WO2021001805A1

WO2021001805A1 - Stable dipyridamole formulations and their methods of preparation

Info

Publication number: WO2021001805A1
Application number: PCT/IB2020/056313
Authority: WO
Inventors: Francisco Javier Galan Valdivia; Jorge BACARDIT CABADO
Original assignee: Ocular Discovery Ltd.
Priority date: 2019-07-04
Filing date: 2020-07-04
Publication date: 2021-01-07

Abstract

An aqueous composition for topical ophthalmic administration comprises 0.005 – 0.08 % (w/v) of dipyridamole and 0.5 – 5% (w/v) of cremophor, wherein said composition has a pH of no more than 8 and wherein said composition is free of benzalkonium chloride. The cremophor can comprise polyoxyethylene (35) hydrogenated castor oil, polyoxyethylene (40) hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil or polyoxyethylene (200) hydrogenated castor oil.

Description

STABLE DIPYRIDAMOLE FORMULATIONS AND THEIR METHODS OF PREPARATION

Background to the invention

[0001] Dipyridamole is a synthetic pyrimido-pyrimidine derivative known for over 50 years to have anti-platelet activity. The compound is understood to act as both a

phosphodiesterase inhibitor and by inhibiting the reuptake of adenosine into platelets, red blood cells and endothelial cells, thereby raising the extracellular concentration of adenosine.

[0002] Dipyridamole is approved in the US as a 25, 50 or 75mg tablet indicated as an adjunct to coumarin anticoagulants in the prevention of postoperative thromboembolic complications of cardiac valve replacement and traded under the name Persantine^®. The drug is also approved as a 5mg/ml intravenous aqueous injection formulated together with 2 mg tartaric acid and 50 mg polyethylene glycol 600 and pH adjusted to between 2.2 and 3.2 by hydrochloric acid. This product is indicated as an alternative to exercise in thallium myocardial perfusion imaging for the evaluation of coronary artery disease in patients who cannot exercise adequately. Together with 25mg aspirin, 200mg dipyridamole is approved in an extended release capsule indicated to reduce the risk of stroke in patients who have had transient ischemia of the brain or completed ischemic stroke due to thrombosis and traded under the name Aggrenox^®.

[0003] EP672417 describes the use of dipyridamole for the reduction of elevated intraocular pressure. The application describes a variety of aqueous eye drop formulations of dipyridamole at doses ranging from 0.01 to 0.5% (w/v) of dipyridamole at a pH of between 4 and 5. Each of these formulations is also disclosed to contain either

benzalkonium chloride or benzethonium chloride.

[0004] Wang et al (1996) discloses the use of a 0.5% (w/v) aqueous formulation of dipyridamole at pH 3 containing tartaric acid in the attempted treatment of epidemic kerato-conjunctivitis and epidemic hemorrhagic conjunctivitis.

[0005] W02014141079 describes the use of a topical composition of dipyridamole for the treatment of eye disorders including those of the lacrimal system and anterior segment. The application describes aqueous eye drop formulations of dipyridamole containing citric acid at doses ranging from 0.0011 to 0.0085% (w/v) at a pH of 6.7.

[0006] W02017017540 describes the use of a topical composition of dipyridamole for the treatment of cataracts, nevus and tumor lesions. The application describes aqueous eye drop formulations of dipyridamole containing citric acid at doses ranging from 0.00425 to 0.0085% (w/v) at a pH of between 6.4 and 6.7 and formulations of dipyridamole diluted in Ringer's solution at doses ranging from 0.0085 to 0.017% (w/v).

[0007] Despite these disclosures, there remains the need for a topical formulation of dipyridamole which can be administered at a pH suitable for chronic ophthalmic administration and which has a long and stable shelf life. Summary of the invention

[0008] In one embodiment, the invention relates to aqueous compositions comprising 0.005 -0.08% (w/v) of dipyridamole and 0.5 - 5% (w/v) of cremophor, wherein said composition is free of benzalkonium chloride.

[0009] In another embodiment, the invention relates to aqueous compositions comprising dipyridamole and 0.5 - 5% (w/v) of cremophor, wherein said composition has a pH of no more than 8 and wherein said composition is free of benzalkonium chloride.

[0010] In a preferred embodiment, the invention relates to aqueous compositions comprising 0.005 - 0.08% (w/v) of dipyridamole and 0.5 - 5% (w/v) of cremophor, wherein said composition has a pH of no more than 8 and wherein said composition is free of benzalkonium chloride.

[0011] In one preferred embodiment, the invention relates to aqueous compositions comprising 0.008% (w/v) of dipyridamole. In another preferred embodiment, the aqueous composition comprises 0.008 - 0.016% (w/v) of dipyridamole. In another preferred embodiment, the aqueous composition comprises 0.005 - 0.025% (w/v) of dipyridamole. In yet another preferred embodiment, the aqueous composition comprises 0.05 - 0.08% (w/v) of dipyridamole.

[0012] In one preferred embodiment, the invention relates to cremophor comprising polyoxyethylene (35) hydrogenated castor oil, polyoxyethylene (40) hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil or polyoxyethylene (200) hydrogenated castor oil. In a more preferred embodiment, the cremophor comprises polyoxyethylene (35) hydrogenated castor oil.

[0013] In one preferred embodiment, the invention relates to aqueous compositions comprising 1, 2, 3 or 4% (w/v) of cremophor.

