IT1237490B - Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico - Google Patents

Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico

Info

Publication number
IT1237490B
IT1237490B IT8921794A IT2179489A IT1237490B IT 1237490 B IT1237490 B IT 1237490B IT 8921794 A IT8921794 A IT 8921794A IT 2179489 A IT2179489 A IT 2179489A IT 1237490 B IT1237490 B IT 1237490B
Authority
IT
Italy
Prior art keywords
delta
kamanycin
idrossibutirril
hydroxybutyrril
benzyoxycarbonlamine
Prior art date
Application number
IT8921794A
Other languages
English (en)
Other versions
IT8921794A0 (it
Inventor
Vincenzo Giobbo
Leonardo Ambrosini
Original Assignee
Chementecno S R L Monza Milano
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chementecno S R L Monza Milano filed Critical Chementecno S R L Monza Milano
Priority to IT8921794A priority Critical patent/IT1237490B/it
Publication of IT8921794A0 publication Critical patent/IT8921794A0/it
Priority to US07/472,262 priority patent/US4985549A/en
Priority to EP19900114750 priority patent/EP0418524A3/en
Priority to KR1019900012565A priority patent/KR0144345B1/ko
Priority to JP2219875A priority patent/JPH03112998A/ja
Application granted granted Critical
Publication of IT1237490B publication Critical patent/IT1237490B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
IT8921794A 1989-09-22 1989-09-22 Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico IT1237490B (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT8921794A IT1237490B (it) 1989-09-22 1989-09-22 Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico
US07/472,262 US4985549A (en) 1989-09-22 1990-01-30 Process for preparing amikacin
EP19900114750 EP0418524A3 (en) 1989-09-22 1990-08-01 Process for preparing amikacin
KR1019900012565A KR0144345B1 (ko) 1989-09-22 1990-08-16 아미카신의 제조방법
JP2219875A JPH03112998A (ja) 1989-09-22 1990-08-21 アミカシンの製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT8921794A IT1237490B (it) 1989-09-22 1989-09-22 Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico

Publications (2)

Publication Number Publication Date
IT8921794A0 IT8921794A0 (it) 1989-09-22
IT1237490B true IT1237490B (it) 1993-06-07

Family

ID=11186939

Family Applications (1)

Application Number Title Priority Date Filing Date
IT8921794A IT1237490B (it) 1989-09-22 1989-09-22 Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico

Country Status (5)

Country Link
US (1) US4985549A (it)
EP (1) EP0418524A3 (it)
JP (1) JPH03112998A (it)
KR (1) KR0144345B1 (it)
IT (1) IT1237490B (it)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0446670B1 (en) * 1990-03-08 1994-09-21 Biochimica Opos Spa Method of preparation of amikacin precursors
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US20080213274A1 (en) * 2005-10-28 2008-09-04 Sabbadini Roger A Compositions and methods for the treatment and prevention of fibrotic, inflammatory, and neovascularization conditions of the eye
US20090074720A1 (en) * 2005-10-28 2009-03-19 Sabbadini Roger A Methods for decreasing immune response and treating immune conditions
US7862812B2 (en) * 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
CN104356182B (zh) * 2014-11-11 2017-05-24 齐鲁天和惠世制药有限公司 一种提高制备阿米卡星收率的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136254A (en) * 1976-06-17 1979-01-23 Schering Corporation Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby
US4230847A (en) * 1976-06-17 1980-10-28 Schering Corporation Aminoglycoside antibiotic compounds
FR2435481A1 (fr) * 1978-09-06 1980-04-04 Roussel Uclaf Nouveaux aminoglycosides derives de la desoxystreptamine et leurs sels, procede de preparation et application a titre de medicaments
IE48972B1 (en) * 1978-11-11 1985-06-26 Microbial Chem Res Found The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
JPS6041692A (ja) * 1983-08-15 1985-03-05 Microbial Chem Res Found ２′，３′−ジデオキシカナマイシンａ誘導体
IT1200774B (it) * 1985-10-10 1989-01-27 Pierrel Spa Procedimento di sentisi dell'amikacina

Also Published As

Publication number Publication date
US4985549A (en) 1991-01-15
EP0418524A3 (en) 1991-09-11
EP0418524A2 (en) 1991-03-27
KR0144345B1 (ko) 1998-07-01
KR910011877A (ko) 1991-08-07
JPH03112998A (ja) 1991-05-14
IT8921794A0 (it) 1989-09-22

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970730