KR970704413A - 조진균증을 치료하기 위한 글리세릴 트리아세테이트의 용도(Use of glyceryl triacetate for treating onychomycoses) - Google Patents

조진균증을 치료하기 위한 글리세릴 트리아세테이트의 용도(Use of glyceryl triacetate for treating onychomycoses) Download PDF

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KR970704413A
KR970704413A KR1019970700298A KR19970700298A KR970704413A KR 970704413 A KR970704413 A KR 970704413A KR 1019970700298 A KR1019970700298 A KR 1019970700298A KR 19970700298 A KR19970700298 A KR 19970700298A KR 970704413 A KR970704413 A KR 970704413A
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formula
radical
glyceryl triacetate
varnish
carbon atoms
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KR100442161B1 (ko
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만프레트 본
카를 크래머
아스트리트 마르쿠스
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엔겔하르트, 위르겐 루츠
훽스트 아크티엔게젤샤프트
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A61Q3/02—Nail coatings

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pyridine Compounds (AREA)

Abstract

활성 화합물로서의 글리세릴 트리아세테이트와 수 불용성 막 형성제를 포함하는 네일 바니쉬는 조진균증의 치료용으로 적당하다. 경우에 따라, 또한 네일 바니쉬는 항진균성 1-하이드록시-2-피리돈 유도체를 추가로 포함할 수 있다.

Description

[발명의 원칙]
조진균증을 치료하기 위한 글리세릴 트리아세테이트의 용도(Use of glyceryl triacetate for treating onychomycoses)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 글리세릴 트리아세테이트와 수 불용성 막 형성제를 포함하는 네일 바니쉬(nail varnish).
  2. 제1항에 있어서, 글리세릴 트리아세테이트를, 비휘발 성분의 양을 기준으로 하여, 6 내지 80중량%의 양으로 포함하는 네일 바니쉬.
  3. 제1항 또는 제2항에 있어서, 메틸 비닐 에테르와 말레산 모노부틸 에스테르와의 공중합체가 수 불용성막 형성제로서 사용되는 네일 바니쉬.
  4. 제1항 내지 제3항 중 어느 한 항에 있어서, 화학식 (1)의 1-하이드록시-2-피리돈을 추가로 포함하는 네일 바니쉬.
    상기 화학식(1)에서, R1,R2및 R3은 동일하거나 상이하며, 수소이거나 탄소수 1내지 4의 알킬이고, R4는 탄소수 6 내지 9의 포화 탄산수소 라디칼 또는 화학식
    의 라디칼[여기서, X는 S 또는 0이고 Y는 수소원자 또는 2개 이하의 할로겐 원자, 예를 들어 염소 및/또는 브롬이고, Z는 단일 결합이거나 2가 라디칼 O, S 또는 -CR2(여기서, R은 H 또는 C1-C4-알킬이다)이거나, 또는 쇄 형태로 결합된 O 및/또는 S원자를 임의로 포함하는 탄소수 2 내지 10의 다른 2가 라디칼(여기서, 라디칼이 2개 이상의 O원자 및/또는 S원자를 함유하는 경우 S원자는 2개 이상의 탄소 원자에 의해 분리되어야 하며, 인접하는 2개의 탄소 원자는 또한 이중 결합에 의해 결합될 수 있고 탄소 원자의 자유 원자가는 H 및/또는 C1-C4-알킬 그룹에 포함된다)이고, Ar은 불소, 염소, 브롬, 메톡시, C1-C4-알킬, 트리플루오로메틸 및 트리플루오로메톡시로 이루어진 그룹으로부터 선택된 3개 이햐의 라디칼에 의해 치환될 수 있는 2개 이하의 환을 갖는 방향족 환 시스템이다]이다.
  5. 제4항에 있어서, Ar이 비페닐, 디페닐알칸 또는 디페닐 에테르로부터 유도된 2환식 시스템인 화학식 (1)의 화학물이 사용되는 네일 바니쉬.
  6. 제4항에 있어서, 화학식 (1)의 화합물이 R4의 위치에 사이클로헥실 라디칼을 함유하는 네일 바니쉬.
  7. 제4항에 있어서, 화학식 (1)의 화합물이 R4의 위치에 화학식 -CH2CH(CH3)-CH2-C(CH3)3의 옥틸 라디칼을 함유하는 네일 바니쉬.
  8. 제4항에 있어서, 6-[4-(4-클로로-페녹시)-페놀시메틸]-1-하이드록시-4-메틸-2-피리돈, 1-하이드록시-4-메틸-6-사이클로헥실-2-피리돈 또는 1-하이드록시-4-메틸-6-(2,4,4-트리메틸펜틸)-2-피리돈이 사용되는 네일 바니쉬.
  9. 제4항 내지 제8항 중의 어느 한 항에 있어서, 화학식 (1)의 화합물을, 비휘발성분의 증량을 기준으로 하여, 2 내지 80중량%, 바람직하게는 10 내지 60중량%, 특히 20 내지 40중량%의 양으로 포함하는 네일 바니쉬.
  10. 조진균증의 치료 및 예방용 약제를 제조하기 위한, 글리세릴 트리아세테이트의 용도.
  11. 용해된 형태의 수 불용성 막형성제를 글리세린 트리아세테이트 및 경우에 따라, 화학식 (1)의 화합물 및 네일 바니쉬의 제조를 통해 통상적으로 사용되는 기타 성분과 혼합함을 포함하여, 제1항 내지 제9항 중의 어느 한 항에 따르는 네일 바니쉬를 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970700298A 1995-05-18 1996-05-03 글리세릴트리아세테이트를포함하는,조진균증치료및예방용네일바니쉬 KR100442161B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19518262.6 1995-05-18
DE19518262A DE19518262A1 (de) 1995-05-18 1995-05-18 Die Verwendung von Glyceryltriacetat zur Behandlung von Onychomykosen

