DK0557171T3 - Azaindoler, fremgangsmåde til deres fremstilling samt lægemidler indeholdende dem - Google Patents

Azaindoler, fremgangsmåde til deres fremstilling samt lægemidler indeholdende dem

Info

Publication number
DK0557171T3
DK0557171T3 DK93400366.6T DK93400366T DK0557171T3 DK 0557171 T3 DK0557171 T3 DK 0557171T3 DK 93400366 T DK93400366 T DK 93400366T DK 0557171 T3 DK0557171 T3 DK 0557171T3
Authority
DK
Denmark
Prior art keywords
cycloalkyl
alkyl
optionally substituted
phenyl
benzyl
Prior art date
Application number
DK93400366.6T
Other languages
Danish (da)
English (en)
Inventor
Denis Descours
Didier Festal
Jacques Decerprit
Original Assignee
Lipha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lipha filed Critical Lipha
Application granted granted Critical
Publication of DK0557171T3 publication Critical patent/DK0557171T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
DK93400366.6T 1992-02-14 1993-02-12 Azaindoler, fremgangsmåde til deres fremstilling samt lægemidler indeholdende dem DK0557171T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9201701A FR2687402B1 (fr) 1992-02-14 1992-02-14 Nouveaux azaindoles, procedes de preparation et medicaments les contenant.

Publications (1)

Publication Number Publication Date
DK0557171T3 true DK0557171T3 (da) 1995-12-04

Family

ID=9426663

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93400366.6T DK0557171T3 (da) 1992-02-14 1993-02-12 Azaindoler, fremgangsmåde til deres fremstilling samt lægemidler indeholdende dem

Country Status (27)

Country Link
US (1) US5338849A (lv)
EP (1) EP0557171B1 (lv)
JP (1) JPH061788A (lv)
KR (1) KR930017905A (lv)
AT (1) ATE125257T1 (lv)
AU (1) AU658475B2 (lv)
CA (1) CA2089470A1 (lv)
CZ (1) CZ16893A3 (lv)
DE (1) DE69300268T2 (lv)
DK (1) DK0557171T3 (lv)
ES (1) ES2076827T3 (lv)
FR (1) FR2687402B1 (lv)
GR (1) GR3017614T3 (lv)
HR (1) HRP930180A2 (lv)
HU (1) HUT64067A (lv)
IL (1) IL104573A0 (lv)
LT (1) LT3065B (lv)
LV (1) LV10453B (lv)
MA (1) MA22797A1 (lv)
MX (1) MX9300745A (lv)
NO (1) NO930505L (lv)
NZ (1) NZ245869A (lv)
OA (1) OA09775A (lv)
SI (1) SI9300076A (lv)
SK (1) SK9093A3 (lv)
TN (1) TNSN93016A1 (lv)
ZA (1) ZA93844B (lv)

