LT4391B - Trinariai radiofarmaciniai kompleksai - Google Patents

Trinariai radiofarmaciniai kompleksai Download PDF

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Publication number
LT4391B
LT4391B LT97-157A LT97157A LT4391B LT 4391 B LT4391 B LT 4391B LT 97157 A LT97157 A LT 97157A LT 4391 B LT4391 B LT 4391B
Authority
LT
Lithuania
Prior art keywords
group
substituted
occurrence
independently selected
independently
Prior art date
Application number
LT97-157A
Other languages
English (en)
Lithuanian (lt)
Other versions
LT97157A (en
Inventor
David Scott Edwards
Shuang Liu
Original Assignee
Dupont Pharmaceuticals Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dupont Pharmaceuticals Company filed Critical Dupont Pharmaceuticals Company
Publication of LT97157A publication Critical patent/LT97157A/xx
Publication of LT4391B publication Critical patent/LT4391B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/004—Acyclic, carbocyclic or heterocyclic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen, sulfur, selenium or tellurium
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
LT97-157A 1995-04-03 1997-10-01 Trinariai radiofarmaciniai kompleksai LT4391B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/415,908 US5744120A (en) 1993-03-30 1995-04-03 Ternary radiopharmaceutical complexes

Publications (2)

Publication Number Publication Date
LT97157A LT97157A (en) 1998-05-25
LT4391B true LT4391B (lt) 1998-10-26

Family

ID=23647726

Family Applications (1)

Application Number Title Priority Date Filing Date
LT97-157A LT4391B (lt) 1995-04-03 1997-10-01 Trinariai radiofarmaciniai kompleksai

Country Status (32)

Country Link
US (2) US5744120A (zh)
EP (2) EP0820312B1 (zh)
JP (1) JPH11503166A (zh)
KR (1) KR100417558B1 (zh)
CN (1) CN1080127C (zh)
AR (1) AR006077A1 (zh)
AT (1) ATE220335T1 (zh)
AU (1) AU719529B2 (zh)
BR (1) BR9608065A (zh)
CA (1) CA2216423C (zh)
CZ (1) CZ291658B6 (zh)
DE (1) DE69622267T2 (zh)
DK (1) DK0820312T3 (zh)
EA (1) EA000636B1 (zh)
EE (1) EE9700250A (zh)
ES (1) ES2179196T3 (zh)
HR (1) HRP960148A2 (zh)
HU (1) HU225674B1 (zh)
IL (1) IL117642A (zh)
LT (1) LT4391B (zh)
LV (1) LV12039B (zh)
MX (1) MX9707430A (zh)
NO (1) NO317177B1 (zh)
NZ (2) NZ333276A (zh)
PL (1) PL185325B1 (zh)
PT (1) PT820312E (zh)
SI (1) SI9620044B (zh)
SK (1) SK283276B6 (zh)
TW (1) TW503110B (zh)
UA (1) UA56127C2 (zh)
WO (1) WO1996031243A1 (zh)
ZA (1) ZA962672B (zh)

