FR2651232B1 - Produits d'addition de l'acide boronique de complexes technetium 99m-dioxime-imine. - Google Patents

Produits d'addition de l'acide boronique de complexes technetium 99m-dioxime-imine.

Info

Publication number
FR2651232B1
FR2651232B1 FR909010683A FR9010683A FR2651232B1 FR 2651232 B1 FR2651232 B1 FR 2651232B1 FR 909010683 A FR909010683 A FR 909010683A FR 9010683 A FR9010683 A FR 9010683A FR 2651232 B1 FR2651232 B1 FR 2651232B1
Authority
FR
France
Prior art keywords
dioxime
technetium
acid addition
boronic acid
addition products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR909010683A
Other languages
English (en)
Other versions
FR2651232A1 (fr
Inventor
Karen E Linder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of FR2651232A1 publication Critical patent/FR2651232A1/fr
Application granted granted Critical
Publication of FR2651232B1 publication Critical patent/FR2651232B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
FR909010683A 1989-08-28 1990-08-27 Produits d'addition de l'acide boronique de complexes technetium 99m-dioxime-imine. Expired - Fee Related FR2651232B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/398,880 US5069900A (en) 1989-08-28 1989-08-28 Boronic acid adducts of technetium-99m dioxime-imine complexes

Publications (2)

Publication Number Publication Date
FR2651232A1 FR2651232A1 (fr) 1991-03-01
FR2651232B1 true FR2651232B1 (fr) 1992-05-29

Family

ID=23577176

Family Applications (1)

Application Number Title Priority Date Filing Date
FR909010683A Expired - Fee Related FR2651232B1 (fr) 1989-08-28 1990-08-27 Produits d'addition de l'acide boronique de complexes technetium 99m-dioxime-imine.

Country Status (7)

Country Link
US (1) US5069900A (fr)
JP (1) JPH03148289A (fr)
CA (1) CA2022579A1 (fr)
DE (1) DE4026867A1 (fr)
FR (1) FR2651232B1 (fr)
GB (1) GB2235448B (fr)
IT (1) IT1243204B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991016035A1 (fr) * 1990-04-26 1991-10-31 The Procter & Gamble Company Compositions chelatrices comprenant des composes d'alpha-diamine
AU6493894A (en) * 1993-03-31 1994-10-24 Mallinckrodt Medical, Inc. Radiopharmaceutical formulations having non-stannous reductants
US6056941A (en) * 1999-07-28 2000-05-02 Bracco Research Usa Kit for the preparation of technetium TC 99m teboroxime myocardial perfusion agent
WO2008059489A2 (fr) 2006-11-13 2008-05-22 Spectrum Dynamics Llc Application à la radioimagerie de nouvelles formules de téboroxime

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4387087A (en) * 1980-04-18 1983-06-07 Research Corporation Cationic lipophilic complexes of 99m Tc and their use for myocardial and hepatobiliary imaging
US4615876A (en) * 1983-04-25 1986-10-07 Curators Of The University Of Missouri Macrocyclic complexes of technetium-99m for use as diagnostic radionuclides
US4705849A (en) * 1985-04-15 1987-11-10 E. R. Squibb & Sons, Inc. Boronic acid adducts of technetium-99m dioxime complexes
US4795626A (en) * 1985-05-10 1989-01-03 University Of Cincinnati 99m Tc.sup.(III) myocardial imaging agents which are non-reducable in vivo
US4714605A (en) * 1986-10-14 1987-12-22 E. R. Squibb & Sons, Inc. Technetium-99m labeled dioxime complexes
US4871836A (en) * 1987-10-13 1989-10-03 E. R. Squibb & Sons, Inc. Boronic acid adducts of rhenium and radioactive isotopes of rhenium dioxime complexes

Also Published As

Publication number Publication date
US5069900A (en) 1991-12-03
DE4026867A1 (de) 1991-03-28
FR2651232A1 (fr) 1991-03-01
JPH03148289A (ja) 1991-06-25
GB2235448A (en) 1991-03-06
CA2022579A1 (fr) 1991-03-01
GB2235448B (en) 1993-03-17
IT9021306A1 (it) 1992-02-27
GB9018209D0 (en) 1990-10-03
IT9021306A0 (it) 1990-08-27
IT1243204B (it) 1994-05-24

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse