LT3065B - New azaindoles, preparation process and medicinal products containing them - Google Patents

New azaindoles, preparation process and medicinal products containing them Download PDF

Info

Publication number
LT3065B
LT3065B LTIP339A LTIP339A LT3065B LT 3065 B LT3065 B LT 3065B LT IP339 A LTIP339 A LT IP339A LT IP339 A LTIP339 A LT IP339A LT 3065 B LT3065 B LT 3065B
Authority
LT
Lithuania
Prior art keywords
urea
azaindol
diisopropylphenyl
cyclopentylmethyl
alkyl
Prior art date
Application number
LTIP339A
Other languages
English (en)
Lithuanian (lt)
Inventor
Didier Festal
Denis Descours
Jacques Decerprit
Original Assignee
Lipha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipha filed Critical Lipha
Publication of LTIP339A publication Critical patent/LTIP339A/xx
Publication of LT3065B publication Critical patent/LT3065B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
LTIP339A 1992-02-14 1993-02-12 New azaindoles, preparation process and medicinal products containing them LT3065B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9201701A FR2687402B1 (fr) 1992-02-14 1992-02-14 Nouveaux azaindoles, procedes de preparation et medicaments les contenant.

Publications (2)

Publication Number Publication Date
LTIP339A LTIP339A (en) 1994-06-15
LT3065B true LT3065B (en) 1994-10-25

Family

ID=9426663

Family Applications (1)

Application Number Title Priority Date Filing Date
LTIP339A LT3065B (en) 1992-02-14 1993-02-12 New azaindoles, preparation process and medicinal products containing them

Country Status (27)

Country Link
US (1) US5338849A (lv)
EP (1) EP0557171B1 (lv)
JP (1) JPH061788A (lv)
KR (1) KR930017905A (lv)
AT (1) ATE125257T1 (lv)
AU (1) AU658475B2 (lv)
CA (1) CA2089470A1 (lv)
CZ (1) CZ16893A3 (lv)
DE (1) DE69300268T2 (lv)
DK (1) DK0557171T3 (lv)
ES (1) ES2076827T3 (lv)
FR (1) FR2687402B1 (lv)
GR (1) GR3017614T3 (lv)
HR (1) HRP930180A2 (lv)
HU (1) HUT64067A (lv)
IL (1) IL104573A0 (lv)
LT (1) LT3065B (lv)
LV (1) LV10453B (lv)
MA (1) MA22797A1 (lv)
MX (1) MX9300745A (lv)
NO (1) NO930505L (lv)
NZ (1) NZ245869A (lv)
OA (1) OA09775A (lv)
SI (1) SI9300076A (lv)
SK (1) SK9093A3 (lv)
TN (1) TNSN93016A1 (lv)
ZA (1) ZA93844B (lv)

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CA2271767A1 (en) 1996-11-19 1998-05-28 Nathan B. Mantlo Aryl and heteroaryl substituted fused pyrrole antiinflammatory agents
RU2219178C2 (ru) 1997-10-20 2003-12-20 Ф.Хоффманн-Ля Рош Аг Бициклические производные, фармацевтическая композиция на их основе и промежуточные соединения
AU765802B2 (en) * 1997-12-16 2003-10-02 Warner-Lambert Company 1-substituted-1-aminomethyl-cycloalkane derivatives (=gabapentin analogues), their preparation and their use in the treatment of neurological disorders
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
CN100379734C (zh) 1999-12-24 2008-04-09 阿文蒂斯药物有限公司 氮杂吲哚类化合物
GB0115109D0 (en) * 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
UA81619C2 (ru) * 2002-02-01 2008-01-25 Астразенека Аб Хиназолиновые соединения, способ их получения (варианты), фармацевтическая композиция на их основе
GB0207637D0 (en) * 2002-04-02 2002-05-15 Karobio Ab Novel compound
SE0301372D0 (sv) * 2003-05-09 2003-05-09 Astrazeneca Ab Novel compounds
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
PT1696920E (pt) * 2003-12-19 2015-01-14 Plexxikon Inc Compostos e métodos para o desenvolvimento de moduladores de ret
ES2398712T3 (es) 2004-03-30 2013-03-21 Vertex Pharmaceuticals Incorporated Azaindoles útiles como inhibidores de JAK y otras proteínas quinasas
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
JP2008503473A (ja) * 2004-06-17 2008-02-07 プレキシコン，インコーポレーテッド Ｃ−ｋｉｔ活性を調節する化合物
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
BRPI0513916A (pt) 2004-07-27 2008-05-20 Sgx Pharmaceuticals Inc moduladores de pirrol-piridina cinase
WO2006015124A2 (en) 2004-07-27 2006-02-09 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US7626021B2 (en) * 2004-07-27 2009-12-01 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US20070293532A1 (en) * 2004-07-28 2007-12-20 Takeda Pharmaceutical Compan6Y Limited Pyrrolo [2,3-C] Pyridine Compound, Process for Producing the Same, and Use
US20060183758A1 (en) * 2005-02-17 2006-08-17 Cb Research And Development, Inc. Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
EP1885723A2 (en) * 2005-05-17 2008-02-13 Plexxikon, Inc. Pyrrolo[2,3-b]pyridine derivatives as protein kinase inhibitors
RS52010B (en) * 2005-06-22 2012-04-30 Plexxikon Inc. DERIVATI PIROLO [2, 3-B] PIRIDINA KAO INHIBITORI PROTEIN KINAZE
TWI424999B (zh) 2006-01-17 2014-02-01 Vertex Pharma 適合作為傑納斯激酶（ｊａｎｕｓ ｋｉｎａｓｅ）抑制劑之氮雜吲哚
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
RU2009122670A (ru) 2006-12-21 2011-01-27 Плекссикон, Инк. (Us) Соединения и способы для модуляции киназ и показания к их применению
PE20121126A1 (es) * 2006-12-21 2012-08-24 Plexxikon Inc Compuestos pirrolo [2,3-b] piridinas como moduladores de quinasa
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
MX2009006700A (es) 2006-12-21 2009-06-30 Vertex Pharma Derivados de 5-ciano-4-(pirolo)[2,3b]piridina-3-il)-pirimidinas utiles como inhibidores de proteina-cinasas.
US20100190777A1 (en) 2007-07-17 2010-07-29 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
FR2946346B1 (fr) 2009-06-05 2011-05-20 Galderma Res & Dev Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946345B1 (fr) 2009-06-05 2011-05-20 Galderma Res & Dev Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946342B1 (fr) 2009-06-05 2011-06-24 Galderma Res & Dev Nouveaux derives de dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946340B1 (fr) 2009-06-05 2011-06-24 Galderma Res & Dev Nouveaux n-phenyl acetamie, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
EP2414356B1 (en) * 2009-04-03 2015-09-02 F.Hoffmann-La Roche Ag Propane-i-sulfonic acid {3-[5-(4-chloro-phenyl)-1h-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide compositions and uses thereof
KR101702609B1 (ko) 2009-06-17 2017-02-03 버텍스 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제의 억제제
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
CN106220623A (zh) 2009-11-06 2016-12-14 普莱希科公司 用于激酶调节的化合物和方法及其适应症
CA2804648C (en) * 2010-07-09 2019-01-22 The Walter And Eliza Hall Institute Of Medical Research Protein kinase inhibitors and methods of treatment
AU2011343642A1 (en) 2010-12-16 2013-05-02 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
EA028821B9 (ru) 2011-02-07 2018-10-31 Плексксикон, Инк. Соединения и способы для модуляции киназ, а также показания к их применению
AR085279A1 (es) 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
RU2019104421A (ru) 2013-11-13 2019-04-17 Вертекс Фармасьютикалз Инкорпорейтед Способы получения ингибиторов репликации вирусов гриппа
NZ719729A (en) 2013-11-13 2022-04-29 Vertex Pharma Inhibitors of influenza viruses replication
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1261179A (fr) 1959-02-04 1961-05-19 Chimiotherapie Lab Franc 12-aza déserpidine et son procédé de préparation
BE659467A (lv) 1964-02-19 1965-08-09

Family Cites Families (6)

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NZ221717A (en) * 1986-09-10 1990-08-28 Sandoz Ltd Azaindole and indolizine derivatives and pharmaceutical compositions
DE3882732T2 (de) * 1987-02-10 1993-12-02 Abbott Lab Indol, Benzofuran, Benzothiophen enthaltende, Lipoxygenase hemmende Verbindungen.
US5153226A (en) * 1989-08-31 1992-10-06 Warner-Lambert Company Acat inhibitors for treating hypocholesterolemia
WO1991004027A1 (en) * 1989-09-15 1991-04-04 Pfizer Inc. New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
DE4022414A1 (de) * 1990-07-13 1992-01-16 Bayer Ag Substituierte pyrrolo-pyridine
FR2674522B1 (fr) * 1991-03-26 1993-07-16 Lipha Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
FR1261179A (fr) 1959-02-04 1961-05-19 Chimiotherapie Lab Franc 12-aza déserpidine et son procédé de préparation
BE659467A (lv) 1964-02-19 1965-08-09

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Title
P.J.GLLIES AT AL.: "Role of a cholesterol substrate pool", EXPERIMENTAL AND MOLEC ULAR PATHOLOGY, pages 329 - 339

Also Published As

Publication number Publication date
IL104573A0 (en) 1993-06-10
NZ245869A (en) 1995-05-26
DE69300268D1 (de) 1995-08-24
FR2687402A1 (fr) 1993-08-20
HUT64067A (en) 1993-11-29
SI9300076A (en) 1993-09-30
NO930505D0 (no) 1993-02-12
ZA93844B (en) 1994-08-08
DK0557171T3 (da) 1995-12-04
CZ16893A3 (en) 1993-12-15
MA22797A1 (fr) 1993-10-01
HU9300372D0 (en) 1993-04-28
JPH061788A (ja) 1994-01-11
TNSN93016A1 (fr) 1994-03-17
OA09775A (fr) 1993-11-30
SK9093A3 (en) 1993-09-09
US5338849A (en) 1994-08-16
LV10453A (lv) 1995-02-20
ES2076827T3 (es) 1995-11-01
EP0557171A1 (fr) 1993-08-25
HRP930180A2 (en) 1995-10-31
LTIP339A (en) 1994-06-15
FR2687402B1 (fr) 1995-06-30
NO930505L (no) 1993-08-16
AU3300593A (en) 1993-08-19
CA2089470A1 (en) 1993-08-15
ATE125257T1 (de) 1995-08-15
MX9300745A (es) 1993-09-01
EP0557171B1 (fr) 1995-07-19
KR930017905A (ko) 1993-09-20
DE69300268T2 (de) 1996-04-04
LV10453B (en) 1995-10-20
AU658475B2 (en) 1995-04-13
GR3017614T3 (en) 1996-01-31

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MM9A Lapsed patents

Effective date: 19960212