LT3441B - Aromatase inhibiting 4(5)-imidazoles - Google Patents

Aromatase inhibiting 4(5)-imidazoles Download PDF

Info

Publication number
LT3441B
LT3441B LTIP582A LTIP582A LT3441B LT 3441 B LT3441 B LT 3441B LT IP582 A LTIP582 A LT IP582A LT IP582 A LTIP582 A LT IP582A LT 3441 B LT3441 B LT 3441B
Authority
LT
Lithuania
Prior art keywords
compounds
formula
imidazole
compound according
halogen
Prior art date
Application number
LTIP582A
Other languages
English (en)
Lithuanian (lt)
Inventor
Arto Johannes Karjalainen
Arja Marketta Kalapudas
Reino Olavi Pelkonen
Marja-Liisa Soedervall
Matti Antero Laehde
Risto Arvo Sakari Lammintausta
Original Assignee
Orion Yhtymae Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orion Yhtymae Oy filed Critical Orion Yhtymae Oy
Publication of LTIP582A publication Critical patent/LTIP582A/xx
Publication of LT3441B publication Critical patent/LT3441B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
LTIP582A 1990-09-21 1993-05-31 Aromatase inhibiting 4(5)-imidazoles LT3441B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB9020629A GB2248058B (en) 1990-09-21 1990-09-21 Aromatase inhibiting 4(5)-imidazoles

Publications (2)

Publication Number Publication Date
LTIP582A LTIP582A (en) 1994-12-27
LT3441B true LT3441B (en) 1995-10-25

Family

ID=10682560

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP582A LT3441B (en) 1990-09-21 1993-05-31 Aromatase inhibiting 4(5)-imidazoles

Country Status (20)

Country Link
EP (1) EP0476944B1 (pt)
JP (1) JPH04230668A (pt)
AT (1) ATE130295T1 (pt)
AU (1) AU640817B2 (pt)
CA (1) CA2051803A1 (pt)
CZ (1) CZ280088B6 (pt)
DE (1) DE69114644T2 (pt)
FI (1) FI914254A (pt)
GB (1) GB2248058B (pt)
HU (1) HUT59107A (pt)
IE (1) IE68934B1 (pt)
IL (1) IL99472A (pt)
LT (1) LT3441B (pt)
LV (1) LV10095B (pt)
NO (1) NO913712L (pt)
NZ (1) NZ239800A (pt)
PL (1) PL167741B1 (pt)
PT (1) PT99019A (pt)
RU (1) RU2036193C1 (pt)
ZA (1) ZA917476B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9125924D0 (en) * 1991-06-18 1992-02-05 Orion Yhtymae Oy Stereoisomers of an imidazole derivative
GB9224144D0 (en) * 1992-11-18 1993-01-06 Erba Carlo Spa Phenyl-imidazolidinone derivatives and process for their preparation
WO2009082268A2 (ru) * 2007-12-21 2009-07-02 Alla Chem, Llc ЛИГАНДЫ α-АДРЕНОЦЕПТОРОВ, ДОПАМИНОВЫХ, ГИСТАМИНОВЫХ, ИМИДАЗОЛИНОВЫХ И СЕРОТОНИНОВЫХ РЕЦЕПТОРОВ И ИХ ПРИМЕНЕНИЕ

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0311447A1 (en) 1987-10-09 1989-04-12 Orion-Yhtymà„ Oy Aromatase inhibiting 4(5)-imidazoles
EP0390558A1 (en) 1989-03-30 1990-10-03 Orion-Yhtymà„ Oy Aromatase inhibiting 4(5)-imidazoles

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4605661A (en) * 1984-06-18 1986-08-12 Eli Lilly And Company Aromastase inhibiting α,α-diarylimidazole-4(5)-propionitriles, α,α-diarylimidazole-4(5)-propionamides, and 4(5)-(2,2-diarylethyl)imidazoles
LU85747A1 (fr) * 1985-01-28 1986-08-04 Continental Pharma Derives d'imidazole leur preparation et utilisation ainsi que les compositions pharmaceutiques contenant des derives
GB8818561D0 (en) * 1988-08-04 1988-09-07 Ici Plc Diphenylethane derivatives
GB2229719B (en) * 1989-03-30 1992-04-29 Farmos Oy Novel aromatase inhibiting 4(5)-imidazoles
GB2231568B (en) * 1989-03-31 1992-07-08 Farmos Oy New aromatase inhibiting 4(5)-imidazoles

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0311447A1 (en) 1987-10-09 1989-04-12 Orion-Yhtymà„ Oy Aromatase inhibiting 4(5)-imidazoles
EP0390558A1 (en) 1989-03-30 1990-10-03 Orion-Yhtymà„ Oy Aromatase inhibiting 4(5)-imidazoles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
M. PASANEN: "Human placental aromatase activity: use of a C18 reversed-phase cartridge for separation of tritiated water or steroid metabolites in placentas from both smoking and non-smoking mothers in vitro", BIOL RES PREGNANCY PERINATOL, 1985, pages 94 - 99

Also Published As

Publication number Publication date
HUT59107A (en) 1992-04-28
FI914254A0 (fi) 1991-09-10
IE68934B1 (en) 1996-07-24
PL291747A1 (en) 1992-10-19
FI914254A (fi) 1992-03-22
CA2051803A1 (en) 1992-03-22
PL167741B1 (pl) 1995-10-31
IE913314A1 (en) 1992-02-25
EP0476944A1 (en) 1992-03-25
AU8382691A (en) 1992-04-09
ATE130295T1 (de) 1995-12-15
LTIP582A (en) 1994-12-27
IL99472A0 (en) 1992-08-18
RU2036193C1 (ru) 1995-05-27
LV10095A (lv) 1994-05-10
IL99472A (en) 1995-11-27
GB2248058B (en) 1994-09-14
NO913712D0 (no) 1991-09-20
NZ239800A (en) 1993-11-25
AU640817B2 (en) 1993-09-02
NO913712L (no) 1992-03-23
PT99019A (pt) 1992-08-31
HU913019D0 (en) 1992-01-28
GB2248058A (en) 1992-03-25
JPH04230668A (ja) 1992-08-19
LV10095B (en) 1995-02-20
DE69114644T2 (de) 1996-05-15
GB9020629D0 (en) 1990-10-31
DE69114644D1 (de) 1995-12-21
CZ280088B6 (cs) 1995-10-18
CS286891A3 (en) 1992-04-15
ZA917476B (en) 1992-05-27
EP0476944B1 (en) 1995-11-15

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MM9A Lapsed patents

Effective date: 19970531