LT3950B - Process for the preparation of (1h-azol-1-ylmethyl)substituted benzotriazole derivatives - Google Patents

Process for the preparation of (1h-azol-1-ylmethyl)substituted benzotriazole derivatives Download PDF

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Publication number
LT3950B
LT3950B LTIP1625A LTIP1625A LT3950B LT 3950 B LT3950 B LT 3950B LT IP1625 A LTIP1625 A LT IP1625A LT IP1625 A LTIP1625 A LT IP1625A LT 3950 B LT3950 B LT 3950B
Authority
LT
Lithuania
Prior art keywords
formula
parts
compound
base
benzotriazole
Prior art date
Application number
LTIP1625A
Other languages
English (en)
Lithuanian (lt)
Inventor
Alfons Herman Marg Raeymaekers
Josephus Ludovicus H Vangelder
Eddy Jean Edgard Freyne
Marc Gaston Venet
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of LTIP1625A publication Critical patent/LTIP1625A/xx
Publication of LT3950B publication Critical patent/LT3950B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
LTIP1625A 1987-06-01 1993-12-16 Process for the preparation of (1h-azol-1-ylmethyl)substituted benzotriazole derivatives LT3950B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5602187A 1987-06-01 1987-06-01

Publications (2)

Publication Number Publication Date
LTIP1625A LTIP1625A (en) 1995-07-25
LT3950B true LT3950B (en) 1996-05-27

Family

ID=22001654

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1625A LT3950B (en) 1987-06-01 1993-12-16 Process for the preparation of (1h-azol-1-ylmethyl)substituted benzotriazole derivatives

Country Status (24)

