LU81057A1 - Sels d'orhithine et d'arginine d'acides cetoniques a chaine ramifiee,et leur utilisation pour le traitement des affections hepatiques et renales - Google Patents

Sels d'orhithine et d'arginine d'acides cetoniques a chaine ramifiee,et leur utilisation pour le traitement des affections hepatiques et renales

Info

Publication number
LU81057A1
LU81057A1 LU81057A LU81057A LU81057A1 LU 81057 A1 LU81057 A1 LU 81057A1 LU 81057 A LU81057 A LU 81057A LU 81057 A LU81057 A LU 81057A LU 81057 A1 LU81057 A1 LU 81057A1
Authority
LU
Luxembourg
Prior art keywords
orhithin
hepatic
treatment
branched chain
arginine salts
Prior art date
Application number
LU81057A
Other languages
English (en)
French (fr)
Inventor
M Walser
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Publication of LU81057A1 publication Critical patent/LU81057A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
LU81057A 1978-03-17 1979-03-16 Sels d'orhithine et d'arginine d'acides cetoniques a chaine ramifiee,et leur utilisation pour le traitement des affections hepatiques et renales LU81057A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/887,570 US4228099A (en) 1978-03-17 1978-03-17 Ornithine and arginine salts of branched chain keto acids and uses in treatment of hepatic and renal disorders

Publications (1)

Publication Number Publication Date
LU81057A1 true LU81057A1 (fr) 1979-09-07

Family

ID=25391422

Family Applications (1)

Application Number Title Priority Date Filing Date
LU81057A LU81057A1 (fr) 1978-03-17 1979-03-16 Sels d'orhithine et d'arginine d'acides cetoniques a chaine ramifiee,et leur utilisation pour le traitement des affections hepatiques et renales

Country Status (17)

Country Link
US (1) US4228099A (sv)
JP (1) JPS5838421B2 (sv)
AU (1) AU517505B2 (sv)
BE (1) BE874900A (sv)
CA (1) CA1115729A (sv)
DE (1) DE2910221A1 (sv)
DK (1) DK153542C (sv)
ES (1) ES478710A1 (sv)
FI (1) FI72118C (sv)
FR (1) FR2419723A1 (sv)
GB (1) GB2017094B (sv)
IE (1) IE48336B1 (sv)
IT (1) IT1202904B (sv)
LU (1) LU81057A1 (sv)
NL (1) NL7902136A (sv)
NO (1) NO151119C (sv)
SE (1) SE446724B (sv)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4296127A (en) * 1979-04-18 1981-10-20 The Johns Hopkins University Mixed salts of essential or semi-essential amino acids and nitrogen-free analogs thereof
DE3438455A1 (de) * 1984-10-19 1986-06-26 Institut Dr. Ziegler, Bettingen L-lysin- und l-histidinpyruvat
US4677121A (en) * 1985-01-22 1987-06-30 The Johns Hopkins University Method of inhibiting muscle protein degradation
US4752619A (en) * 1985-12-23 1988-06-21 The Johns Hopkins University Nutritional supplement for treatment of uremia
US4744990A (en) * 1986-09-25 1988-05-17 W. R. Grace & Co. Hydantoins as animal food supplements
US4871552A (en) * 1986-09-25 1989-10-03 W. R. Grace & Co.-Conn. Hydantoins as animal food supplements
US5639731A (en) * 1987-05-22 1997-06-17 Pripps Bryggerier Ab Amino acids for the preparation of a beverage
FR2615734B1 (fr) * 1987-05-27 1989-12-01 Synthelabo Compositions pharmaceutiques contenant un melange de sels de cetoacides et d'amino-acides utiles pour le traitement de l'uremie
FR2618331B1 (fr) * 1987-07-23 1991-10-04 Synthelabo Compositions pharmaceutiques utiles pour le traitement de l'uremie
AT393080B (de) * 1988-11-25 1991-08-12 Lubec Gert Pharmazeutische verwendung von arginin (salzen)
AT393079B (de) * 1989-03-06 1991-08-12 Lubec Gert Pharmazeutische verwendung von agmatin
SE462463B (sv) * 1988-12-02 1990-07-02 Decken Alexandra V D Livs- och fodermedel innehaallande ketosyror
JP2522034B2 (ja) * 1988-12-27 1996-08-07 味の素株式会社 α−ケト酸・アミノ酸塩化合物及びその製造方法
US5210098A (en) * 1990-09-21 1993-05-11 Regents Of The University Of Minnesota Use of pyruvate to treat acute renal failure
US5234696A (en) * 1991-12-27 1993-08-10 Abbott Laboratories Method of producing tablets, tablets produced thereby, and method of treatment using same
WO1996010927A1 (fr) 1994-10-07 1996-04-18 Firmenich S.A. Compositions aromatisantes et procede d'aromatisation
US5591736A (en) * 1995-07-03 1997-01-07 The Johns Hopkins University Method of retarding the progression of chronic renal failure
EP1377339A4 (en) * 2001-04-04 2006-05-31 Critical Therapeutics Inc PROCEDURE FOR PREVENTING AKUTER NIERENINSUFFIZIENZ
JP4778913B2 (ja) * 2004-11-15 2011-09-21 協和発酵バイオ株式会社 Ｌ−オルニチン結晶およびその製造方法
EP2319581B1 (en) * 2004-11-26 2015-02-25 UCL Business PLC Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy
GB0426141D0 (en) * 2004-11-26 2004-12-29 Ucl Biomedica Plc Treatment
WO2010115055A1 (en) 2009-04-03 2010-10-07 Ocera Therapeutics, Inc. L-ornithine phenyl acetate and methods of making thereof
AU2010258888B2 (en) 2009-06-08 2014-08-07 Ocera Therapeutics, Inc. Treatment of portal hypertension and restoration of liver function using L-ornithine phenylacetate
EA028395B1 (ru) 2010-10-06 2017-11-30 Осера Терапьютикс, Инк. Способы получения фенилацетата l-орнитина
BR112017010761B1 (pt) 2014-11-24 2022-10-18 Ucl Business Plc Tratamento de doenças associadas à ativação de célula estrelada hepática com o uso de terapias de redução de amônia
EP3337473A4 (en) 2015-08-18 2019-04-17 Ocera Therapeutics, Inc. TREATMENT AND PREVENTION OF MUSCLE WOUND BY L-ORNITHIN IN COMBINATION WITH AT LEAST ONE PHENYL ACETATE AND PHENYL BUTYRATE
CN106674057A (zh) * 2015-11-09 2017-05-17 江西乐维生物药业有限公司 L-精氨酸a-酮基异己酸盐的制备方法
US11219611B2 (en) 2015-11-13 2022-01-11 Ocera Therapeutics, Inc. Formulations of L-ornithine phenylacetate
WO2017090007A1 (en) * 2015-11-29 2017-06-01 Rao M Surya Compositions and methods for the treatment of urea cycle disorders and hepatic diseases
KR20200024145A (ko) 2017-05-11 2020-03-06 오세라 테라퓨틱스, 아이엔씨. L-오르니틴 페닐아세테이트의 제조방법
EP3716966A4 (en) 2017-11-29 2021-08-18 Hull, Edgar, L., Jr. ALPHA-KETOACID COMPOSITIONS FOR THE TREATMENT OF HYPOALBUMINEMIA
US11484579B2 (en) 2017-11-29 2022-11-01 Edgar L Hull Vitamins and alpha keto acid compositions for use in a treatment program for chronic kidney disease patients

