WO2004087935A2 - Fermentation process for the preparation of pravastatin - Google Patents
Fermentation process for the preparation of pravastatin Download PDFInfo
- Publication number
- WO2004087935A2 WO2004087935A2 PCT/IB2004/001003 IB2004001003W WO2004087935A2 WO 2004087935 A2 WO2004087935 A2 WO 2004087935A2 IB 2004001003 W IB2004001003 W IB 2004001003W WO 2004087935 A2 WO2004087935 A2 WO 2004087935A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compactin
- pravastatin
- concentration
- formula
- substantially pure
- Prior art date
Links
- 0 CC[C@](C)C(O[C@@](C1)[C@]([C@](CC)CCC[C@](C[C@](C*)O)O)C(C)=C[C@]1O)=O Chemical compound CC[C@](C)C(O[C@@](C1)[C@]([C@](CC)CCC[C@](C[C@](C*)O)O)C(C)=C[C@]1O)=O 0.000 description 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04725114A EP1613760A2 (en) | 2003-04-01 | 2004-04-01 | Fermentation process for the preparation of pravastatin |
CA002521276A CA2521276A1 (en) | 2003-04-01 | 2004-04-01 | Fermentation process for the preparation of pravastatin |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN559DE2003 | 2003-04-01 | ||
IN559/DEL/2003 | 2003-04-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2004087935A2 true WO2004087935A2 (en) | 2004-10-14 |
WO2004087935A3 WO2004087935A3 (en) | 2005-01-13 |
Family
ID=33104991
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/IB2004/001003 WO2004087935A2 (en) | 2003-04-01 | 2004-04-01 | Fermentation process for the preparation of pravastatin |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1613760A2 (en) |
CA (1) | CA2521276A1 (en) |
WO (1) | WO2004087935A2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1953233A1 (en) * | 2007-02-02 | 2008-08-06 | LEK Pharmaceuticals d.d. | Fermentation process for preparing pravastatin |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998045410A1 (en) * | 1997-04-10 | 1998-10-15 | Yungjin Pharmaceutical Ind. Co., Ltd. | A new microorganism streptomyces exfoliatus yj-118 and a method for producing pravastatin sodium by using the strain |
WO2000017182A1 (en) * | 1998-09-18 | 2000-03-30 | Lek Pharmaceutical And Chemical Company D.D. | PROCESS FOR OBTAINING HMG-CoA REDUCTASE INHIBITORS OF HIGH PURITY |
US20010026934A1 (en) * | 1995-06-07 | 2001-10-04 | Arnold Demain | Conversion of compactin to pravastatin by actinomadura |
US20020081675A1 (en) * | 1999-02-03 | 2002-06-27 | Antonia Jekkel | Microbial process for preparing pravastatin |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3463875B2 (en) * | 2001-08-06 | 2003-11-05 | 三共株式会社 | How to purify pravastatin |
-
2004
- 2004-04-01 WO PCT/IB2004/001003 patent/WO2004087935A2/en not_active Application Discontinuation
- 2004-04-01 EP EP04725114A patent/EP1613760A2/en not_active Withdrawn
- 2004-04-01 CA CA002521276A patent/CA2521276A1/en not_active Abandoned
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20010026934A1 (en) * | 1995-06-07 | 2001-10-04 | Arnold Demain | Conversion of compactin to pravastatin by actinomadura |
WO1998045410A1 (en) * | 1997-04-10 | 1998-10-15 | Yungjin Pharmaceutical Ind. Co., Ltd. | A new microorganism streptomyces exfoliatus yj-118 and a method for producing pravastatin sodium by using the strain |
WO2000017182A1 (en) * | 1998-09-18 | 2000-03-30 | Lek Pharmaceutical And Chemical Company D.D. | PROCESS FOR OBTAINING HMG-CoA REDUCTASE INHIBITORS OF HIGH PURITY |
US20020081675A1 (en) * | 1999-02-03 | 2002-06-27 | Antonia Jekkel | Microbial process for preparing pravastatin |
Non-Patent Citations (4)
Title |
---|
DATABASE WPI Section Ch, Week 200250 Derwent Publications Ltd., London, GB; Class B05, AN 2002-471387 XP002301127 -& JP 2002 128739 A (SANKYO CO LTD) 9 May 2002 (2002-05-09) * |
GRAHEK R ET AL: "Chromatographic purification of some 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors" JOURNAL OF CHROMATOGRAPHY, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, NL, vol. 918, no. 2, 25 May 2001 (2001-05-25), pages 319-324, XP004239132 ISSN: 0021-9673 * |
HOSOBUCHI M ET AL: "APPLICATION OF COMPUTER TO MONITORING AND CONTROL OF FERMENTATION PROCESS: MICROBIAL CONVERSION OF ML-236B NA TO PRAVASTATIN" BIOTECHNOLOGY AND BIOENGINEERING, INTERSCIENCE PUBLISHERS, LONDON, GB, vol. 42, no. 7, 1993, pages 815-820, XP002036625 ISSN: 0006-3592 cited in the application * |
PARK JOO-WOONG ET AL: "Bioconversion of compactin into pravastatin by Streptomyces sp." BIOTECHNOLOGY LETTERS, vol. 25, no. 21, November 2003 (2003-11), pages 1827-1831, XP008033522 ISSN: 0141-5492 * |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1953233A1 (en) * | 2007-02-02 | 2008-08-06 | LEK Pharmaceuticals d.d. | Fermentation process for preparing pravastatin |
WO2008092950A1 (en) | 2007-02-02 | 2008-08-07 | Lek Pharmaceuticals D.D. | Fermentation process for preparing pravastatin |
Also Published As
Publication number | Publication date |
---|---|
EP1613760A2 (en) | 2006-01-11 |
CA2521276A1 (en) | 2004-10-14 |
WO2004087935A3 (en) | 2005-01-13 |
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