25
GB848401888A GB8401888D0 (en) 1984-01-25 1984-01-25 Heterocyclic compounds
GB848425959A GB8425959D0 (en) 1984-10-15 1984-10-15 Heterocyclic compounds
GB8425959 1984-10-15

Publications (1)

Publication Number Publication Date
LU85743A1 true LU85743A1 (fr) 1986-08-04

Family

ID=26287221

Family Applications (2)

Application Number Title Priority Date Filing Date
LU85743A LU85743A1 (fr) 1984-01-25 1985-01-25 Composes heterocycliques
LU88268C LU88268I2 (no) 1984-01-25 1985-01-25

Family Applications After (1)

Application Number Title Priority Date Filing Date
LU88268C LU88268I2 (no) 1984-01-25 1985-01-25

Country Status (29)

Country Link
KR (1) KR920003064B1 (no)
AT (1) AT392276B (no)
AU (1) AU579132B2 (no)
BE (1) BE901576A (no)
CA (1) CA1252793A (no)
CH (1) CH664152A5 (no)
CY (1) CY1479A (no)
CZ (1) CZ404391A3 (no)
DE (2) DE3502508A1 (no)
DK (1) DK169521B1 (no)
ES (3) ES8609309A1 (no)
FI (1) FI84349C (no)
FR (1) FR2561244B1 (no)
GB (1) GB2153821B (no)
GR (1) GR850219B (no)
HK (1) HK33189A (no)
HU (1) HU193592B (no)
IE (1) IE57809B1 (no)
IL (1) IL74165A (no)
IT (1) IT1182150B (no)
LU (2) LU85743A1 (no)
NL (2) NL190373C (no)
NO (2) NO164025C (no)
NZ (1) NZ210940A (no)
PH (1) PH22672A (no)
PT (1) PT79890B (no)
SE (1) SE460359B (no)
SG (1) SG7089G (no)
SK (1) SK404391A3 (no)

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US5204356A (en) * 1985-07-24 1993-04-20 Glaxo Group Limited Treatment of anxiety
GB8518742D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518745D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518658D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Medicaments
GB8617994D0 (en) * 1986-07-23 1986-08-28 Glaxo Group Ltd Heterocyclic compounds
HU895334D0 (en) * 1986-07-30 1990-01-28 Sandoz Ag Process for the preparation of nasal pharmaceutical compositions
AT396870B (de) * 1986-08-07 1993-12-27 Sandoz Ag Verfahren zur herstellung einer galenischen formulierung zur nasalen verabreichung von serotoninantagonisten
GB8623819D0 (en) * 1986-10-03 1986-11-05 Glaxo Group Ltd Heterocyclic compounds
GB8627909D0 (en) * 1986-11-21 1986-12-31 Glaxo Group Ltd Medicaments
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GB8628475D0 (en) * 1986-11-28 1987-01-07 Glaxo Group Ltd Medicaments
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GB8812002D0 (en) * 1988-05-20 1988-06-22 Glaxo Group Ltd Chemical compounds
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GB8630071D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
GB8630079D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
US5190954A (en) * 1986-12-17 1993-03-02 Glaxo Group Limited Methods for the treatment of cognitive disorders
EP0278173B1 (en) * 1986-12-17 1993-11-03 Glaxo Group Limited Use of heterocyclic derivatives in the treatment of depressions
JP2608078B2 (ja) * 1986-12-17 1997-05-07 グラクソ、グループ、リミテッド 医 薬
US4918080A (en) * 1987-04-14 1990-04-17 Glaxo Group Limited Imidazollyl containing ketone derivatives
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DK185489A (da) * 1988-04-22 1989-10-23 Duphar Int Res Imidazolylmethyl-cycloalkanoebaaindoloner, deres fremstilling og anvendelse
US4985422A (en) * 1988-04-27 1991-01-15 Glaxo Group Limited Lactam derivatives
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
AU627221B2 (en) * 1988-09-27 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
US5173493A (en) * 1988-09-27 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Pyridoindole derivatives and processes for preparation thereof
US5290785A (en) * 1988-09-27 1994-03-01 Fujisawa Pharmaceutical Co., Ltd. Therapeutic agent for ischemic diseases
FR2639944B1 (fr) * 1988-12-06 1991-01-18 Adir Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP0377238A1 (en) * 1988-12-22 1990-07-11 Duphar International Research B.V New annelated indolo (3,2-c)-lactams
CA2004911A1 (en) * 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
KR900013959A (ko) * 1989-03-13 1990-10-22 원본미기재 γ-카르블린 또는 그들의 제약학적으로 허용 가능한 산부가염 및/또는 수화물, 및 그들로 구성되는 제약학적 조성물
ATE97803T1 (de) * 1989-04-21 1993-12-15 Sandoz Ag Therapeutische verwendung von 5-ht3-rezeptorantagonisten.
GB8914804D0 (en) * 1989-06-28 1989-08-16 Glaxo Group Ltd Process
US5276050A (en) * 1989-08-01 1994-01-04 Glaxo Group Limited Medicaments
GB8917557D0 (en) * 1989-08-01 1989-09-13 Glaxo Group Ltd Medicaments
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
GB2236751B (en) 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
EP1022025A3 (en) * 1991-06-26 2002-06-05 Sepracor, Inc. Method and compositions for treating emesis nausea and other disorders using optically pure R(+) ondansetron
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
ES2043535B1 (es) * 1992-03-13 1994-08-01 Vita Invest Sa Procedimiento para la obtencion de la 1,2,3,9-tetrahidro-9-metil-3-(2-metil-1h-imidazol-1-il)metil*-4h-carbazol-4-ona.
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
HU212934B (en) 1992-10-14 1996-12-30 Richter Gedeon Vegyeszet Process for producing novel alkoxalylated carbazolone derivatives
US5607938A (en) * 1993-03-08 1997-03-04 Fujisawa Pharmaceutical Co., Ltd. Medicament for treating or preventing cerebrovascular infarction
GB9310756D0 (en) * 1993-05-25 1993-07-14 Glaxo Lab Sa Compositions
GB2327348A (en) * 1994-06-28 1999-01-27 Kenneth Francis Prendergast Pharmaceutical use of ondansetron
GB9423588D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
US6365743B1 (en) 1995-10-13 2002-04-02 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
AU702594B2 (en) * 1995-10-13 1999-02-25 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US5969137A (en) * 1996-09-19 1999-10-19 Virginia Commonwealth University Benzylamidine derivatives with serotonin receptor binding activity
WO2000051582A2 (en) 1999-03-01 2000-09-08 Sepracor Inc. Methods for treating apnea and apnea disorders using optically pure r(+)ondansetron
EP1207160A1 (en) * 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
JP2005529142A (ja) 2002-04-29 2005-09-29 テバ ジョジセルジャール レースベニュタールシャシャーグ １，２，３，９−テトラヒドロ−９−メチル−３−［（２−メチル−１ｈ−イミダゾル−１−イル）メチル］−４ｈ−カルバゾル−４−オンの製造方法
FI6164U1 (fi) * 2003-01-09 2004-03-15 Synthon Bv Ondansetronmuotoja
GB2398071B (en) * 2003-01-24 2006-06-07 Synthon Bv Process for making ondansetron and intermediate thereof
ES2238001B1 (es) * 2004-01-21 2006-11-01 Vita Cientifica, S.L. Nuevas formas polimorficas de ondansetron, procedimientos para su preparacion, composiciones farmaceuticas que los contienen y su uso como aantiemeticos.
WO2005108392A2 (en) 2004-05-07 2005-11-17 Taro Pharmaceutical Industries Ltd. Process for preparing ondansetron hydrochloride dihydrate having a defined particle size
WO2007004041A2 (en) * 2005-07-05 2007-01-11 Orchid Research Laboratories Limited New compounds and their pharmaceutical use
EP2253316B1 (en) 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
KR101779991B1 (ko) 2009-05-20 2017-09-19 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 병소성 전정 질환을 치료하기 위한 세로토닌 5-ｈｔ3 수용체 길항제의 용도
CN115611864A (zh) * 2022-11-01 2023-01-17 常州兰陵制药有限公司 一种昂丹司琼类化合物及其制备方法与应用