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US5744120A (en) * 1993-03-30 1998-04-28 The Dupont Merick Pharmaceutical Company Ternary radiopharmaceutical complexes
JP2954355B2 (ja) * 1993-04-08 1999-09-27 ダイアテク，インコーポレイテッド 血栓イメージング用の放射性同位体標識化合物
US5855867A (en) * 1995-03-29 1999-01-05 The Curators Of The University Of Missouri Hydroxymethyl phosphine compounds for use as diagnostic and therapeutic pharmaceuticals and method of making same
US5739313A (en) 1995-11-13 1998-04-14 Regents Of The University Of Minnesota Radionuclide labeling of vitamin B12 and coenzymes thereof
EP0888130B1 (en) * 1996-03-13 2003-07-02 Bristol-Myers Squibb Pharma Company New ternary radiopharmaceutical complexes
US6416733B1 (en) * 1996-10-07 2002-07-09 Bristol-Myers Squibb Pharma Company Radiopharmaceuticals for imaging infection and inflammation
US20030124053A1 (en) * 1996-10-07 2003-07-03 Barrett John Andrew Radiopharmaceuticals for imaging infection and inflammation
US6403054B1 (en) * 1997-05-28 2002-06-11 Bristol-Myers Squibb Pharma Company Ternary ligand complexes useful as radiopharmaceuticals
US7060251B1 (en) * 1997-09-08 2006-06-13 The General Hospital Corporation Imaging agents for early detection and monitoring of cardiovascular plaque
AU9307498A (en) * 1997-09-08 1999-03-29 General Hospital Corporation, The Imaging agents for early detection and monitoring of cardiovascular plaque
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
US6524553B2 (en) 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
SK13952000A3 (sk) 1998-03-31 2001-12-03 Dupont Pharmaceuticals Company Farmaceutické zlúčeniny na zobrazovanie porúch angiogenézy
EP1068222A1 (en) * 1998-04-03 2001-01-17 Du Pont Pharmaceuticals Company Radiopharmaceuticals for imaging infection and inflammation and for imaging and treatment of cancer
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6794518B1 (en) * 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
US6511649B1 (en) * 1998-12-18 2003-01-28 Thomas D. Harris Vitronectin receptor antagonist pharmaceuticals
BR9917079A (pt) 1998-12-18 2001-10-30 Du Pont Pharm Co Compostos antagonistas de receptor devitronectina, kit, composição metalofarmacêuticade diagnóstico ou terapêutica, composição deagente de contraste para ultra-som, composiçãoradiofarmacêutica terapêutica, composiçãofarmacêutica de diagnóstico, método detratamento da artrite reumatóide, do cancêr e darestenose em um paciente, método de formação deimagem da angiogênese terapêutica, do câncer, denovos vasos sanguìneos, da arteriosclerose, darestenose, da isquemia e da lesão por reperfusãodo miocárdio em um paciente
CA2349333A1 (en) 1998-12-18 2000-06-22 Du Pont Pharmaceuticals Company Vitronectin receptor antagonist pharmaceuticals
US6346547B1 (en) 1999-02-08 2002-02-12 Checkpoint, Genetics, Inc. N-substituted amino acids, antioxidant pharmaceutical compositions containing n-substituted amino acids and methods for preventing cardiovascular diseases and/or preventing and/or treating antioxidant responsive diseases therewith
US6844425B1 (en) * 1999-02-24 2005-01-18 Mallinckrodt Inc. Combination of intercalating organometallic complexes and tumor seeking biomolecules for DNA cleavage and radiotherapy
US6808698B1 (en) 1999-03-26 2004-10-26 Bristol-Myers Squibb Pharma Company Method for localization of blood clots
BR0010517A (pt) * 1999-03-26 2002-01-08 Du Pont Pharm Co Métodos de formação de imagem de um trombo, de um êmbolo pulmonar, de um trombo arterial e de um trombo coronariano
US6806363B1 (en) 1999-04-16 2004-10-19 Mayo Foundation For Medical Education & Research Cobalamin conjugates useful as antitumor agents
EP1239887A1 (en) 1999-10-15 2002-09-18 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging and therapeutic agents
US7591995B2 (en) 1999-10-15 2009-09-22 Mayo Foundation For Medical Education And Research Cobalamin conjugates useful as imaging and therapeutic agents
US6534038B2 (en) * 2000-04-07 2003-03-18 Bristol-Myers Squibb Pharma Company Ternary ligand complexes useful as radiopharmaceuticals
AU2001261728A1 (en) 2000-05-17 2001-11-26 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands for diagnostic imaging
EP1268450A1 (en) 2000-06-01 2003-01-02 Bristol-Myers Squibb Pharma Company Lactams substituted by cyclic succinates as inhibitors of a-beta protein production
HUP0400758A3 (en) * 2000-11-03 2005-02-28 Bristol Myers Squibb Pharma Co Simultaneous dual isotope imaging of cardiac perfusion and cardiac inflammation
WO2002055111A2 (en) * 2000-11-27 2002-07-18 Bristol Myers Squibb Medical I Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
US6776977B2 (en) 2001-01-09 2004-08-17 Bristol-Myers Squibb Pharma Company Polypodal chelants for metallopharmaceuticals
US20020094316A1 (en) * 2001-01-09 2002-07-18 Shuang Liu Polypodal chelants for metallopharmaceuticals
US6517814B2 (en) 2001-01-09 2003-02-11 Bristol-Myers Squibb Pharma Company Macrocyclic chelants useful for metallopharmaceuticals
WO2002067761A2 (en) 2001-02-23 2002-09-06 Bristol-Myers Squibb Pharma Company Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque
AU2002331042B2 (en) * 2001-08-08 2007-10-25 Bristol-Myers Squibb Pharma Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
US6838074B2 (en) 2001-08-08 2005-01-04 Bristol-Myers Squibb Company Simultaneous imaging of cardiac perfusion and a vitronectin receptor targeted imaging agent
US7319149B2 (en) * 2003-06-13 2008-01-15 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US7317104B2 (en) 2003-06-13 2008-01-08 Bristol-Myers Squibb Pharma Company Chelants and macrocyclic metal complex radiopharmaceuticals thereof
US20050106100A1 (en) * 2003-09-03 2005-05-19 Harris Thomas D. Compounds containing matrix metalloproteinase substrates and methods of their use
KR20080022588A (ko) * 2005-06-30 2008-03-11 브리스톨-마이어스 스퀴브 파마 컴퍼니 영상화제로서의 히드라지드 컨쥬게이트
US8668900B2 (en) 2011-02-15 2014-03-11 Kuwait University Cancer-imaging agent and method of radioimaging using the same

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US8218861B2 (en) 2007-10-11 2012-07-10 Kwe International, Inc. Color quantization based on desired upper bound for relative quantization step

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EP0569132A1 (en) 1992-05-02 1993-11-10 Johnson Matthey Public Limited Company Improvements in radiolabelling
WO1994022494A1 (en) 1993-03-30 1994-10-13 The Du Pont Merck Pharmaceutical Company RADIOLABELED PLATELET GPIIb/IIIa RECEPTOR ANTAGONISTS AS IMAGING AGENTS FOR THE DIAGNOSIS OF THROMBOEMBOLIC DISORDERS
US8218861B2 (en) 2007-10-11 2012-07-10 Kwe International, Inc. Color quantization based on desired upper bound for relative quantization step

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Also Published As

Publication number Publication date
TW503110B (en) 2002-09-21
ZA962672B (en) 1997-10-03
EP1195168A3 (en) 2007-05-30
DE69622267D1 (de) 2002-08-14
PL322583A1 (en) 1998-02-02
PL185325B1 (pl) 2003-04-30
EE9700250A (et) 1998-04-15
UA56127C2 (uk) 2003-05-15
HUP9801949A3 (en) 2000-09-28
PT820312E (pt) 2002-10-31
LV12039A (lv) 1998-05-20
AU719529B2 (en) 2000-05-11
WO1996031243A1 (en) 1996-10-10
NZ308284A (en) 1999-05-28
NO317177B1 (no) 2004-09-06
AR006077A1 (es) 1999-08-11
KR100417558B1 (ko) 2004-03-19
SK132997A3 (en) 1999-01-11
SI9620044B (sl) 1999-02-28
CZ291658B6 (cs) 2003-04-16
JPH11503166A (ja) 1999-03-23
US6010679A (en) 2000-01-04
SI9620044A (sl) 1998-06-30
NZ333276A (en) 2000-07-28
ATE220335T1 (de) 2002-07-15
HU225674B1 (en) 2007-06-28
LV12039B (en) 1998-10-20
CA2216423A1 (en) 1996-10-10
EP0820312A1 (en) 1998-01-28
IL117642A0 (en) 1996-07-23
EA000636B1 (ru) 1999-12-29
CA2216423C (en) 2004-03-09
EA199700291A1 (ru) 1998-04-30
NO974549D0 (no) 1997-10-02
US5744120A (en) 1998-04-28
EP1195168A2 (en) 2002-04-10
MX9707430A (es) 1997-12-31
IL117642A (en) 2003-04-10
EP0820312B1 (en) 2002-07-10
DK0820312T3 (da) 2002-09-02
HRP960148A2 (en) 1997-10-31
CN1080127C (zh) 2002-03-06
AU5787496A (en) 1996-10-23
DE69622267T2 (de) 2003-02-20
HUP9801949A2 (hu) 1999-02-01
BR9608065A (pt) 1999-06-29
LT97157A (en) 1998-05-25
NO974549L (no) 1997-12-02
EP0820312A4 (en) 1998-03-18
KR19980703560A (ko) 1998-11-05
CN1185116A (zh) 1998-06-17
CZ302797A3 (cs) 1998-11-11
ES2179196T3 (es) 2003-01-16
SK283276B6 (sk) 2003-05-02

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Free format text: DUPONT PHARMACEUTICALS COMPANY,CHESTNUT RUN PLAZA, 974 CENTRE ROAD, WILMINGTON, DELAWARE 19805,US,19990306,

PD9A Change of patent owner

Free format text: 20020712 * BRISTOL-MYERS SQUIBB PHARMA COMPANY,US

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Effective date: 20080403