GR850219B - - Google Patents

Info

Publication number
GR850219B
GR850219B GR850219A GR850100219A GR850219B GR 850219 B GR850219 B GR 850219B GR 850219 A GR850219 A GR 850219A GR 850100219 A GR850100219 A GR 850100219A GR 850219 B GR850219 B GR 850219B
Authority
GR
Greece
Application number
GR850219A
Other languages
Greek (el)
Inventor
Ian Harold Coates
James Angus Bell
David Cedric
George Blanch Ewan
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848401888A external-priority patent/GB8401888D0/en
Priority claimed from GB848425959A external-priority patent/GB8425959D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of GR850219B publication Critical patent/GR850219B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
GR850219A 1984-01-25 1985-01-25 GR850219B (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848401888A GB8401888D0 (en) 1984-01-25 1984-01-25 Heterocyclic compounds
GB848425959A GB8425959D0 (en) 1984-10-15 1984-10-15 Heterocyclic compounds

Publications (1)

Publication Number Publication Date
GR850219B true GR850219B (no) 1985-05-23

Family

ID=26287221

Family Applications (1)

Application Number Title Priority Date Filing Date
GR850219A GR850219B (no) 1984-01-25 1985-01-25

Country Status (29)

Country Link
KR (1) KR920003064B1 (no)
AT (1) AT392276B (no)
AU (1) AU579132B2 (no)
BE (1) BE901576A (no)
CA (1) CA1252793A (no)
CH (1) CH664152A5 (no)
CY (1) CY1479A (no)
CZ (1) CZ404391A3 (no)
DE (2) DE3502508A1 (no)
DK (1) DK169521B1 (no)
ES (3) ES8609309A1 (no)
FI (1) FI84349C (no)
FR (1) FR2561244B1 (no)
GB (1) GB2153821B (no)
GR (1) GR850219B (no)
HK (1) HK33189A (no)
HU (1) HU193592B (no)
IE (1) IE57809B1 (no)
IL (1) IL74165A (no)
IT (1) IT1182150B (no)
LU (2) LU88268I2 (no)
NL (2) NL190373C (no)
NO (2) NO164025C (no)
NZ (1) NZ210940A (no)
PH (1) PH22672A (no)
PT (1) PT79890B (no)
SE (1) SE460359B (no)
SG (1) SG7089G (no)
SK (1) SK404391A3 (no)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
DE3680123D1 (en) * 1985-01-23 1991-08-14 Glaxo Group Ltd Tetrahydrocarbazolonderivate.
DE385517T1 (de) * 1985-03-14 1991-07-25 Beecham Group P.L.C., Brentford, Middlesex, Gb Arzneimittel zur behandlung von erbrechen.
US5578628A (en) * 1985-06-25 1996-11-26 Glaxo Group Limited Medicaments for the treatment of nausea and vomiting
GB8516083D0 (en) * 1985-06-25 1985-07-31 Glaxo Group Ltd Heterocyclic compounds
GB8518741D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518658D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Medicaments
US5204356A (en) * 1985-07-24 1993-04-20 Glaxo Group Limited Treatment of anxiety
GB8518742D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518745D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8617994D0 (en) * 1986-07-23 1986-08-28 Glaxo Group Ltd Heterocyclic compounds
NL8701682A (nl) * 1986-07-30 1988-02-16 Sandoz Ag Werkwijze voor het therapeutisch toepassen van serotonine antagonisten, aktieve verbindingen en farmaceutische preparaten die deze verbindingen bevatten.
AT396870B (de) * 1986-08-07 1993-12-27 Sandoz Ag Verfahren zur herstellung einer galenischen formulierung zur nasalen verabreichung von serotoninantagonisten
GB8623819D0 (en) * 1986-10-03 1986-11-05 Glaxo Group Ltd Heterocyclic compounds
EP0279114B2 (en) * 1986-11-21 1995-08-23 Glaxo Group Limited Medicaments for the treatment or prevention of the withdrawal syndrome
GB8627909D0 (en) * 1986-11-21 1986-12-31 Glaxo Group Ltd Medicaments
GR871809B (en) * 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
US5202343A (en) * 1986-11-28 1993-04-13 Glaxo Group Limited Tricyclic ketones useful as HT3 -receptor antagonists
GB8812002D0 (en) * 1988-05-20 1988-06-22 Glaxo Group Ltd Chemical compounds
GB8628475D0 (en) * 1986-11-28 1987-01-07 Glaxo Group Ltd Medicaments
US4973594A (en) * 1986-12-17 1990-11-27 Glaxo Group Limited Medicaments
US5200414A (en) * 1986-12-17 1993-04-06 Glaxo Group Limited Methods for the treatment of cognitive disorders
IE60991B1 (en) * 1986-12-17 1994-09-07 Glaxo Group Ltd Use of ketone derivatives in the treatment of cognitive disorders
GB8630079D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
US5190954A (en) * 1986-12-17 1993-03-02 Glaxo Group Limited Methods for the treatment of cognitive disorders
GB8630071D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
EP0291172B1 (en) * 1987-04-14 1992-11-19 Glaxo Group Limited Ketone derivatives
DE3874229T2 (de) * 1987-06-16 1993-03-25 British Tech Group Verwendung von dioxopiperidin-derivaten zur herstellung eines topischen praeparates als analgetika.
DE3822792C2 (de) * 1987-07-11 1997-11-27 Sandoz Ag Neue Verwendung von 5HT¶3¶-Antagonisten
GB8723157D0 (en) * 1987-10-02 1987-11-04 Beecham Group Plc Compounds
CA1304082C (en) * 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
EP0317088A1 (en) * 1987-10-22 1989-05-24 Glaxo Group Limited Ketone derivatives
