ES2076827T3 - Azaindoles, procedimientos de preparacion y medicamentos que los contienen. - Google Patents

Azaindoles, procedimientos de preparacion y medicamentos que los contienen.

Info

Publication number
ES2076827T3
ES2076827T3 ES93400366T ES93400366T ES2076827T3 ES 2076827 T3 ES2076827 T3 ES 2076827T3 ES 93400366 T ES93400366 T ES 93400366T ES 93400366 T ES93400366 T ES 93400366T ES 2076827 T3 ES2076827 T3 ES 2076827T3
Authority
ES
Spain
Prior art keywords
cycloalkyl
alkyl
optionally substituted
phenyl
benzyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93400366T
Other languages
English (en)
Inventor
Didier Festal
Denis Descours
Jacques Decerprit
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA SAS
LIPHA Liyonnaise Industrielle Pharmaceutique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LIPHA SAS, LIPHA Liyonnaise Industrielle Pharmaceutique filed Critical LIPHA SAS
Application granted granted Critical
Publication of ES2076827T3 publication Critical patent/ES2076827T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)

Abstract

ESTOS COMPUESTOS RESPONDEN A LA FORMULA, EN LA QUE, UNO DE LOS GRUPOS X1 A X4 REPRESENTA EL NITROGENO Y LOS OTROS UN RADICAL CH, R1 Y R2 REPRESENTAN H, HALOGENO, ALQUILO, HIDROXIMETILO, DIALQUILAMINOALQUILO, DIALQUILAMINOALQUILOXIMETILO, CARBOXILO, CARBOXILATO DE ETILO, PIPERIDINO, ALCENILO, CICLOALQUILO, CICLOALCENILO, ALQUILTIO,BENCILO, FENILO, TIOFENO O PIRIDINO EVENTUALMENTE SUSTITUIDOS, R3 Y R4 REPRESENTAN H, HALOGENO, ALQUILO, CICLOALQUILO, ALCOXI O ALQUILTIO, R5 Y R6 REPRESENTAN HM ALQUILO, ALCENILO CICLOALQUILO, CICLOALCENILO, ALCOXIALQUILO, ALQUILTIOALQUILO, O FORMAN JUNTOS CADENAS ALQUILENO O ALQUILENOOXIALQUILENO, R7 REPRESENTA H, ALQUILO O CICLOALQUILO, UNO DE LOS RADICALES R5 Y R7 PUEDE TAMBIEN REPRESENTAR FENILO O BENCILO EVENTUALMENTE SUSTITUIDOS, R8 REPRESENTA H, ALQUILO, CICLOALQUILO, FENILO O BENCILO EVENTUALMENTE SUSTITUIDOS, R9 REPRESENTA FENILO, NAFTILO O HETEROCICLILO EVENTUALMENTE SUSTITUIDOS, ASI COMO SUS FORMAS TAUTOMERAS, SUS PROCESOS DE PREPARACION Y APLICACIONM COMO MEDICAMENTOS HIPOLIPIDEMIANTES Y ANTIATEROMATOSOS.
ES93400366T 1992-02-14 1993-02-12 Azaindoles, procedimientos de preparacion y medicamentos que los contienen. Expired - Lifetime ES2076827T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9201701A FR2687402B1 (fr) 1992-02-14 1992-02-14 Nouveaux azaindoles, procedes de preparation et medicaments les contenant.

Publications (1)

Publication Number Publication Date
ES2076827T3 true ES2076827T3 (es) 1995-11-01

Family

ID=9426663

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93400366T Expired - Lifetime ES2076827T3 (es) 1992-02-14 1993-02-12 Azaindoles, procedimientos de preparacion y medicamentos que los contienen.

Country Status (27)

Country Link
US (1) US5338849A (es)
EP (1) EP0557171B1 (es)
JP (1) JPH061788A (es)
KR (1) KR930017905A (es)
AT (1) ATE125257T1 (es)
AU (1) AU658475B2 (es)
CA (1) CA2089470A1 (es)
CZ (1) CZ16893A3 (es)
DE (1) DE69300268T2 (es)
DK (1) DK0557171T3 (es)
ES (1) ES2076827T3 (es)
FR (1) FR2687402B1 (es)
GR (1) GR3017614T3 (es)
HR (1) HRP930180A2 (es)
HU (1) HUT64067A (es)
IL (1) IL104573A0 (es)
LT (1) LT3065B (es)
LV (1) LV10453B (es)
MA (1) MA22797A1 (es)
MX (1) MX9300745A (es)
NO (1) NO930505L (es)
NZ (1) NZ245869A (es)
OA (1) OA09775A (es)
SI (1) SI9300076A (es)
SK (1) SK9093A3 (es)
TN (1) TNSN93016A1 (es)
ZA (1) ZA93844B (es)

