LT3813B - Process for preparing 3-formamido-4-hydroxy-alpha£n£1-methyl-2(p-methoxyphenyl)ethylaminomethyl|benzyl alkohol fumarate (formoterol) and related compounds and derivatives thereof - Google Patents

Process for preparing 3-formamido-4-hydroxy-alpha£n£1-methyl-2(p-methoxyphenyl)ethylaminomethyl|benzyl alkohol fumarate (formoterol) and related compounds and derivatives thereof Download PDF

Info

Publication number
LT3813B
LT3813B LTIP1715A LTIP1715A LT3813B LT 3813 B LT3813 B LT 3813B LT IP1715 A LTIP1715 A LT IP1715A LT IP1715 A LTIP1715 A LT IP1715A LT 3813 B LT3813 B LT 3813B
Authority
LT
Lithuania
Prior art keywords
compound
straight
carbon atoms
branched alkyl
alkyl group
Prior art date
Application number
LTIP1715A
Other languages
English (en)
Lithuanian (lt)
Inventor
Jan Trofast
Katarina Mansson
Edib Jakupovic
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of LTIP1715A publication Critical patent/LTIP1715A/xx
Publication of LT3813B publication Critical patent/LT3813B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/14—Preparation of carboxylic acid amides by formation of carboxamide groups together with reactions not involving the carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Steroid Compounds (AREA)
LTIP1715A 1990-09-26 1993-12-30 Process for preparing 3-formamido-4-hydroxy-alpha£n£1-methyl-2(p-methoxyphenyl)ethylaminomethyl|benzyl alkohol fumarate (formoterol) and related compounds and derivatives thereof LT3813B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9003057A SE9003057D0 (sv) 1990-09-26 1990-09-26 New process

Publications (2)

Publication Number Publication Date
LTIP1715A LTIP1715A (en) 1995-07-25
LT3813B true LT3813B (en) 1996-03-25

Family

ID=20380456

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP1715A LT3813B (en) 1990-09-26 1993-12-30 Process for preparing 3-formamido-4-hydroxy-alpha£n£1-methyl-2(p-methoxyphenyl)ethylaminomethyl|benzyl alkohol fumarate (formoterol) and related compounds and derivatives thereof

Country Status (28)

Country Link
EP (1) EP0550612B1 (ru)
JP (1) JP2801401B2 (ru)
KR (1) KR0179639B1 (ru)
AT (1) ATE134990T1 (ru)
AU (1) AU652386B2 (ru)
BG (1) BG61605B1 (ru)
CA (1) CA2091343C (ru)
CZ (1) CZ284256B6 (ru)
DE (1) DE69117768T2 (ru)
DK (1) DK0550612T3 (ru)
EE (1) EE02979B1 (ru)
ES (1) ES2084831T3 (ru)
FI (1) FI111714B (ru)
GR (1) GR3020134T3 (ru)
HK (1) HK52297A (ru)
HU (1) HU214054B (ru)
IE (1) IE74387B1 (ru)
IS (1) IS1684B (ru)
LT (1) LT3813B (ru)
LV (1) LV10770B (ru)
NO (1) NO301709B1 (ru)
PL (1) PL166434B1 (ru)
PT (1) PT99051B (ru)
RU (1) RU2079486C1 (ru)
SE (1) SE9003057D0 (ru)
SG (1) SG43150A1 (ru)
SK (1) SK22793A3 (ru)
WO (1) WO1992005147A1 (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6866839B2 (en) 1991-04-05 2005-03-15 Sepracor Inc. Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol
US5795564A (en) * 1991-04-05 1998-08-18 Sepracor, Inc. Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol
US6299863B1 (en) 1992-04-03 2001-10-09 Sepracor Inc. Aerosol formulations containing micronized optically pure (R,R) formoterol for bronchodilating therapy
US5629200A (en) * 1993-11-18 1997-05-13 Daicel Chemical Industries, Ltd. Production of optically active 2-amino-1-phenylethanol derivatives by asymetrical assimilation
SE9404080L (sv) * 1993-12-28 1995-06-29 Ciba Geigy Ag Förfarande för framställning av en optiskt ren enantiomer av formoterol
US6040344A (en) * 1996-11-11 2000-03-21 Sepracor Inc. Formoterol process
ATE219047T1 (de) * 1996-11-11 2002-06-15 Sepracor Inc Verfahren zur herstellung von optisch reinen isomeren des formoterols
US6303145B2 (en) 1999-05-10 2001-10-16 Sepracor Inc. (S,R) formoterol methods and compositions
AR028948A1 (es) 2000-06-20 2003-05-28 Astrazeneca Ab Compuestos novedosos
WO2002066027A1 (de) * 2001-02-22 2002-08-29 Universitätsklinikum Charite Medizinische Fakultät Der Humboldt-Universität Zu Berlin, Akademische Verwaltung - Forschung Mittel zur hemmung von tumorzellen
US6472563B1 (en) 2001-11-09 2002-10-29 Sepracor Inc. Formoterol tartrate process and polymorph
TWI359675B (en) 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
TW200738634A (en) 2005-08-02 2007-10-16 Astrazeneca Ab New salt
WO2008035380A2 (en) * 2006-09-19 2008-03-27 Natco Pharma Limited An improved process for the preparation of high purity formoterol and its pharmaceutically acceptable salts
TW200825084A (en) 2006-11-14 2008-06-16 Astrazeneca Ab New compounds 521
US20100288022A1 (en) * 2007-10-29 2010-11-18 Mylan India Private Limited Novel chromatography methods
JP4837800B2 (ja) 2008-05-13 2011-12-14 アストラゼネカ・アクチエボラーグ ムスカリンｍ３受容体アンタゴニストとしてのキヌクリジン誘導体
CN101921200B (zh) * 2009-06-16 2014-01-15 上海医药工业研究院 一种n-苄基-1-(4-甲氧基苯基)-2-丙胺的制备方法
WO2011061527A1 (en) 2009-11-17 2011-05-26 Astrazeneca Ab Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases
CN115368250A (zh) * 2022-09-02 2022-11-22 博诺康源(北京)药业科技有限公司 拆分福莫特罗手性中间体的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2305092A1 (de) 1972-02-05 1973-08-16 Yamanouchi Pharma Co Ltd Alpha-aminomethylbenzylalkoholderivate
JPS643121A (en) 1987-06-25 1989-01-06 Mitsubishi Kasei Corp Remedy for endometriosis
ES2005492A6 (es) 1987-12-23 1989-03-01 Lasa Lab Procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2((2- (4-metoxifenil)-1metiletil)amino)etil)fenil)foramida (i).

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1468156A (en) * 1973-07-19 1977-03-23 Ici Ltd Phenylethylamine derivatives

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2305092A1 (de) 1972-02-05 1973-08-16 Yamanouchi Pharma Co Ltd Alpha-aminomethylbenzylalkoholderivate
DE2366625C2 (ru) 1972-02-05 1988-06-09 Yamanouchi Pharmaceutical Co., Ltd., Tokio/Tokyo, Jp
JPS643121A (en) 1987-06-25 1989-01-06 Mitsubishi Kasei Corp Remedy for endometriosis
ES2005492A6 (es) 1987-12-23 1989-03-01 Lasa Lab Procedimiento de obtencion de n-(2-hidroxi-5-(1-hidroxi-2((2- (4-metoxifenil)-1metiletil)amino)etil)fenil)foramida (i).