[0014] In another preferred embodiment, the invention relates to aqueous compositions of dipyridamole wherein an increase of less than 0.6% in the amount of total impurity is found after 12 months stability testing at room temperature.

[0015] In another preferred embodiment, the invention relates to a method of

manufacturing an aqueous composition of dipyridamole comprising dissolving dipyridamole in cremophor heated to more than 85^°C, preparing an aqueous solution of methylcellulose and EDTA, adding said aqueous solution to the dipyridamole dissolved in cremophor and then buffering the resultant mixture to a pH of about 5.8 - 8.

Detailed description of the invention

[0016] The present invention is directed to aqueous compositions comprising 0.005 - 0.08% (w/v) of dipyridamole and 0.5 - 5% (w/v) of cremophor, wherein said composition is free of benzalkonium chloride.

[0017] As used herein, the term 'aqueous composition' refers to pharmaceutically acceptable compositions wherein the solvent of which consists of at least 50% by weight of water. The remainder of the solvent can be selected from any water-soluble solvent such as ethanol, polyethylene glycol, propylene glycol and glycerol. In one preferred embodiment, the term "aqueous composition" preferably denotes compositions wherein the solvent consists of at least 80% by weight of water. In a more preferred embodiment, the term denotes compositions wherein the solvent consists of at least 90% by weight of water. In a most preferred embodiment, the term denotes compositions wherein the solvent consists exclusively of water.

[0018] As used herein, the term 'dipyridamole' refers to the compound 2-[[2-[bis(2- hydroxyethyl)amino]-4,8-di(piperidin-l-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2- hydroxyethyl)amino]ethanol, pharmaceutically acceptable salts, hydrates and solvates thereof.

[0019] As used herein, the term 'pharmaceutically acceptable salts' refers to

pharmaceutically or physiologically acceptable salts including, for example, inorganic acid salts, such as salts of hydrochloric acid, phosphoric acid, bromic acid, iodic acid, perchloric acid, stannic acid, and sulfuric acid, organic acid salts such as salts of acetic acid, trifluoroacetic acid, citric acid, maleic acid, succinic acid, oxalic acid, benzoic acid, tartaric acid, fumaric acid, mandelic acid, propionic acid, lactic acid, glycolic acid, gluconic acid, galaturonic acid, glutamic acid, glutaric acid, glucuronic acid, aspartic acid, ascorbic acid, carbonic acid, vanillic acid, hydroiodic acid, mandelic acid, mucic acid, nitric acid, pamoic acid, pantothenic acid, succinic acid, and tartaric acid, and sulfonic acid salts, such as salts of methane sulfonic acid, ethane sulfonic acid, benzene sulfonic acid, p-toluene sulfonic acid, camphoric acid, and naphthalene sulfonic acid, amino acid salts such as salts of glycine, arginine, and lysine, and amine salts, such as salts of triethyl amine, triethylamine, ammonia, pyridine, and picoline.

[0020] As used herein, the term 'hydrate' refers to dipyridamole or a pharmaceutically acceptable salt thereof having a stoichiometric or non-stoichiometric amount of water bound by non-covalent intermolecular forces. The hydrate may comprise at least one equivalent of water, for example, one to five equivalents of water. It may be prepared by crystallizing the compounds, or pharmaceutically acceptable salt thereof, in water or an aqueous solvent.

[0021] As used herein, the term 'solvate' refers to dipyridamole or a pharmaceutically acceptable salts thereof having a stoichiometric or non-stoichiometric amount of a solvent bound by non-covalent intermolecular forces. In a preferred embodiment, the solvent is non-volatile, non-toxic, and suitable for administration to humans including, for example, ethanol, methanol, propanol, and methylene chloride.

[0022] In one embodiment, the aqueous composition comprises 0.005 - 0.08% (w/v) of dipyridamole. In a preferred embodiment, the aqueous composition comprises 0.005, 0.01, 0.015, 0.02, 0.025, 0.03, 0.035, 0.04, 0.045, 0.05, 0.055, 0.06, 0.065, 0.07, 0.075 or 0.08% (w/v) of dipyridamole. In a more preferred embodiment, the aqueous composition comprises 0.05 - 0.08% (w/v) of dipyridamole.

[0023] In one embodiment, the aqueous composition comprises 0.005 - 0.016% (w/v) of dipyridamole. In a preferred embodiment, the aqueous composition comprises 0.005,

0.006, 0.007, 0.008, 0.009, 0.01, 0.011, 0.012, 0.013, 0.014, 0.015 or 0.016% (w/v) of dipyridamole. In a more preferred embodiment, the aqueous composition comprises 0.008 - 0.016% (w/v) of dipyridamole. In a most preferred embodiment, the aqueous composition comprises 0.008% (w/v) of dipyridamole.

[0024] As used herein, the term 'cremophor' refers to polyoxyethylene hydrogenated castor oil. Where a number is associated with the term, it relates to a polyoxyethylene hydrogenated castor oil prepared by reacting said number of moles of ethylene oxide for each mole of castor oil. For example, polyoxyethylene (35) hydrogenated castor oil refers to polyoxyethylene hydrogenated castor oil prepared by reacting 35 moles of ethylene oxide with each mole of castor oil, whilst polyoxyethylene (40) hydrogenated castor oil refers to polyoxyethylene hydrogenated castor oil prepared by reacting 40 moles of ethylene oxide with each mole of castor oil.

[0025] In one embodiment, the cremophor refers to polyoxyethylene (35) hydrogenated castor oil, polyoxyethylene (40) hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil or polyoxyethylene (200) hydrogenated castor oil. In a preferred embodiment, the cremophor refers to polyoxyethylene (35) hydrogenated castor oil.

[0026] In one embodiment, the aqueous composition comprises 0.5 - 5% (w/v) of cremophor. In a preferred embodiment, the aqueous composition comprises 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor. In another preferred embodiment, the aqueous composition comprises 1, 2, 3 or 4% (w/v) of cremophor. In a more preferred embodiment, the aqueous composition comprises 1% (w/v) of cremophor. In another more preferred embodiment, the aqueous composition comprises 2% (w/v) of cremophor. In another more preferred embodiment, the aqueous composition comprises 3% (w/v) of cremophor. In another more preferred embodiment, the aqueous composition comprises 4% (w/v) of cremophor.

[0027] As used herein, the term 'benzalkonium chloride' refers to a mixture of

benzyldimethylalkylammonium chlorides typically containing a Cs-is alkyl chain.

[0028] As used herein, the term 'free of benzalkonium chloride' refers to compositions containing no benzalkonium chloride.

[0029] The present invention is further directed to aqueous compositions comprising dipyridamole and 0.5 - 5% (w/v) of cremophor, wherein said composition has a pH of no more than 8, wherein said composition is free of benzalkonium chloride.

[0030] In one embodiment, the aqueous compositions have a pH of between about 5.8 - 8. In a preferred embodiment, the aqueous compositions have a pH of about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a preferred embodiment, the aqueous compositions have a pH of about between about 6.5 - 7.4. In a more preferred

embodiment, the aqueous compositions have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions have a pH of about 7.2.

[0031] In one embodiment, the aqueous compositions comprise 0.005 - 0.08% (w/v) of dipyridamole and 0.5 - 5% (w/v) of cremophor. In a preferred embodiment, the aqueous compositions comprise 0.005, 0.01, 0.015, 0.02, 0.025, 0.03, 0.035, 0.04, 0.045, 0.05, 0.055, 0.06, 0.065, 0.07, 0.075 or 0.08% (w/v) of dipyridamole and 0.5 - 5% (w/v) of cremophor. In a more preferred embodiment, the aqueous composition comprises 0.05 - 0.08% (w/v) of dipyridamole and 0.5 - 5% (w/v) of cremophor.

[0032] In another embodiment, the aqueous compositions comprise 0.005 - 0.08% (w/v) of dipyridamole and 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor. In a preferred embodiment, the aqueous composition comprises 0.05 - 0.08% (w/v) of dipyridamole and 1, 2, 3 or 4% (w/v) of cremophor. In a more preferred embodiment, the aqueous composition comprises 0.005 - 0.025% (w/v) of dipyridamole and 1% (w/v) of cremophor. In another more preferred embodiment, the aqueous composition comprises 0.005 - 0.08% (w/v) of dipyridamole and 4% (w/v) of cremophor.

[0033] In one embodiment, the aqueous compositions comprise 0.005 - 0.016% (w/v) of dipyridamole and 0.5 - 5% (w/v) of cremophor. In a preferred embodiment, the aqueous compositions comprise 0.005, 0.006, 0.007, 0.008, 0.009, 0.01, 0.011, 0.012, 0.013, 0.014, 0.015 or 0.016% (w/v) of dipyridamole and 0.5 - 5% (w/v) of cremophor. In a more preferred embodiment, the aqueous composition comprises 0.008 - 0.016% (w/v) of dipyridamole and 0.5 - 5% (w/v) of cremophor. In a most preferred embodiment, the aqueous composition comprises 0.008% (w/v) of dipyridamole and 0.5 - 5% (w/v) of cremophor.

[0034] In another embodiment, the aqueous compositions comprise 0.005 - 0.016% (w/v) of dipyridamole and 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor. In a preferred embodiment, the aqueous composition comprises 0.005 - 0.016% (w/v) of dipyridamole and 1, 2, 3 or 4% (w/v) of cremophor. In a more preferred embodiment, the aqueous composition comprises 0.005 - 0.016% (w/v) of dipyridamole and 1% (w/v) of cremophor.

In another more preferred embodiment, the aqueous composition comprises 0.005 - 0.016% (w/v) of dipyridamole and 2% (w/v) of cremophor. In another more preferred embodiment, the aqueous composition comprises 0.005 - 0.016% (w/v) of dipyridamole and 3% (w/v) of cremophor. In another more preferred embodiment, the aqueous composition comprises 0.005 - 0.016% (w/v) of dipyridamole and 4% (w/v) of cremophor.

[0035] In one embodiment, the aqueous compositions comprise dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise dipyridamole and 0.5 - 5%

(w/v) of cremophor and have a pH of about 7.2.

[0036] In another embodiment, the aqueous compositions comprise dipyridamole, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise dipyridamole, 1, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise dipyridamole, 1% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0037] In one embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous

compositions comprise 0.005% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0038] In another embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 1, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0039] In one embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous

compositions comprise 0.006% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0040] In another embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 1, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0041] In one embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0042] In another embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 1, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0043] In one embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0044] In another embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 1, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0045] In one embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous

compositions comprise 0.009% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0046] In another embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 1, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0047] In one embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous

compositions comprise 0.01% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0048] In another embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 1, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.01% (w/v)

dipyridamole, 1% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0049] In one embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0050] In another embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 1, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0051] In one embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0052] In another embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 1, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0053] In one embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0054] In another embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 1, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0055] In one embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0056] In another embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 1, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0057] In one embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0058] In another embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 1, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0059] In one embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0060] In another embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 1, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0061] In one embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0062] In another embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 1, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02%

(w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0063] In one embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0064] In another embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 0.5, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 1, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0065] In one embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0066] In another embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 1.5, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0067] In one embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0068] In another embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 1.5, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0069] In one embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0070] In another embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 1.5, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0071] In one embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0072] In another embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 1.5, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0073] In one embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0074] In another embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 1.5, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0075] In one embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0076] In another embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 1.5, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0077] In one embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0078] In another embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 1.5, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0079] In one embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0080] In another embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 1.5, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0081] In one embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0082] In another embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 1.5, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0083] In one embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0084] In another embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 1.5, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0085] In one embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about

7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole and 1.5 - 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole and 0.5 - 5% (w/v) of cremophor and have a pH of about 7.2.

[0086] In another embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 1.5, 2, 2.5, 3, 3.5, 4, 4.5 or 5% (w/v) of cremophor and have a pH of no more than 8. In another preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 1.5, 2, 3 or 4% (w/v) of cremophor and have a pH of no more than 8. In a more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of no more than 8. In another more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of no more than 8.

[0087] In one embodiment, the aqueous compositions comprise 0.005% (w/v)

dipyridamole, 0.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 7.2.

[0088] In another embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 7.2.

[0089] In another embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0090] In another embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0091] In another embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0092] In another embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0093] In another embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0094] In another embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2.

[0095] In another embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0096] In another embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.005% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2.

[0097] In one embodiment, the aqueous compositions comprise 0.006% (w/v)

dipyridamole, 0.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 7.2.

[0098] In another embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 7.2.

[0099] In another embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0100] In another embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0101] In another embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0102] In another embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0103] In another embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0104] In another embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2. [0105] In another embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0106] In another embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.006% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2.

[0107] In one embodiment, the aqueous compositions comprise 0.007% (w/v)

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 7.2.

[0108] In another embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 7.2.

[0109] In another embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0110] In another embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0111] In another embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0112] In another embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0113] In another embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0114] In another embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2.

[0115] In another embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0116] In another embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.007% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2.

[0117] In one embodiment, the aqueous compositions comprise 0.008% (w/v)

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 7.2.

[0118] In another embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 7.2.

[0119] In another embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0120] In another embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0121] In another embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0122] In another embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0123] In another embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0124] In another embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2.

[0125] In another embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2. [0126] In another embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2.

[0127] In one embodiment, the aqueous compositions comprise 0.009% (w/v)

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 7.2.

[0128] In another embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 7.2.

[0129] In another embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0130] In another embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0131] In another embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0132] In another embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0133] In another embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0134] In another embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2.

[0135] In another embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0136] In another embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.009% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2.

[0137] In one embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.01% (w/v)

dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 7.2.

[0138] In another embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 7.2.

[0139] In another embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0140] In another embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0141] In another embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0142] In another embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0143] In another embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0144] In another embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2.

[0145] In another embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0146] In another embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.01% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2. [0147] In one embodiment, the aqueous compositions comprise 0.011% (w/v)

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 7.2.

[0148] In another embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 7.2.

[0149] In another embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0150] In another embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0151] In another embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0152] In another embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0153] In another embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0154] In another embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2.

[0155] In another embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0156] In another embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.011% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2.

[0157] In one embodiment, the aqueous compositions comprise 0.012% (w/v)

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 7.2.

[0158] In another embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 7.2.

[0159] In another embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0160] In another embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0161] In another embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0162] In another embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0163] In another embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0164] In another embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2.

[0165] In another embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0166] In another embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.012% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2.

[0167] In one embodiment, the aqueous compositions comprise 0.013% (w/v)

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 7.2. [0168] In another embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 7.2.

[0169] In another embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0170] In another embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0171] In another embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0172] In another embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0173] In another embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0174] In another embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2.

[0175] In another embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0176] In another embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.013% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2.

[0177] In one embodiment, the aqueous compositions comprise 0.014% (w/v)

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 7.2.

[0178] In another embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 7.2.

[0179] In another embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0180] In another embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0181] In another embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0182] In another embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0183] In another embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0184] In another embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2.

[0185] In another embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0186] In another embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.014% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2.

[0187] In one embodiment, the aqueous compositions comprise 0.015% (w/v)

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 7.2.

[0188] In another embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 7.2. [0189] In another embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0190] In another embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0191] In another embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0192] In another embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0193] In another embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0194] In another embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2.

[0195] In another embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0196] In another embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2.

[0197] In one embodiment, the aqueous compositions comprise 0.016% (w/v)

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 0.5% (w/v) of cremophor and have a pH of about 7.2.

[0198] In another embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 1% (w/v) of cremophor and have a pH of about 7.2.

