LT3671B - Substituted 1-(1h-imidazol-4-il)alkylbenzamides - Google Patents

Substituted 1-(1h-imidazol-4-il)alkylbenzamides Download PDF

Info

Publication number
LT3671B
LT3671B LTIP827A LTIP827A LT3671B LT 3671 B LT3671 B LT 3671B LT IP827 A LTIP827 A LT IP827A LT IP827 A LTIP827 A LT IP827A LT 3671 B LT3671 B LT 3671B
Authority
LT
Lithuania
Prior art keywords
imidazol
methyl
hydroxy
ethyl
chlorohydrate
Prior art date
Application number
LTIP827A
Other languages
English (en)
Lithuanian (lt)
Inventor
Eric Cossement
Jean-Pierre Geerts
Jean Gobert
Philippe Michel
Ernst Wuelfert
Original Assignee
Ucb Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Sa filed Critical Ucb Sa
Publication of LTIP827A publication Critical patent/LTIP827A/xx
Publication of LT3671B publication Critical patent/LT3671B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Adhesives Or Adhesive Processes (AREA)
  • Lubricants (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
LTIP827A 1988-04-28 1993-08-03 Substituted 1-(1h-imidazol-4-il)alkylbenzamides LT3671B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB888810067A GB8810067D0 (en) 1988-04-28 1988-04-28 Substituted 1-(1h-imidazol-4-yl)alkyl-benzamides

Publications (2)

Publication Number Publication Date
LTIP827A LTIP827A (en) 1995-02-27
LT3671B true LT3671B (en) 1996-01-25

Family

ID=10636026

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP827A LT3671B (en) 1988-04-28 1993-08-03 Substituted 1-(1h-imidazol-4-il)alkylbenzamides

Country Status (30)

Country Link
US (1) US4923865A (xx)
EP (1) EP0341231B1 (xx)
JP (1) JP2840288B2 (xx)
KR (1) KR970011275B1 (xx)
AT (1) ATE82571T1 (xx)
AU (1) AU610796B2 (xx)
BR (2) BR1100052A (xx)
CA (1) CA1310966C (xx)
CY (1) CY1758A (xx)
DE (1) DE68903531T2 (xx)
DK (1) DK205589A (xx)
ES (1) ES2052969T3 (xx)
FI (1) FI101791B1 (xx)
GB (1) GB8810067D0 (xx)
GR (1) GR3006836T3 (xx)
HK (1) HK9494A (xx)
HU (1) HU203877B (xx)
IE (1) IE63698B1 (xx)
IL (1) IL90087A0 (xx)
LT (1) LT3671B (xx)
LV (1) LV10437B (xx)
MY (1) MY104084A (xx)
NO (1) NO173331C (xx)
NZ (1) NZ228897A (xx)
PH (1) PH25461A (xx)
PL (2) PL156250B1 (xx)
PT (1) PT90368B (xx)
RU (3) RU1830063C (xx)
UA (1) UA12835A1 (xx)
ZA (1) ZA893140B (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9310965D0 (en) * 1993-05-27 1993-07-14 Ucb Sa 2-hydroxy-3-(1h-imidazol-4-yl)alkyl)benzenecarboximidamides
ATE234290T1 (de) * 1993-11-15 2003-03-15 Schering Corp Phenylalkyl-imidazole als h3-rezeptor- antagonisten
JP3294961B2 (ja) * 1993-12-10 2002-06-24 杏林製薬株式会社 新規イミダゾール誘導体及びその製造法
GB9521680D0 (en) * 1995-10-23 1996-01-03 Orion Yhtymo Oy New use of imidazole derivatives
DE10161818A1 (de) * 2001-12-14 2003-06-26 Gruenenthal Gmbh Substituierte 1,5-Diaminopentan-3-ol-Verbindungen
NZ554374A (en) * 2004-10-07 2010-11-26 Vitae Pharmaceuticals Inc Diaminoalkane aspartic protease inhibitors
TWI411607B (zh) * 2005-11-14 2013-10-11 Vitae Pharmaceuticals Inc 天門冬胺酸蛋白酶抑制劑
CL2007002689A1 (es) 2006-09-18 2008-04-18 Vitae Pharmaceuticals Inc Compuestos derivados de piperidin-1-carboxamida, inhibidores de la renina; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como hipertension, insuficiencia cardiaca, fibrosis cardiaca, entre otras.
WO2009096996A1 (en) * 2007-06-20 2009-08-06 Smithkline Beecham Corporation Renin inhibitors
US20100160424A1 (en) * 2007-06-20 2010-06-24 Baldwin John J Renin inhibitors
US20090226549A1 (en) * 2008-03-06 2009-09-10 Kenneth John Hughes Herbal extracts and flavor systems for oral products and methods of making the same
EP2307396A1 (en) * 2008-06-20 2011-04-13 Vitae Pharmaceuticals, Inc. Renin inhibitors and method of use thereof
CA2729052A1 (en) * 2008-06-26 2009-12-30 Vitae Pharmaceuticals, Inc. Salts of methyl 2-((r)-(3-chlorophenyl)((r)-1-((s)-2-(methylamino)-3((r)-tetrahydro-2h-pyran-3-yl)propylcarbamoyl)piperidin-3-yl)methoxy)ethylcarbamate
AR077692A1 (es) * 2009-08-06 2011-09-14 Vitae Pharmaceuticals Inc Sales de 2-((r)-(3-clorofenil) ((r)-1-((s) -2-(metilamino)-3-((r)-tetrahidro-2h-piran-3-il) propilcarbamoil) piperidin -3-il) metoxi) etilcarbamato de metilo
CA2825599C (en) 2011-02-01 2021-07-13 The Board Of Trustees Of The University Of Illinois 4-methyl-n-hydroxybenzamide compounds as histone deacetylase (hdac) inhibitors

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024839A1 (en) 1979-08-20 1981-03-11 Minnesota Mining And Manufacturing Company Photopolymerizable mixtures and methods of making viscoelastic and pressure sensitive adhesive products therewith
EP0058047A1 (en) 1981-02-05 1982-08-18 Farmos-Yhtyma Oy Substituted imidazole derivatives and their preparation and use
EP0072615A1 (en) 1981-07-10 1983-02-23 Farmos Group Ltd. Substituted imidazole derivatives and their preparation and use
EP0269559A2 (de) 1986-10-21 1988-06-01 Visita Mtc Ltd. Hubeinrichtung

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU518569B2 (en) * 1979-08-07 1981-10-08 Farmos-Yhtyma Oy 4-benzyl- and 4-benzoyl imidazole derivatives
GB8626287D0 (en) * 1986-11-04 1986-12-03 Ucb Sa Substituted 1h-imidazoles
GB8714013D0 (en) * 1987-06-16 1987-07-22 Ici Plc (substituted-aralkyl)heterocyclic compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0024839A1 (en) 1979-08-20 1981-03-11 Minnesota Mining And Manufacturing Company Photopolymerizable mixtures and methods of making viscoelastic and pressure sensitive adhesive products therewith
EP0058047A1 (en) 1981-02-05 1982-08-18 Farmos-Yhtyma Oy Substituted imidazole derivatives and their preparation and use
EP0072615A1 (en) 1981-07-10 1983-02-23 Farmos Group Ltd. Substituted imidazole derivatives and their preparation and use
EP0269559A2 (de) 1986-10-21 1988-06-01 Visita Mtc Ltd. Hubeinrichtung

