LT2005107A - Enantiomeriškai gryno mirtazapino gavimo būdas - Google Patents

Enantiomeriškai gryno mirtazapino gavimo būdas

Info

Publication number
LT2005107A
LT2005107A LT2005107A LT2005107A LT2005107A LT 2005107 A LT2005107 A LT 2005107A LT 2005107 A LT2005107 A LT 2005107A LT 2005107 A LT2005107 A LT 2005107A LT 2005107 A LT2005107 A LT 2005107A
Authority
LT
Lithuania
Prior art keywords
preparation
enantiomerically pure
mirtazapine
acid
pure mirtazapine
Prior art date
Application number
LT2005107A
Other languages
English (en)
Other versions
LT5382B (lt
Inventor
Johannes Hubertus Wieringa
Adrianus Antonius Martinus Van De Ven
Gerardus Johannes Kemperman
Original Assignee
Akzo Nobel N. V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N. V. filed Critical Akzo Nobel N. V.
Publication of LT2005107A publication Critical patent/LT2005107A/lt
Publication of LT5382B publication Critical patent/LT5382B/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Išradimas pateikia enantiomeriškai gryno mirtazapino gavimo būdą, kur minėtas būdas apima junginio,kurio formulė (II), kurioje X yra paliekanti grupė, žiedo uždarymo pakopą, kur minėta pakopa apima poveikį rūgštimi, pagal kurį mirtazapinas su enantiomeriniu pertekliumi yra sudaromas (II) formulės junginio su enantiomeriniu pertekliumi žiedo uždarymu, veikiant tinkama rūgštimi be tirpiklio arba tinkamu rūgšties ir organinio tirpiklio deriniu.
LT2005107A 2003-07-10 2005-12-12 ENANTIOMERISKAI GRYNO MIRTAZAPINO GAVIMO BuDAS LT5382B (lt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03102095 2003-07-10

Publications (2)

Publication Number Publication Date
LT2005107A true LT2005107A (lt) 2006-06-27
LT5382B LT5382B (lt) 2006-11-27

Family

ID=34042934

Family Applications (1)

Application Number Title Priority Date Filing Date
LT2005107A LT5382B (lt) 2003-07-10 2005-12-12 ENANTIOMERISKAI GRYNO MIRTAZAPINO GAVIMO BuDAS

Country Status (35)

Country Link
US (2) US8058436B2 (lt)
EP (1) EP1656365B1 (lt)
JP (1) JP4668184B2 (lt)
KR (1) KR20060056315A (lt)
CN (1) CN100558722C (lt)
AR (1) AR046494A1 (lt)
AT (1) ATE433965T1 (lt)
AU (1) AU2004255874B2 (lt)
BR (1) BRPI0412447A (lt)
CA (1) CA2531165C (lt)
CO (1) CO5640123A2 (lt)
CY (1) CY1109327T1 (lt)
DE (1) DE602004021605D1 (lt)
DK (1) DK1656365T3 (lt)
EC (1) ECSP066271A (lt)
ES (1) ES2327123T3 (lt)
HR (1) HRP20051019A2 (lt)
IL (1) IL172549A0 (lt)
IS (1) IS2674B (lt)
LT (1) LT5382B (lt)
LV (1) LV13441B (lt)
MX (1) MXPA06000325A (lt)
NO (1) NO20056175L (lt)
NZ (1) NZ544360A (lt)
PE (1) PE20050323A1 (lt)
PL (1) PL1656365T3 (lt)
PT (1) PT1656365E (lt)
RS (1) RS20050972A (lt)
RU (1) RU2352566C2 (lt)
SG (1) SG144914A1 (lt)
SI (1) SI1656365T1 (lt)
TW (1) TWI335915B (lt)
UA (1) UA83666C2 (lt)
WO (1) WO2005005410A1 (lt)
ZA (1) ZA200600019B (lt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5080050B2 (ja) * 2005-09-26 2012-11-21 住友化学株式会社 光学活性なピペラジン化合物の製造方法
CN102126982A (zh) * 2005-09-26 2011-07-20 住友化学株式会社 光学活性的哌嗪化合物的制造方法
TW200808804A (en) * 2006-05-22 2008-02-16 Organon Nv Mirtazapine for the treatment of neuropathic pain
TW200815370A (en) * 2006-06-16 2008-04-01 Organon Nv Stereoselective synthesis of (S)-1-methyl-3-phenylpiperazine
US8273883B2 (en) 2007-02-09 2012-09-25 Kaneka Corporation Method for producing optically active 2-arylpiperazine derivative
JP5192707B2 (ja) 2007-03-22 2013-05-08 住友化学株式会社 ミルタザピンの製造方法
US7994314B2 (en) 2007-04-11 2011-08-09 N.V. Organon Method for the preparation of an enantiomerically pure benzazepine
MX2009010967A (es) 2007-04-11 2009-12-15 Organon Nv Un metodo para la preparacion de mirtazapina.
KR101485418B1 (ko) * 2013-05-29 2015-01-26 주식회사 메디켐코리아 고순도 미르타자핀의 제조방법
HRP20211040T1 (hr) 2015-02-27 2021-10-01 Dechra Limited Poticanje apetita, upravljanje gubitkom težine, i liječenje anoreksije kod pasa i mačaka
KR102540021B1 (ko) * 2020-12-02 2023-06-07 (주)유케이케미팜 대량 생산에 적합한 미르타자핀의 제조방법

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3959470A (en) * 1972-11-28 1976-05-25 Mikhail Davidovich Mashkovsky Psychotropic medicinal preparation
NL189199C (nl) * 1975-04-05 1993-02-01 Akzo Nv Werkwijze ter bereiding van farmaceutische preparaten met werking op het centraal zenuwstelsel op basis van benz(aryl)azepinederivaten, de verkregen gevormde farmaceutische preparaten, alsmede werkwijze ter bereiding van de toe te passen benz(aryl)azepinederivaten.
TW206227B (lt) * 1989-10-05 1993-05-21 Sankyo Co
BR9815098A (pt) 1997-11-14 2000-10-10 Akzo Nobel Nv Uso de mirtazapina ou de um seu sal farmaceuticamente aceitável, e, processo para o tratamento de apnéias do sono em um aninal.
JPH11222407A (ja) * 1997-11-14 1999-08-17 Sankyo Co Ltd 新規殺菌剤
US20030069417A1 (en) * 1999-04-19 2003-04-10 Claude Singer Novel synthesis and crystallization of piperazine ring-containing compounds
KR20020019902A (ko) * 1999-04-19 2002-03-13 추후보정 피페라진 고리 함유 화합물의 신규한 합성법 및 결정화법
US6068695A (en) * 1999-07-13 2000-05-30 Bayer Corporation Process for the continuous preparation of quinacridones
AU6476300A (en) 1999-09-30 2001-05-10 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a piperazine derivative
AU6474200A (en) * 1999-12-13 2001-06-18 Sumika Fine Chemicals Co., Ltd. Process for the preparation of a pyridinemethanol compound
EP1658850A1 (en) 2000-02-11 2006-05-24 Akzo Nobel N.V. The use of mirtazapine for the treatment of sleep disorders
JP2001342188A (ja) * 2000-03-27 2001-12-11 Takeda Chem Ind Ltd 縮合ピラゾール誘導体、その製造法および用途
TW200538100A (en) * 2004-04-21 2005-12-01 Akzo Nobel Nv Mirtazapine salts

Also Published As

Publication number Publication date
ZA200600019B (en) 2007-01-31
CN1820000A (zh) 2006-08-16
RU2006103992A (ru) 2006-06-27
AR046494A1 (es) 2005-12-14
UA83666C2 (ru) 2008-08-11
SI1656365T1 (sl) 2009-10-31
PE20050323A1 (es) 2005-05-16
MXPA06000325A (es) 2006-03-30
JP2009513537A (ja) 2009-04-02
US20100179319A1 (en) 2010-07-15
ECSP066271A (es) 2006-07-28
CN100558722C (zh) 2009-11-11
TW200510426A (en) 2005-03-16
ES2327123T3 (es) 2009-10-26
ATE433965T1 (de) 2009-07-15
BRPI0412447A (pt) 2006-09-19
US20060229300A1 (en) 2006-10-12
EP1656365B1 (en) 2009-06-17
CO5640123A2 (es) 2006-05-31
US8058436B2 (en) 2011-11-15
CA2531165C (en) 2011-08-30
HK1086841A1 (en) 2006-09-29
LT5382B (lt) 2006-11-27
DE602004021605D1 (de) 2009-07-30
CA2531165A1 (en) 2005-01-20
PL1656365T3 (pl) 2009-10-30
RS20050972A (sr) 2008-06-05
AU2004255874B2 (en) 2010-10-28
RU2352566C2 (ru) 2009-04-20
SG144914A1 (en) 2008-08-28
HRP20051019A2 (en) 2006-02-28
EP1656365A1 (en) 2006-05-17
AU2004255874A1 (en) 2005-01-20
IS2674B (is) 2010-09-15
CY1109327T1 (el) 2014-07-02
NZ544360A (en) 2008-05-30
DK1656365T3 (da) 2009-09-14
PT1656365E (pt) 2009-09-01
LV13441B (en) 2006-08-20
NO20056175L (no) 2006-01-23
IS8184A (is) 2005-12-15
WO2005005410A1 (en) 2005-01-20
TWI335915B (en) 2011-01-11
KR20060056315A (ko) 2006-05-24
IL172549A0 (en) 2006-04-10
JP4668184B2 (ja) 2011-04-13

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Legal Events

Date Code Title Description
PC9A Transfer of patents

Owner name: N.V.ORGANON, NL

Effective date: 20061220

MM9A Lapsed patents

Effective date: 20120705