ATE85619T1 - Herstellung von als radiopharmazeutische produkte verwendbare nitruroverbindungen. - Google Patents

Herstellung von als radiopharmazeutische produkte verwendbare nitruroverbindungen.

Info

Publication number
ATE85619T1
ATE85619T1 AT89903166T AT89903166T ATE85619T1 AT E85619 T1 ATE85619 T1 AT E85619T1 AT 89903166 T AT89903166 T AT 89903166T AT 89903166 T AT89903166 T AT 89903166T AT E85619 T1 ATE85619 T1 AT E85619T1
Authority
AT
Austria
Prior art keywords
preparation
pct
radiopharmaceutical
ligand
date sep
Prior art date
Application number
AT89903166T
Other languages
English (en)
Inventor
Roberto Pasqualini
Luciano Magon
Andre Bardy
Adriano Duatti
Andrea Marchi
Original Assignee
Cis Bio Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8803044A external-priority patent/FR2628428B1/fr
Priority claimed from FR8815414A external-priority patent/FR2639638B1/fr
Application filed by Cis Bio Int filed Critical Cis Bio Int
Application granted granted Critical
Publication of ATE85619T1 publication Critical patent/ATE85619T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • G01N33/575—
    • G01N33/5752—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT89903166T 1988-03-09 1989-03-08 Herstellung von als radiopharmazeutische produkte verwendbare nitruroverbindungen. ATE85619T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR8803044A FR2628428B1 (fr) 1988-03-09 1988-03-09 Procede de preparation de complexes de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques
FR8815414A FR2639638B1 (fr) 1988-11-25 1988-11-25 Procede de preparation de complexes de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques
PCT/FR1989/000094 WO1989008657A2 (fr) 1988-03-09 1989-03-08 Preparation de complexes nitruro utilisables comme produits radiopharmaceutiques

Publications (1)

Publication Number Publication Date
ATE85619T1 true ATE85619T1 (de) 1993-02-15

Family

ID=26226545

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89903166T ATE85619T1 (de) 1988-03-09 1989-03-08 Herstellung von als radiopharmazeutische produkte verwendbare nitruroverbindungen.

Country Status (9)

