KR960703024A - 질내 전달계(intravaginal delivery system) - Google Patents

질내 전달계(intravaginal delivery system) Download PDF

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Publication number
KR960703024A
KR960703024A KR1019950705668A KR19950705668A KR960703024A KR 960703024 A KR960703024 A KR 960703024A KR 1019950705668 A KR1019950705668 A KR 1019950705668A KR 19950705668 A KR19950705668 A KR 19950705668A KR 960703024 A KR960703024 A KR 960703024A
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South Korea
Prior art keywords
delivery system
intravaginal delivery
support means
active agent
intravaginal
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KR1019950705668A
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KR100312764B1 (ko
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레티넨 마티
탈링 크리스틴
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유하니 포스티·칼레비 카우마
레이라스 오이
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/08—Pessaries, i.e. devices worn in the vagina to support the uterus, remedy a malposition or prevent conception, e.g. combined with devices protecting against contagion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Reproductive Health (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
  • Paper (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • External Artificial Organs (AREA)
  • Prostheses (AREA)
  • Details Of Garments (AREA)
  • Particle Formation And Scattering Control In Inkjet Printers (AREA)

Abstract

본 발명의 목적은 굴신가능한 지지 수단, 및 이 지지수단에 의해 지지되며 활성제를 함유하는 전달 수단으로 이루어진 질내 전달계를 제공하는 것이다. 이 계는 실제로 열린 링 형태의 코어 요소(1′), 및 상기 코어 요소의 길이의 일부를 벨트 형식으로 감싸고 있는, 적어도 하나 이상의 소매상 폴리머 몸체(2)로 이루어진 전달 수단으로 구성되어 있다.

Description

질내 전달계(INTRAVAGINAL DELIVERY SYSTEM)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (12)

  1. 굴신가능한 지지 수단 및 활성제를 함유하면서 상기 지지 수단에 의해 지지되는 전달 수단으로 이루어진 질내 전달계로서, 지지 수단(1)은 실질적으로 열린 링 형태의 코어 요소(1′)로 구성되어 있도 전달 수단은 상기 코어요소 길이의 일부를 벨트처럼 감싸는 적어도 하나 이상의 소매상 폴리머 몸체(2)로 구성되어 있는 것이 특징인 질내 전달계.
  2. 제1항에 있어서, 소매상 몸체가 폴리디메틸실록산과 같은 폴리실록산, 폴리우레탄 또는 EVA-코폴리머로 만들어진 것이 특징인 질내 전달계.
  3. 제1항에 있어서, 지지 수단이 천연 고무, 부틸 고무, 및 폴리디메틸실록산 탄성체와 같은 가교된 고무, 에틸비닐아세테이트(EVA)와 같은 굴신가능한 열가소성 수지, 스티렌 코폴리머(SEBS, SBS, SIS)와 같은 열가소성 탄성체, 폴리우레탄 또는 열가소성 폴리올레핀인 것이 특징인 질내 전달계.
  4. 제1항 내지 3항 중 어느 한 항에 있어서, 소매상 몸체의 내부 표면이 활성제가 소매상 몸체로부터 지지 수단으로 이동하는 것을 실질적으로 방지하는 소재와 접촉되어 있는 것이 특징인 질내 전달계.
  5. 제4항에 있어서, 지지 수단이 진적으로 활성제의 이동을 방지하는 소재로 만들어진 것이 특징인 질내 전달계.
  6. 전술한 항 중 어느 한 항에 있어서, 전달 수단이 각각 상이한 활성제를 함유하는 두 개의 소매상 몸체로 형성된 것이 특징인 질내 전달계.
  7. 제1항 내지 6항 중 어느 한 항에 있어서, 소매상 몸체가 프로게스테이션 제제 또는 에스트로겐 제제를 함유하는 것이 특징인 질내 전달계.
  8. 제1항 내지 5항 또는 7항 중 어느 한 항에 있어서, 동일한 활성제를 함유하는 두 개의 소매상 몸체를 포함하는 것이 특징인 질내 전달계.
  9. 전술한 항 중 어느 한 항에 있어서, 소매상 몸체가 활성제의 확산을 가능케 하는 막(4), 특히 폴리실록산막으로 코팅되어 있는 것이 특징인 질내 전달계.
  10. 폐경기 치료와 같은 호르몬 치료에 이용되기 위한, 전술한 항 중 어느 한 항에 따른 질내 전달계의 용도.
  11. 활성제 및 폴리머를 함유하는 소매상 몸체의 직경을 예컨대 기계적으로 팽창에 의해 신장시킴으로써 확대시키고, 이것을 이 상태에서 코어 요소 상에 장착한 다음 지지 수단 상에 팽팽하게 고정시키는 것으로 이루어짐을 특징으로 하는 제1항에 따른 전달계의 제조방법.
  12. 제11항에 있어서, 소매상 몸체가, 코어 요소 상에 장착될 경우, 소매 상에 외층을 형성하게 될 폴리머막과의 공사출에 의해 만들어지는 것이 특징인 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019950705668A 1993-06-17 1994-06-15 질내전달시스템 KR100312764B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI932789 1993-06-17
FI932789A FI95768C (fi) 1993-06-17 1993-06-17 Emättimensisäinen antosysteemi
PCT/FI1994/000255 WO1995000199A1 (en) 1993-06-17 1994-06-15 Intravaginal delivery system

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KR960703024A true KR960703024A (ko) 1996-06-19
KR100312764B1 KR100312764B1 (ko) 2002-11-23

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US (1) US5694947A (ko)
EP (1) EP0703802B1 (ko)
JP (1) JP3803714B2 (ko)
KR (1) KR100312764B1 (ko)
CN (1) CN1126574C (ko)
AT (1) ATE177657T1 (ko)
AU (1) AU674758B2 (ko)
BR (1) BR9407118A (ko)
CZ (1) CZ284989B6 (ko)
DE (1) DE69417232T2 (ko)
DK (1) DK0703802T3 (ko)
EE (1) EE03202B1 (ko)
ES (1) ES2130423T3 (ko)
FI (1) FI95768C (ko)
GR (1) GR3030565T3 (ko)
HU (1) HU217950B (ko)
LT (1) LT3455B (ko)
LV (1) LV12452B (ko)
MY (1) MY113965A (ko)
NO (1) NO311498B1 (ko)
PL (1) PL176664B1 (ko)
RU (1) RU2121824C1 (ko)
TW (1) TW286273B (ko)
WO (1) WO1995000199A1 (ko)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI95768C (fi) * 1993-06-17 1996-03-25 Leiras Oy Emättimensisäinen antosysteemi
GB9522403D0 (en) * 1995-11-01 1996-01-03 Hoechst Roussel Ltd Intravaginal drug delivery device
US5972372A (en) * 1996-07-31 1999-10-26 The Population Council, Inc. Intravaginal rings with insertable drug-containing core
JP2002513690A (ja) * 1998-05-01 2002-05-14 エフイ−アイ エンタープライジズ，リミティド 制御放出デバイスの射出成形製造方法
US6476079B1 (en) * 1999-12-23 2002-11-05 Leiras Oy Devices for the delivery of drugs having antiprogestinic properties
GB0009914D0 (en) 2000-04-20 2000-06-07 Metris Therapeutics Limited Device
US20070043332A1 (en) * 2003-07-10 2007-02-22 Galen (Chemiclas) Liimited Intravaginal drug delivery devices
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
US8173593B2 (en) 2005-07-19 2012-05-08 The Population Council, Inc. Methods and compositions for emergency contraception using endothelin receptor antagonists
RU2463018C2 (ru) * 2006-11-20 2012-10-10 Н.В. Органон Устройство доставки лекарственного средства, имеющее спиральную форму
TW200927141A (en) * 2007-11-22 2009-07-01 Bayer Schering Pharma Oy Vaginal delivery system
EP2062568A1 (en) * 2007-11-22 2009-05-27 Bayer Schering Pharma Oy Vaginal delivery system
AU2009206328A1 (en) * 2008-01-25 2009-07-30 The University Of Utah Research Foundation Linear order release polymer
ES2645630T3 (es) 2008-02-04 2017-12-07 Ferring B.V. Anillos intravaginales monolíticos que comprenden progesterona y métodos de fabricación y usos de los mismos
FI20095550A0 (fi) * 2009-05-19 2009-05-19 Bayer Schering Pharma Oy Vaginaalinen antojärjestelmä
FI20095563A (fi) * 2009-05-20 2010-11-21 Bayer Schering Pharma Oy Vaginaalinen antojärjestelmä
EP4108216A1 (en) 2009-06-03 2022-12-28 Forsight Vision5, Inc. Anterior segment drug delivery
DE102010003494A1 (de) * 2010-03-31 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Parenterales Abgabesystem, das Aromatasehemmer und Gestagene freisetzt, für die Behandlung von Endometriose
US8580294B2 (en) 2010-10-19 2013-11-12 International Partnership For Microbicides Platinum-catalyzed intravaginal rings
CN104168902A (zh) 2011-08-26 2014-11-26 智利圣地亚哥大学 阴道内给药非类固醇抗炎药物美洛昔康和吡罗昔康用于中断女性排卵过程的用途
GB201115592D0 (en) * 2011-09-09 2011-10-26 Vivosens Medical Gmbh Flexible ring pessary
CN103917202B (zh) 2011-09-14 2016-06-29 弗赛特影像5股份有限公司 眼插入件装置和方法
CN103007427B (zh) * 2011-09-21 2016-01-20 上海市计划生育科学研究所 缓控释宫内释药器及其制备方法
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
PT2782584T (pt) 2011-11-23 2021-09-02 Therapeuticsmd Inc Preparações e terapias de substituição para hormonoterapias naturais combinadas
