ES485830A1 - Proceso para la produccion de un derivado selectivamente a- cilado n-protegido, de un antibiotico aminoglicoidico. - Google Patents
Proceso para la produccion de un derivado selectivamente a- cilado n-protegido, de un antibiotico aminoglicoidico.Info
- Publication number
- ES485830A1 ES485830A1 ES485830A ES485830A ES485830A1 ES 485830 A1 ES485830 A1 ES 485830A1 ES 485830 A ES485830 A ES 485830A ES 485830 A ES485830 A ES 485830A ES 485830 A1 ES485830 A1 ES 485830A1
- Authority
- ES
- Spain
- Prior art keywords
- acylated
- zinc
- aminoglycosidic antibiotic
- complex
- acylation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
Abstract
Proceso para la producción de un derivado selectivamente acilado, N-protegido de un antibiótico aminogliosídico, comprendiendo este antibiótico aminoglicosídico una mitad desoxiestreptamina que tienen un grupo 3- aminoglicosilo o 3-alquilaminoglicosilo enlazado con el grupo 6-hidroxi de la mitad desoxiestreptamina, y teniendo el derivado selectivamente acilado, N-protegido algunos de sus grupos amino selectivamente protegidos con un grupo acilo, que comprende los pasos consistentes en: (a) hacer reaccionar un reactivo de acilación que tiene un grupo acilo a introducir como el grupo amino-protector , con un complejo de antibiótico aminoglicosídico-cationes de zinc que ha sido formado por reacción del antibiótico aminoglicosídico con una sal de zinc en un disolvente orgánico inerte, para producir un complejo de cationes de zinc con el derivado selectivamente N-acilado del antibiótico aminoglicosídico que tiene acilados los grupos amino inicialmente no acomplejados, y (b) hacer reaccionar al complejo de cationes de zinc con el derivado selectivamente N-acilado del antibiótico aminoglicosídico, con un reactivo que retire los cationes de zinc de dicho complejo, para producir el deseado derivado selectivamente acilado, N-protegido del antibiótico aminoglicosídico.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP13840278A JPS5564598A (en) | 1978-11-11 | 1978-11-11 | Preparation of aminoglycoside antibiotic having selectively protected amino group |
| JP7306479A JPS55164696A (en) | 1979-06-12 | 1979-06-12 | Preparation of protected derivative of aminoglycoside antibiotic substance wherein amino groups other than 1-position are selectively protected, and preparation of 1-n- alpha-hydroxy-omega-aminoalkanoyl -aminoglycoside antibiotic substance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES485830A1 true ES485830A1 (es) | 1980-10-01 |
Family
ID=26414188
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES485830A Expired ES485830A1 (es) | 1978-11-11 | 1979-11-08 | Proceso para la produccion de un derivado selectivamente a- cilado n-protegido, de un antibiotico aminoglicoidico. |
| ES492479A Granted ES492479A0 (es) | 1978-11-11 | 1980-06-16 | Proceso para la produccion de un derivado n-acilado, selec- tivamente protegido, de un antibiotico aminoglicosidico |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES492479A Granted ES492479A0 (es) | 1978-11-11 | 1980-06-16 | Proceso para la produccion de un derivado n-acilado, selec- tivamente protegido, de un antibiotico aminoglicosidico |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4297485A (es) |
