KR910011877A - 아미카신의 제조방법 - Google Patents

아미카신의 제조방법 Download PDF

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Publication number
KR910011877A
KR910011877A KR1019900012565A KR900012565A KR910011877A KR 910011877 A KR910011877 A KR 910011877A KR 1019900012565 A KR1019900012565 A KR 1019900012565A KR 900012565 A KR900012565 A KR 900012565A KR 910011877 A KR910011877 A KR 910011877A
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South Korea
Prior art keywords
compound
group
process according
suspended
ion exchange
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KR1019900012565A
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KR0144345B1 (ko
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지오비오 빈센쪼
암브로시니 레오나르도
Original Assignee
프랭코 폴라스트리
케멘테크노 에스.알.엘.
지오반니 봄바르디에리
아이알씨에이 에스.피.에이.
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Publication of KR910011877A publication Critical patent/KR910011877A/ko
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Publication of KR0144345B1 publication Critical patent/KR0144345B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

아미카신의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

1-N-(L(-)-r-벤질옥시카보닐아미노--하이드록시부티릴)-3,6'-디-N-벤질옥시카보닐-카나마이신A(Ⅱ)를 알콜, 케톤, 디메틸포름아미드, 아세토니트닐 지방족 에스테르 탄화수소, 염소화된 용매 및 물로 이루어진 그룹중에서 선택된 용매중에서 1:5 내지 1:25의 비로 현탁시키고, Pt/C, Pd/C와 라니 니켈의 혼합물 및 Pd/C로 이루어진 그룹중에서 선택된 적합한 촉매를 화합물(Ⅱ)의 중량과 거의 동일한 양으로 첨가한 다음, 10 내지 100%의 포름산 수용액을 화합물(Ⅱ)에 대해 약 1:1의 비로 0 내지 100℃에서 서서히 가하고, 생성물(Ⅰ) 및 카나마이신 A를 함유하는 반응 혼합물을 2N NH3용액으로 용출시킴으로써 이온 교환 수지 컬럼을 통해 침출시키고, 화합물(Ⅰ)의 분획을 분리하고 용매를 감압하에 증발시켜 아미카신(Ⅰ)을 제조하는 방법.
제1항에 있어서, 화합물(Ⅱ)를 물 중에 현탁시키는 방법.
제1항 또는 2항에 있어서, 화합물(Ⅱ)를 물 중에 1:10의 비로 현탁시키는 방법.
제1항 내지 3항중 어느 한 항에 있어서, 반응을 20내지 25℃에서 수행하는 방법.
제1항 내지 4항중 어느 한 항에 있어서, 25%의 포름산 수용액을 사용하는 방법.
제1항 내지 5항중 어느 한 항에 있어서, 촉매가 2.5%의 Pd/C인 방법.
제1항 내지 6항중 어느 한 항에 있어서, 폴리실옥산 유도체로 이루어진 그룹중에서 선택된 계면활성제를 사용하는 방법.
제1항 내지 7항중 어느 한 항에 있어서, 이온 교환 수지를 약산성 이온 교환 수지로 이루어진 그룹중에서 선택하는 방법.
제1항 내지 8항중 어느 한 항에 있어서, 카나마이신A를 함유하는 용출물 분획을 분리하여 감압하에 증발시키는 방법.
※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900012565A 1989-09-22 1990-08-16 아미카신의 제조방법 KR0144345B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT8921794A IT1237490B (it) 1989-09-22 1989-09-22 Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico
IT21794A/89 1989-09-22
IT21794A89 1989-12-20

Publications (2)

Publication Number Publication Date
KR910011877A true KR910011877A (ko) 1991-08-07
KR0144345B1 KR0144345B1 (ko) 1998-07-01

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Application Number Title Priority Date Filing Date
KR1019900012565A KR0144345B1 (ko) 1989-09-22 1990-08-16 아미카신의 제조방법

Country Status (5)

Country Link
US (1) US4985549A (ko)
EP (1) EP0418524A3 (ko)
JP (1) JPH03112998A (ko)
KR (1) KR0144345B1 (ko)
IT (1) IT1237490B (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69104092T2 (de) * 1990-03-08 1995-01-26 Opos Biochimica Srl Verfahren zur Herstellung von Amikacin-Vorläufern.
US7794713B2 (en) * 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US20090074720A1 (en) * 2005-10-28 2009-03-19 Sabbadini Roger A Methods for decreasing immune response and treating immune conditions
US20080213274A1 (en) * 2005-10-28 2008-09-04 Sabbadini Roger A Compositions and methods for the treatment and prevention of fibrotic, inflammatory, and neovascularization conditions of the eye
US7862812B2 (en) * 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
CN104356182B (zh) * 2014-11-11 2017-05-24 齐鲁天和惠世制药有限公司 一种提高制备阿米卡星收率的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4136254A (en) * 1976-06-17 1979-01-23 Schering Corporation Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby
US4230847A (en) * 1976-06-17 1980-10-28 Schering Corporation Aminoglycoside antibiotic compounds
FR2435481A1 (fr) * 1978-09-06 1980-04-04 Roussel Uclaf Nouveaux aminoglycosides derives de la desoxystreptamine et leurs sels, procede de preparation et application a titre de medicaments
IE48972B1 (en) * 1978-11-11 1985-06-26 Microbial Chem Res Found The production of a selectively protected n-acylated derivative of an aminoglycosidic antibiotic
JPS6041692A (ja) * 1983-08-15 1985-03-05 Microbial Chem Res Found ２′，３′−ジデオキシカナマイシンａ誘導体
IT1200774B (it) * 1985-10-10 1989-01-27 Pierrel Spa Procedimento di sentisi dell'amikacina

Also Published As

Publication number Publication date
IT8921794A0 (it) 1989-09-22
IT1237490B (it) 1993-06-07
JPH03112998A (ja) 1991-05-14
US4985549A (en) 1991-01-15
KR0144345B1 (ko) 1998-07-01
EP0418524A2 (en) 1991-03-27
EP0418524A3 (en) 1991-09-11

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