Country Link
US (1) US5300278A (de)
EP (1) EP0403524B1 (de)
JP (1) JPH07110869B2 (de)
AT (1) ATE85619T1 (de)
AU (1) AU619538B2 (de)
CA (1) CA1340899C (de)
DE (1) DE68904905T2 (de)
RU (1) RU2026300C1 (de)
WO (1) WO1989008657A2 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2664166A1 (fr) * 1990-07-04 1992-01-10 Cis Bio Int Procede de preparation de complexes nitruro de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques.
US5744120A (en) * 1993-03-30 1998-04-28 The Dupont Merick Pharmaceutical Company Ternary radiopharmaceutical complexes
US5750088A (en) * 1993-03-30 1998-05-12 The Dupont Merck Pharmaceutical Company Stable hydrazones linked to a peptide moiety as reagents for the preparation of radiopharmaceuticals
DK0710228T3 (da) * 1993-07-19 1998-09-21 Resolution Pharm Inc Hydraziner med N3S-konfiguration som radionuclidchelatorer
US5751629A (en) 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US6416714B1 (en) 1995-04-25 2002-07-09 Discovery Partners International, Inc. Remotely programmable matrices with memories
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US6017496A (en) 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
US5874214A (en) 1995-04-25 1999-02-23 Irori Remotely programmable matrices with memories
US6329139B1 (en) 1995-04-25 2001-12-11 Discovery Partners International Automated sorting system for matrices with memory
FR2736834B1 (fr) * 1995-07-17 1997-08-29 Cis Bio Int Produits radiopharmaceutiques a tropisme cardiaque comportant un complexe nitruro d'un metal de transition et ayant une clairance myocardique rapide
US5879659A (en) * 1996-03-13 1999-03-09 Dupont Pharmaceuticals Company Ternary radiopharmaceutical complexes
AU730120B2 (en) * 1996-12-18 2001-02-22 Nihon Medi-Physics Co., Ltd. Radioactive transition metal nitride heterocomplex
US6403054B1 (en) * 1997-05-28 2002-06-11 Bristol-Myers Squibb Pharma Company Ternary ligand complexes useful as radiopharmaceuticals
ATE329925T1 (de) 2000-03-16 2006-07-15 Univ California Chemoselektive anknüpfung durch verwendung eines phosphins
ATE293125T1 (de) * 2000-05-12 2005-04-15 Wisconsin Alumni Res Found Ligationsverfahren und reagenzien zur bildung einer amid-bindung
US7256259B2 (en) * 2000-05-12 2007-08-14 Wisconsin Alumni Research Foundation Methods for ligation of molecules to surfaces
ES2315295T3 (es) * 2000-07-28 2009-04-01 Nihon Medi-Physics Co., Ltd. Radiofarmaco para obtencion de imagenes diagnosticas que contiene un heterocomplejo de nitruro de tecnecio-99m.
TWI252847B (en) * 2001-07-10 2006-04-11 Synta Pharmaceuticals Corp Synthesis of taxol enhancers
EP1534718A4 (de) * 2002-06-07 2006-06-07 Wisconsin Alumni Res Found Chemische synthese von reagenzien für die peptidkupplung
BRPI0610219A2 (pt) * 2005-04-15 2010-06-08 Synta Pharmaceuticals Corp métodos de tratamento de um ser humano com cáncer e composição de farmacêutica
ES2369027T3 (es) 2006-01-20 2011-11-24 Nihon Medi-Physics Co., Ltd. Compuesto intermedio de un complejo de nitruro de tecnecio para la formación de imágenes radiodiagnósticas.
EP2057117A2 (de) 2006-08-21 2009-05-13 Synta Pharmaceuticals Corporation Verbindungen zur behandlung proliferativer erkrankungen
WO2008027445A2 (en) * 2006-08-31 2008-03-06 Synta Pharmaceuticals Corp. Combination with bis(thiohydrazide amides) for treating cancer
RU2366434C1 (ru) * 2007-12-07 2009-09-10 Институт неорганической химии им. А.В. Николаева Сибирского отделения Российской Академии наук Гексаядерные кластерные комплексы рения на основе радиоактивных изотопов, обладающие противоопухолевыми свойствами

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4387087A (en) * 1980-04-18 1983-06-07 Research Corporation Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging
US4374821A (en) * 1982-06-28 1983-02-22 E. R. Squibb & Sons, Inc. Myocardial imaging agent and method
JPS59146971A (ja) * 1983-02-04 1984-08-23 株式会社　満尾総合研究所 複合体の製造法と製造装置
WO1985003063A1 (en) * 1983-12-29 1985-07-18 The Commonwealth Of Australia PREPARATION OF 99mTC RADIOPHARMACEUTICALS
US4897255A (en) * 1985-01-14 1990-01-30 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
US5002754A (en) * 1988-06-15 1991-03-26 University Of Cincinnati Technetium (III/II) imaging agents
US4917879A (en) * 1989-05-19 1990-04-17 University Of Cincinnati 99MTC(III) myocardial imaging agents that are effective in humans

Also Published As

Publication number Publication date
AU3351889A (en) 1989-10-05
WO1989008657A3 (fr) 1989-10-19
RU2026300C1 (ru) 1995-01-09
CA1340899C (en) 2000-02-15
EP0403524B1 (de) 1993-02-10
DE68904905T2 (de) 1993-07-22
JPH07110869B2 (ja) 1995-11-29
US5300278A (en) 1994-04-05
DE68904905D1 (de) 1993-03-25
JPH03504964A (ja) 1991-10-31
EP0403524A1 (de) 1990-12-27
WO1989008657A2 (fr) 1989-09-21
AU619538B2 (en) 1992-01-30

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee