KR870007696A - 위내 체류형 과립 - Google Patents

위내 체류형 과립 Download PDF

Info

Publication number
KR870007696A
KR870007696A KR870001462A KR870001462A KR870007696A KR 870007696 A KR870007696 A KR 870007696A KR 870001462 A KR870001462 A KR 870001462A KR 870001462 A KR870001462 A KR 870001462A KR 870007696 A KR870007696 A KR 870007696A
Authority
KR
South Korea
Prior art keywords
core
layer
granules according
foam layer
bicarbonate
Prior art date
Application number
KR870001462A
Other languages
English (en)
Other versions
KR910004578B1 (ko
Inventor
마사끼 이찌가와
스미오 와다나베
야스오 미야께
Original Assignee
나이또오 류우지
에자이 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 나이또오 류우지, 에자이 가부시끼가이샤 filed Critical 나이또오 류우지
Publication of KR870007696A publication Critical patent/KR870007696A/ko
Application granted granted Critical
Publication of KR910004578B1 publication Critical patent/KR910004578B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Abstract

내용 없음

Description

위내 체류형 과립
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 제약상 유효성분으로 이루어지는 핵심 ; 이 핵심상에 피복된 발포층 및 이층에 피복된 팽창막으로 이루어지는 것을 특징으로 하는 위내 체류형과립.
  2. 제 1 항에 있어서, 상기 발포층은 중탄산염 또는 중탄산염과 유기산의 조합으로 이루어지는 것을 특징으로 하는 위내 체류형 과립.
  3. 제 1 항에 있어서, 상기 발포층은 중탄산염으로 이루어지는 내층과 유기산으로 이루어지는 또다른 외층으로 이루어지는 것을 특징으로 하는 위대 체류형 과립.
  4. 제 1 항에 있어서, 상기 팽창막은 위액이 통과하도록 허용하며 위액과 발포층간의 작용에 의해 생성된 발포에 의해 팽창되도록 하는 중합체로 이루어지는것을 특징으로 하는 위내 체류형 과립.
  5. 제 1 항에 있어서, 상기 핵심, 상기 핵심을 기준으로 상기 발포층 5 내지 20중량 퍼센트, 그리고 상기 핵심을 기준으로 상기 팽창막 5 내지 20중량 퍼센트로 이루어지는 것을 특징으로 하는 위내 체류형 과립.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870001462A 1986-02-24 1987-02-21 위내 체류형 과립의 제조방법 KR910004578B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP37450 1986-02-24
JP61037450A JPS62195323A (ja) 1986-02-24 1986-02-24 胃内滞留型粒子
JP61-37450 1986-02-24

Publications (2)

Publication Number Publication Date
KR870007696A true KR870007696A (ko) 1987-09-21
KR910004578B1 KR910004578B1 (ko) 1991-07-06

Family

ID=12497838

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870001462A KR910004578B1 (ko) 1986-02-24 1987-02-21 위내 체류형 과립의 제조방법

Country Status (9)