EP2641602A1 (en) 2012-03-23 2013-09-25 PregLem S.A. Method for treating gynecological diseases
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
TR201808748T4 (tr) 2012-09-03 2018-07-23 Ecosea Farming S A Hidrobiyolojik türlerin kültürü ve/veya korunmasına yönelik rezervuar-kafes daldırma sistemi.
JP6298068B2 (ja) 2012-10-26 2018-03-20 フォーサイト・ビジョン５・インコーポレイテッドＦｏｒｓｉｇｈｔ Ｖｉｓｉｏｎ５，Ｉｎｃ． 眼に対する薬物徐放用眼科システム
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10172869B2 (en) 2013-04-10 2019-01-08 Preglem Sa Progesterone receptor modulators for use in the therapy of uterine fibroids
US10137031B2 (en) 2013-11-14 2018-11-27 International Partnership For Microbicides, Inc. Combination therapy intravaginal rings
CN112618143A (zh) * 2014-04-01 2021-04-09 保利医学公司 避孕装置及相关装置
JP2017516768A (ja) 2014-05-22 2017-06-22 セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． 天然の併用ホルモン補充療法剤及び療法
KR20230142816A (ko) * 2014-06-26 2023-10-11 타리스 바이오메디컬 엘엘씨 탄성 폴리머-약물 매트릭스 시스템을 포함하는 방광내 약물 전달 장치 및 방법
EP3283004A4 (en) 2015-04-13 2018-12-05 Forsight Vision5, Inc. Ocular insert composition of semi-crystalline or crystalline pharmaceutically active agent
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
KR20180126582A (ko) 2016-04-01 2018-11-27 쎄러퓨틱스엠디, 인코퍼레이티드 스테로이드 호르몬 약제학적 조성물
CN110403565B (zh) * 2018-04-27 2022-02-11 西安交通大学医学院第一附属医院 一种胶囊内窥镜磁与麦芒仿生双驱动装置
CN109771124A (zh) * 2019-01-31 2019-05-21 山东省药学科学院 一种具有形状记忆功能的子宫托
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1264731A (en) * 1917-03-19 1918-04-30 Carl Willers Pneumatic die-cushion.
US3545439A (en) 1968-01-04 1970-12-08 Upjohn Co Medicated devices and methods
US3967618A (en) * 1969-04-01 1976-07-06 Alza Corporation Drug delivery device
US3911911A (en) * 1969-06-16 1975-10-14 Reese Hospital Michael Anti-fertility device
US3920805A (en) * 1971-12-09 1975-11-18 Upjohn Co Pharmaceutical devices and method
GB1465684A (en) * 1973-07-27 1977-02-23 Emmett L Contraceptive device
IL48277A (en) * 1974-10-18 1978-03-10 Schering Ag Vaginal ring
DE2616064A1 (de) * 1976-04-09 1977-10-20 Schering Ag Vaginalring iii
US3995634A (en) * 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal cavity dispensing means and method
US4215691A (en) * 1978-10-11 1980-08-05 Alza Corporation Vaginal contraceptive system made from block copolymer
US4292965A (en) * 1978-12-29 1981-10-06 The Population Council, Inc. Intravaginal ring
DE3040978A1 (de) * 1980-10-28 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Vaginalring
DE3175137D1 (en) * 1981-12-30 1986-09-18 Population Council Inc Method of making intrauterine devices
JPS5919151U (ja) * 1982-07-28 1984-02-06 ニツポ−株式会社 痔疾治療器
GB8403138D0 (en) * 1984-02-07 1984-03-14 Graham N B Sustained release of active ingredient
ZA857643B (en) * 1984-10-12 1986-05-28 Akzo Nv Release system for two or more active substances
US4596576A (en) * 1984-10-12 1986-06-24 Akzo N.V. Release system for two or more active substances
SE8602666D0 (sv) * 1986-06-16 1986-06-16 Leo Ab Intravaginal devices
US4822161A (en) * 1988-01-19 1989-04-18 Jimmy Michael F Illuminating spectacle apparatus
JPH02185264A (ja) * 1988-12-16 1990-07-19 Ferring Bv 膀胱内又は尿管へ薬を送り込む方法及び装置
KR100236355B1 (ko) * 1990-03-16 2000-01-15 이데이 노부유끼 와이프 패턴의 발생장치
JP3186105B2 (ja) * 1991-07-26 2001-07-11 日本電気株式会社 半導体装置のテストモード設定・解除回路
FI95768C (fi) * 1993-06-17 1996-03-25 Leiras Oy Emättimensisäinen antosysteemi