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8805269D0 (en) * 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
US5116984A (en) * 1988-04-07 1992-05-26 Glaxo Group Limited Imidazole derivatives
DK185489A (da) * 1988-04-22 1989-10-23 Duphar Int Res Imidazolylmethyl-cycloalkanoebaaindoloner, deres fremstilling og anvendelse
EP0339959A3 (en) * 1988-04-27 1991-03-20 Glaxo Group Limited Lactam derivatives
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
US5173493A (en) * 1988-09-27 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Pyridoindole derivatives and processes for preparation thereof
US5290785A (en) * 1988-09-27 1994-03-01 Fujisawa Pharmaceutical Co., Ltd. Therapeutic agent for ischemic diseases
AU627221B2 (en) * 1988-09-27 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
FR2639944B1 (fr) * 1988-12-06 1991-01-18 Adir Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP0377238A1 (en) * 1988-12-22 1990-07-11 Duphar International Research B.V New annelated indolo (3,2-c)-lactams
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
CA2004911A1 (en) * 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
CA2012092A1 (en) * 1989-03-13 1990-09-13 Tadao Okegawa 5-ht3 receptor antagonist
ATE97803T1 (de) * 1989-04-21 1993-12-15 Sandoz Ag Therapeutische verwendung von 5-ht3-rezeptorantagonisten.
GB8914804D0 (en) * 1989-06-28 1989-08-16 Glaxo Group Ltd Process
US5276050A (en) * 1989-08-01 1994-01-04 Glaxo Group Limited Medicaments
GB8917557D0 (en) * 1989-08-01 1989-09-13 Glaxo Group Ltd Medicaments
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
GB2236751B (en) 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
JPH06508836A (ja) * 1991-06-26 1994-10-06 セプラコア，インコーポレーテッド 光学的に純粋なｒ（＋）オンダンセトロンを使用する嘔吐、吐き気および他の障害の治療のための方法および組成物
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
ES2043535B1 (es) * 1992-03-13 1994-08-01 Vita Invest Sa Procedimiento para la obtencion de la 1,2,3,9-tetrahidro-9-metil-3-(2-metil-1h-imidazol-1-il)metil*-4h-carbazol-4-ona.
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
HU212934B (en) 1992-10-14 1996-12-30 Richter Gedeon Vegyeszet Process for producing novel alkoxalylated carbazolone derivatives
AU683447B2 (en) * 1993-03-08 1997-11-13 Fujisawa Pharmaceutical Co., Ltd. Medicament for treating or preventing cerebrovascular diseases
GB9310756D0 (en) * 1993-05-25 1993-07-14 Glaxo Lab Sa Compositions
GB2325409B (en) * 1994-06-28 1999-02-10 Kenneth Francis Prendergast Pharmaceutical use of ondansetron/cyclodextrin complexes
GB9423588D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
US6365743B1 (en) 1995-10-13 2002-04-02 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
AU702594B2 (en) * 1995-10-13 1999-02-25 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US5969137A (en) * 1996-09-19 1999-10-19 Virginia Commonwealth University Benzylamidine derivatives with serotonin receptor binding activity
WO2000051582A2 (en) 1999-03-01 2000-09-08 Sepracor Inc. Methods for treating apnea and apnea disorders using optically pure r(+)ondansetron
EP1207160A1 (en) * 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
PT1499623E (pt) 2002-04-29 2007-08-10 Teva Gyogyszergyar Zartkoeruee ''processo papa a preparação de 1, 2, 3, 9-tetra-hidro-9-metil-3- [(2-metil-1h-imidazol-1-il) metil] -4h-carbazol-4-ona''
FI6164U1 (fi) * 2003-01-09 2004-03-15 Synthon Bv Ondansetronmuotoja
GB2398071B (en) * 2003-01-24 2006-06-07 Synthon Bv Process for making ondansetron and intermediate thereof
ES2238001B1 (es) * 2004-01-21 2006-11-01 Vita Cientifica, S.L. Nuevas formas polimorficas de ondansetron, procedimientos para su preparacion, composiciones farmaceuticas que los contienen y su uso como aantiemeticos.
US7288660B2 (en) 2004-05-07 2007-10-30 Taro Pharmaceutical Industries Limited Process for preparing ondansetron hydrochloride dihydrate having a defined particle size
US20090170872A1 (en) * 2005-07-05 2009-07-02 Orchid Research Laboratories Limited Compounds and Their Pharmaceutical Use
ES2432618T3 (es) 2009-05-20 2013-12-04 Inserm (Institut National De La Santé Et De La Recherche Medicale) Antagonistas del receptor 5-HT3 de serotonina para usar en el tratamiento o prevención de una patología del oído interno con déficit vestibular
SI2432467T1 (en) 2009-05-20 2018-06-29 Inserm (Institut National De La Sante Et De La Recherche Medicale) ANTAGONIST RECEPTOR SEROTONINA 5-HT3 FOR THE USE IN THE TREATMENT OF LEASE VESTIBULAR DISEASES
CN115611864A (zh) * 2022-11-01 2023-01-17 常州兰陵制药有限公司 一种昂丹司琼类化合物及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3740404A (en) * 1969-05-09 1973-06-19 American Cyanamid Co Piperidinomethylenedihydrocarbazolones
US3634420A (en) * 1969-05-09 1972-01-11 American Cyanamid Co 3(morpholinomethyl)-2 3-dihydro-carbazol-4(1h)-ones
DE3680123D1 (en) * 1985-01-23 1991-08-14 Glaxo Group Ltd Tetrahydrocarbazolonderivate.

