FR2639638B1 - Procede de preparation de complexes de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques - Google Patents

Procede de preparation de complexes de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques

Info

Publication number
FR2639638B1
FR2639638B1 FR8815414A FR8815414A FR2639638B1 FR 2639638 B1 FR2639638 B1 FR 2639638B1 FR 8815414 A FR8815414 A FR 8815414A FR 8815414 A FR8815414 A FR 8815414A FR 2639638 B1 FR2639638 B1 FR 2639638B1
Authority
FR
France
Prior art keywords
radiopharmaceuticals
synthesis
preparation
transition metal
metal complexes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
FR8815414A
Other languages
English (en)
Other versions
FR2639638A1 (fr
Inventor
Roberto Pasqualini
Andre Bardy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oris Industrie SA
Original Assignee
Oris Industrie SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR8815414A priority Critical patent/FR2639638B1/fr
Application filed by Oris Industrie SA filed Critical Oris Industrie SA
Priority to US07/571,570 priority patent/US5300278A/en
Priority to CA000593139A priority patent/CA1340899C/fr
Priority to DE8989903166T priority patent/DE68904905T2/de
Priority to EP89903166A priority patent/EP0403524B1/fr
Priority to AU33518/89A priority patent/AU619538B2/en
Priority to JP1502987A priority patent/JPH07110869B2/ja
Priority to PCT/FR1989/000094 priority patent/WO1989008657A2/fr
Priority to AT89903166T priority patent/ATE85619T1/de
Publication of FR2639638A1 publication Critical patent/FR2639638A1/fr
Priority to SU904831069A priority patent/RU2026300C1/ru
Application granted granted Critical
Publication of FR2639638B1 publication Critical patent/FR2639638B1/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
FR8815414A 1988-03-09 1988-11-25 Procede de preparation de complexes de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques Expired - Lifetime FR2639638B1 (fr)

Priority Applications (10)

Application Number Priority Date Filing Date Title
FR8815414A FR2639638B1 (fr) 1988-11-25 1988-11-25 Procede de preparation de complexes de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques
AT89903166T ATE85619T1 (de) 1988-03-09 1989-03-08 Herstellung von als radiopharmazeutische produkte verwendbare nitruroverbindungen.
DE8989903166T DE68904905T2 (de) 1988-03-09 1989-03-08 Herstellung von als radiopharmazeutische produkte verwendbare nitruroverbindungen.
EP89903166A EP0403524B1 (fr) 1988-03-09 1989-03-08 Preparation de complexes nitruro utilisables comme produits radiopharmaceutiques
AU33518/89A AU619538B2 (en) 1988-03-09 1989-03-08 Preparation of nitruro compounds usable as radio-pharmaceutical products
JP1502987A JPH07110869B2 (ja) 1988-03-09 1989-03-08 放射性医薬品として使用できる９９ｍＴｃ、１８６Ｒｅまたは１８８Ｒｅの窒化物錯体の製造方法
US07/571,570 US5300278A (en) 1988-03-09 1989-03-08 Process for the preparation of 99m Tc, 186 Re or 188 Re nitride complexes usable as radiopharmaceutical products
CA000593139A CA1340899C (fr) 1988-03-09 1989-03-08 Process for the preparation of 99m tc, 186 re or 188 re nitruro complexes useful as radiopharmaceutical products
PCT/FR1989/000094 WO1989008657A2 (fr) 1988-03-09 1989-03-08 Preparation de complexes nitruro utilisables comme produits radiopharmaceutiques
SU904831069A RU2026300C1 (ru) 1988-03-09 1990-09-07 Способ получения комплексов переходных металлов

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8815414A FR2639638B1 (fr) 1988-11-25 1988-11-25 Procede de preparation de complexes de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques

Publications (2)

Publication Number Publication Date
FR2639638A1 FR2639638A1 (fr) 1990-06-01
FR2639638B1 true FR2639638B1 (fr) 1991-07-26

Family

ID=9372250

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8815414A Expired - Lifetime FR2639638B1 (fr) 1988-03-09 1988-11-25 Procede de preparation de complexes de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques

Country Status (1)

Country Link
FR (1) FR2639638B1 (fr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61501087A (ja) * 1983-12-29 1986-05-29 オ−ストラリア国 テクネチウム−９９ｍ−標識放射医薬の製造

Also Published As

Publication number Publication date
FR2639638A1 (fr) 1990-06-01

Similar Documents

Publication Publication Date Title
FR2645533B1 (fr) Procede de synthese de sulfonylimidures
MA22922A1 (fr) Procede pour la preparation de nouveaux composes .
PT83401B (fr) Procede pour la production de compositions energetiques microcellulaires
MA21962A1 (fr) Procede pour la preparation d'inhibiteurs de proteass retrovirales .
MA21645A1 (fr) Procede pour la preparation de nouveaux derives d'rtemisinine.
MA22955A1 (fr) Procede pour la preparation de nouveaux composes .
MA22860A1 (fr) Procede pour la preparation de nouveaux composes.
FR2635393B1 (fr) Procede d'elimination des faces cachees, pour la synthese d'une image filaire tridimensionnelle
MA21148A1 (fr) Procede de preparation de compose b-lactamique et intermediaires pour sa synthese .
FR2662178B1 (fr) Procede de preparation d'intermediaires utiles dans la synthese de benzothiazepines.
FR2577559B1 (fr) Procede pour l'homopolymerisation anionique d'alpha-trifluoromethylacrylate
PT80464A (fr) Procede de preparation d'une composition detergente pour blanchiment par photoactivation
FR2665446B1 (fr) Procede et catalyseur comprenant un compose de lanthanide comme additif promoteur pour la synthese directe du dimethyldichlorosilane.
FR2550538B1 (fr) Procede pour la synthese de l'aspartam
FR2639638B1 (fr) Procede de preparation de complexes de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques
FR2628428B1 (fr) Procede de preparation de complexes de metaux de transition utilisables comme produits radiopharmaceutiques ou pour la synthese de nouveaux produits radiopharmaceutiques
RO85812A (fr) Procede pour la preparation des derives d'azolylpentene
MA22927A1 (fr) Procede pour la preparation de nouveaux composes.
BE869767A (fr) Procede pour la preparation continue d'aldehydes
FR2497801B1 (fr) Procede pour la preparation d'aldehydes 6-phenoxypicoliniques, et produits ainsi obtenus
FR2634765B1 (fr) Procede pour la preparation de levo- et de dextro-dropropizine
ITTO930551A1 (it) Procedimento per la produzione di leghe d'acciaio contenenti vanadio
FR2651232B1 (fr) Produits d'addition de l'acide boronique de complexes technetium 99m-dioxime-imine.
RO85313A (fr) Procede pour la preparation des anilides d'ergolyne
FR2558477B1 (fr) Procede de preparation de diphthalocyanines metalliques, produits obtenus et leur application a titre d'agents electrochromes

Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse