LT3065B - New azaindoles, preparation process and medicinal products containing them - Google Patents

New azaindoles, preparation process and medicinal products containing them Download PDF

Info

Publication number
LT3065B
LT3065B LTIP339A LTIP339A LT3065B LT 3065 B LT3065 B LT 3065B LT IP339 A LTIP339 A LT IP339A LT IP339 A LTIP339 A LT IP339A LT 3065 B LT3065 B LT 3065B
Authority
LT
Lithuania
Prior art keywords
urea
azaindol
diisopropylphenyl
cyclopentylmethyl
alkyl
Prior art date
Application number
LTIP339A
Other languages
English (en)
Lithuanian (lt)
Inventor
Didier Festal
Denis Descours
Jacques Decerprit
Original Assignee
Lipha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipha filed Critical Lipha
Publication of LTIP339A publication Critical patent/LTIP339A/xx
Publication of LT3065B publication Critical patent/LT3065B/lt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
LTIP339A 1992-02-14 1993-02-12 New azaindoles, preparation process and medicinal products containing them LT3065B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9201701A FR2687402B1 (fr) 1992-02-14 1992-02-14 Nouveaux azaindoles, procedes de preparation et medicaments les contenant.

Publications (2)

Publication Number Publication Date
LTIP339A LTIP339A (en) 1994-06-15
LT3065B true LT3065B (en) 1994-10-25

Family

ID=9426663

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP339A LT3065B (en) 1992-02-14 1993-02-12 New azaindoles, preparation process and medicinal products containing them

Country Status (27)

Country Link
US (1) US5338849A (lv)
EP (1) EP0557171B1 (lv)
JP (1) JPH061788A (lv)
KR (1) KR930017905A (lv)
AT (1) ATE125257T1 (lv)
AU (1) AU658475B2 (lv)
CA (1) CA2089470A1 (lv)
CZ (1) CZ16893A3 (lv)
DE (1) DE69300268T2 (lv)
DK (1) DK0557171T3 (lv)
ES (1) ES2076827T3 (lv)
FR (1) FR2687402B1 (lv)
GR (1) GR3017614T3 (lv)
HR (1) HRP930180A2 (lv)
HU (1) HUT64067A (lv)
IL (1) IL104573A0 (lv)
LT (1) LT3065B (lv)
LV (1) LV10453B (lv)
MA (1) MA22797A1 (lv)
MX (1) MX9300745A (lv)
NO (1) NO930505L (lv)
NZ (1) NZ245869A (lv)
OA (1) OA09775A (lv)
SI (1) SI9300076A (lv)
SK (1) SK9093A3 (lv)
TN (1) TNSN93016A1 (lv)
ZA (1) ZA93844B (lv)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9226855D0 (en) * 1992-12-23 1993-02-17 Erba Carlo Spa Vinylene-azaindole derivatives and process for their preparation
US5547966A (en) * 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
KR20000057137A (ko) 1996-11-19 2000-09-15 스티븐 엠. 오드레 아릴 및 헤테로아릴로 치환된 융합 피롤 항염증제
NZ503685A (en) 1997-10-20 2002-05-31 F Fused pyrrole compounds as kinase inhibitors
CN1495160A (zh) * 1997-12-16 2004-05-12 ��ʲ 1-取代-1-氨基甲基-环烷衍生物(=加巴喷丁类似物)、其制备及其在治疗神经病方面的用途
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
DZ3377A1 (fr) 1999-12-24 2001-07-05 Aventis Pharma Ltd Azaindoles
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
CA2473572C (en) * 2002-02-01 2011-05-10 Astrazeneca Ab Quinazoline compounds
GB0207637D0 (en) * 2002-04-02 2002-05-15 Karobio Ab Novel compound
SE0301372D0 (sv) * 2003-05-09 2003-05-09 Astrazeneca Ab Novel compounds
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
PT1696920E (pt) * 2003-12-19 2015-01-14 Plexxikon Inc Compostos e métodos para o desenvolvimento de moduladores de ret
CN101676285A (zh) 2004-03-30 2010-03-24 沃泰克斯药物股份有限公司 用作jak和其它蛋白激酶抑制剂的氮杂吲哚
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
JP2008503473A (ja) * 2004-06-17 2008-02-07 プレキシコン,インコーポレーテッド C−kit活性を調節する化合物
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
US7626021B2 (en) * 2004-07-27 2009-12-01 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
SG156685A1 (en) * 2004-07-27 2009-11-26 Sgx Pharmaceuticals Inc Fused ring heterocycle kinase modulators
AU2005269386A1 (en) 2004-07-27 2006-02-09 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
KR102152809B1 (ko) * 2004-07-28 2020-09-07 다케다 야쿠힌 고교 가부시키가이샤 피롤로〔2,3-c〕피리딘 화합물, 그 제조 방법 및 용도
US20060183758A1 (en) * 2005-02-17 2006-08-17 Cb Research And Development, Inc. Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
EP1885723A2 (en) * 2005-05-17 2008-02-13 Plexxikon, Inc. Pyrrolo[2,3-b]pyridine derivatives as protein kinase inhibitors
US7863288B2 (en) * 2005-06-22 2011-01-04 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
NZ592968A (en) * 2006-01-17 2012-08-31 Vertex Pharma Azaindoles substituted with either triazine or pyrimidine useful as inhibitors of janus kinases consisting of JAK1, JAK2, JAK3, and TYK2
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
PE20121126A1 (es) * 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
CN101678022A (zh) 2006-12-21 2010-03-24 弗特克斯药品有限公司 可用作蛋白激酶抑制剂的5-氰基-4-(吡咯并[2,3b]吡啶-3-基)嘧啶衍生物
CA2673736A1 (en) 2006-12-21 2008-07-03 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
JP2010533729A (ja) 2007-07-17 2010-10-28 プレキシコン,インコーポレーテッド キナーゼ調節のための化合物と方法、及びそのための適応
FR2946346B1 (fr) 2009-06-05 2011-05-20 Galderma Res & Dev Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946345B1 (fr) 2009-06-05 2011-05-20 Galderma Res & Dev Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946342B1 (fr) 2009-06-05 2011-06-24 Galderma Res & Dev Nouveaux derives de dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946340B1 (fr) 2009-06-05 2011-06-24 Galderma Res & Dev Nouveaux n-phenyl acetamie, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
HUE027598T2 (en) 2009-04-03 2016-10-28 Hoffmann La Roche Propane-1-sulfonic acid {3- [5- (4-chlorophenyl) -1H-pyrrolo [2,3-B] pyridine-3-carbonyl] -2,4-difluorophenyl} amide compositions and their uses
NZ619259A (en) 2009-06-17 2015-07-31 Vertex Pharma Inhibitors of influenza viruses replication
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
CA2780190C (en) 2009-11-06 2020-05-05 Plexxikon, Inc. Compounds and methods for kinase modulation, and indications therefor
EP2590982B1 (en) * 2010-07-09 2017-08-23 The Walter and Eliza Hall Institute of Medical Research Protein kinase inhibitors and methods of treatment
CN103492381A (zh) 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
US9624213B2 (en) 2011-02-07 2017-04-18 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
AR085279A1 (es) 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
CA2930297C (en) 2013-11-13 2022-04-05 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
CN105849100B (zh) 2013-11-13 2019-07-16 沃泰克斯药物股份有限公司 流感病毒复制抑制剂
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated インフルエンザウイルスの複製の阻害剤を調製する方法
JP6857617B2 (ja) 2015-05-13 2021-04-14 バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated インフルエンザウイルスの複製の阻害剤

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1261179A (fr) 1959-02-04 1961-05-19 Chimiotherapie Lab Franc 12-aza déserpidine et son procédé de préparation
BE659467A (lv) 1964-02-19 1965-08-09

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT85662B (pt) * 1986-09-10 1990-06-29 Sandoz Sa Processo para a preparacao de derivados de aza-indol e de indolizina e de composicoes farmaceuticas que os contem
ES2059408T3 (es) * 1987-02-10 1994-11-16 Abbott Lab Un proceso para la preparacion de un compuesto.
US5153226A (en) * 1989-08-31 1992-10-06 Warner-Lambert Company Acat inhibitors for treating hypocholesterolemia
MX22406A (es) * 1989-09-15 1994-01-31 Pfizer Nuevos derivados de n-aril y n-heteroarilamidas y urea como inhibidores de acil coenzima a: acil transferasa del colesterol (acat).
DE4022414A1 (de) * 1990-07-13 1992-01-16 Bayer Ag Substituierte pyrrolo-pyridine
FR2674522B1 (fr) * 1991-03-26 1993-07-16 Lipha Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1261179A (fr) 1959-02-04 1961-05-19 Chimiotherapie Lab Franc 12-aza déserpidine et son procédé de préparation
BE659467A (lv) 1964-02-19 1965-08-09

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
P.J.GLLIES AT AL.: "Role of a cholesterol substrate pool", EXPERIMENTAL AND MOLEC ULAR PATHOLOGY, pages 329 - 339

Also Published As

Publication number Publication date
ATE125257T1 (de) 1995-08-15
LTIP339A (en) 1994-06-15
NO930505D0 (no) 1993-02-12
FR2687402B1 (fr) 1995-06-30
TNSN93016A1 (fr) 1994-03-17
KR930017905A (ko) 1993-09-20
OA09775A (fr) 1993-11-30
MA22797A1 (fr) 1993-10-01
MX9300745A (es) 1993-09-01
HRP930180A2 (en) 1995-10-31
GR3017614T3 (en) 1996-01-31
AU3300593A (en) 1993-08-19
DE69300268T2 (de) 1996-04-04
DK0557171T3 (da) 1995-12-04
NO930505L (no) 1993-08-16
LV10453A (lv) 1995-02-20
CA2089470A1 (en) 1993-08-15
NZ245869A (en) 1995-05-26
DE69300268D1 (de) 1995-08-24
ES2076827T3 (es) 1995-11-01
CZ16893A3 (en) 1993-12-15
FR2687402A1 (fr) 1993-08-20
HU9300372D0 (en) 1993-04-28
HUT64067A (en) 1993-11-29
EP0557171A1 (fr) 1993-08-25
SK9093A3 (en) 1993-09-09
EP0557171B1 (fr) 1995-07-19
JPH061788A (ja) 1994-01-11
US5338849A (en) 1994-08-16
ZA93844B (en) 1994-08-08
IL104573A0 (en) 1993-06-10
SI9300076A (en) 1993-09-30
LV10453B (en) 1995-10-20
AU658475B2 (en) 1995-04-13

Similar Documents

Publication Publication Date Title
LT3065B (en) New azaindoles, preparation process and medicinal products containing them
EP0705831B1 (de) Cycloalkano-indol- und -azaindol-derivate
US5159083A (en) Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands
AU656615B2 (en) Inhibitors of HIV reverse transcriptase
RU2351596C2 (ru) Производные n-[гетероарил(пиперидин-2-ил)метил]бензамида и их применение в терапии
DE60015927T2 (de) Phenylharnstoff und phenylthioharnstoffderivate
EP1499589B1 (fr) Derives de n-¬phenyl(piperidin-2-yl)methyl|benzamide, leur preparation et leur application en therapeutique
TWI393708B (zh) 異羥肟酸脂化合物,其用途及其之合成方法
US6635647B2 (en) Decahydro-isoquinolines
CA2585735A1 (en) Novel compounds of substituted and unsubstituted adamantyl amides
CA2380032A1 (en) Amine and amide derivatives as ligands for the neuropeptide y y5 receptor useful in the treatment of obesity and other disorders
CS402991A3 (en) Dichloroaniline derivatives, process of their preparation andpharmaceutical compositions comprising them
JP2001525399A (ja) 選択的β3アドレナリン作動性作動薬
KR20180095811A (ko) 질환 치료용 복소환식 화합물
WO2012073146A1 (en) Kat ii inhibitors
WO2005030754A1 (en) Indole or quinoline derivatives as non-pepticid npy y2 receptor inhibitors useful for the treatment of anxiolytic and depressive disorders and obesity
EP4306528A1 (en) Hemtac small molecule degradation agent and use thereof
US6232337B1 (en) Selective β3 adrenergic agonists
CS268189B2 (en) Method of quinazolinediones and pyridopyrimidinodiones production
US4012373A (en) Pyrazolo[3',4'-2,3]pyrido[4,5-e]b-benzo-1,5-diazepinones
JPS6396187A (ja) インドローピラジノーベンゾジアゼピン誘導体
CA3136725A1 (en) Inhibitors of cd40-cd154 binding
JPH0971564A (ja) ベンズアミドオキシム誘導体及びその医薬用途
EP0414903A1 (en) New thioproline derivative
PL91401B1 (lv)

Legal Events

Date Code Title Description
MM9A Lapsed patents

Effective date: 19960212