KR970043038A - 스트렙토마이세스엑스포리아투스(streptomycesexfoliatus)yj-118과이를이용한프라바스타틴나트륨의제조방법 - Google Patents

스트렙토마이세스엑스포리아투스(streptomycesexfoliatus)yj-118과이를이용한프라바스타틴나트륨의제조방법 Download PDF

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Publication number
KR970043038A
KR970043038A KR1019970013290A KR19970013290A KR970043038A KR 970043038 A KR970043038 A KR 970043038A KR 1019970013290 A KR1019970013290 A KR 1019970013290A KR 19970013290 A KR19970013290 A KR 19970013290A KR 970043038 A KR970043038 A KR 970043038A
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South Korea
Prior art keywords
formula
pravastatin
streptomycesexfoliatus
streptomyces exfoliatus
microorganism
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KR1019970013290A
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English (en)
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KR100210482B1 (ko
Inventor
이주경
박주웅
서동진
이상춘
김지윤
Original Assignee
김종인
영진약품공업 주식회사
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Application filed by 김종인, 영진약품공업 주식회사 filed Critical 김종인
Priority to KR1019970013290A priority Critical patent/KR100210482B1/ko
Priority to US09/402,784 priority patent/US6306629B1/en
Priority to JP52595598A priority patent/JP2001519654A/ja
Priority to PCT/KR1997/000130 priority patent/WO1998045410A1/en
Priority to CN97182193A priority patent/CN1126815C/zh
Priority to EP97930870A priority patent/EP0975738A1/en
Publication of KR970043038A publication Critical patent/KR970043038A/ko
Application granted granted Critical
Publication of KR100210482B1 publication Critical patent/KR100210482B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Abstract

본 발명은 스트렙토마이세스 엑스포리아투스(Streptomyces exfoliatus) YJ-118과 이를 이용한 프라바스타틴 나트륨의 제조방법에 관한 것으로서, 더욱 상세하기로는 신균주 스트렙토마이세스 엑스포리아투스(Streptomyces exfoliatus) YJ-118를 사용한 미생물의 효소적-하이드록실화 반응을 이용하여 고지혈증 치료제로 유용한 다음 화학식 1로 표시되는 프라바스타틴 나트륨을 고수율 및 고순도로 제조하는 방법에 관한 것이다.

Description

스트렙토마이세스 엑스포리아투스(Streptomyces exfoliatus)YJ-118과 이를 이용한 프라바스타틴 나트륨의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
도 1은 프라바스타틴 나트륨의 적외선 흡수 스펙트럼이고;
도 2는 프라바스타틴 나트륨의13C-NMR 스펙트럼이고;
도 3은 프라바스타틴 나트륨의1H-NMR 스펙트럼이다.

Claims (4)

  1. 스트렙토마이세스 엑스포리아투스(Streptomyces exfoliatus) YJ-118 균주.
  2. 다음 화학식 2a 또는 화학식 2b로 표시되는 프라바스타틴 전구체를 미생물에 의한 효소적-하이드록실화 반응시켜 다음 화학식 1로 표시되는 프라바스타틴 나트륨을 제조하는 방법에 있어서,
    상기 미생물로는 스트렙토마이세스 엑스포리아투스(Streptomyces exfoliatus) YJ-118를 사용하는 것을 특징으로 하는 프라바스타틴 나트륨의 제조방법.
    화학식 2a
    화학식 2b
    상기 화학식 2b에서, R은 H 또는 Na이다.
    화학식 1
  3. 제 2 항에 있어서, 미생물 종자 배양을 위한 제1배지에 상기 프라바스타틴 전구체를 0.05%(w/v) 미만의 농도로 첨가하는 것을 특징으로 하는 프라바스타틴 나트륨의 제조방법.
  4. 제 2 항에 있어서, 미생물 배양을 위한 제2배지에 상기 프라바스타틴 전구체를 0.1 ∼ 5.0%(w/v) 첨가하는 것을 특징으로 하는 프라바스타틴 나트륨의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019970013290A 1997-04-10 1997-04-10 스트렙토마이세스엑스포리아투스(streptomycesexfoliatus)yj-118과이를이용한프라바스타틴나트륨의제조방법 KR100210482B1 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
KR1019970013290A KR100210482B1 (ko) 1997-04-10 1997-04-10 스트렙토마이세스엑스포리아투스(streptomycesexfoliatus)yj-118과이를이용한프라바스타틴나트륨의제조방법
US09/402,784 US6306629B1 (en) 1997-04-10 1997-06-20 Microorganism streptomyces exfoliatus yj-118 and a method for producing pravastatin sodium by using the strain
JP52595598A JP2001519654A (ja) 1997-04-10 1997-06-30 ストレプトミセス・エキソフォリアツスｙｊ−１１８と上記菌株を利用するプラバスタチンナトリウムの製造方法
PCT/KR1997/000130 WO1998045410A1 (en) 1997-04-10 1997-06-30 A new microorganism streptomyces exfoliatus yj-118 and a method for producing pravastatin sodium by using the strain
CN97182193A CN1126815C (zh) 1997-04-10 1997-06-30 新型微生物“脱叶链霉菌yj－118”及使用该菌株生产普伐他丁钠的方法
EP97930870A EP0975738A1 (en) 1997-04-10 1997-06-30 A new microorganism streptomyces exfoliatus yj-118 and a method for producing pravastatin sodium by using the strain

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019970013290A KR100210482B1 (ko) 1997-04-10 1997-04-10 스트렙토마이세스엑스포리아투스(streptomycesexfoliatus)yj-118과이를이용한프라바스타틴나트륨의제조방법

Publications (2)

Publication Number Publication Date
KR970043038A true KR970043038A (ko) 1997-07-26
KR100210482B1 KR100210482B1 (ko) 1999-07-15

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KR1019970013290A KR100210482B1 (ko) 1997-04-10 1997-04-10 스트렙토마이세스엑스포리아투스(streptomycesexfoliatus)yj-118과이를이용한프라바스타틴나트륨의제조방법

Country Status (6)

Country Link
US (1) US6306629B1 (ko)
EP (1) EP0975738A1 (ko)
JP (1) JP2001519654A (ko)
KR (1) KR100210482B1 (ko)
CN (1) CN1126815C (ko)
WO (1) WO1998045410A1 (ko)

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SI20305A (sl) * 1999-08-06 2001-02-28 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Kristali natrijeve soli pravastatina
AU782143B2 (en) * 1998-09-18 2005-07-07 Lek Pharmaceuticals D.D. Crystals of the sodium salt of pravastatin
US6682913B1 (en) * 1999-02-03 2004-01-27 Institute For Drug Research Ltd. Microbial process for preparing pravastatin
EP1491522A1 (en) * 1999-02-03 2004-12-29 Institute for Drug Research Ltd. Microbial process for preparing pravastatin
AU779306B2 (en) 1999-12-14 2005-01-13 Teva Gyogyszergyar Reszvenytarsasag Novel forms of pravastatin sodium
EP1523978A3 (en) * 1999-12-14 2007-12-12 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Crystalline forms of pravastatin sodium
HU225432B1 (hu) * 2001-09-27 2006-11-28 Biocon Ltd Eljárás pravasztatin nátriumsó elõállítására streptomyces flavidovirens DSM 14455 törzs alkalmazásával
KR100414334B1 (ko) * 2001-09-29 2004-01-07 코바이오텍 (주) 프라바스타틴 나트륨의 생산 방법
EP1452602A1 (en) * 2003-02-25 2004-09-01 Antibiotic Co., Method for production of pravastatin by fermentation
WO2004087935A2 (en) * 2003-04-01 2004-10-14 Ranbaxy Laboratories Limited Fermentation process for the preparation of pravastatin
KR100470078B1 (ko) * 2003-06-12 2005-02-04 씨제이 주식회사 컴팩틴을 프라바스타틴으로 전환할 수 있는 스트렙토마이세스 종(Ｓｔｒｅｐｔｏｍｙｃｅｓ ｓｐ.)ＣＪＰＶ 975652 및 그를 이용한 프라바스타틴의 제조방법
CN1244688C (zh) 2003-07-09 2006-03-08 上海天伟生物制药有限公司 生产普伐他汀钠的微生物和方法
WO2005051372A2 (en) 2003-11-24 2005-06-09 Teva Gyógyszergyár Zártköruen Muködo Részvénytársaság Method of purifying pravastatin
TWI252253B (en) * 2004-01-09 2006-04-01 Chinese Petroleum Corp A novel Pseudonocardia sp RMRC PAH4 and a process for bioconverting compactin into pravastatin using the same
KR100630817B1 (ko) 2004-07-08 2006-10-02 코바이오텍 (주) 프라바스타틴 나트륨 고생성 변이주 및 이를 이용한프라바스타틴 나트륨의 생산방법
US20060194984A1 (en) * 2005-02-09 2006-08-31 Vilmos Keri Methods of making pravastatin sodium
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Publication number Publication date
EP0975738A1 (en) 2000-02-02
KR100210482B1 (ko) 1999-07-15
WO1998045410A1 (en) 1998-10-15
CN1126815C (zh) 2003-11-05
JP2001519654A (ja) 2001-10-23
CN1254373A (zh) 2000-05-24
US6306629B1 (en) 2001-10-23

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