Country Link
US (1) US4844905A (ko)
EP (1) EP0235718B1 (ko)
JP (1) JPS62195323A (ko)
KR (1) KR910004578B1 (ko)
AT (1) ATE68969T1 (ko)
CA (1) CA1288697C (ko)
DE (1) DE3774148D1 (ko)
ES (1) ES2051698T3 (ko)
GR (1) GR3003031T3 (ko)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62103012A (ja) * 1985-10-23 1987-05-13 Eisai Co Ltd 多重顆粒
IL87710A (en) * 1987-09-18 1992-06-21 Ciba Geigy Ag Covered floating retard form for controlled release in gastric juice
GB8724763D0 (en) * 1987-10-22 1987-11-25 Aps Research Ltd Sustained-release formulations
GB8809421D0 (en) * 1988-04-21 1988-05-25 Fordonal Sa Antacid compositions with prolonged gastric residence time
US5096714A (en) * 1988-06-28 1992-03-17 Hauser-Kuhrts, Inc. Prolonged release drug tablet formulations
US5445826A (en) * 1988-06-28 1995-08-29 Cibus Pharmaceutical, Inc. Delivery system containing a gel-forming dietary fiber and a drug
JPH082781B2 (ja) * 1988-10-18 1996-01-17 嘉明 川島 中空顆粒状医薬及びその製法
US5232704A (en) * 1990-12-19 1993-08-03 G. D. Searle & Co. Sustained release, bilayer buoyant dosage form
US5641535A (en) * 1991-03-14 1997-06-24 Wacker-Chemie Gmbh Process for the microencapsulation of water-emulsifiable non-thermoplastic substances
US5198229A (en) * 1991-06-05 1993-03-30 Alza Corporation Self-retaining gastrointestinal delivery device
US6764697B1 (en) * 1991-06-27 2004-07-20 Alza Corporation System for delaying drug delivery up to seven hours
US5993860A (en) * 1993-06-17 1999-11-30 Venture Lending NSADI delivery employing a powdered hydrocolloid gum obtainable from higher plants
DE4406424A1 (de) * 1994-02-28 1995-08-31 Bayer Ag Expandierbare Arzneiformen
US5560928A (en) * 1995-06-23 1996-10-01 Defelice; Stephen L. Nutritional and/or dietary composition and method of using the same
US5789014A (en) * 1995-12-25 1998-08-04 Shin-Etsu Chemical Co., Ltd. Method of manufacturing a solid preparation coated with non-solvent coating
US5891474A (en) * 1997-01-29 1999-04-06 Poli Industria Chimica, S.P.A. Time-specific controlled release dosage formulations and method of preparing same
US5788987A (en) * 1997-01-29 1998-08-04 Poli Industria Chimica Spa Methods for treating early morning pathologies
GB9710699D0 (en) 1997-05-24 1997-07-16 Danbiosyst Uk Gastro-retentive controlled release system
SE9702533D0 (sv) * 1997-07-01 1997-07-01 Astra Ab New oral formulation
US6607751B1 (en) * 1997-10-10 2003-08-19 Intellipharamaceutics Corp. Controlled release delivery device for pharmaceutical agents incorporating microbial polysaccharide gum
AP1224A (en) 1998-03-19 2003-11-14 Bristol Myers Squibb Co Biphasic controlled release delivery system for high solubility pharmaceuticals and method.
KR100296413B1 (ko) * 1998-04-01 2001-11-14 김선진 세파클러함유서방성정제
ES2249816T3 (es) * 1998-07-30 2006-04-01 Merck Sante Pastilla para la liberacion extendida de un farmaco en el estomago.
DE19850309A1 (de) * 1998-10-30 2000-05-04 Lohmann Therapie Syst Lts Expandierbares gastroretensives Therapiesystem mit verlängerter Magenverweildauer
FR2797185B1 (fr) * 1999-08-06 2001-10-26 Galenix Dev Composition pharmaceutique flottante comprenant une phase active et une phase non active
PT1251832E (pt) * 2000-02-04 2007-01-31 Depomed Inc Forma de dosagem constituída por invólucro-e-núcleo que conduz a uma libertação do fármaco de ordem zero
AU2001232020A1 (en) * 2000-02-09 2001-08-20 West Pharmaceutical Services Drug Delivery And Clinical Research Centre Limited Floating drug delivery composition