Families Citing this family (49)

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GB9226855D0 (en) * 1992-12-23 1993-02-17 Erba Carlo Spa Vinylene-azaindole derivatives and process for their preparation
US5547966A (en) * 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
HUP9903330A2 (hu) 1996-11-19 2000-03-28 Amgen Inc. Gyulladásgátló hatású, aril- és heteroaril csoporttal szubsztituált kondenzált pirrolszármazékok, valamint ezeket tartalmazó gyógyászati készítmények
NZ503685A (en) 1997-10-20 2002-05-31 F Fused pyrrole compounds as kinase inhibitors
BR9814286A (pt) * 1997-12-16 2000-10-03 Warner Lambert Co Derivados de 1-substituìdo-1-aminometil-cicloalcano (=análogos de gabapentina), sua preparação e seu uso no tratamento de distúrbios neurológicos
US6187777B1 (en) 1998-02-06 2001-02-13 Amgen Inc. Compounds and methods which modulate feeding behavior and related diseases
SK287882B6 (sk) 1999-12-24 2012-02-03 Aventis Pharma Limited Azaindoles derivatives, pharmaceutical composition containing thereof and their use
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
CN101607958A (zh) * 2002-02-01 2009-12-23 阿斯特拉曾尼卡有限公司 喹唑啉化合物
GB0207637D0 (en) * 2002-04-02 2002-05-15 Karobio Ab Novel compound
SE0301372D0 (sv) * 2003-05-09 2003-05-09 Astrazeneca Ab Novel compounds
US20070066641A1 (en) * 2003-12-19 2007-03-22 Prabha Ibrahim Compounds and methods for development of RET modulators
CN1925855B (zh) * 2003-12-19 2010-06-16 普莱希科公司 开发Ret调节剂的化合物和方法
TWI372624B (en) 2004-03-30 2012-09-21 Vertex Pharma Azaindoles useful as inhibitors of jak and other protein kinases
US7498342B2 (en) * 2004-06-17 2009-03-03 Plexxikon, Inc. Compounds modulating c-kit activity
US20060058339A1 (en) * 2004-06-17 2006-03-16 Ibrahim Prabha N Compounds modulating c-kit activity and uses therefor
WO2006015124A2 (en) 2004-07-27 2006-02-09 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
US7626021B2 (en) * 2004-07-27 2009-12-01 Sgx Pharmaceuticals, Inc. Fused ring heterocycle kinase modulators
KR20070053237A (ko) * 2004-07-27 2007-05-23 에스지엑스 파마슈티컬스, 인코포레이티드 피롤로-피리딘 키나제 조절제
US7361764B2 (en) 2004-07-27 2008-04-22 Sgx Pharmaceuticals, Inc. Pyrrolo-pyridine kinase modulators
KR101913531B1 (ko) * 2004-07-28 2018-10-30 다케다 야쿠힌 고교 가부시키가이샤 피롤로〔2,3-ｃ〕피리딘 화합물, 그 제조 방법 및 용도
US20060183758A1 (en) * 2005-02-17 2006-08-17 Cb Research And Development, Inc. Method for synthesis of AZA-annelated pyrroles, thiophenes, and furans
BRPI0610066A2 (pt) * 2005-05-17 2010-05-25 Plexxikon Inc compostos que modulam atividade de c-kit e c-fms e usos para estes
MX2007016463A (es) * 2005-06-22 2008-03-04 Plexxikon Inc Derivados de pirrolo [2,3-b] piridina como inhibidores de proteina cinasa.
EP1973911B1 (en) 2006-01-17 2016-01-13 Vertex Pharmaceuticals Incorporated Azaindoles useful for the treatment of (inter alia) proliferative, cardiac, neurodegenerative, autoimmune or inflammatory disorders
WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
TW200838517A (en) 2006-12-21 2008-10-01 Vertex Pharma Compounds useful as protein kinases inhibitors
WO2008079909A1 (en) * 2006-12-21 2008-07-03 Plexxikon, Inc. Pyrrolo [2,3-b] pyridines as kinase modulators
PE20081581A1 (es) * 2006-12-21 2008-11-12 Plexxikon Inc COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA
CN101641351A (zh) 2006-12-21 2010-02-03 普莱希科公司 用于激酶调节的化合物和方法及其适应症
JP2010533729A (ja) 2007-07-17 2010-10-28 プレキシコン，インコーポレーテッド キナーゼ調節のための化合物と方法、及びそのための適応
FR2946345B1 (fr) 2009-06-05 2011-05-20 Galderma Res & Dev Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946340B1 (fr) 2009-06-05 2011-06-24 Galderma Res & Dev Nouveaux n-phenyl acetamie, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946342B1 (fr) 2009-06-05 2011-06-24 Galderma Res & Dev Nouveaux derives de dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
FR2946346B1 (fr) 2009-06-05 2011-05-20 Galderma Res & Dev Nouveaux derives dioxo-imidazolidine, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contenant.
CR20170089A (es) 2009-04-03 2017-07-17 Plexxikon Inc Composiciones del acido propano-1--sulfonico {3-[5-(4-cloro-fenil)-1h-pirrolo [2,3-b] piridina-3-carbonil] -2,4-difluoro-fenil}-amida y el uso de las mismas
AU2010262905B2 (en) 2009-06-17 2015-04-16 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
US8329724B2 (en) 2009-08-03 2012-12-11 Hoffmann-La Roche Inc. Process for the manufacture of pharmaceutically active compounds
JP2013510166A (ja) 2009-11-06 2013-03-21 プレキシコン インコーポレーテッド キナーゼ調節のための化合物、方法およびその適用
US8962830B2 (en) * 2010-07-09 2015-02-24 The Walter And Eliza Hall Institute Of Medical Research Protein kinase inhibitors and methods of treatment
CN103492381A (zh) 2010-12-16 2014-01-01 沃泰克斯药物股份有限公司 流感病毒复制的抑制剂
US9624213B2 (en) 2011-02-07 2017-04-18 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
TWI558702B (zh) 2011-02-21 2016-11-21 普雷辛肯公司 醫藥活性物質的固態形式
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
EP3068782B1 (en) 2013-11-13 2018-05-23 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
NZ719729A (en) 2013-11-13 2022-04-29 Vertex Pharma Inhibitors of influenza viruses replication
JP6704416B2 (ja) 2015-05-13 2020-06-03 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤を調製する方法
MA42422A (fr) 2015-05-13 2018-05-23 Vertex Pharma Inhibiteurs de la réplication des virus de la grippe

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FR1261179A (fr) * 1959-02-04 1961-05-19 Chimiotherapie Lab Franc 12-aza déserpidine et son procédé de préparation
US3354174A (en) * 1964-02-19 1967-11-21 Sterling Drug Inc 1-and 2-benzimidazolyl-lower-alkylamidoximes, amidines-, and guanidines
PT85662B (pt) * 1986-09-10 1990-06-29 Sandoz Sa Processo para a preparacao de derivados de aza-indol e de indolizina e de composicoes farmaceuticas que os contem
ES2059408T3 (es) * 1987-02-10 1994-11-16 Abbott Lab Un proceso para la preparacion de un compuesto.
US5153226A (en) * 1989-08-31 1992-10-06 Warner-Lambert Company Acat inhibitors for treating hypocholesterolemia
WO1991004027A1 (en) * 1989-09-15 1991-04-04 Pfizer Inc. New n-aryl and n-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme a: cholesterol acyl transferase (acat)
DE4022414A1 (de) * 1990-07-13 1992-01-16 Bayer Ag Substituierte pyrrolo-pyridine
FR2674522B1 (fr) * 1991-03-26 1993-07-16 Lipha Nouveaux derives de l'indole, procedes de preparation et medicaments les contenant.

Also Published As

Publication number Publication date
IL104573A0 (en) 1993-06-10
LTIP339A (en) 1994-06-15
EP0557171B1 (fr) 1995-07-19
TNSN93016A1 (fr) 1994-03-17
NO930505D0 (no) 1993-02-12
FR2687402B1 (fr) 1995-06-30
CZ16893A3 (en) 1993-12-15
MA22797A1 (fr) 1993-10-01
CA2089470A1 (en) 1993-08-15
OA09775A (fr) 1993-11-30
US5338849A (en) 1994-08-16
DE69300268D1 (de) 1995-08-24
AU658475B2 (en) 1995-04-13
GR3017614T3 (en) 1996-01-31
LV10453A (lv) 1995-02-20
KR930017905A (ko) 1993-09-20
AU3300593A (en) 1993-08-19
NO930505L (no) 1993-08-16
LT3065B (en) 1994-10-25
DE69300268T2 (de) 1996-04-04
HRP930180A2 (en) 1995-10-31
DK0557171T3 (da) 1995-12-04
JPH061788A (ja) 1994-01-11
ATE125257T1 (de) 1995-08-15
ZA93844B (en) 1994-08-08
NZ245869A (en) 1995-05-26
LV10453B (en) 1995-10-20
EP0557171A1 (fr) 1993-08-25
HU9300372D0 (en) 1993-04-28
SK9093A3 (en) 1993-09-09
HUT64067A (en) 1993-11-29
MX9300745A (es) 1993-09-01
SI9300076A (en) 1993-09-30
FR2687402A1 (fr) 1993-08-20

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