LU81192A1 - Nouveaux derives heterocycliques agissant sur les recepteurs d'histamine,leurs procedes de preparation et leur utilisation - Google Patents

Nouveaux derives heterocycliques agissant sur les recepteurs d'histamine,leurs procedes de preparation et leur utilisation Download PDF

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Publication number
LU81192A1
LU81192A1 LU81192A LU81192A LU81192A1 LU 81192 A1 LU81192 A1 LU 81192A1 LU 81192 A LU81192 A LU 81192A LU 81192 A LU81192 A LU 81192A LU 81192 A1 LU81192 A1 LU 81192A1
Authority
LU
Luxembourg
Prior art keywords
group
formula
methyl
compound
alk
Prior art date
Application number
LU81192A
Other languages
English (en)
French (fr)
Inventor
B Price
J Bradshaw
D Judd
J Clitherow
M Smith
J Mackinnon
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of LU81192A1 publication Critical patent/LU81192A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
LU81192A 1978-04-26 1979-04-26 Nouveaux derives heterocycliques agissant sur les recepteurs d'histamine,leurs procedes de preparation et leur utilisation LU81192A1 (fr)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB1646878 1978-04-26
GB1646878 1978-04-26
GB7847689 1978-12-08
GB7847689 1978-12-08
GB7907422 1979-03-02
GB7907422 1979-03-02

Publications (1)

Publication Number Publication Date
LU81192A1 true LU81192A1 (fr) 1980-05-07

Family

ID=27257387

Family Applications (1)

Application Number Title Priority Date Filing Date
LU81192A LU81192A1 (fr) 1978-04-26 1979-04-26 Nouveaux derives heterocycliques agissant sur les recepteurs d'histamine,leurs procedes de preparation et leur utilisation

Country Status (20)

Country Link
US (3) US4318913A (de)
AR (1) AR228941A1 (de)
AT (1) AT376212B (de)
AU (1) AU531224B2 (de)
CA (1) CA1143727A (de)
CH (1) CH647767A5 (de)
DE (2) DE2954639C2 (de)
DK (1) DK173579A (de)
ES (4) ES8102104A1 (de)
FI (1) FI791360A (de)
FR (1) FR2432511B1 (de)
IL (1) IL57178A (de)
IT (1) IT1162304B (de)
LU (1) LU81192A1 (de)
NL (1) NL7903313A (de)
NO (1) NO791387L (de)
NZ (1) NZ190299A (de)
PH (1) PH19534A (de)
SE (1) SE7903698L (de)
YU (2) YU100379A (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR228941A1 (es) * 1978-04-26 1983-05-13 Glaxo Group Ltd Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos
YU56680A (en) * 1979-03-02 1983-04-30 Glaxo Group Ltd Process for obtaining new 1,2,4-triazole derivatives
US4410523A (en) * 1979-10-22 1983-10-18 Glaxo Group Limited Heterocyclic derivatives
US4777179A (en) * 1979-10-23 1988-10-11 Glaxo Group Limited Heterocyclic derivatives, processes for the use thereof and pharmaceutical compositions containing them
FR2477150A1 (fr) * 1980-02-28 1981-09-04 Glaxo Group Ltd Nouveaux derives heterocycliques, procedes pour leur preparation et compositions pharmaceutiques les comportant
AU548426B2 (en) * 1980-08-27 1985-12-12 Glaxo Group Limited 3-amino-(1,2,4)-triazoles
ATE13057T1 (de) * 1980-12-30 1985-05-15 Glaxo Group Ltd Verfahren zur herstellung eines furanderivates.
DK558181A (da) * 1981-01-30 1982-07-31 Smithkline Corp Fremgangsmaade til fremstilling af 3,5-diamino-1,2,4-triazoler
US4526973A (en) * 1981-05-18 1985-07-02 Bristol-Myers Company Chemical compounds
US4522943A (en) * 1981-05-18 1985-06-11 Bristol-Myers Company Chemical compounds
IE53068B1 (en) * 1981-06-15 1988-05-25 Merck & Co Inc Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors
EP0070743A3 (de) * 1981-07-22 1983-10-12 Glaxo Group Limited Pharmazeutische Zusammensetzungen, die Verbindungen enthalten, die auf Histamin-Rezeptoren einwirken
CA1192545A (en) * 1982-02-16 1985-08-27 Glaxo Group Limited Heterocyclic derivatives as histamine h.sub.2- antagonists
US4485104A (en) * 1982-02-24 1984-11-27 Glaxo Group Limited 1,2,4-Triazole-3-amines and their pharmaceutical use
US4482552A (en) * 1982-02-26 1984-11-13 Glaxo Group Limited Triazole compounds and their pharmaceutical use
DE3366369D1 (en) * 1982-03-17 1986-10-30 Smith Kline French Lab Pyridine derivatives
US4520025A (en) * 1982-07-21 1985-05-28 William H. Rorer, Inc. Bicyclic nitrogen heterocyclic ethers and thioethers, and their pharmaceutical uses
US4543352A (en) * 1983-04-29 1985-09-24 William H. Rorer, Inc. Naphthalene aminoalkylene ethers and thioethers, and their pharmaceutical uses
US4529723A (en) * 1983-04-29 1985-07-16 William H. Rorer, Inc. Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use
US4481360A (en) * 1983-08-26 1984-11-06 The Upjohn Company 4H-1,2,4-Triazol-3-yl compounds
DE3336410A1 (de) * 1983-10-06 1985-04-18 Ludwig Heumann & Co GmbH, 8500 Nürnberg Sulfenamidderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE3404786A1 (de) * 1984-02-10 1985-08-14 Ludwig Heumann & Co GmbH, 8500 Nürnberg Neue alkanolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltendes arzneimittel
US4812451A (en) * 1984-10-19 1989-03-14 A. H. Robins Company, Incorporated 1-(aminoalkyl and aminoalkylamino)carbonyl and thiocarbonyl)-α,.alpha.
US4812452A (en) * 1984-10-19 1989-03-14 A. H. Robins Company, Incorporated 1-((aminoalkyl and aminoalkylamino) carbonyl and thiocarbonyl)-α,α-diarylpyrrolidine, piperidine and homopiperidineacetamides and acetonitriles
EP0226653B1 (de) * 1985-12-20 1989-02-22 LITEF GmbH Verfahren zur Kurswinkelbestimmung mittels und zur automatischen Kalibration eines in einem Luftfahrzeug fest montierten Dreiachsen-Magnetometers
US4988828A (en) * 1987-11-27 1991-01-29 Fujirebio Kabushiki Kaisha Phenoxypropyl derivatives
US5028716A (en) * 1989-01-30 1991-07-02 Taisho Pharmaceutical Co., Ltd. 3,5-diamino-1,2,4-triazole derivatives
GB9009437D0 (en) * 1990-04-26 1990-06-20 Glaxo Group Ltd Chemical compounds
US20230349922A1 (en) 2020-08-11 2023-11-02 Université De Strasbourg H2 Blockers Targeting Liver Macrophages for the Prevention and Treatment of Liver Disease and Cancer

