LU81881A1 - Procede de preparation d'un derive n-acyle selectivement protege d'un antibiotique aminoglycosidique - Google Patents

Procede de preparation d'un derive n-acyle selectivement protege d'un antibiotique aminoglycosidique Download PDF

Info

Publication number
LU81881A1
LU81881A1 LU81881A LU81881A LU81881A1 LU 81881 A1 LU81881 A1 LU 81881A1 LU 81881 A LU81881 A LU 81881A LU 81881 A LU81881 A LU 81881A LU 81881 A1 LU81881 A1 LU 81881A1
Authority
LU
Luxembourg
Prior art keywords
group
zinc
amino
antibiotic
derivative
Prior art date
Application number
LU81881A
Other languages
English (en)
French (fr)
Original Assignee
Microbial Chem Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP13840278A external-priority patent/JPS5564598A/ja
Priority claimed from JP7306479A external-priority patent/JPS55164696A/ja
Application filed by Microbial Chem Res Found filed Critical Microbial Chem Res Found
Publication of LU81881A1 publication Critical patent/LU81881A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
LU81881A 1978-11-11 1979-11-09 Procede de preparation d'un derive n-acyle selectivement protege d'un antibiotique aminoglycosidique LU81881A1 (fr)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP13840278A JPS5564598A (en) 1978-11-11 1978-11-11 Preparation of aminoglycoside antibiotic having selectively protected amino group
JP13840278 1978-11-11
JP7306479 1979-06-12
JP7306479A JPS55164696A (en) 1979-06-12 1979-06-12 Preparation of protected derivative of aminoglycoside antibiotic substance wherein amino groups other than 1-position are selectively protected, and preparation of 1-n- alpha-hydroxy-omega-aminoalkanoyl -aminoglycoside antibiotic substance

Publications (1)

Publication Number Publication Date
LU81881A1 true LU81881A1 (fr) 1980-01-25

Family

ID=26414188

Family Applications (1)

Application Number Title Priority Date Filing Date
LU81881A LU81881A1 (fr) 1978-11-11 1979-11-09 Procede de preparation d'un derive n-acyle selectivement protege d'un antibiotique aminoglycosidique

Country Status (20)

