LT5240B - Polifenolių turinti maistinė farmacinė kompozicija, skirta vėžio gydymui - Google Patents
Polifenolių turinti maistinė farmacinė kompozicija, skirta vėžio gydymui Download PDFInfo
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- LT5240B LT5240B LT2004076A LT2004076A LT5240B LT 5240 B LT5240 B LT 5240B LT 2004076 A LT2004076 A LT 2004076A LT 2004076 A LT2004076 A LT 2004076A LT 5240 B LT5240 B LT 5240B
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- pharmaceutical composition
- lysine
- proline
- ascorbate
- cancer
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Landscapes
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| EP (1) | EP1465614B1 (fr) |
| JP (1) | JP2005519055A (fr) |
| KR (1) | KR20040073559A (fr) |
| CN (1) | CN100377706C (fr) |
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| AU (1) | AU2003235762B2 (fr) |
| BR (1) | BR0302672A (fr) |
| CA (1) | CA2471932A1 (fr) |
| DE (1) | DE60318387T2 (fr) |
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| HK (1) | HK1086489A1 (fr) |
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| LT (1) | LT5240B (fr) |
| LV (1) | LV13248B (fr) |
| MX (1) | MXPA04006717A (fr) |
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| NZ (1) | NZ533737A (fr) |
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| UA (1) | UA80692C2 (fr) |
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| US9034310B2 (en) * | 2002-02-21 | 2015-05-19 | Stephen B. Cantrell | Interferon-statin combination cancer therapy |
| US7115283B2 (en) * | 2003-05-06 | 2006-10-03 | Access Business Group International Llc | Preparations for sustained release of nutraceuticals and methods of controllably releasing nutraceuticals |
| US20040253319A1 (en) * | 2003-06-11 | 2004-12-16 | Shrirang Netke | Pharmaceutical compositions and method for alleviating side-effects of estrogen replacement therapy |
| JP2008509877A (ja) * | 2003-09-05 | 2008-04-03 | ラート・マティアス | 通常、ビタミンｃ、マグネシウム、緑茶抽出物を含む心血管系疾患を抑制するための医薬調合物 |
| US8377904B2 (en) * | 2004-02-09 | 2013-02-19 | Hill's Pet Nutrition, Inc. | Composition and method for use in cartilage affecting conditions |
| US20050176674A1 (en) * | 2004-02-09 | 2005-08-11 | Friesen Kim G. | Composition and method for use in cartilage affecting conditions |
| KR100601080B1 (ko) * | 2004-08-26 | 2006-07-19 | 가톨릭대학교 산학협력단 | (-)-에피갈로카테킨 갈레이트를 유효성분으로 하는류마티스성 관절염 치료제 |
| EP2502649A1 (fr) | 2005-02-03 | 2012-09-26 | TopoTarget UK Limited | Polythérapie à base d'inhibiteurs d'HDAC et d'erlotinib pour le traitement du cancer |
| BRPI0520227A2 (pt) * | 2005-04-11 | 2009-04-22 | Matthias Rath | uso de uma composiÇço nutriente para o tratamento de sarcoma e cÂncer de pràstata |
| WO2006108430A1 (fr) | 2005-04-11 | 2006-10-19 | Matthias Rath | Composition nutritive comprenant des polyphenols de the vert destinee a traiter l'osteosarcome |
| KR101329437B1 (ko) | 2005-05-13 | 2013-11-14 | 토포타겟 유케이 리미티드 | Ｈｄａｃ 억제제의 약학 제형 |
| EP1924257A4 (fr) * | 2005-07-26 | 2012-08-08 | Mitsui Norin Kk | Compositions de 3-hydroxyflavane stabilisé et procédés apparentés |
| WO2007033356A2 (fr) * | 2005-09-14 | 2007-03-22 | Mitsui Norin Co., Ltd | Compositions et procedes de modification d'enzymes de detoxification par des catechines du the vert |
| JP5377968B2 (ja) * | 2005-11-10 | 2013-12-25 | トポターゲット ユーケー リミテッド | 癌治療のために単独で用いるまたは化学療法薬と併用するヒストンデアセチラーゼ（ｈｄａｃ）阻害剤 |
| US20070212426A1 (en) * | 2006-03-10 | 2007-09-13 | Matthias Rath | Composition and method of retarding viral activity and reducing viral replication |
| CA2689717C (fr) * | 2006-06-16 | 2016-10-18 | Summa Health System | Medicament anti-cancereux non toxique combinant de l'ascorbate, du magnesium et une naphtoquinone |
| GB0615781D0 (en) * | 2006-08-09 | 2006-09-20 | Coressence Ltd | Prebiotic composition |
| US20080114054A1 (en) * | 2006-11-14 | 2008-05-15 | Rath Microbes | Compositions and methods for reducing antimicrobial resistance of microbes |
| US8617544B2 (en) * | 2007-05-01 | 2013-12-31 | Richard L. Kozlenko | Compositions and methods for controlling lipid metabolism |
| GB0710536D0 (en) * | 2007-06-01 | 2007-07-11 | Veritron Ltd | Plant extract and its therapeutic use |
| CN101868446A (zh) * | 2007-09-25 | 2010-10-20 | 托波塔吉特英国有限公司 | 某些异羟肟酸化合物的合成方法 |
| GB0725077D0 (en) * | 2007-12-21 | 2008-01-30 | Univ Murcia | Antifolate com[ounds for the treatment of melanoma |
| MX2010009642A (es) * | 2008-03-07 | 2010-09-22 | Topotarget As | Metodos de tratamiento utilizando infusion continua prolongada de belinostat. |
| RU2395281C2 (ru) * | 2008-09-04 | 2010-07-27 | Всеволод Иванович Киселев | Фармацевтическая композиция для лечения диспластических процессов шейки матки |
| US9034834B2 (en) | 2008-11-04 | 2015-05-19 | Vymedic, Llc | Antiviral supplement formulations |
| US8677463B2 (en) * | 2008-12-05 | 2014-03-18 | At&T Intellectual Property I, Lp | System and method for managing multiple sub accounts within a subcriber main account in a data distribution system |
| JP2009143928A (ja) * | 2008-12-26 | 2009-07-02 | Kyushu Univ | ガロイルカテキン類の抗酸化活性の促進方法 |
| GB0900555D0 (en) * | 2009-01-14 | 2009-02-11 | Topotarget As | New methods |
| CN105816498A (zh) | 2009-04-27 | 2016-08-03 | 玫琳凯有限公司 | 植物性抗痤疮制剂 |
| IT1397522B1 (it) * | 2009-12-21 | 2013-01-16 | Solartium Entpr Ltd | Uso di una combinazione per il trattamento dell'osteoartrosi |
| GB201015784D0 (en) | 2010-09-20 | 2010-10-27 | Bionature E A Ltd | Anti-cancer compounds |
| KR102245069B1 (ko) | 2011-12-19 | 2021-04-26 | 마리 케이 인코포레이티드 | 피부톤 향상을 위한 식물 추출물의 조합물 |
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| US20140154702A1 (en) * | 2012-11-30 | 2014-06-05 | Endocyte, Inc. | Methods For Treating Cancer Using Combination Therapies |
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| BE1023772B9 (fr) * | 2013-05-17 | 2017-08-02 | Valore | Composition a base d'un complexe de (+)-catechine et d'acide amine pour le traitement et la prevention du cancer |
| GB2520794A (en) * | 2013-07-26 | 2015-06-03 | Tata Memorial Ct | Plant poly-phenol and copper (II) mediated degradation of DNA and RNA |
| IN2013MU01528A (fr) * | 2013-07-26 | 2015-06-26 | Tata Memorial Ct | |
| KR102323049B1 (ko) | 2014-03-10 | 2021-11-05 | 마리 케이 인코포레이티드 | 피부 라이트닝 조성물 |
| BE1022579A9 (fr) * | 2014-11-10 | 2016-10-06 | Valore | Composition antimétastatique comprenant au moins un composé de type flavanol |
| CN105061533B (zh) * | 2015-09-18 | 2018-02-09 | 福州大学 | 六甲氧基二氢黄酮‑鼠李糖基‑鼠李糖苷及其应用 |
| CN106138036A (zh) * | 2016-04-29 | 2016-11-23 | 陈西敬 | 抗坏血酸棕榈酸酯在制备抗肿瘤药物中的应用 |
| CA3038327C (fr) * | 2016-10-03 | 2024-03-12 | Houn Simon Hsia | Compositions et methodes pour ameliorer la radiotherapie du cancer |
| US12029765B2 (en) | 2017-06-13 | 2024-07-09 | Houn Simon Hsia | Compositions and methods for treating cancer |
| US10905725B2 (en) | 2017-06-13 | 2021-02-02 | Houn Simon Hsia | Compositions and methods for enhancing cancer chemotherapy |
| KR20200078467A (ko) | 2017-06-13 | 2020-07-01 | 호운 사이먼 샤 | 암 방사선요법을 향상시키기 위한 조성물 및 방법 |
| CN111529709A (zh) * | 2020-06-03 | 2020-08-14 | 北京易思腾翻译服务有限公司 | 一种可用于体重控制且可逆转动脉粥样硬化的组合物 |
| WO2022124386A1 (fr) * | 2020-12-07 | 2022-06-16 | L' Oreal | Composition comprenant de l'acide ascorbique et un acide aminé cyclique |
| IT202200010592A1 (it) * | 2022-05-23 | 2023-11-23 | Neilos S R L | “Composizione nutraceutica o farmaceutica per l’infertilità maschile” |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5962517A (en) | 1997-01-31 | 1999-10-05 | Murad; Howard | Pharmaceutical compositions and methods for treating acne |
| WO2007076492A2 (fr) | 2005-12-28 | 2007-07-05 | Sandisk Corporation | Procedes et systemes d'ecriture dans des memoires remanentes procurant une duree de service accrue |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4243363A1 (de) * | 1992-12-21 | 1994-06-23 | Ulrich Dr Med Kuebler | Behandlungsverfahren für Hauttrockenheit |
| US5817695A (en) * | 1997-12-24 | 1998-10-06 | Pellico; Michael A. | Nutritional product with high fat, low carbohydrate and amino acid imbalance |