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Publication number Publication date
CZ284989B6 (cs) 1999-04-14
CZ320895A3 (en) 1996-07-17
PL176664B1 (pl) 1999-07-30
KR100312764B1 (ko) 2002-11-23
DK0703802T3 (da) 1999-10-11
CN1126574C (zh) 2003-11-05
FI95768C (fi) 1996-03-25
AU674758B2 (en) 1997-01-09
LV12452A (lv) 2000-04-20
FI932789A0 (fi) 1993-06-17
PL312193A1 (en) 1996-04-01
NO311498B1 (no) 2001-12-03
WO1995000199A1 (en) 1995-01-05
US5694947A (en) 1997-12-09
JPH08511240A (ja) 1996-11-26
GR3030565T3 (en) 1999-10-29
AU6848194A (en) 1995-01-17
HUT74548A (en) 1997-01-28
ES2130423T3 (es) 1999-07-01
EP0703802B1 (en) 1999-03-17
DE69417232D1 (de) 1999-04-22
LTIP1957A (en) 1995-01-31
HU9503290D0 (en) 1996-01-29
EE03202B1 (et) 1999-08-16
MY113965A (en) 2002-07-31
ATE177657T1 (de) 1999-04-15
DE69417232T2 (de) 1999-11-04
EP0703802A1 (en) 1996-04-03
TW286273B (ko) 1996-09-21
HU217950B (hu) 2000-05-28
RU2121824C1 (ru) 1998-11-20
NO955029D0 (no) 1995-12-12
BR9407118A (pt) 1996-09-03
FI95768B (fi) 1995-12-15
LT3455B (en) 1995-10-25
CN1125403A (zh) 1996-06-26
JP3803714B2 (ja) 2006-08-02
FI932789A (fi) 1994-12-18
NO955029L (no) 1995-12-12
LV12452B (en) 2000-09-20

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