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Publication Number Publication Date
KR970704413A true KR970704413A (ko) 1997-09-06
KR100442161B1 KR100442161B1 (ko) 2004-10-02

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KR1019970700298A KR100442161B1 (ko) 1995-05-18 1996-05-03 글리세릴트리아세테이트를포함하는,조진균증치료및예방용네일바니쉬

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US (1) US6162420A (ko)
EP (1) EP0777457B1 (ko)
JP (1) JP3653098B2 (ko)
KR (1) KR100442161B1 (ko)
CN (1) CN1193730C (ko)
AR (1) AR002743A1 (ko)
AT (1) ATE221763T1 (ko)
AU (1) AU699323B2 (ko)
BG (1) BG63589B1 (ko)
BR (1) BR9606662B1 (ko)
CA (1) CA2195455A1 (ko)
CY (1) CY2386B1 (ko)
CZ (1) CZ290526B6 (ko)
DE (2) DE19518262A1 (ko)
DK (1) DK0777457T3 (ko)
ES (1) ES2180774T3 (ko)
HK (1) HK1011936A1 (ko)
HU (1) HU226246B1 (ko)
IL (1) IL118289A (ko)
MA (1) MA23870A1 (ko)
MX (1) MX9700470A (ko)
MY (1) MY124480A (ko)
NO (1) NO312395B1 (ko)
NZ (1) NZ307555A (ko)
OA (1) OA10395A (ko)
PL (1) PL184648B1 (ko)
PT (1) PT777457E (ko)
RO (1) RO120039B1 (ko)
TW (1) TW496738B (ko)
UA (1) UA44280C2 (ko)
WO (1) WO1996036311A1 (ko)
ZA (1) ZA963935B (ko)

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DE19643831A1 (de) 1996-10-30 1998-05-07 Hoechst Ag Verwendung von 1-Hydroxy-2-pyridonen zur Behandlung von schwer therapierbaren Schleimhauterkrankungen
DE19639816A1 (de) * 1996-09-27 1998-04-02 Hoechst Ag Antimykotische Mittel mit hoher Wirkstofffreisetzung
US20040039030A1 (en) * 1996-09-27 2004-02-26 Hoechst Akeengesellschaft Use of 1-hydroxy-2-pyridones for the treatment of seborrheic dermatitis
DE19639817A1 (de) 1996-09-27 1998-04-02 Hoechst Ag Verwendung von 1-Hydroxy-2-pyridonen zur Behandlung von Hautinfektionen
RO118174B1 (ro) * 1997-08-21 2003-03-28 Aventis Pharma Deutschland Gmbh Lac de unghii şi utilizarea acestuia
US6401724B1 (en) * 1999-10-11 2002-06-11 Par Pharmaceuticals Incorporated Method of applying a cosmetic nail lacquer or polish to a nail
DE10011081A1 (de) * 2000-03-09 2001-09-13 Aventis Pharma Gmbh Antiinfektive Wirkstoffkombinationen und ihre Verwendung zur topischen Behandlung von Pilzerkrankungen der Fuß- und Fingernägel
US6664292B2 (en) * 2001-06-04 2003-12-16 Mark H. Bogart Methods for the treatment of nail fungus and other microbial and mycotic conditions and compositions useful therefor
US7135194B2 (en) * 2002-09-27 2006-11-14 Birnbaum Jay E Subunguicide, and method for treating onychomycosis
US8404751B2 (en) * 2002-09-27 2013-03-26 Hallux, Inc. Subunguicide, and method for treating onychomycosis
CA2711807A1 (en) 2008-01-08 2009-07-16 Akthelia Pharmaceuticals Agonists for antimicrobial peptide systems
DE102008041049A1 (de) * 2008-08-06 2010-02-11 Sonja Spohler Verwendung einer antimykotischen Zusammensetzung zur topischen Behandlung von Pilzerkrankungen von Fuß- und Fingernägeln
CN103110566A (zh) * 2013-01-31 2013-05-22 巫国谊 一种纠正婴幼儿吮吸手指不良习惯的外用涂剂
US8697753B1 (en) 2013-02-07 2014-04-15 Polichem Sa Method of treating onychomycosis
US9498612B2 (en) 2013-03-14 2016-11-22 Hallux, Inc. Method of treating infections, diseases or disorders of nail unit
CN110693754B (zh) * 2019-11-16 2022-08-23 烟台东方化学有限公司 一种抗菌消炎的吡啶酮组合物及包含其的化妆品

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DE3544983A1 (de) * 1985-12-19 1987-06-25 Hoechst Ag Antimykotisch wirksamer nagellack
DE3720147A1 (de) * 1987-06-16 1988-12-29 Hoechst Ag Antimykotisch wirksamer nagellack sowie verfahren zu dessen herstellung
CA2008775C (en) * 1989-02-24 1998-12-22 Alberto Ferro Nail lacquer
US5066484A (en) * 1990-04-30 1991-11-19 Revlon, Inc. Nail enamels containing glyceryl, glycol or citrate esters
DE4212105A1 (de) * 1992-04-10 1993-10-14 Roehm Pharma Gmbh Nagellack zur Behandlung von Onychomykosen
FR2697749B1 (fr) * 1992-11-12 1995-01-13 Oreal Composition cosmétique filmogène à base d'un copolymère chloré greffé résultant du greffage d'une polyoléfine chlorée et de monomères insaturés du type acrylique, styrénique et/ou vinylique.
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KR100442161B1 (ko) 2004-10-02
PL184648B1 (pl) 2002-11-29
NO970198D0 (no) 1997-01-16
RO120039B1 (ro) 2005-08-30
HU226246B1 (en) 2008-07-28
MA23870A1 (fr) 1996-12-31
CN1156958A (zh) 1997-08-13
UA44280C2 (uk) 2002-02-15
BR9606662B1 (pt) 2010-08-10
HUP9700153A3 (en) 1999-01-28
CZ290526B6 (cs) 2002-08-14
EP0777457B1 (de) 2002-08-07
CY2386B1 (en) 2004-09-10
HK1011936A1 (en) 1999-07-23
HU9700153D0 (en) 1997-03-28
AR002743A1 (es) 1998-04-29
ATE221763T1 (de) 2002-08-15
TW496738B (en) 2002-08-01
EP0777457A1 (de) 1997-06-11
JP3653098B2 (ja) 2005-05-25
ZA963935B (en) 1996-11-25
BG101138A (en) 1998-03-31
IL118289A (en) 2000-08-31
DE19518262A1 (de) 1996-11-21
DK0777457T3 (da) 2002-11-11
OA10395A (fr) 2001-12-04
PT777457E (pt) 2002-12-31
US6162420A (en) 2000-12-19
HUP9700153A2 (hu) 1998-03-02
AU5693696A (en) 1996-11-29
PL318312A1 (en) 1997-06-09
MY124480A (en) 2006-06-30
BR9606662A (pt) 1997-10-28
NZ307555A (en) 1998-01-26
ES2180774T3 (es) 2003-02-16
DE59609538D1 (de) 2002-09-12
JPH10503219A (ja) 1998-03-24
BG63589B1 (bg) 2002-06-28
CA2195455A1 (en) 1996-11-21
MX9700470A (es) 1998-05-31
CZ14197A3 (en) 1997-04-16
NO312395B1 (no) 2002-05-06
IL118289A0 (en) 1996-09-12
AU699323B2 (en) 1998-12-03
WO1996036311A1 (de) 1996-11-21
NO970198L (no) 1997-01-16
CN1193730C (zh) 2005-03-23

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