LT4052B - Crystalline anhydrous mycophenolate mofetil and intravenous formulation thereof - Google Patents
Crystalline anhydrous mycophenolate mofetil and intravenous formulation thereof Download PDFInfo
- Publication number
- LT4052B LT4052B LT96-028A LT96028A LT4052B LT 4052 B LT4052 B LT 4052B LT 96028 A LT96028 A LT 96028A LT 4052 B LT4052 B LT 4052B
- Authority
- LT
- Lithuania
- Prior art keywords
- compound
- crystalline anhydrous
- temperature
- composition
- salt
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12184193A | 1993-09-15 | 1993-09-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
LT96028A LT96028A (en) | 1996-08-26 |
LT4052B true LT4052B (en) | 1996-10-25 |
Family
ID=22399119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LT96-028A LT4052B (en) | 1993-09-15 | 1996-03-15 | Crystalline anhydrous mycophenolate mofetil and intravenous formulation thereof |
Country Status (32)
Country | Link |
---|---|
US (2) | US5543408A (xx) |
EP (1) | EP0724581B1 (xx) |
JP (1) | JP3411038B2 (xx) |
KR (1) | KR100349772B1 (xx) |
CN (1) | CN1060770C (xx) |
AT (1) | ATE173475T1 (xx) |
AU (1) | AU677435B2 (xx) |
BR (1) | BR9407469A (xx) |
CA (1) | CA2171836C (xx) |
CZ (1) | CZ292423B6 (xx) |
DE (1) | DE69414720T2 (xx) |
DK (1) | DK0724581T3 (xx) |
ES (1) | ES2123831T3 (xx) |
FI (1) | FI119639B (xx) |
HK (1) | HK1012624A1 (xx) |
HU (1) | HU217300B (xx) |
IL (1) | IL110970A (xx) |
LT (1) | LT4052B (xx) |
LV (1) | LV11326B (xx) |
MX (1) | MXPA94007099A (xx) |
NO (1) | NO314727B1 (xx) |
NZ (1) | NZ273801A (xx) |
PH (1) | PH30685A (xx) |
PL (1) | PL178522B1 (xx) |
RO (2) | RO118427B1 (xx) |
RU (1) | RU2132849C1 (xx) |
SG (1) | SG55006A1 (xx) |
SI (1) | SI9420052B (xx) |
TW (1) | TW370527B (xx) |
UA (1) | UA49797C2 (xx) |
WO (1) | WO1995007902A1 (xx) |
ZA (1) | ZA947088B (xx) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9512854D0 (en) * | 1995-06-23 | 1995-08-23 | Wellcome Found | Novel formulation |
IN188985B (xx) | 1998-12-09 | 2002-11-30 | Biocon Ltd | |
GB0301259D0 (en) | 2003-01-20 | 2003-02-19 | Novartis Ag | Organic compounds |
GB0307553D0 (en) * | 2003-04-01 | 2003-05-07 | Novartis Ag | Organic compounds |
US20050187170A1 (en) * | 2003-06-16 | 2005-08-25 | Biocryst Pharmaceuticals, Inc. | Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors |
ATE402157T1 (de) * | 2003-09-11 | 2008-08-15 | Sandoz Ag | Verfahren zur herstellung von mycophenolatmofetil |
US7683188B2 (en) * | 2004-04-26 | 2010-03-23 | TEVA Gyógyszergyár Zártkōrūen Mūkōdō Részvénytársaság | Process for preparation of mycophenolic acid and ester derivatives thereof |
WO2005105769A2 (en) * | 2004-04-27 | 2005-11-10 | Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg - | Mycophenolate mofetil impurity |
US20110104186A1 (en) | 2004-06-24 | 2011-05-05 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
TW200611692A (en) * | 2004-07-20 | 2006-04-16 | Teva Gyogyszergyar Reszvenytarsasag | Processes for preparation of crystalline mycophenolate sodium |
CN100383520C (zh) * | 2004-09-20 | 2008-04-23 | 复旦大学 | 一种测定人血浆中霉酚酸及其代谢物的方法 |
WO2006086500A2 (en) * | 2005-02-08 | 2006-08-17 | Aspreva Pharmaceuticals Sa | Compositions and methods for treating vascular, autoimmune and inflammatory diseases |
WO2006086498A2 (en) * | 2005-02-08 | 2006-08-17 | Aspreva Pharmaceuticals Sa | Treatment of vascular, autoimmune and inflammatory diseases using low dosages of impdh inhibitors |
US20080281111A1 (en) * | 2005-04-26 | 2008-11-13 | Sandor Molnar | Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid |
US20100204470A1 (en) | 2006-06-27 | 2010-08-12 | Sandoz Ag | method for salt preparation |
CN101953807A (zh) * | 2010-10-09 | 2011-01-26 | 山西普德药业有限公司 | 一种注射用吗替麦考酚酯冻干粉针剂及其制备方法 |
US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
CA2906580C (en) | 2013-03-14 | 2019-10-29 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
US9168246B2 (en) | 2013-06-27 | 2015-10-27 | Veloxis Pharmaceutical A/S | Regimen for suppressing organ rejection |
WO2015127450A1 (en) | 2014-02-24 | 2015-08-27 | Alkermes Pharma Ireland Limited | Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases |
US11918684B2 (en) | 2017-03-13 | 2024-03-05 | Liqmeds Worldwide Limited | Pharmaceutical composition of oral suspension of immunosuppressive agents |
EP4301380A1 (en) | 2021-03-03 | 2024-01-10 | Sana Biotechnology, Inc. | Immunosuppressive therapies for use with cardiomyocyte cell therapies, and associated methods and compositions |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4753935A (en) | 1987-01-30 | 1988-06-28 | Syntex (U.S.A.) Inc. | Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4328213A (en) * | 1979-11-28 | 1982-05-04 | Schering Corporation | Stable injectable labetalol formulation |
US4478829A (en) * | 1983-04-28 | 1984-10-23 | Armour Pharmaceutical Company | Pharmaceutical preparation containing purified fibronectin |
-
1994
- 1994-09-12 NZ NZ273801A patent/NZ273801A/en not_active IP Right Cessation
- 1994-09-12 BR BR9407469A patent/BR9407469A/pt not_active Application Discontinuation
- 1994-09-12 AT AT94928054T patent/ATE173475T1/de active
- 1994-09-12 DK DK94928054T patent/DK0724581T3/da active
- 1994-09-12 ES ES94928054T patent/ES2123831T3/es not_active Expired - Lifetime
- 1994-09-12 RU RU96107396A patent/RU2132849C1/ru active
- 1994-09-12 PL PL94313480A patent/PL178522B1/pl unknown
- 1994-09-12 DE DE69414720T patent/DE69414720T2/de not_active Expired - Lifetime
- 1994-09-12 WO PCT/US1994/010142 patent/WO1995007902A1/en active IP Right Grant
- 1994-09-12 SI SI9420052A patent/SI9420052B/sl unknown
- 1994-09-12 CN CN94193413A patent/CN1060770C/zh not_active Expired - Lifetime
- 1994-09-12 CZ CZ1996788A patent/CZ292423B6/cs not_active IP Right Cessation
- 1994-09-12 KR KR1019960701354A patent/KR100349772B1/ko not_active IP Right Cessation
- 1994-09-12 JP JP50925595A patent/JP3411038B2/ja not_active Expired - Lifetime
- 1994-09-12 AU AU77238/94A patent/AU677435B2/en not_active Expired
- 1994-09-12 EP EP94928054A patent/EP0724581B1/en not_active Expired - Lifetime
- 1994-09-12 SG SG1996001679A patent/SG55006A1/en unknown
- 1994-09-12 HU HU9600652A patent/HU217300B/hu unknown
- 1994-09-12 CA CA002171836A patent/CA2171836C/en not_active Expired - Lifetime
- 1994-09-12 RO ROA200201154A patent/RO118427B1/ro unknown
- 1994-09-12 RO RO96-00567A patent/RO118075B1/ro unknown
- 1994-09-14 PH PH48985A patent/PH30685A/en unknown
- 1994-09-14 ZA ZA947088A patent/ZA947088B/xx unknown
- 1994-09-14 TW TW083108484A patent/TW370527B/zh not_active IP Right Cessation
- 1994-09-14 IL IL11097094A patent/IL110970A/en not_active IP Right Cessation
- 1994-12-05 US US08/349,236 patent/US5543408A/en not_active Expired - Lifetime
- 1994-12-09 UA UA96031026A patent/UA49797C2/uk unknown
-
1995
- 1995-06-02 US US08/459,991 patent/US5545637A/en not_active Expired - Lifetime
-
1996
- 1996-03-13 FI FI961169A patent/FI119639B/fi not_active IP Right Cessation
- 1996-03-15 NO NO19961075A patent/NO314727B1/no not_active IP Right Cessation
- 1996-03-15 LT LT96-028A patent/LT4052B/lt not_active IP Right Cessation
- 1996-03-15 LV LVP-96-85A patent/LV11326B/en unknown
-
1997
- 1997-12-05 MX MXPA94007099A patent/MXPA94007099A/es active IP Right Grant
-
1998
- 1998-12-17 HK HK98113833A patent/HK1012624A1/xx not_active IP Right Cessation
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4753935A (en) | 1987-01-30 | 1988-06-28 | Syntex (U.S.A.) Inc. | Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions |
US4786637A (en) | 1987-01-30 | 1988-11-22 | Syntex (U.S.A.) Inc. | Treatment of allograft rejection with mycophenolic acid morpholinoethylester and derivatives thereof |
US4808592A (en) | 1987-01-30 | 1989-02-28 | Syntex (U.S.A.) Inc. | Method of treating diseases by administering morpholinoethylester of mycophenolic acid and derivatives thereof |
US4948793A (en) | 1987-01-30 | 1990-08-14 | Syntex (U.S.A.) Inc. | Treatment of autoimmune diseases with the morpholinoethyl ester of mycophenolic acid, and derivatives thereof |
US4952579A (en) | 1987-01-30 | 1990-08-28 | Syntex (U.S.A.) Inc. | Method of treating diseases by administering morpholino-ethylester of mycophenolic acid or derivatives thereof |
US4992467A (en) | 1987-01-30 | 1991-02-12 | Syntex (U.S.A.) Inc. | Treatment of autoimmune diseases with mycophenolic acid, and derivatives and formulations thereof |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK9A | Expiry of a patent |
Effective date: 20140912 |