| AR (1) | AR241915A1 (es) |
| AT (1) | AT367066B (es) |
| AU (1) | AU529682B2 (es) |
| CA (1) | CA1118416A (es) |
| CH (2) | CH650004A5 (es) |
| DE (2) | DE2953878C2 (es) |
| DK (1) | DK476679A (es) |
| ES (2) | ES485830A1 (es) |
| FR (2) | FR2441631A1 (es) |
| GB (2) | GB2065123B (es) |
| IE (1) | IE48972B1 (es) |
| IN (1) | IN151454B (es) |
| IT (1) | IT1166021B (es) |
| LU (1) | LU81881A1 (es) |
| MX (1) | MX6181E (es) |
| NL (1) | NL7907892A (es) |
| PH (2) | PH16263A (es) |
| SE (2) | SE446632B (es) |
| YU (1) | YU44185B (es) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55105699A (en) * | 1979-02-05 | 1980-08-13 | Microbial Chem Res Found | 3',4'-dideoxykanamycin a and its 1-n-aminoalkanoyl derivative |
| US4424344A (en) | 1980-09-22 | 1984-01-03 | Eli Lilly And Company | 2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process |
| US4424345A (en) | 1980-09-22 | 1984-01-03 | Eli Lilly And Company | 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process |
| US4468512A (en) * | 1980-09-22 | 1984-08-28 | Eli Lilly And Company | 1-N-Acylated and 1-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides |
| IT1200774B (it) * | 1985-10-10 | 1989-01-27 | Pierrel Spa | Procedimento di sentisi dell'amikacina |
| US4833232A (en) * | 1986-05-02 | 1989-05-23 | Exxon Research And Engineering Company | Synthesis of novel highly intrinsic conducting organic polymers |
| ES2100380T3 (es) * | 1989-06-21 | 1997-06-16 | Schering Corp | Compuestos de (s)-isoserina protegidos en n. |
| US5442047A (en) * | 1991-12-04 | 1995-08-15 | Schering Corporation | Process for preparing isepamicin |
| IT1237490B (it) * | 1989-09-22 | 1993-06-07 | Chementecno S R L Monza Milano | Procedimento per la sintesi della 1 n (s delta ammino alfa idrossibutirril)kamanycin a basato sul trattamento della 1 n (s delta benzilossicarbonilammino alfa idrossibutirril) 3,6' di n benzilossicarbonilkanamycin a con acido formico |
| ATE111917T1 (de) * | 1990-03-08 | 1994-10-15 | Opos Biochimica Srl | Verfahren zur herstellung von amikacin- vorläufern. |
| US5488038A (en) | 1992-11-27 | 1996-01-30 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | Dibekacin derivatives and arbekacin derivatives active against resistant bacteria |
| KR0139021B1 (ko) * | 1995-02-09 | 1998-04-30 | 김은영 | 1-엔(n)-에틸시소마이신의 제조방법 |
| KR100927626B1 (ko) * | 2002-09-18 | 2009-11-20 | 쯔지앙 하이썬 파머슈티컬 컴퍼니, 리미티드 | 이세파마이신의 제조 방법 |
| KR100467506B1 (ko) * | 2002-10-01 | 2005-01-24 | 경동제약 주식회사 | 이세파마이신의 제조방법 |
| US7794713B2 (en) | 2004-04-07 | 2010-09-14 | Lpath, Inc. | Compositions and methods for the treatment and prevention of hyperproliferative diseases |
| US7862812B2 (en) | 2006-05-31 | 2011-01-04 | Lpath, Inc. | Methods for decreasing immune response and treating immune conditions |
| AU2009299118B2 (en) | 2008-10-03 | 2015-12-17 | Glycan Biosciences Llc | Anionic conjugates of glycosylated bacterial metabolite |
| CN101928310B (zh) * | 2010-03-26 | 2012-09-05 | 常州方圆制药有限公司 | 3,2’,6’-三-N-乙酰基庆大霉素C1a的制备方法 |
| CN102250166A (zh) * | 2010-05-21 | 2011-11-23 | 江西济民可信集团有限公司 | 一种依替米星硫酸盐的制备方法 |
| CN102746349B (zh) * | 2012-06-27 | 2014-07-30 | 常州方圆制药有限公司 | 一种硫酸依替米星中间体3，2’，6’-三-N-乙酰基庆大霉素Cla的合成方法 |