Also Published As

Publication number Publication date
SE8500368D0 (sv) 1985-01-25
SE8500368L (sv) 1985-07-26
DK35785A (da) 1985-07-26
ES8708224A1 (es) 1987-10-01
GB8501889D0 (en) 1985-02-27
FI84349C (fi) 1991-11-25
SG7089G (en) 1989-06-09
IL74165A (en) 1988-11-15
KR850005439A (ko) 1985-08-26
NL940009I1 (nl) 1994-07-18
ATA20485A (de) 1990-08-15
FI850323A0 (fi) 1985-01-25
IT8547600A0 (it) 1985-01-25
GB2153821A (en) 1985-08-29
NZ210940A (en) 1989-08-29
ES539852A0 (es) 1986-07-16
DE3502508C2 (no) 1990-05-03
PT79890A (en) 1985-02-01
BE901576A (fr) 1985-07-25
CY1479A (en) 1989-07-21
PT79890B (en) 1987-02-03
SE460359B (sv) 1989-10-02
AU3809785A (en) 1985-08-01
NO164025C (no) 1990-08-22
HU193592B (en) 1987-11-30
KR920003064B1 (ko) 1992-04-13
LU88268I2 (no) 1994-02-03
FI84349B (fi) 1991-08-15
NO850300L (no) 1985-07-26
FR2561244A1 (fr) 1985-09-20
NO1994022I1 (no) 1994-11-09
DK35785D0 (da) 1985-01-25
CH664152A5 (fr) 1988-02-15
FR2561244B1 (fr) 1988-03-04
NL190373B (nl) 1993-09-01
NL190373C (nl) 1994-02-01
LU85743A1 (fr) 1986-08-04
IE57809B1 (en) 1993-04-21
ES548430A0 (es) 1987-10-01
CZ404391A3 (en) 1993-04-14
AT392276B (de) 1991-02-25
HK33189A (en) 1989-04-28
HUT37784A (en) 1986-02-28
DK169521B1 (da) 1994-11-21
PH22672A (en) 1988-11-14
CA1252793A (en) 1989-04-18
ES8801247A1 (es) 1987-12-16
NL940009I2 (nl) 1999-05-03
NL8500202A (nl) 1985-08-16
DE3502508A1 (de) 1985-08-14
NO164025B (no) 1990-05-14
AU579132B2 (en) 1988-11-17
ES8609309A1 (es) 1986-07-16
IT1182150B (it) 1987-09-30
DE19375046I2 (de) 2002-10-10
GB2153821B (en) 1988-01-20
SK277923B6 (en) 1995-08-09
ES556101A0 (es) 1987-12-16
IE850187L (en) 1985-07-25
FI850323L (fi) 1985-07-26
SK404391A3 (en) 1995-08-09

Similar Documents

Publication Publication Date Title
DE3427298C2 (no)
DE3446542C2 (no)
DE8429161U1 (no)
DE3525959C2 (no)
DE3420219C2 (no)
GR73988B (no)
AU2557584A (no)
DE8437153U1 (no)
DE7325846U1 (no)
BG45164A1 (no)
BG45135A1 (no)
BG45280A1 (no)
BG45279A1 (no)
BG45273A1 (no)
BG45272A1 (no)
BG45254A1 (no)
BG45245A1 (no)
LU88268I2 (no)
BG45202A1 (no)
BG45182A1 (no)
BG45181A1 (no)
BG45166A1 (no)
BG45165A1 (no)
BG38294A1 (no)
CA1265261C (no)

Legal Events

Date Code Title Description
NF Restoration of lapsed right

Effective date: 20030328