Country Link
US (1) US4297485A (nl)
AR (1) AR241915A1 (nl)
AT (1) AT367066B (nl)
AU (1) AU529682B2 (nl)
CA (1) CA1118416A (nl)
CH (2) CH650005A5 (nl)
DE (2) DE2945010C2 (nl)
DK (1) DK476679A (nl)
ES (2) ES485830A1 (nl)
FR (2) FR2441631A1 (nl)
GB (2) GB2036020B (nl)
IE (1) IE48972B1 (nl)
IN (1) IN151454B (nl)
IT (1) IT1166021B (nl)
LU (1) LU81881A1 (nl)
MX (1) MX6181E (nl)
NL (1) NL7907892A (nl)
PH (2) PH16263A (nl)
SE (2) SE446632B (nl)
YU (1) YU44185B (nl)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55105699A (en) * 1979-02-05 1980-08-13 Microbial Chem Res Found 3',4'-dideoxykanamycin a and its 1-n-aminoalkanoyl derivative
US4424345A (en) 1980-09-22 1984-01-03 Eli Lilly And Company 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process
US4468512A (en) * 1980-09-22 1984-08-28 Eli Lilly And Company 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides
US4424344A (en) 1980-09-22 1984-01-03 Eli Lilly And Company 2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process
IT1200774B (it) * 1985-10-10 1989-01-27 Pierrel Spa Procedimento di sentisi dell'amikacina
US4833232A (en) * 1986-05-02 1989-05-23 Exxon Research And Engineering Company Synthesis of novel highly intrinsic conducting organic polymers
DE69008052T2 (de) * 1989-06-21 1994-07-28 Schering Corp., Kenilworth, N.J. Verfahren zur Herstellung von Isepamicin.
US5442047A (en) * 1991-12-04 1995-08-15 Schering Corporation Process for preparing isepamicin
IT1237490B (it) * 1989-09-22 1993-06-07 Chementecno S R L Monza Milano Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico
DE69104092T2 (de) * 1990-03-08 1995-01-26 Opos Biochimica Srl Verfahren zur Herstellung von Amikacin-Vorläufern.
US5488038A (en) 1992-11-27 1996-01-30 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Dibekacin derivatives and arbekacin derivatives active against resistant bacteria
KR0139021B1 (ko) * 1995-02-09 1998-04-30 김은영 1-엔(n)-에틸시소마이신의 제조방법
KR100927626B1 (ko) * 2002-09-18 2009-11-20 쯔지앙 하이썬 파머슈티컬 컴퍼니, 리미티드 이세파마이신의 제조 방법
KR100467506B1 (ko) * 2002-10-01 2005-01-24 경동제약 주식회사 이세파마이신의 제조방법
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
WO2010037179A1 (en) 2008-10-03 2010-04-08 Glycan Biosciences Pty Ltd Anionic conjugates of glycosylated bacterial metabolite
CN101928310B (zh) * 2010-03-26 2012-09-05 常州方圆制药有限公司 3,2’,6’-三-N-乙酰基庆大霉素C1a的制备方法
CN102250166A (zh) * 2010-05-21 2011-11-23 江西济民可信集团有限公司 一种依替米星硫酸盐的制备方法
CN102746349B (zh) * 2012-06-27 2014-07-30 常州方圆制药有限公司 一种硫酸依替米星中间体3，2’，6’-三-N-乙酰基庆大霉素Cla的合成方法
CN111138505B (zh) * 2020-02-17 2021-10-08 山东安信制药有限公司 一种阿米卡星的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI52847C (fi) * 1971-09-15 1977-12-12 Suomen Sokeri Oy Menetelmä ainakin kaksi hydroksyyliryhmää sisältävien yhdisteiden alky yli-, alkenyyli- tai asyylijohdannaisten valmistamiseksi
US3781268A (en) * 1972-01-27 1973-12-25 Bristol Myers Co Antibiotic derivatives of kanamycin
GB1402427A (en) * 1972-05-03 1975-08-06 Ranks Hovis Mcdougall Ltd Antibiotics
US4107424A (en) * 1972-10-06 1978-08-15 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai 1-N-[(S)-α-hydroxy-ω-aminoacyl] derivatives of 3',4'-dideoxykanamycin B and 3'-deoxykanamycin B antibiotics
JPS5324415B2 (nl) * 1972-10-06 1978-07-20
US4001208A (en) * 1972-10-06 1977-01-04 Zaidan Hojin Biseibutsu Kagaku Kenkyo Kai 1-N-[(S)-α-hydroxy-ω-aminoacyl]
GB1441202A (en) * 1973-05-15 1976-06-30 Microbial Chem Res Found 1-n-isoserylkanamycins and the production thereof
JPS554118B2 (nl) * 1973-08-29 1980-01-29
JPS5635195B2 (nl) * 1974-01-24 1981-08-15
US4136254A (en) * 1976-06-17 1979-01-23 Schering Corporation Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby

Also Published As

Publication number Publication date
ATA707979A (de) 1981-10-15
FR2441631B1 (nl) 1982-02-19
ES485830A1 (es) 1980-10-01
DE2945010A1 (de) 1980-05-22
AU529682B2 (en) 1983-06-16
FR2441631A1 (fr) 1980-06-13
US4297485A (en) 1981-10-27
AU5262279A (en) 1980-05-15
GB2065123A (en) 1981-06-24
CH650004A5 (de) 1985-06-28
GB2036020B (en) 1983-01-06
YU274379A (en) 1983-02-28
MX6181E (es) 1984-12-07
DK476679A (da) 1980-05-12
AT367066B (de) 1982-05-25
IE48972B1 (en) 1985-06-26
IT1166021B (it) 1987-04-29
CA1118416A (en) 1982-02-16
SE8406344L (sv) 1984-12-13
FR2482109B1 (nl) 1983-10-14
DE2945010C2 (de) 1984-02-23
YU44185B (en) 1990-04-30
IN151454B (nl) 1983-04-23
NL7907892A (nl) 1980-05-13
GB2036020A (en) 1980-06-25
ES492479A0 (es) 1981-06-01
PH16263A (en) 1983-08-23
SE7908850L (sv) 1980-05-12
ES8105747A1 (es) 1981-06-01
AR241915A1 (es) 1993-01-29
CH650005A5 (de) 1985-06-28
SE446632B (sv) 1986-09-29
PH15906A (en) 1983-04-15
IT7909592A0 (it) 1979-11-12
IE792026L (en) 1980-05-11
SE463264B (sv) 1990-10-29
DE2953878C2 (de) 1984-05-24
FR2482109A1 (fr) 1981-11-13
SE8406344D0 (sv) 1984-12-13
GB2065123B (en) 1982-12-22

Similar Documents

Publication Publication Date Title
LU81881A1 (fr) Procede de preparation d'un derive n-acyle selectivement protege d'un antibiotique aminoglycosidique
EP1408066B1 (en) Block copolymer reduced in impurity content; polymeric carrier; pharmaceutical preparations in polymeric form and process for the preparation of the same
WO1990012805A1 (en) Postostatin and related compound thereof, or their salts
JP5339310B2 (ja) 糖鎖リガンド複合体、およびそのリガンド複合体を用いたタンパク質の分析方法
EP0751150B1 (fr) Dérivés de cyclodextrines, leur préparation et leur utilisation pour incorporer des molecules hydrophobes dans des systèmes de tensioactifs organisés
CH618706A5 (nl)
JPH0637512B2 (ja) アミカシンの合成方法
CH622528A5 (en) Process for the preparation of aminoglycoside antibiotics
AU2022256098B2 (en) Large scale preparation of pseudo-trisaccharide aminoglycosides and of intermediates thereof
BE879925A (fr) Procede nouveau de preparation d'un derive n-acyle selectivement protege d'un antibiotique amino-glycosidique
CA1100953A (en) PREPARATION OF 1-N¬.omega.-AMINO-.alpha.-HYDROXYALKANOYL| KANAMYCINS
CA1212941A (en) 1-N-(.omega.-AMINO-.alpha.-HYDROXYALKANOYL)-2',3'-DIDEOXY- KANAMYCIN A AND THE PRODUCTION OF THE SAME
EP0421848A1 (fr) Procédé de solubilisation de peptides et procédé de synthèse de peptides
FR2461716A1 (fr) Nouveaux composes antibiotiques du groupe phleomycine-bleomycine, leur procede d'obtention et leur application en therapeutique
FR2493318A1 (fr) Nouveaux derives de nitrosouree
EP1696935B1 (fr) Nouveaux derives de la morphine-6-glucuronide, compositions pharmaceutiques les contenant, leur procede de preparation et leurs utilisations
FR2497800A1 (fr) Nouveaux derives de nitrosouree
FR2640627A1 (fr) Nouveaux fluorures d'aldosaminyle, leur preparation et leur utilisation pour la fabrication d'oligosaccharides amines lies (1 -> 4)
CA1131628A (en) Production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
EP0566459B1 (fr) Réactif et procédé catalytique utile pour cliver une fonction protégée
WO2006053972A2 (fr) Agents de silanisation a groupement saccharidique terminal et leurs utilisations, notamment pour la fonctionnalisation de supports solides
BE844112A (fr) Nouveaux derives d'un antibiotique denomme xk-62-2 et leurs procede deproduction, et les compositions pharmaceutiques qui les contiennent
JP4726477B2 (ja) 糖鎖合成におけるキャッピング試薬
CA2031484C (fr) Milieu reactionnel et solubilisant de peptides et procede de synthese utilisant ce milieu
CA2093989A1 (fr) Reactif et procede catalytique utile pour cliver une fonction protegee