[0199] In another embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0200] In another embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0201] In another embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0202] In another embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0203] In another embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0204] In another embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2.

[0205] In another embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0206] In another embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.016% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2.

[0207] In another embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0208] In another embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0209] In another embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0210] In another embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0211] In another embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0212] In another embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2.

[0213] In another embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0214] In another embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.015 - 0.02% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about

7.2.

[0215] In another embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0216] In another embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about

7.2.

[0217] In another embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0218] In another embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about

7.2. [0219] In another embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0220] In another embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2.

[0221] In another embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0222] In another embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.021 - 0.025% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2.

[0223] In another embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0224] In another embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0225] In another embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0226] In another embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0227] In another embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0228] In another embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about

7.2.

[0229] In another embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0230] In another embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.026 - 0.03% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about

7.2.

[0231] In another embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0232] In another embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about

7.2. [0233] In another embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0234] In another embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0235] In another embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0236] In another embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2.

[0237] In another embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0238] In another embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.031 - 0.035% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2.

[0239] In another embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0240] In another embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0241] In another embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0242] In another embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about

7.2.

[0243] In another embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0244] In another embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about

7.2.

[0245] In another embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0246] In another embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.036 - 0.04% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about

7.2. [0247] In another embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0248] In another embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0249] In another embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0250] In another embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0251] In another embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0252] In another embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2.

[0253] In another embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0254] In another embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.041 - 0.045% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2.

[0255] In another embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0256] In another embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about

7.2.

[0257] In another embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0258] In another embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about

7.2.

[0259] In another embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0260] In another embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about

7.2. [0261] In another embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0262] In another embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.046 - 0.05% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2.

[0263] In another embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0264] In another embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0265] In another embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0266] In another embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0267] In another embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0268] In another embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2

[0269] In another embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0270] In another embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.051- 0.055% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about

7.2.

[0271] In another embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0272] In another embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about

7.2.

[0273] In another embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0274] In another embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about

7.2. [0275] In another embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0276] In another embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2.

[0277] In another embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0278] In another embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.056 - 0.06% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2.

[0279] In another embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0280] In another embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0281] In another embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0282] In another embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.02% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0283] In another embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0284] In another embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about

7.2.

[0285] In another embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0286] In another embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.061 - 0.065% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about

7.2.

[0287] In another embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0288] In another embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about

7.2.

[0289] In another embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0290] In another embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0291] In another embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0292] In another embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2.

[0293] In another embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2. [0294] In another embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.066 - 0.07% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2.

[0295] In another embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0296] In another embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0297] In another embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0298] In another embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about

7.2.

[0299] In another embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2.

[0300] In another embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about

7.2.

[0301] In another embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0302] In another embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.071 - 0.075% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about

7.2.

[0303] In another embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 1.5% (w/v) of cremophor and have a pH of about 7.2.

[0304] In another embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 7.2.

[0305] In another embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 2.5% (w/v) of cremophor and have a pH of about 7.2.

[0306] In another embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 7.2.

[0307] In another embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 3.5% (w/v) of cremophor and have a pH of about 7.2. [0308] In another embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about

7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 7.2.

[0309] In another embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about

6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 4.5% (w/v) of cremophor and have a pH of about 7.2.

[0310] In another embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of between about 5.8, about 5.9, about 6, about 6.1, about 6.2, about 6.3, about 6.4, about 6.5, about 6.6, about 6.7, about 6.8, about 6.9, about 7.0, about 7.1, about 7.2, about 7.3, about 7.4, about 7.5, about 7.6, about 7.7, about 7.8, about 7.9 or about 8. In a more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 6.5. In another more preferred embodiment, the aqueous compositions comprise 0.076 - 0.08% (w/v) dipyridamole, 5% (w/v) of cremophor and have a pH of about 7.2.

[0311] In one embodiment, the aqueous compositions comprise 0.008% (w/v)

dipyridamole, 1% (w/v) of cremophor and have a pH of about 6.5, wherein the cremophor is selected from the group consisting of polyoxyethylene (35) hydrogenated castor oil, polyoxyethylene (40) hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil or polyoxyethylene (200) hydrogenated castor oil. In a more preferred embodiment, the cremophor is polyoxyethylene (35) hydrogenated castor oil.

[0312] In another embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 2% (w/v) of cremophor and have a pH of about 6.5, wherein the cremophor is selected from the group consisting of polyoxyethylene (35) hydrogenated castor oil, polyoxyethylene (40) hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil or polyoxyethylene (200) hydrogenated castor oil. In a more preferred embodiment, the cremophor is polyoxyethylene (35) hydrogenated castor oil.

[0313] In another embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 3% (w/v) of cremophor and have a pH of about 6.5, wherein the cremophor is selected from the group consisting of polyoxyethylene (35) hydrogenated castor oil, polyoxyethylene (40) hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil or polyoxyethylene (200) hydrogenated castor oil. In a more preferred embodiment, the cremophor is polyoxyethylene (35) hydrogenated castor oil.