| EP0938897A1 (fr) * | 1997-12-26 | 1999-09-01 | Japanese Foundation For Cancer Research | Inhibiteur de la telomerase |
| AT407821B (de) * | 1998-03-24 | 2001-06-25 | Franz Dr Stueckler | Mittel auf der basis von naturstoffen |
| WO2000057875A1 (fr) * | 1999-03-30 | 2000-10-05 | Purdue Research Foundation | Compositions renfermant des catechines du the en tant qu'inhibiteurs specifiques de la proliferation du cancer |
| EP1200075A4 (fr) | 1999-06-15 | 2003-05-02 | Nutri Logics Inc | Compositions de nutriments destines a reduire le risque de maladie, traitement associe, et methode de selection des constituants |
| US6299925B1 (en) * | 1999-06-29 | 2001-10-09 | Xel Herbaceuticals, Inc. | Effervescent green tea extract formulation |
| US6448030B1 (en) * | 2000-02-18 | 2002-09-10 | University Of Nevada-Las Vegas | Method for predicting the efficacy of anti-cancer drugs |
| ATE327747T1 (de) * | 2000-10-09 | 2006-06-15 | Matthias Dr Med Rath | Therapeutische kombination des ascorbats mit lysin und arginin für verhinderung und behandlung des krebses |
-
2003
- 2003-01-13 RU RU2004124384/15A patent/RU2301666C2/ru active IP Right Revival
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- 2003-01-13 ES ES03729250T patent/ES2298519T3/es not_active Expired - Lifetime
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- 2003-01-13 EP EP03729250A patent/EP1465614B1/fr not_active Expired - Lifetime
- 2003-01-13 UA UA20040705602A patent/UA80692C2/uk unknown
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- 2003-01-13 DE DE60318387T patent/DE60318387T2/de not_active Expired - Lifetime
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- 2003-01-13 YU YU75003A patent/YU75003A/sh unknown
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- 2003-01-13 MX MXPA04006717A patent/MXPA04006717A/es active IP Right Grant
- 2003-01-13 US US10/342,044 patent/US7041699B2/en not_active Expired - Fee Related
- 2003-01-13 AT AT03729250T patent/ATE382343T1/de active
- 2003-09-05 NO NO20033950A patent/NO20033950L/no not_active Application Discontinuation
-
2004
- 2004-06-25 ZA ZA200405075A patent/ZA200405075B/en unknown
- 2004-08-03 HR HR20040704A patent/HRP20040704A2/hr not_active Application Discontinuation
- 2004-08-11 LT LT2004076A patent/LT5240B/lt unknown
- 2004-09-09 LV LVP-04-93A patent/LV13248B/en unknown
-
2006
- 2006-02-06 US US11/348,927 patent/US20060142212A1/en not_active Abandoned
- 2006-06-07 HK HK06106522A patent/HK1086489A1/xx not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5962517A (en) | 1997-01-31 | 1999-10-05 | Murad; Howard | Pharmaceutical compositions and methods for treating acne |
| WO2007076492A2 (fr) | 2005-12-28 | 2007-07-05 | Sandisk Corporation | Procedes et systemes d'ecriture dans des memoires remanentes procurant une duree de service accrue |
Non-Patent Citations (7)
| Title |
|---|
| AHMAD N ET AL.: "Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells", J NATL CANCER INST., 1997, pages 1881 - 1886 |
| CAO Y, CAO R.: "Angiogenesis inhibited by drinking tea", NATURE, 1999, pages 381, XP000953295, DOI: doi:10.1038/18793 |
| CHEN L, LEE MJ, LI H, YANG CS.: "Absorption, distribution, elimination of tea polyphenols in rats", DRUG METAB DISPOS., 1997, pages 1045 - 1050, XP055259807 |
| H-H. SHERRY CHOW ET AL.: "Phase I pharmacokinetic study of tea polyphenols following single-dose administration of epigallocatechin gallate and Polyphenon E", CANCER EPIDEMIOL. BIOMARKERS PREV., 2001, pages 53 - 58, XP002366662 |
| JENNIFER RC BELL, ET AL.: "(+)-Catechin in human plasma after ingestion of a single serving of reconstituted red wine1,2,3", AMERICAN SOCIETY FOR CLINICAL NUTRITION, 2000, pages 103 - 108 |
| MUKHTAR H, AHMAD N.: "Tea polyphenols: prevention of cancer and optimizing health.", AM J CLIN NUTR., 2000, pages 1698 - 1702 |
| YANG CS, CHEN L ET AL.: "Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers", CANCER EPIDEMIOL BIOMARKERS PREV., 1998, pages 351 - 355 |
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