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
A. DENARO ET AL.: "Headache and noradrenergic involvement: the effects of α2-stimulants and α2-antagonists", ACTA PSYCHIATRICA SCANDINAVICA, 1985, pages 20 - 25
BRALET AM , ET AL.: "Brain edema and blood-brain barrier permeability following quantitative cere-bral microembolism", STROKE, 1979, pages 34 - 38
EPSTEIN SE ET AL.: "Protection of ischemic myocardium by nitroglycerin: Experimental and clinical results", CIRCULATION, 1976, pages 191 - 197
G.M. DREW: "Pharmacological characterization of the presynaptic α-adrenoceptors regulating cholinergic activity in the guinea-pig ileum", BR J PHARMACOL., 1978, pages 293 - 300
I. C. MEDGETT, M. W. MCCULLOCH, M. J. RAND: "Partial agonist action of clonidine on prejunctional and postjunctional α-adrenoceptors", NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1978, pages 215 - 221
JOHN F. MARSHALL ET AL.: "Sensory Neglect Produced by Lateral Hypothalamic Damage", SCIENCE, 1971, pages 523 - 525
M LA PONCIN-LAFITTE ET AL.: "Demonstration of a vertebro-basilar support in carotid complications", JOURNAL DE PHARMACOLOGIE, 1983, pages 99 - 102
M. ANDRÉJAK, Y. POMMIER, P. MOUILLÉ, H. SCH: "Effects of some α-adrenoceptor agonists and antagonists on the guinea-pig ileum", NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1980, pages 83 - 87
M. J. RAND ET AL.: "Central Action Drugs in Blood Pressure Regulation", pages: 94 - 132
MAROKO PR ET AL: "fects of metabolic and pharmacologic nterventions on myocardial infarct size following coronary occlusion", CIRCULATION, 1976, pages 162 - 168
MOTULSKY HJ, INSEL PA: "Adrenergic receptors in man: direct identification, physiologic regulation, and clinical alterations", N ENGL J MED., 1982, pages 18 - 29
YOSHIHIRO KIYOTA ET AL.: "Cerebral embolization leads to memory impairment of several learning tasks in rats", PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1986, pages 687 - 692

Also Published As

Publication number Publication date
HU203877B (en) 1991-10-28
UA12835A1 (uk) 1997-02-28
ES2052969T3 (es) 1994-07-16
EP0341231A1 (fr) 1989-11-08
NO173331C (no) 1993-12-08
HK9494A (en) 1994-02-09
FI101791B (fi) 1998-08-31
PT90368A (pt) 1989-11-10
LV10437A (lv) 1995-02-20
EP0341231B1 (fr) 1992-11-19
NO173331B (no) 1993-08-23
MY104084A (en) 1993-11-30
BR1100064A (pt) 1999-12-07
GR3006836T3 (xx) 1993-06-30
FI891975A (fi) 1989-10-29
JPH01313467A (ja) 1989-12-18
US4923865A (en) 1990-05-08
LTIP827A (en) 1995-02-27
ZA893140B (en) 1990-01-31
ATE82571T1 (de) 1992-12-15
CA1310966C (en) 1992-12-01
IE63698B1 (en) 1995-05-31
NO891760L (no) 1989-10-30
AU610796B2 (en) 1991-05-23
FI101791B1 (fi) 1998-08-31
BR1100052A (pt) 1999-12-07
DE68903531D1 (de) 1992-12-24
RU1836353C (ru) 1993-08-23
CY1758A (en) 1994-07-15
AU3373089A (en) 1989-11-02
IL90087A0 (en) 1989-12-15
IE891360L (en) 1989-10-28
DK205589A (da) 1989-10-29
DK205589D0 (da) 1989-04-27
RU1814647C (ru) 1993-05-07
DE68903531T2 (de) 1993-04-29
PH25461A (en) 1991-07-01
JP2840288B2 (ja) 1998-12-24
HUT51257A (en) 1990-04-28
PL161362B1 (pl) 1993-06-30
NZ228897A (en) 1990-08-28
KR890016017A (ko) 1989-11-28
LV10437B (en) 1996-04-20
RU1830063C (ru) 1993-07-23
PT90368B (pt) 1994-08-31
NO891760D0 (no) 1989-04-27
FI891975A0 (fi) 1989-04-26
KR970011275B1 (ko) 1997-07-09
PL156250B1 (pl) 1992-02-28
GB8810067D0 (en) 1988-06-02

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Effective date: 20020803