[0314] In another embodiment, the aqueous compositions comprise 0.008% (w/v) dipyridamole, 4% (w/v) of cremophor and have a pH of about 6.5, wherein the cremophor is selected from the group consisting of polyoxyethylene (35) hydrogenated castor oil, polyoxyethylene (40) hydrogenated castor oil, polyoxyethylene (60) hydrogenated castor oil or polyoxyethylene (200) hydrogenated castor oil. In a more preferred embodiment, the cremophor is polyoxyethylene (35) hydrogenated castor oil.

[0315] The present invention is further directed to aqueous compositions of dipyridamole which have an osmolarity of between 270 and 330 mOsm / I.

[0316] As used herein, the term‘osmolarity’ refers to the concentration of osmotically active particles in solution as measured at any time point over a 2 year period following the composition’s preparation. Osmolarity may be quantitatively expressed in osmoles of solute per litre of solution.

[0317] The present invention is further directed to aqueous compositions of dipyridamole wherein an increase of less than 0.6% in the amount of total impurity is found after long term stability testing at room temperature.

[0318] In one embodiment, the amount of total impurity is calculated based on analysis of the area of the impurity peaks as shown by HPLC.

[0319] As used herein, the term 'long term' refers to a time period of between 6 months and 3 years.

[0320] As used herein, the term 'stability testing at room temperature' refers to testing performed on compositions stored at 25°C ± 2°C / 60% RH ± 5% RH, as per FDA Guidance "Q1A(R2) Stability Testing of New Drug Substances and Products".

[0321] In one embodiment, the long term stability testing is performed after 6 months. In another embodiment, the testing is performed after 9 months, after 12 months, after 18 months, after 24 months, after 30 months or after 36 months. In a preferred embodiment, the long term stability testing is performed after 12 months.

[0322] As used herein, the term 'suitable for use as ophthalmic compositions’ refers to ophthalmic compositions which maintain dipyridamole stability without the development of impurities whilst maintaining osmolarity and pH over a long term.

[0323] Together with water, cremophor and dipyridamole, the aqueous compositions of the present invention can also include additional ophthalmically acceptable excipients such as viscosity agents, buffering agents, isotonicity adjusting agents, chelating agents and agents to adjust the pH, present in an amount ranging from 0.01% w/v to about 99.9% w/v.

[0324] Examples of viscosity agents include carbomers, carboxymethylcelluloses or hydroxypropyl methylcelluloses hydroxyethylcelluloses, ethyl celluloses, methylcelluloses, sodium carboxymethylcelluloses and polyvinyl. Buffering agents include boric acid, sodium borate, sodium phosphates (including mono, di- and tribasic phosphates, such as sodium phosphate monobasic monohydrate, sodium phosphate dibasic heptahydrate, and mixtures thereof). The pH of the buffered aqueous compositions can be adjusted by the addition of an effective amount of either a base or an acid. Any suitable base or acid can be employed to adjust the pH of the buffered aqueous compositions which does not provide the solution with toxic or deleterious properties which could harm either ophthalmic devices or the eye. An example of a base which can be used to adjust the pH of the buffered aqueous compositions is IN sodium hydroxide, an example of an acid which can be used to adjust the pH of the buffered aqueous compositions is IN hydrochloric acid. Isotonicity adjusting agents include inorganic salts such as magnesium chloride or magnesium sulfate, lithium, sodium or potassium chloride, lithium, sodium or potassium hydrogen phosphate, lithium, sodium or potassium dihydrogen phosphate, salts of organic acids such as sodium or potassium acetate, magnesium succinate, sodium benzoate, sodium citrate or sodium ascorbate; sodium carbonate or sodium bicarbonate; carbohydrates such as mannitol, sorbitol, arabinose, ribose, xylose, glucose, dextrose, fructose, mannose, galactose, sucrose, maltose, lactose, raffinose, inositol, xylitol, maltitol; water-soluble amino acids such as glycine, leucine, alanine, or methionine; urea and the like, and mixtures thereof. Chelating agents include edetic acid, edetic acid salts like disodium edetate, sodium edetate, edetate calcium disodium and trisodium edetate, malic acid and the like and mixtures thereof.

[0325] The aqueous compositions of the present invention may be packaged in end use containers of suitable material with which they are compatible and which will not permit the formulations to degrade or the components to permeate through the material. Suitable materials include glass and plastics such as polyethylene terephthalate, polypropylene or low density polyethylene (LDPE), and can be manufactured as vials, ampoules or as squeezable containers. The container may be itself either a preformed sterile vial or ampoule that is filled and sealed, or it may be formed, filled and sealed in one process (Blow-Fill-Seal technology).

[0326] The aqueous compositions of the present invention can be prepared by mixing dipyridamole, cremophor, water and other excipients in a controlled manner. Surprisingly, it has now been found that dipyridamole dissolves in significantly greater quantities at temperatures of more than 85^°C than at room temperature, or even at temperatures of up to 65^°C and that the dipyridamole dissolved at such high temperatures stays in solution even once the mixture has cooled to room temperature. Said cooled cremophor dipyridamole mixture can then be added to water, which may already contain additional excipients such as viscosity agents, buffering agents, isotonicity adjusting agents and chelating agents and then have its pH adjusted to between 6.5 and 7.4 by pH adjusting agents.

[0327] This invention will be better understood by reference to the Examples, which follow. Those of skill in the art will readily appreciate that the specific experiments detailed are only illustrative of the invention as described more fully in the claims which follow thereafter.