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WO1999020624A1 (en) 1997-10-20 1999-04-29 F.Hoffmann-La Roche Ag Bicyclic kinase inhibitors
ES2227896T3 (es) * 1997-12-16 2005-04-01 Warner-Lambert Company Llc Derivados de 1-aminometil-cicloalcanos sustituidos en 1 (=analogos de gabapentina), su preparacion y su uso en el tratamiento de trastornos neurologicos.
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
CZ301750B6 (cs) 1999-12-24 2010-06-09 Aventis Pharma Limited Bicyklický pyrrolový derivát, jeho použití pri výrobe léciva, farmaceutická kompozice tento derivát obsahující a pro použití pri lécení
GB0115109D0 (en) * 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
US7268230B2 (en) * 2002-02-01 2007-09-11 Astrazeneca Ab Quinazoline compounds
GB0207637D0 (en) * 2002-04-02 2002-05-15 Karobio Ab Novel compound
SE0301372D0 (sv) * 2003-05-09 2003-05-09 Astrazeneca Ab Novel compounds
PT1696920E (pt) * 2003-12-19 2015-01-14 Plexxikon Inc Compostos e métodos para o desenvolvimento de moduladores de ret
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
RU2403252C2 (ru) 2004-03-30 2010-11-10 Вертекс Фармасьютикалз Инкорпорейтед Азаиндолы, полезные в качестве ингибиторов jak и других протеинкиназ
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
TW200616632A (en) * 2004-06-17 2006-06-01 Plexxikon Inc Compounds modulating c-kit activity and uses therefor
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
WO2006015124A2 (en) * 2004-07-27 2006-02-09 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
JP2008508303A (ja) 2004-07-27 2008-03-21 エスジーエックス ファーマシューティカルズ、インコーポレイテッド ピロロ−ピリジンキナーゼモジュレーター
US7626021B2 (en) * 2004-07-27 2009-12-01 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US20070293532A1 (en) * 2004-07-28 2007-12-20 Takeda Pharmaceutical Compan6Y Limited Pyrrolo [2,3-C] Pyridine Compound, Process for Producing the Same, and Use
US20060183758A1 (en) * 2005-02-17 2006-08-17 Cb Research And Development, Inc. Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
AU2006272951A1 (en) * 2005-05-17 2007-02-01 Plexxikon, Inc. Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors
MY153898A (en) 2005-06-22 2015-04-15 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
NZ601687A (en) * 2006-01-17 2014-03-28 Vertex Pharma Azaindoles useful as inhibitors of janus kinases
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
BRPI0720695A2 (pt) 2006-12-21 2014-02-18 Plexxikon Inc Compostos e métodos para modulação de cinase, e indicações para estes
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
PE20081581A1 (es) * 2006-12-21 2008-11-12 Plexxikon Inc COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
AU2007338754A1 (en) 2006-12-21 2008-07-03 Vertex Pharmaceuticals Incorporated 5-cyan0-4- (pyrrolo [2, 3B] pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
WO2009012283A1 (en) 2007-07-17 2009-01-22 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
FR2946346B1 (fr) 2009-06-05 2011-05-20 Galderma Res & Dev Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946342B1 (fr) 2009-06-05 2011-06-24 Galderma Res & Dev Nouveaux derives de dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946340B1 (fr) 2009-06-05 2011-06-24 Galderma Res & Dev Nouveaux n-phenyl acetamie, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946345B1 (fr) 2009-06-05 2011-05-20 Galderma Res & Dev Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
MX349923B (es) 2009-04-03 2017-08-21 Hoffmann La Roche Composiciones del ácido propano-1-sulfónico {3-[5-(4-cloro-fenil)- 1h-pirrolo [2,3-b]-piridina-3-carbonil]-2,4-difluoro-fenil]-amida y el uso de las mismas.
RS57869B1 (sr) 2009-06-17 2018-12-31 Vertex Pharma Inhibitori replikacije virusa gripa
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
ES2633317T3 (es) 2009-11-06 2017-09-20 Plexxikon, Inc. Compuestos y métodos para la modulación de quinasas, e indicaciones para ello
AU2011276955B2 (en) * 2010-07-09 2014-11-06 The Walter And Eliza Hall Institute Of Medical Research Protein kinase inhibitors and methods of treatment
RU2013132681A (ru) 2010-12-16 2015-01-27 Вертекс Фармасьютикалз Инкорпорейтед Ингибиторы репликации вирусов гриппа
PT2672967T (pt) 2011-02-07 2018-12-07 Plexxikon Inc Compostos e métodos de modulação da quinase e suas indicações
AR085279A1 (es) 2011-02-21 2013-09-18 Plexxikon Inc Formas solidas de {3-[5-(4-cloro-fenil)-1h-pirrolo[2,3-b]piridina-3-carbonil]-2,4-difluor-fenil}-amida del acido propano-1-sulfonico
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
RS57541B1 (sr) 2013-11-13 2018-10-31 Vertex Pharma Postupci za pripremu inhibitora replikacije virusa gripa
ES2741444T3 (es) 2013-11-13 2020-02-11 Vertex Pharma Inhibidores de la replicación de virus de la gripe
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
EP3294735B8 (en) 2015-05-13 2022-01-05 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication

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Publication number Priority date Publication date Assignee Title
FR1261179A (fr) * 1959-02-04 1961-05-19 Chimiotherapie Lab Franc 12-aza déserpidine et son procédé de préparation
US3354174A (en) * 1964-02-19 1967-11-21 Sterling Drug Inc 1-and 2-benzimidazolyl-lower-alkylamidoximes, amidines-, and guanidines
IL83821A0 (en) * 1986-09-10 1988-02-29 Sandoz Ag Azaindole and indolizine derivatives,their production and pharmaceutical compositions containing them
ES2059408T3 (es) * 1987-02-10 1994-11-16 Abbott Lab Un proceso para la preparacion de un compuesto.
US5153226A (en) * 1989-08-31 1992-10-06 Warner-Lambert Company Acat inhibitors for treating hypocholesterolemia
WO1991004027A1 (en) * 1989-09-15 1991-04-04 Pfizer Inc. New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
DE4022414A1 (de) * 1990-07-13 1992-01-16 Bayer Ag Substituierte pyrrolo-pyridine
FR2674522B1 (fr) * 1991-03-26 1993-07-16 Lipha Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.

Also Published As

Publication number Publication date
LV10453A (lv) 1995-02-20
TNSN93016A1 (fr) 1994-03-17
OA09775A (fr) 1993-11-30
HUT64067A (en) 1993-11-29
IL104573A0 (en) 1993-06-10
NZ245869A (en) 1995-05-26
LT3065B (en) 1994-10-25
ZA93844B (en) 1994-08-08
HU9300372D0 (en) 1993-04-28
EP0557171B1 (fr) 1995-07-19
FR2687402B1 (fr) 1995-06-30
AU3300593A (en) 1993-08-19
SI9300076A (en) 1993-09-30
SK9093A3 (en) 1993-09-09
MX9300745A (es) 1993-09-01
DE69300268T2 (de) 1996-04-04
KR930017905A (ko) 1993-09-20
GR3017614T3 (en) 1996-01-31
CA2089470A1 (en) 1993-08-15
JPH061788A (ja) 1994-01-11
HRP930180A2 (en) 1995-10-31
NO930505D0 (no) 1993-02-12
ES2076827T3 (es) 1995-11-01
EP0557171A1 (fr) 1993-08-25
LV10453B (en) 1995-10-20
CZ16893A3 (en) 1993-12-15
US5338849A (en) 1994-08-16
ATE125257T1 (de) 1995-08-15
MA22797A1 (fr) 1993-10-01
DE69300268D1 (de) 1995-08-24
AU658475B2 (en) 1995-04-13
NO930505L (no) 1993-08-16
FR2687402A1 (fr) 1993-08-20
LTIP339A (en) 1994-06-15

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