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA814483A (en) * 1969-06-03 Abe Kyuji L-ornithine-l-aspartate
GB1034358A (en) 1963-05-01 1966-06-29 Chugai Pharmaceutical Co Ltd Body-protein-biosynthesis promoting composition
FR1432756A (fr) 1965-02-11 1966-03-25 D Opochimiotherapie Lab Pyruvates d'amino-acides et leur procédé de préparation
US3441650A (en) * 1965-07-23 1969-04-29 Lab Jacques Logeais Sa Therapy of ammonical intoxications by di-l-ornithine alpha-ketoglutarate
DE2335215B2 (de) * 1972-07-13 1979-04-05 The Johns Hopkins University, Baltimore, Md. (V.St.A.) Verwendung einer Mischung bei der Bekämpfung von zur Urämie führenden Nierenerkrankungen
US4100293A (en) * 1974-04-15 1978-07-11 The Johns Hopkins University Treatment of hepatic disorders with therapeutic compositions comprising keto analogs of essential amino acids
US3950529A (en) * 1975-02-03 1976-04-13 Massachusetts General Hospital Amino acid formulations for patients with liver disease and method of using same

Also Published As

Publication number Publication date
FI72118B (fi) 1986-12-31
GB2017094A (en) 1979-10-03
BE874900A (fr) 1979-07-16
JPS54163518A (en) 1979-12-26
SE446724B (sv) 1986-10-06
AU4515479A (en) 1979-09-20
FI790901A (fi) 1979-09-18
NL7902136A (nl) 1979-09-19
DK110879A (da) 1979-09-18
CA1115729A (en) 1982-01-05
DK153542B (da) 1988-07-25
JPS5838421B2 (ja) 1983-08-23
IT1202904B (it) 1989-02-15
NO151119B (no) 1984-11-05
FI72118C (sv) 1987-04-13
GB2017094B (en) 1982-07-07
ES478710A1 (es) 1980-01-16
IE790993L (en) 1979-09-17
DE2910221A1 (de) 1979-09-20
DE2910221C2 (sv) 1988-04-28
NO151119C (no) 1985-02-13
NO790903L (no) 1979-09-18
FR2419723B1 (sv) 1982-10-29
SE7902401L (sv) 1979-10-16
US4228099A (en) 1980-10-14
DK153542C (da) 1988-12-05
AU517505B2 (en) 1981-08-06
IE48336B1 (en) 1984-12-12
FR2419723A1 (fr) 1979-10-12
IT7921071A0 (it) 1979-03-16

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