| CN111138505B (zh) * | 2020-02-17 | 2021-10-08 | 山东安信制药有限公司 | 一种阿米卡星的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI52847C (fi) * | 1971-09-15 | 1977-12-12 | Suomen Sokeri Oy | Menetelmä ainakin kaksi hydroksyyliryhmää sisältävien yhdisteiden alky yli-, alkenyyli- tai asyylijohdannaisten valmistamiseksi |
| US3781268A (en) * | 1972-01-27 | 1973-12-25 | Bristol Myers Co | Antibiotic derivatives of kanamycin |
| GB1402427A (en) * | 1972-05-03 | 1975-08-06 | Ranks Hovis Mcdougall Ltd | Antibiotics |
| US4001208A (en) * | 1972-10-06 | 1977-01-04 | Zaidan Hojin Biseibutsu Kagaku Kenkyo Kai | 1-N-[(S)-α-hydroxy-ω-aminoacyl] |
| US4107424A (en) * | 1972-10-06 | 1978-08-15 | Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai | 1-N-[(S)-α-hydroxy-ω-aminoacyl] derivatives of 3',4'-dideoxykanamycin B and 3'-deoxykanamycin B antibiotics |
| JPS5324415B2 (es) * | 1972-10-06 | 1978-07-20 | ||
| GB1441202A (en) * | 1973-05-15 | 1976-06-30 | Microbial Chem Res Found | 1-n-isoserylkanamycins and the production thereof |
| JPS554118B2 (es) * | 1973-08-29 | 1980-01-29 | ||
| JPS5635195B2 (es) * | 1974-01-24 | 1981-08-15 | ||
| US4136254A (en) * | 1976-06-17 | 1979-01-23 | Schering Corporation | Process of selectively blocking amino functions in aminoglycosides using transition metal salts and intermediates used thereby |
-
1979
- 1979-10-23 IE IE2026/79A patent/IE48972B1/en not_active IP Right Cessation
- 1979-10-24 IN IN1104/CAL/79A patent/IN151454B/en unknown
- 1979-10-25 SE SE7908850A patent/SE446632B/sv not_active IP Right Cessation
- 1979-10-26 NL NL7907892A patent/NL7907892A/nl not_active Application Discontinuation
- 1979-10-29 CH CH9682/79A patent/CH650004A5/de not_active IP Right Cessation
- 1979-10-29 CH CH184/84A patent/CH650005A5/de not_active IP Right Cessation
- 1979-11-02 AT AT0707979A patent/AT367066B/de not_active IP Right Cessation
- 1979-11-02 US US06/090,591 patent/US4297485A/en not_active Expired - Lifetime
- 1979-11-08 DE DE2953878A patent/DE2953878C2/de not_active Expired
- 1979-11-08 DE DE2945010A patent/DE2945010C2/de not_active Expired
- 1979-11-08 PH PH23263A patent/PH16263A/en unknown
- 1979-11-08 MX MX798478U patent/MX6181E/es unknown
- 1979-11-08 FR FR7928015A patent/FR2441631A1/fr active Granted
- 1979-11-08 YU YU2743/79A patent/YU44185B/xx unknown
- 1979-11-08 ES ES485830A patent/ES485830A1/es not_active Expired
- 1979-11-08 AU AU52622/79A patent/AU529682B2/en not_active Expired
- 1979-11-09 DK DK476679A patent/DK476679A/da not_active Application Discontinuation
- 1979-11-09 CA CA000339531A patent/CA1118416A/en not_active Expired
- 1979-11-09 GB GB8103076A patent/GB2065123B/en not_active Expired
- 1979-11-09 LU LU81881A patent/LU81881A1/fr unknown
- 1979-11-09 GB GB7938894A patent/GB2036020B/en not_active Expired
- 1979-11-09 AR AR79278828A patent/AR241915A1/es active
- 1979-11-12 IT IT09592/79A patent/IT1166021B/it active
-
1980
- 1980-06-16 ES ES492479A patent/ES492479A0/es active Granted
- 1980-12-22 PH PH25015A patent/PH15906A/en unknown
-
1981
- 1981-06-03 FR FR8110968A patent/FR2482109A1/fr active Granted
-
1984
- 1984-12-13 SE SE8406344A patent/SE463264B/sv not_active IP Right Cessation
Also Published As
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