CA2397832C (en) * 2000-02-10 2009-11-03 Bpsi Holdings, Inc. Acrylic enteric coating compositions
DE10014588A1 (de) 2000-03-27 2001-10-04 Basf Ag Wirkstoffhaltige Schwimmformen enthaltend Polyvinylacetat und Polyvinylpyrrolidon, deren Verwendung und Herstellung
DE10031043A1 (de) * 2000-06-26 2002-02-14 Bayer Ag Retardzubereitungen von Chinolonantibiotika und Verfahren zu ihrer Herstellung
US6491950B1 (en) * 2000-08-07 2002-12-10 Kos Pharmaceuticals, Inc. Controlled release pharmaceutical composition
US20110171296A1 (en) * 2000-10-30 2011-07-14 Biohit Oyj Method and preparation for binding acetaldehyde in saliva, the stomach and the large intestine
FI121528B (fi) * 2000-10-30 2010-12-31 Biohit Oyj Farmaseuttinen koostumus syöpään sairastumisen riskin vähentämiseen paikallisesti sitomalla asetaldehydi syljessä, mahalaukussa tai paksusuolessa
AU2002252364B2 (en) * 2001-03-13 2005-08-25 Penwest Pharmaceuticals Co. Chronotherapeutic dosage forms
EP1245227A1 (en) * 2001-03-31 2002-10-02 Jagotec Ag A pharmaceutical tablet system that floats in the stomach for programmed release of active substance and process of producing buoyant material contained in same
CN1520286B (zh) * 2001-07-04 2010-12-01 太阳医药工业有限公司 胃滞留控制药物释出系统
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
FR2843117B1 (fr) 2002-07-30 2004-10-15 Flamel Tech Sa Polyaminoacides fonctionnalises par au moins un groupement hydrophobe et leurs applications notamment therapeutiques
JP2006506362A (ja) * 2002-10-11 2006-02-23 デポメド・ディベロップメント・リミテッド 胃内保持型レボドパデリバリー形態
US20040086566A1 (en) * 2002-11-04 2004-05-06 Alpharma, Inc. Waxy matrix dosage forms
WO2004112756A1 (en) * 2003-06-26 2004-12-29 Isa Odidi Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
AU2004273958A1 (en) * 2003-09-19 2005-03-31 Penwest Pharmaceuticals Co. Chronotherapeutic dosage forms
EA200600598A1 (ru) * 2003-09-19 2006-08-25 Пенвест Фармасьютикалз Ко. Лекарственные формы замедленного высвобождения
US20050175695A1 (en) 2003-11-25 2005-08-11 Catherine Castan Carvedilol free base, salts, anhydrous forms or solvates thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods
TW200533391A (en) 2004-03-25 2005-10-16 Sun Pharmaceutical Ind Ltd Gastric retention drug delivery system
ZA200701576B (en) * 2004-04-30 2008-09-25 Astellas Pharma Inc Time-limited release type granular pharmaceutical composition for oral administration and intraoral rapid disintegration tablet containing the composition
US8394409B2 (en) * 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US20060024361A1 (en) * 2004-07-28 2006-02-02 Isa Odidi Disintegrant assisted controlled release technology
DE102004040458B4 (de) * 2004-08-20 2009-01-29 Meinert, H., Prof. Dr. Glaskörpertamponadepräparat und seine Verwendung
US10624858B2 (en) * 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
DE102004042139B4 (de) * 2004-08-31 2009-06-10 Aristocon Verwaltungs- Gmbh Perorale Darreichungsformen zur Erzielung eines Retardierungseffektes nach der Arzneimitteleinnahme mit einer Mahlzeit
FR2878159B1 (fr) * 2004-11-24 2008-10-17 Flamel Technologies Sa Medicament oral a liberation modifiee d'au moins un principe actif sous forme multimicrocapsulaire
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
US20190083399A9 (en) * 2006-04-03 2019-03-21 Isa Odidi Drug delivery composition