Example 1 : Dipyridamole solubility and stability studies [0328] The solubility of dipyridamole in a variety of aqueous mixtures was assessed after mixing and storage at either 4^°C refrigerated conditions or at 25^°C room temperature. The results of this assessment are shown in Table 1.

Table 1

DYP - Dipyridamole RT - Room Temperature storage FR - Refrigerated storage

[0329] As can be seen from Table 1, none of the compositions tested demonstrated suitable properties for use as an ophthalmic composition. Many failed to dissolve. Those that did dissolve presented initially as a transparent solution but showed a loss of solubility of between 5 - 96% over 3 months storage.

Example 2 - further aqueous dipyridamole composition

[0330] Despite none of the compositions of Example 1 demonstrating suitable properties for use as an ophthalmic composition, certain excipients did appear to improve the properties of the composition. With these in mind, a composition consisting of 8mg of dipyridamole dissolved in 100ml of Ringer’s solution, to which 10 drops of Tween 20 were added, was prepared. This composition showed good initial solubility but by 6 months of storage at room temperature, this had fallen over 40% to 4.5mg/100ml.

Example 3 - aqueous co-solvent dipyridamole compositions

[0331] In an attempt to improve the solubility of dipyridamole, aqueous co-solvent compositions using ethanol, PEG 400 and propylene glycol were prepared and then tested for solubility and stability over time.

[0332] 170mg of dipyridamole was mixed together with 4ml of absolute ethanol, 3ml of PEG 400 and 3ml of propylene glycol to form a concentrated solution. The resultant solution was then mixed with water to make aqueous co-solvent solutions. These compositions had good initial solubility and the advantages of being able to be buffered and adjusted for tonicity. The compositions prepared are shown in Table 2 Table 2

[0333] Samples of Compositions A, B and C were stored at 4^°C refrigerated conditions or at 25^°C for more than 6 months and, using HPLC, assayed for stability. The results of this stability assay, calculated as the percentage reduction in dipyridamole as found in the solution, are shown in Table 4.

Table 4

RT - Room Temperature storage FR - Refrigerated storage

[0334] As can be seen from Table 4, none of the compositions tested maintained stability over a time period of up to 6 months and were deemed unsuitable for use as ophthalmic compositions.

Example 4 - dipyridamole cremophor compositions - manufacture

[0335] lOmg of polyoxyethylene (35) hydrogenated castor oil (Cremophor EL) was heated to 90^°C. 80g of dipyridamole was gradually added to the oil whilst stirring at 800-1000rpm. The mixture was allowed to cool to room temperature whilst keeping the vessel closed and protected from light to form Solution A.

[0336] 0.5g EDTA, 5.5g NaCI and 7.8mg of NaFhPC ^F O were each added to 200ml of purified water and stirred at 500rpm at 40Hz for 15 minutes until fully dissolved, forming Solution B.

[0337] 4.5g of 4000 cps hydroxypropyl methylcellulose (Methocel FM) was dissolved in 700ml of purified water at 90^°C. The mixture was stirred at 800-1000rpm at 50Flz for 20 minutes until the completely methylcellulose dissolved and then the solution was allowed to cool to room temperature to form Solution C.

[0338] Solution A was gradually added to Solution B whilst continuously stirring at 400- 500rpm for 20 minutes. The resultant solution was then gradually added to Solution C whilst continuously stirring at 400-500rpm for an additional 20 minutes.

[0339] The pH of the resultant solution was adjusted to 6.5 by the addition of either IN NaOFI or IN HCI and the volume increased to 1000ml by adding purified water. The resultant 1% cremophor solution was then sterilized by filtering through a 0.22micron filter and filled together with a nitrogen flush into either individual low-density polyethylene (LDPE) or glass vials.

[0340] The composition of the resultant 1% dipyridamole cremophor solution is shown in Table 5. Table 5

[0341] In a similar manner to that described above, 2%, 3% and 4% dipyridamole cremophor solutions at a pH of 6.5 were prepared using 20g, 30g or 40g, respectively, of polyoxyethylene (35) hydrogenated castor oil (Cremophor EL) in the preparation of Solution A.

Example 5 - 24 month shelf life testing of dipyridamole cremophor compositions

[0342] The 1%, 2%, 3% and 4% dipyridamole cremophor solutions at a pH of 6.5 of Example 4 were stored at 4^°C refrigerated conditions or at 25^°C for 24 months, over which time the solutions were assayed for changes in stability, osmolarity, pH and purity. LDPE, clear glass and amber glass vials under refrigerated conditions were stored in the dark.

[0343] The stability and purity of the solutions over 12 months was assayed using a Kromasil C18, 4.6*250mm, 5pm HPLC column, at a detection set at 295nm (mobile phase potassium phosphate buffer pH 7.0 + methanol). The stability of the solutions, as shown in Table 6, was calculated as the % (w/w) of dipyridamole identified based on the area of the dipyridamole peak in the sample relative to the sample.

Table 6

RT - Room Temperature storage FR - Refrigerated storage

[0344] The purity of the solutions, as shown in Table 7, was calculated as (100 - % (w/w)) of the total impurities identified based on the area of the impurity peaks in the sample. Table 7

RT - Room Temperature storage FR - Refrigerated storage

[0345] The osmolarity and pH over 24 months of the solutions were assayed and the results shown in Table 8 (osmolarity) and Table 9 (pH).

Table 8

RT - Room Temperature storage FR - Refrigerated storage

Table 9

RT - Room Temperature storage FR - Refrigerated storage

Example 6 - 24 month shelf life testing of dipyridamole cremophor compositions

[0346] The 1%, 2%, 3% and 4% dipyridamole cremophor solutions at a pH of 6.5 of Example 4 were stored at 4^°C refrigerated conditions, at 25^°C or at 37^°C for 24 months, over which time the solutions were assayed for changes in stability, osmolarity, pH and purity. LDPE, clear glass and amber glass vials under refrigerated conditions were stored in the dark.

[0347] The stability and purity of the solutions at 18 and 24 months was assayed using a Kromasil C18, 4.6*250mm, 5pm HPLC column, at a detection set at 295nm (mobile phase potassium phosphate buffer pH 7.0 + methanol) and wherein the assay sample was diluted with 9 parts methanol before injection and the related substance sample was diluted to O.lmg/ml and also had its pH adjusted by 0.1N NaOFI to 7.0 during the dilution. The stability of the solutions at Day 0, 18 and 24 months is shown in Table 10.

Table 10

RT - Room Temperature storage FR - Refrigerated storage

The purity of the solutions at Day 0, 18 and 24 months is shown in Table 11.

Table 11

RT - Room Temperature storage FR - Refrigerated storage

The osmolarity and pH over 24 months of the solutions were assayed and the results shown in Table 12 (osmolarity) and Table 13 (pH). Table 12

RT - Room Temperature storage FR - Refrigerated storage

Table 13

RT - Room Temperature storage FR - Refrigerated storage

Example 7 - additional dipyridamole cremophor compositions [0348] A concentrated solution of dipyridamole in cremophor was prepared and then further diluted with cremophor to provide a range of stock solutions of dipyridamole with concentrations ranging from 2 - 19 mg/ml. lg samples of each of these stock solutions were added to lOOg samples of both the 1% and 4% dipyridamole cremophor solutions of Example 4, with the pH adjusted to 4, 6.5, 7.2 or 8 by HCI and NaOH, and the samples placed on storage at room temperature.

[0349] After 30 days, the samples were analysed by HPLC and their respective

concentrations of dipyridamole calculated. The results of the highest concentrations of dipyridamole which did not precipitate and stayed in solution for at least 30 days is shown in Table 14.

Table 14

Example 8 - further dipyridamole cremophor compositions

[0350] As per Example 4, multiple 1%, 2%, 3% and 4% dipyridamole cremophor solutions are prepared. These solutions are pH adjusted to between 5.8 and 8 and contain between 0.009 and 0.012 %(w/v) of dipyridamole. As per Example 5, the solutions are assayed for changes in stability, osmolarity, pH and purity over a time period of up to 6 to 9 months.

Claims

We Claim:

1. An aqueous composition for topical ophthalmic administration comprising 0.005 - 0.08 % (w/v) of dipyridamole and 0.5 - 5% (w/v) of cremophor, wherein said composition has a pH of no more than 8 and wherein said composition is free of benzalkonium chloride.

2. The aqueous composition of claim 1 comprising 0.005 - 0.025% (w/v) of dipyridamole.

3. The aqueous composition of claim 1 comprising 0.05 - 0.08% (w/v) of dipyridamole.

4. The aqueous composition of claim 1 comprising 0.008 - 0.016% (w/v) of dipyridamole.

5. The aqueous composition of claim 1 comprising 0.008% (w/v) of dipyridamole.

6. The aqueous composition of claim 1, wherein the cremophor comprises polyoxyethylene (35) hydrogenated castor oil, polyoxyethylene (40) hydrogenated castor oil,

polyoxyethylene (60) hydrogenated castor oil or polyoxyethylene (200) hydrogenated castor oil.

7. The aqueous composition of claim 1 comprising 1% (w/v) of cremophor.

8. The aqueous composition of claim 1 comprising 2% (w/v) of cremophor.

9. The aqueous composition of claim 1 comprising 3% (w/v) of cremophor.

10. The aqueous composition of claim 1 comprising 4% (w/v) of cremophor.

11. The aqueous composition of claim 1 wherein the pH is between about 6.5 and 8.

12. The aqueous composition of any of claims 6 - 11, wherein the cremophor comprises polyoxyethylene (35) hydrogenated castor oil.

13. The aqueous composition of claim 12 comprising 0.008% (w/v) of dipyridamole.

14. The aqueous composition of claim 1 wherein the pH is about 6.5.

15. The aqueous composition of claim 1 wherein the pH is about 7.2.

16. The aqueous composition of claim 1 wherein the pH is about 8.

17. The aqueous composition of claim 1 wherein the composition has an osmolarity of between 270 - 330 mOsm/l.

18. The aqueous composition of claim 1 wherein an increase of less than 0.6% in the amount of total impurity is found after 12 months stability testing at room temperature.

19. An aqueous composition for topical ophthalmic administration comprising 0.008 % (w/v) of dipyridamole and 1 - 4% (w/v) of polyoxyethylene (35) hydrogenated castor oil, wherein said composition has a pH of about 6.5 and wherein said composition is free of benzalkonium chloride.

20. A method of manufacturing an aqueous composition of dipyridamole comprising;

a. dissolving dipyridamole in cremophor heated to more than 85^°C,

b. preparing an aqueous solution of methylcellulose and EDTA,

c. adding said aqueous solution to the dipyridamole dissolved in cremophor, d. buffering the resultant mixture to a pH of about 5.8 - 8.