Country Link
EP (1) EP0293978B1 (xx)
JP (1) JPH0662612B2 (xx)
KR (1) KR970000952B1 (xx)
CN (1) CN1022184C (xx)
AU (1) AU603446B2 (xx)
BG (2) BG50278A3 (xx)
CA (1) CA1307271C (xx)
CY (1) CY1866A (xx)
DE (1) DE3884055T2 (xx)
DK (1) DK175218B1 (xx)
ES (1) ES2059490T3 (xx)
FI (1) FI90078C (xx)
HK (1) HK114795A (xx)
HU (2) HU201056B (xx)
IE (1) IE61823B1 (xx)
IL (1) IL86551A (xx)
LT (1) LT3950B (xx)
LV (1) LV10452B (xx)
NO (1) NO169900C (xx)
NZ (1) NZ224714A (xx)
PT (1) PT87623B (xx)
RU (1) RU1838308C (xx)
UA (1) UA11192A (xx)
ZA (1) ZA883861B (xx)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5157046A (en) * 1988-11-29 1992-10-20 Janssen Pharmaceutica N.V. Method of treating epithelial disorders
CA2002859C (en) * 1988-11-29 1998-12-29 Jean P. F. Van Wauwe Method of treating epithelial disorders
GB8827820D0 (en) * 1988-11-29 1988-12-29 Janssen Pharmaceutica Nv (1h-azol-1-ylmethyl)substituted quinoline derivatives
DE59010171D1 (de) * 1989-07-14 1996-04-11 Ciba Geigy Ag Substituierte Benzonitrile
US5066656A (en) * 1989-11-01 1991-11-19 Janssen Pharmaceutica N.V. Pharmacologically active (6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1H-benzotriazole derivatives
CA2026792A1 (en) * 1989-11-01 1991-05-02 Michael N. Greco (6,7-dihydro-5h-pyrrolo[1,2-c]imidazol-5-yl)- and (5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl) substituted 1h-benzotriazole derivatives
NZ236440A (en) * 1989-12-15 1993-07-27 Merck & Co Inc Reversal of sexual phenotype in poultry using an inhibitor of steroid biotransformation and/or aromatase inhibitor, poultry produced by this process
EP0445073A1 (de) * 1990-02-27 1991-09-04 Ciba-Geigy Ag Benzofurane
DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung
EP0457716A1 (de) * 1990-04-20 1991-11-21 Ciba-Geigy Ag Naphthalinderivate
TW224461B (xx) * 1990-09-18 1994-06-01 Ciba Geigy Ag
US5162337A (en) * 1990-10-05 1992-11-10 Merck & Co., Inc. Animal growth promotion
TW210334B (xx) * 1990-12-12 1993-08-01 Ciba Geigy Ag
CH683151A5 (de) * 1991-04-24 1994-01-31 Ciba Geigy Ag Antikonzeption bei weiblichen Primaten ohne Beeinflussung des menstruellen Zyklus.
UA41295C2 (uk) 1991-09-02 2001-09-17 Яманугі Фармасетікл Ко., Лтд Триазолілзаміщені третинні амінні сполуки або їх солі як інгібітор ароматази та фармацевтична композиція на їх основі
US5635521A (en) * 1991-09-23 1997-06-03 Sandoz Ltd. Imidazolylmethyl-pyridines
JP2700595B2 (ja) * 1992-05-21 1998-01-21 呉羽化学工業株式会社 アゾール誘導体を含有する抗アロマターゼ剤
JPH08502990A (ja) * 1992-11-10 1996-04-02 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 鏡像体的に純粋な６−［（４−クロロフェニル）（１ｈ−１，２，４−トリアゾール−１−イル）メチル−１−メチル−１ｈ−ベンゾトリアゾールの製造方法
AU682947B2 (en) * 1994-05-27 1997-10-23 Mochida Pharmaceutical Co., Ltd. Novel azolyl methyl phenyl derivatives having aromatase inhibitory activity
WO1997006788A1 (en) * 1995-08-14 1997-02-27 Janssen Pharmaceutica N.V. Transdermal administration of vorozole
IT1286866B1 (it) * 1996-10-28 1998-07-17 Menarini Farma Ind Composti furano-eterociclici,loro preparazione ed uso come inibitori di aromatasi
US6331553B1 (en) * 1996-12-24 2001-12-18 Chugai Seiyaku Kabushiki Kaisha Aromatic amine derivatives having NOS inhibiting action
EP1295880A4 (en) * 2000-06-28 2004-05-06 Ssp Co Ltd IMIDAZOLE DERIVATIVES OR SALTS THEREOF, AND MEDICINAL PRODUCTS CONTAINING DERIVATIVES OR SALTS
MXPA05009459A (es) * 2003-03-03 2006-05-17 Array Biopharma Inc Inhibidores de p38 y sus metodos de uso.
US7135575B2 (en) 2003-03-03 2006-11-14 Array Biopharma, Inc. P38 inhibitors and methods of use thereof
JP5475235B2 (ja) 2005-01-21 2014-04-16 アステックス・セラピューティクス・リミテッド 医薬化合物
ES2329614T3 (es) * 2005-04-29 2009-11-27 Janssen Pharmaceutica Nv Derivados de benzotriazol como antagonistas de los receptores cannabinoides.
US7572807B2 (en) 2005-06-09 2009-08-11 Bristol-Myers Squibb Company Heteroaryl 11-beta-hydroxysteroid dehydrogenase type I inhibitors
CN101291950B (zh) 2005-09-15 2013-01-02 科学与工业研究会 咪唑基取代的类固醇和茚满-1-酮衍生物
CN101415685B (zh) 2006-01-31 2011-08-24 阿雷生物药品公司 激酶抑制剂及其使用方法
US8916552B2 (en) 2006-10-12 2014-12-23 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044045A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
US9394290B2 (en) * 2010-10-21 2016-07-19 Universitaet Des Saarlandes Campus Saarbruecken Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4410539A (en) 1980-10-23 1983-10-18 Pfizer Inc. Heterocyclic thromboxane synthetase inhibitors and pharmaceutical compositions containing them
EP0165781A1 (en) 1984-06-18 1985-12-27 Eli Lilly And Company Aromatase inhibiting N-substituted imidazole derivatives
US4609666A (en) 1984-06-18 1986-09-02 Eli Lilly And Company Aromatase inhibiting derivatives of α,α-bis(4-halophenyl)methyltetrazoles and triazoles
US4902025A (en) 1987-12-31 1990-02-20 Joseph Albrecht, Bohrfutterfabrik Gmbh & Co. Self-clamping or self-tightening chuck

