ZA88342B - Polymer complexes of metals useful as pharmaceutical agents - Google Patents

Polymer complexes of metals useful as pharmaceutical agents

Info

Publication number
ZA88342B
ZA88342B ZA880342A ZA88342A ZA88342B ZA 88342 B ZA88342 B ZA 88342B ZA 880342 A ZA880342 A ZA 880342A ZA 88342 A ZA88342 A ZA 88342A ZA 88342 B ZA88342 B ZA 88342B
Authority
ZA
South Africa
Prior art keywords
pharmaceutical agents
polymer complexes
metals useful
metals
useful
Prior art date
Application number
ZA880342A
Inventor
Gries Heinz
Klieger Erich
Renneke Franz-Josef
Muetzel Wolfgang
Deutsch Julius
Conrad Juergen
Niedballa Ulrich
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of ZA88342B publication Critical patent/ZA88342B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6887—Antibody-chelate conjugates using chelates for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0206—Polyalkylene(poly)amines
ZA880342A 1987-01-19 1988-01-19 Polymer complexes of metals useful as pharmaceutical agents ZA88342B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19873701665 DE3701665A1 (en) 1987-01-19 1987-01-19 POLYMER COMPLEXES, METHOD FOR THE PRODUCTION THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THEM

Publications (1)

Publication Number Publication Date
ZA88342B true ZA88342B (en) 1988-07-04

Family

ID=6319226

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA880342A ZA88342B (en) 1987-01-19 1988-01-19 Polymer complexes of metals useful as pharmaceutical agents

Country Status (10)

Country Link
EP (1) EP0277088A2 (en)
JP (1) JPS6454028A (en)
AU (1) AU1064988A (en)
DE (1) DE3701665A1 (en)
DK (1) DK22688A (en)
IE (1) IE880127L (en)
IL (1) IL85139A0 (en)
NO (1) NO880179L (en)
PT (1) PT86572B (en)
ZA (1) ZA88342B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208139B2 (en) 1989-11-21 2007-04-24 Schering Ag Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3806795A1 (en) * 1988-02-29 1989-09-07 Schering Ag POLYMER-TIED COMPLEX IMAGERS, THEIR COMPLEXES AND CONJUGATES, METHOD FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THEM
US5681543A (en) * 1988-02-29 1997-10-28 Shering Aktiengesellschaft Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI
GB8900719D0 (en) * 1989-01-13 1989-03-08 Nycomed As Compounds
FR2645862B1 (en) * 1989-04-18 1991-07-12 Esteve Labor Dr SUBSTITUTED ISOTHIAZOLO-PYRYDONE AZETIDINYL DERIVATIVES, THEIR PREPARATION AND THEIR APPLICATION AS MEDICAMENTS
US5384108A (en) * 1989-04-24 1995-01-24 Mallinckrodt Medical, Inc. Magnetic resonance imaging agents
GB8916781D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
DE4017439C2 (en) * 1990-05-30 1994-06-23 Deutsches Krebsforsch Polyether-substituted tumor agents
DE4039920A1 (en) * 1990-12-14 1992-06-17 Basf Ag NEW POLYETHYLENIMINE AND POLYVINYLAMINE DERIVATIVES, CARRIER MATERIALS COATED WITH THESE DERIVATIVES ON THE BASIS OF ALUMINUM AND THE USE THEREOF FOR THE PRODUCTION OF OFFSET PRINTING PLATES
JP2901787B2 (en) * 1991-07-15 1999-06-07 日本メジフィジックス株式会社 Nuclear magnetic resonance contrast agent
JP2894879B2 (en) * 1991-10-04 1999-05-24 日本メジフィジックス株式会社 Diagnostic contrast agent
US5324503A (en) * 1992-02-06 1994-06-28 Mallinckrodt Medical, Inc. Iodo-phenylated chelates for x-ray contrast
WO1994008624A2 (en) * 1992-10-14 1994-04-28 Sterling Winthrop Inc. Therapeutic and diagnostic imaging compositions and methods
EP1419786A1 (en) 2002-11-13 2004-05-19 Bracco Imaging S.p.A. Method for the selective and quantitative functionalization of immunoglobulin fab fragments, conjugate compounds obtained with the same and compositions thereof
ITPD20030174A1 (en) * 2003-07-31 2003-10-29 Univ Padova POLYMERIC CONJUGATES FOR DIAGNOSTICS AND THERAPY
DE102005039154A1 (en) * 2005-08-17 2007-03-01 GÖPFERICH, Achim, Prof. Dr. Biodegradable polymers for the transport of nucleic acids into cells
MX2022014143A (en) 2020-05-12 2022-11-30 Basf Se Use of carboxymethylated polymer of lysines as dispersing agent and compositions comprising the same.

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7208139B2 (en) 1989-11-21 2007-04-24 Schering Ag Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them

Also Published As

Publication number Publication date
EP0277088A2 (en) 1988-08-03
JPS6454028A (en) 1989-03-01
IE880127L (en) 1988-07-19
PT86572B (en) 1991-12-31
PT86572A (en) 1988-02-01
DK22688A (en) 1988-07-20
NO880179D0 (en) 1988-01-18
NO880179L (en) 1988-07-20
DE3701665A1 (en) 1988-07-28
DK22688D0 (en) 1988-01-19
AU1064988A (en) 1988-07-21
IL85139A0 (en) 1988-06-30

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