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1419994A (en) 1973-05-03 1976-01-07 Smith Kline French Lab Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them
SU557574A1 (ru) 1975-07-02 1978-03-05 Ордена Трудового Красного Знамени Научно-Исследовательский Институт Экспериментальной Медицины Амн Ссср Способ получени 3-амино-5-(2-аминоэтил)-1,2,4-триазола
SU596577A1 (ru) 1976-02-23 1978-03-05 Ордена Трудового Красного Знамени Научно-Исследовательский Институт Экспериментальной Медицины -Метил- "/4-(5 амино-1,2,4триазолил-3)-бутил/-тиомочевина, про вл юща антигистаминовую активность, и способ ее получени
GB1565966A (en) * 1976-08-04 1980-04-23 Allen & Hanburys Ltd Aminoalkyl furan derivatives
GB1601459A (en) * 1977-05-17 1981-10-28 Allen & Hanburys Ltd Aminoalkyl thiophene derivatives
IE46886B1 (en) * 1977-05-17 1983-10-19 Allen & Hanburys Ltd Aminoalkyl-benzene derivatives
US4115860A (en) * 1977-06-02 1978-09-19 Lockheed Electronics Co., Inc. Plural load power controller with time-shared processor
DE2835695A1 (de) 1977-08-29 1979-03-15 Yamanouchi Pharma Co Ltd Neue heterocyclische verbindungen, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten
AR228941A1 (es) * 1978-04-26 1983-05-13 Glaxo Group Ltd Procedimiento para preparar nuevos derivados de 3,5-diamino-1,2,4-triazol que son activos contra receptores histaminicos
US4293557A (en) * 1979-07-03 1981-10-06 Teikoku Hormone Mfg. Co., Ltd. Antiulcer phenoxypropylamine derivatives
DE3175201D1 (en) * 1980-04-30 1986-10-02 Merck & Co Inc Aminothiadiazoles as gastric secretion inhibitors
US4390701A (en) * 1981-05-18 1983-06-28 Bristol-Myers Company 1-Amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione
GR77847B (de) * 1981-12-14 1984-09-25 American Home Prod
JPS6067474A (ja) * 1983-09-24 1985-04-17 Wakamoto Pharmaceut Co Ltd 新規な１，３，４−チアジアゾ−ル誘導体及びそれを有効成分とする抗潰瘍剤
DE3513184A1 (de) * 1985-04-12 1986-10-16 Ludwig Heumann & Co GmbH, 8500 Nürnberg 1,3,4-thiadiazolderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
DK173579A (da) 1979-10-27
FR2432511B1 (fr) 1986-04-25
IT1162304B (it) 1987-03-25
NO791387L (no) 1979-10-29
AT376212B (de) 1984-10-25
ES488676A0 (es) 1980-12-16
PH19534A (en) 1986-05-20
IL57178A0 (en) 1979-07-25
SE7903698L (sv) 1979-10-27
AU4648279A (en) 1979-11-01
US4442110A (en) 1984-04-10
CH647767A5 (de) 1985-02-15
ES488677A0 (es) 1980-12-16
DE2954639C2 (de) 1990-09-27
ES8101565A1 (es) 1980-12-16
FR2432511A1 (fr) 1980-02-29
CA1143727A (en) 1983-03-29
ES8101564A1 (es) 1980-12-16
ES8101563A1 (es) 1980-12-16
US4764612A (en) 1988-08-16
NL7903313A (nl) 1979-10-30
ES479988A0 (es) 1980-08-16
YU100379A (en) 1983-04-30
AR228941A1 (es) 1983-05-13
US4318913A (en) 1982-03-09
IL57178A (en) 1984-11-30
DE2917026A1 (de) 1979-11-08
ES8102104A1 (es) 1980-08-16
IT7948856A0 (it) 1979-04-26
AU531224B2 (en) 1983-08-18
YU16183A (en) 1983-04-30
ES488678A0 (es) 1980-12-16
NZ190299A (en) 1982-05-31
ATA316679A (de) 1984-03-15
FI791360A (fi) 1979-10-27

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