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4801594A (en) * 1984-06-18 1989-01-31 Eli Lilly And Company Aromatase inhibitors
US4602025A (en) * 1984-06-18 1986-07-22 Eli Lilly And Company Aromatase inhibitors
US4659730A (en) * 1984-06-18 1987-04-21 Eli Lilly And Company Aromatase inhibiting imidazole derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4410539A (en) 1980-10-23 1983-10-18 Pfizer Inc. Heterocyclic thromboxane synthetase inhibitors and pharmaceutical compositions containing them
EP0165781A1 (en) 1984-06-18 1985-12-27 Eli Lilly And Company Aromatase inhibiting N-substituted imidazole derivatives
US4609666A (en) 1984-06-18 1986-09-02 Eli Lilly And Company Aromatase inhibiting derivatives of α,α-bis(4-halophenyl)methyltetrazoles and triazoles
US4902025A (en) 1987-12-31 1990-02-20 Joseph Albrecht, Bohrfutterfabrik Gmbh & Co. Self-clamping or self-tightening chuck

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
IUPAC-IUB COMM. ON BIOCHEM. NOMENCLATURE: "IUPAC tentative rules for the nomenclature of organic chemistry. Section E. Fundamental stereochemistry", J. ORG. CHEM., 1970, pages 2849 - 2867
J. IAN MASON, BARBARA A. MURRY, MICHAEL OLCOT: "Imidazole antimycotics: Inhibitors of steroid aromatase", BIOCHEMICAL PHARMACOLOGY, 1985, pages 1087, XP023849128, DOI: doi:10.1016/0006-2952(85)90613-6
R.S. CAHN, C.K. INGOLD, V. PRELOG: "Specification of Molecular Chirality", ANGEW. CHEM. INT. ED. ENGL., 1966, pages 385 - 511

Also Published As

Publication number Publication date
PT87623A (pt) 1988-06-01
IE61823B1 (en) 1994-11-30
NO169900C (no) 1992-08-19
KR970000952B1 (ko) 1997-01-21
RU1838308C (ru) 1993-08-30
FI90078C (fi) 1993-12-27
CN88103408A (zh) 1988-12-14
KR890000469A (ko) 1989-03-14
CN1022184C (zh) 1993-09-22
IL86551A0 (en) 1988-11-15
HU211482A9 (en) 1995-11-28
AU603446B2 (en) 1990-11-15
FI882552A0 (fi) 1988-05-31
FI90078B (fi) 1993-09-15
LV10452A (lv) 1995-02-20
BG50278A3 (en) 1992-06-15
JPS63316775A (ja) 1988-12-26
IL86551A (en) 1992-07-15
NO882390L (no) 1988-12-02
CY1866A (en) 1988-05-26
ES2059490T3 (es) 1994-11-16
LTIP1625A (en) 1995-07-25
HU201056B (en) 1990-09-28
EP0293978A2 (en) 1988-12-07
DK295288D0 (da) 1988-05-31
DK295288A (da) 1988-12-02
BG60429B2 (bg) 1995-03-31
DE3884055D1 (de) 1993-10-21
PT87623B (pt) 1992-09-30
CA1307271C (en) 1992-09-08
UA11192A (uk) 1996-12-25
EP0293978B1 (en) 1993-09-15
AU1653788A (en) 1988-12-01
ZA883861B (en) 1990-01-31
NO882390D0 (no) 1988-05-31
NZ224714A (en) 1990-03-27
JPH0662612B2 (ja) 1994-08-17
LV10452B (en) 1995-08-20
HK114795A (en) 1995-07-21
DK175218B1 (da) 2004-07-12
IE881640L (en) 1988-12-01
DE3884055T2 (de) 1994-01-27
NO169900B (no) 1992-05-11
FI882552A (fi) 1988-12-02
HUT49132A (en) 1989-08-28
EP0293978A3 (en) 1990-06-13

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Effective date: 20131216