Also Published As

Publication number Publication date
SK22793A3 (en) 1993-07-07
HU214054B (en) 1997-12-29
LV10770A (lv) 1995-08-20
CZ44293A3 (en) 1994-01-19
WO1992005147A1 (en) 1992-04-02
IS3756A7 (is) 1992-03-27
PT99051B (pt) 1999-02-26
ATE134990T1 (de) 1996-03-15
CA2091343A1 (en) 1992-03-27
FI931333A0 (fi) 1993-03-25
DE69117768T2 (de) 1996-08-29
IE74387B1 (en) 1997-07-30
PT99051A (pt) 1992-08-31
HUT65912A (en) 1994-07-28
FI111714B (fi) 2003-09-15
EP0550612A1 (en) 1993-07-14
LV10770B (en) 1996-04-20
NO931058D0 (no) 1993-03-23
HU9300867D0 (en) 1993-06-28
EP0550612B1 (en) 1996-03-06
KR0179639B1 (ko) 1999-05-15
DE69117768D1 (de) 1996-04-11
AU8652091A (en) 1992-04-15
ES2084831T3 (es) 1996-05-16
JPH06501262A (ja) 1994-02-10
SG43150A1 (en) 1997-10-17
BG97576A (bg) 1994-03-31
RU2079486C1 (ru) 1997-05-20
IE913373A1 (en) 1992-04-08
SE9003057D0 (sv) 1990-09-26
LTIP1715A (en) 1995-07-25
HK52297A (en) 1997-05-02
DK0550612T3 (da) 1996-07-22
JP2801401B2 (ja) 1998-09-21
CA2091343C (en) 2002-07-09
EE02979B1 (et) 1997-04-15
GR3020134T3 (en) 1996-08-31
NO301709B1 (no) 1997-12-01
AU652386B2 (en) 1994-08-25
NO931058L (no) 1993-03-23
PL166434B1 (pl) 1995-05-31
CZ284256B6 (cs) 1998-10-14
BG61605B1 (bg) 1998-01-30
IS1684B (is) 1998-02-24
FI931333A (fi) 1993-04-22

Similar Documents

Publication Publication Date Title
LT3813B (en) Process for preparing 3-formamido-4-hydroxy-alpha£n£1-methyl-2(p-methoxyphenyl)ethylaminomethyl|benzyl alkohol fumarate (formoterol) and related compounds and derivatives thereof
US5434304A (en) Process for preparing formoterol and related compounds
US5665733A (en) 3-phenylisoquinol-1(2H)-one derivatives their preparation and their therapeutic application
JP2758502B2 (ja) （−）−リトドリン
US4134991A (en) Derivatives of 2-(3-phenyl-2-aminopropionyloxy)-acetic acid
FI62528C (fi) Ett nytt foerfarande foer framstaellning av 1-(3,5-dihydroxifenyl)-1-hydroxi-2-(1-metyl-2-(4-hydroxifenyl)-etyl)-aminoetan
US4131686A (en) Novel benzylalcohol derivatives and processes for preparing the same
SU1282815A3 (ru) Способ получени оптически активных транс-1Н-пропил-6-оксо-гидрохинолинов
US4451473A (en) 3,7-Diazabicyclo [3.3.1] nonanes having anti-arrhythmic activity
US4559361A (en) Naphthalenecarboxamides, their production and use
FI61868C (fi) Foerfarande foer framstaellning av terapeutiskt anvaendbara 2-enylbicyklooktan- och oktenderivat
CS236097B1 (en) Acylderivatives of 2-piperazinochinazoline and method of their preparation
SU497764A3 (ru) Способ получени производных норборнана
CA1209586A (en) Naphthalenecarboxamides, their production and use
US4709086A (en) Process for the preparation of 4-benzyl aspartate
FR2555580A1 (fr) Nouveaux composes azabicycliques, procede pour les preparer et medicaments les contenant
PL82685B1 (en) Dibenzazepine derivatives and their preparation[ie34441b1]
JPS60243070A (ja) １↓−シクロヘキシル↓−３，４↓−ジヒドロイソキノリン誘導体
EP0127708B1 (en) Trans-dl-1-alkyl-6-alkoxyoctahydroquinolines
CS247575B1 (cs) Deriváty 1-fenoxy-3-fenoxyethylamino-2-propanolu a způsob jejich přípravy
KR800000539B1 (ko) 아미노-페닐-에탄올아민의 제조방법
DD264427A5 (de) Verfahren zur herstellung von cyycloalkano (1.2-b)indolsulfonamiden
EP0108822A1 (en) Antiglaucoma compounds
HU181589B (hu) Eljárás 7,8-dihidroxi-l-(szulfamoilfenil)-2,3,4,5-tetrahidro-lH-3-benzazepin-származékok előállítására
CS262412B2 (en) Process for preparing d-2-/6-methoxy-2-naphthyl/propionic acid

Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 19981230