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US3634420A (en) * 1969-05-09 1972-01-11 American Cyanamid Co 3(morpholinomethyl)-2 3-dihydro-carbazol-4(1h)-ones
US3740404A (en) * 1969-05-09 1973-06-19 American Cyanamid Co Piperidinomethylenedihydrocarbazolones
DE3680123D1 (en) * 1985-01-23 1991-08-14 Glaxo Group Ltd Tetrahydrocarbazolonderivate.

Also Published As

Publication number Publication date
HUT37784A (en) 1986-02-28
SE460359B (sv) 1989-10-02
FR2561244B1 (fr) 1988-03-04
NO850300L (no) 1985-07-26
GR850219B (no) 1985-05-23
FI850323L (fi) 1985-07-26
DK35785D0 (da) 1985-01-25
PT79890A (en) 1985-02-01
PH22672A (en) 1988-11-14
IL74165A (en) 1988-11-15
KR850005439A (ko) 1985-08-26
SG7089G (en) 1989-06-09
CA1252793A (en) 1989-04-18
ES548430A0 (es) 1987-10-01
CH664152A5 (fr) 1988-02-15
BE901576A (fr) 1985-07-25
IT8547600A0 (it) 1985-01-25
FI850323A0 (fi) 1985-01-25
IE57809B1 (en) 1993-04-21
HK33189A (en) 1989-04-28
DE3502508C2 (no) 1990-05-03
SK277923B6 (en) 1995-08-09
DK35785A (da) 1985-07-26
IT1182150B (it) 1987-09-30
NO1994022I1 (no) 1994-11-09
ATA20485A (de) 1990-08-15
DE19375046I2 (de) 2002-10-10
SK404391A3 (en) 1995-08-09
DK169521B1 (da) 1994-11-21
AU3809785A (en) 1985-08-01
CZ404391A3 (en) 1993-04-14
FI84349B (fi) 1991-08-15
DE3502508A1 (de) 1985-08-14
NL940009I2 (nl) 1999-05-03
ES8801247A1 (es) 1987-12-16
SE8500368L (sv) 1985-07-26
NL940009I1 (nl) 1994-07-18
AU579132B2 (en) 1988-11-17
GB2153821B (en) 1988-01-20
NZ210940A (en) 1989-08-29
LU88268I2 (no) 1994-02-03
SE8500368D0 (sv) 1985-01-25
FI84349C (fi) 1991-11-25
HU193592B (en) 1987-11-30
ES556101A0 (es) 1987-12-16
KR920003064B1 (ko) 1992-04-13
ES8708224A1 (es) 1987-10-01
PT79890B (en) 1987-02-03
GB2153821A (en) 1985-08-29
NL190373B (nl) 1993-09-01
ES539852A0 (es) 1986-07-16
NL8500202A (nl) 1985-08-16
GB8501889D0 (en) 1985-02-27
IE850187L (en) 1985-07-25
NO164025C (no) 1990-08-22
AT392276B (de) 1991-02-25
CY1479A (en) 1989-07-21
ES8609309A1 (es) 1986-07-16
FR2561244A1 (fr) 1985-09-20
NO164025B (no) 1990-05-14
NL190373C (nl) 1994-02-01

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