LU82650A1 - 3-(hydroxy ou hydroxymethyl)-5-(4-pyridinyl)-2(1h)-pyridinones,leur preparation et leur utilisation comme agents cardiotoniques - Google Patents

3-(hydroxy ou hydroxymethyl)-5-(4-pyridinyl)-2(1h)-pyridinones,leur preparation et leur utilisation comme agents cardiotoniques Download PDF

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Publication number
LU82650A1
LU82650A1 LU82650A LU82650A LU82650A1 LU 82650 A1 LU82650 A1 LU 82650A1 LU 82650 A LU82650 A LU 82650A LU 82650 A LU82650 A LU 82650A LU 82650 A1 LU82650 A1 LU 82650A1
Authority
LU
Luxembourg
Prior art keywords
pyridinyl
pyridinone
hydroxy
hydroxymethyl
acid
Prior art date
Application number
LU82650A
Other languages
English (en)
French (fr)
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of LU82650A1 publication Critical patent/LU82650A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/69—Two or more oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
LU82650A 1979-09-10 1980-07-23 3-(hydroxy ou hydroxymethyl)-5-(4-pyridinyl)-2(1h)-pyridinones,leur preparation et leur utilisation comme agents cardiotoniques LU82650A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7388579 1979-09-10
US06/073,885 US4225601A (en) 1979-09-10 1979-09-10 3-Hydroxy or hydroxymethyl-5-(4-pyridinyl)2(1H)-pyridinones, useful as cardiotonic agents and their preparation

Publications (1)

Publication Number Publication Date
LU82650A1 true LU82650A1 (fr) 1981-03-24

Family

ID=22116385

Family Applications (1)

Application Number Title Priority Date Filing Date
LU82650A LU82650A1 (fr) 1979-09-10 1980-07-23 3-(hydroxy ou hydroxymethyl)-5-(4-pyridinyl)-2(1h)-pyridinones,leur preparation et leur utilisation comme agents cardiotoniques

Country Status (21)

Country Link
US (1) US4225601A (xx)
JP (1) JPS5668670A (xx)
KR (1) KR830003470A (xx)
AR (1) AR223716A1 (xx)
AU (1) AU6003080A (xx)
BE (1) BE884329A (xx)
DE (1) DE3027901A1 (xx)
DK (1) DK314180A (xx)
ES (1) ES493583A0 (xx)
FI (1) FI802298A (xx)
FR (1) FR2465722A1 (xx)
GB (1) GB2058751A (xx)
IL (1) IL60360A0 (xx)
IT (1) IT1132192B (xx)
LU (1) LU82650A1 (xx)
NL (1) NL8004126A (xx)
NO (1) NO802138L (xx)
NZ (1) NZ194106A (xx)
PT (1) PT71427A (xx)
SE (1) SE8004934L (xx)
ZA (1) ZA803679B (xx)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361569A (en) * 1981-08-26 1982-11-30 Sterling Drug Inc. 3-(Hydroxy or hydroxymethyl)-6-methyl-5-(4-pyridinyl)-2(1H)-pyridinone and cardiotonic use thereof
US4432979A (en) * 1981-10-26 1984-02-21 William H. Rorer, Inc. Pyridone compounds
US4463008A (en) * 1982-11-10 1984-07-31 Sterling Drug Inc. 2-Alkoxy-5-(pyridinyl)pyridines and cardiotonic use thereof
US6068581A (en) * 1998-04-29 2000-05-30 Timm Medical Technologies, Inc. Method and apparatus for testing and exercising pelvic muscles
EP2542077A4 (en) * 2010-03-04 2013-08-21 Merck Sharp & Dohme CATECHOL O-METHYL TRANSFERASE INHIBITORS AND USE THEREOF IN THE TREATMENT OF PSYCHOTIC DISORDERS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4072746A (en) * 1975-10-14 1978-02-07 Sterling Drug Inc. 3-Amino-5-(pyridinyl)-2(1H)-pyridinones

Also Published As

Publication number Publication date
BE884329A (fr) 1981-01-16
FR2465722A1 (fr) 1981-03-27
IT1132192B (it) 1986-06-25
DK314180A (da) 1981-03-11
US4225601A (en) 1980-09-30
GB2058751A (en) 1981-04-15
PT71427A (en) 1980-07-01
ES8106514A1 (es) 1981-07-01
AR223716A1 (es) 1981-09-15
IL60360A0 (en) 1980-09-16
NZ194106A (en) 1982-03-30
ZA803679B (en) 1981-06-24
SE8004934L (sv) 1981-03-11
NO802138L (no) 1981-03-11
FI802298A (fi) 1981-03-11
ES493583A0 (es) 1981-07-01
NL8004126A (nl) 1981-03-12
IT8023422A0 (it) 1980-07-14
KR830003470A (ko) 1983-06-20
AU6003080A (en) 1981-03-19
JPS5668670A (en) 1981-06-09
DE3027901A1 (de) 1981-03-26

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