US9561188B2 (en) 2006-04-03 2017-02-07 Intellipharmaceutics Corporation Controlled release delivery device comprising an organosol coat
US10960077B2 (en) * 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
US20110171275A1 (en) * 2007-08-20 2011-07-14 Team Academy Of Pharmaceutical Science Gastroretentive drug delivery system, preparation method and use thereof
WO2010020098A1 (zh) 2008-08-18 2010-02-25 北京天衡药物研究院 胃滞留药物释出系统及其制备方法和用途
EP2133071A1 (en) * 2008-06-09 2009-12-16 Université de la Méditerranée Process for making gastroretentive dosage forms
US9901551B2 (en) 2009-04-20 2018-02-27 Ambra Bioscience Llc Chemosensory receptor ligand-based therapies
EP2421524B1 (en) 2009-04-20 2018-08-08 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
US8828953B2 (en) * 2009-04-20 2014-09-09 NaZura BioHealth, Inc. Chemosensory receptor ligand-based therapies
FR2945947B1 (fr) 2009-05-29 2011-07-29 Flamel Tech Sa Compositions pharmaceutiques flottantes a liberation controlee
DE102009024949B3 (de) 2009-06-11 2011-02-24 Andrä, Wilfried, Prof. Dr. Anordnung zur ferngesteuerten Wirkstoff-Freisetzung
WO2011004799A1 (ja) 2009-07-06 2011-01-13 杏林製薬株式会社 中空構造を有する錠剤
FR2949061B1 (fr) * 2009-08-12 2013-04-19 Debregeas Et Associes Pharma Microgranules flottants
MX2013004364A (es) 2010-10-19 2013-07-02 Elcelyx Therapeutics Inc Terapias a base de ligando del receptor quimiosensorial.
EP2444064A1 (en) * 2010-10-22 2012-04-25 Meliatys Process for making multiparticulate gastroretentive dosage forms
EP3763419A1 (en) 2011-01-07 2021-01-13 Anji Pharma (US) LLC Chemosensory receptor ligand-based therapies
WO2013158928A2 (en) 2012-04-18 2013-10-24 Elcelyx Therapeutics, Inc. Chemosensory receptor ligand-based therapies
JP2016164149A (ja) * 2015-02-27 2016-09-08 尾木 大 コーティング剤組成物
CN109310653A (zh) 2016-03-17 2019-02-05 硫创治疗公司 用于控制释放半胱胺和系统治疗半胱胺敏感性病症的组合物
EP3445336B1 (en) * 2016-04-19 2020-10-28 CONARIS research institute AG Shellac microcapsule formulations and compositions
US10987311B2 (en) 2017-06-16 2021-04-27 Kashiv Specialty Pharmaceuticals, Llc Extended release compositions comprising pyridostigmine
EP3648747B1 (en) 2017-06-16 2022-09-07 Amneal Complex Products Research LLC Gastroretentive dosage forms for sustained drug delivery
US10588863B2 (en) 2017-06-16 2020-03-17 Kashiv Biosciences, Llc Extended release compositions comprising pyridostigmine
CA3076392A1 (en) 2017-09-20 2019-03-28 Thiogenesis Therapeutics, Inc. Methods for the treatment of cysteamine sensitive disorders
US11337919B2 (en) * 2017-12-18 2022-05-24 Tris Pharma, Inc. Modified release drug powder composition comprising gastro-retentive RAFT forming systems having trigger pulse drug release
WO2019126215A1 (en) 2017-12-18 2019-06-27 Tris Pharma, Inc. Ghb pharmaceutical compositions comprising a floating interpenetrating polymer network forming system
EP3609472B1 (en) 2018-06-18 2020-12-30 Kashiv Specialty Pharmaceuticals, LLC Extended release compositions comprising pyridostigmine
EP3970701A1 (en) 2018-06-27 2022-03-23 Amneal Complex Products Research LLC Self-regulating osmotic gastroretentive drug delivery systems
US20240016745A1 (en) * 2020-12-08 2024-01-18 Towa Pharmaceutical Co., Ltd. Timed-elution masking particles and oral pharmaceutical composition containing the same
WO2023214018A1 (en) 2022-05-06 2023-11-09 Galenix Innovations Gastro-retentive swellable sustained release composition

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3667929A (en) * 1969-07-30 1972-06-06 George W Fleming Jr Method of effecting dissolution of solutes in water and compositions therefor
GB1566609A (en) * 1977-03-10 1980-05-08 Reckitt & Colmann Prod Ltd Pharmaceutical compositions containing cholestyramine and alginic acid
US4101650A (en) * 1977-04-06 1978-07-18 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Pepstatin floating minicapsules
JPS5911563B2 (ja) * 1980-02-27 1984-03-16 日本原子力研究所 多層構造の徐放性複合体を製造する方法
JPS57171428A (en) * 1981-04-13 1982-10-22 Sankyo Co Ltd Preparation of coated solid preparation
IE56151B1 (en) * 1983-10-20 1991-05-08 Elan Corp Plc Tablet formulation
US4600645A (en) * 1985-01-31 1986-07-15 Warner-Lambert Company Process for treating dosage forms

Also Published As

Publication number Publication date
ATE68969T1 (de) 1991-11-15
CA1288697C (en) 1991-09-10
GR3003031T3 (en) 1993-02-17
US4844905A (en) 1989-07-04
EP0235718A3 (en) 1988-02-24
DE3774148D1 (de) 1991-12-05
EP0235718B1 (en) 1991-10-30
EP0235718A2 (en) 1987-09-09
KR910004578B1 (ko) 1991-07-06
JPS62195323A (ja) 1987-08-28
ES2051698T3 (es) 1994-07-01

Similar Documents

Publication Publication Date Title
KR870007696A (ko) 위내 체류형 과립
KR960703024A (ko) 질내 전달계(intravaginal delivery system)
KR870002832A (ko) 제약 조성물
PE20061160A1 (es) Sistema de administracion de farmacos con retencion gastrica
ATE37836T1 (de) Koextrudierte mehrschichtbahn und daraus hergestellte etiketthuelse.
MX9307847A (es) Materiales de espuma polimericos, relativamente delgados, no expandidos, pero expandibles al contacto con los fluidos acuosos del cuerpo, proceso para su preparacion y articulos absorbentes que los incluyen.
BR9806174A (pt) Péletes tendo um núcleo revestido com um antifúngico e um polìmero
AU6541786A (en) Process for producing an administration or dosage form of drugs, reagents or other active ingredients
CA2172887A1 (en) Foamed polymer and process for production thereof
KR850002954A (ko) 젤라틴 캡슐
MX10086A (es) Un sistema para la administracion de substancias activas no solubles en agua y procedimiento para su preparacion.
CA2208575A1 (en) Absorbent foams made from high internal phase emulsions useful for acquiring aqueous fluids
KR900700081A (ko) 부양성 경구용 투약 치료 기제(浮揚性 經口用 投藥 治療 基劑)
KR880009639A (ko) 서방성 매트릭스 제형
ATE33103T1 (de) Mikrokapseln deren abgabe langfristig kontrolliert wird.
KR900017572A (ko) 필름 피복 정제
RU2001114501A (ru) Расширяющаяся гастроретенционная терапевтическая система с длительным временем пребывания в желудке
ATE158177T1 (de) Sol-gesteuerte thermokolloidmatrix auf gelatine basis für perorale retardformen
PE84399A1 (es) Formas de dosificacion de sertralina de liberacion retardada
KR910004177A (ko) 발포성 제제 조성물
KR840000234A (ko) (n-아세틸-파라-아미노페놀)-제산제 조성물
KR890011588A (ko) 간 섬유증 억제제
IE44736L (en) Vaginal ring.
KR920019365A (ko) 디리트로마이신을 함유하는 약학 제형
PT946150E (pt) Preparado oral que contem numa matriz que pode intumescer-se num meio aquoso pelo menos uma substancia activa farmaceutica

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 19960704

Year of fee payment: 6

LAPS Lapse due to unpaid annual fee