DE3175137D1 - Method of making intrauterine devices - Google Patents

Method of making intrauterine devices

Info

Publication number
DE3175137D1
DE3175137D1 DE8181201409T DE3175137T DE3175137D1 DE 3175137 D1 DE3175137 D1 DE 3175137D1 DE 8181201409 T DE8181201409 T DE 8181201409T DE 3175137 T DE3175137 T DE 3175137T DE 3175137 D1 DE3175137 D1 DE 3175137D1
Authority
DE
Germany
Prior art keywords
drug
attachment
silicone rubber
sleeve
fillerless
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8181201409T
Other languages
German (de)
Inventor
Dale N Robertson
John Braun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Population Council Inc
Original Assignee
Population Council Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Population Council Inc filed Critical Population Council Inc
Application granted granted Critical
Publication of DE3175137D1 publication Critical patent/DE3175137D1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F6/00—Contraceptive devices; Pessaries; Applicators therefor
    • A61F6/06—Contraceptive devices; Pessaries; Applicators therefor for use by females
    • A61F6/14—Contraceptive devices; Pessaries; Applicators therefor for use by females intra-uterine type
    • A61F6/142—Wirelike structures, e.g. loops, rings, spirals
    • A61F6/144—Wirelike structures, e.g. loops, rings, spirals with T-configuration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0039—Devices retained in the uterus for a prolonged period, e.g. intrauterine devices for contraception

Landscapes

  • Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Accessories And Tools For Shearing Machines (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

A medicated intrauterine device includes a preexisting contraceptive intrauterine platform (11) and an attachment (15) formed as a cylindrical sleeve (16) of base polymer containing a drug such as an antifertility agent. Local controlled release administration of the drug is added to the contraceptive effect of the preexisting platform. The attachment (15) can be made by centrifuging a medical grade of room temperature vulcanizing silicone rubber to remove reinforcing fillers therefrom. A selected quantity of the drug is mixed into the fillerless silicone rubber, and the drug and silicone mixture is injected into a multicavity mold. After the mixture sets and the sleeves (16) are removed from the mold, the sleeves are trimmed, then swollen by immersion in a solvent, and slipped onto the stem (12). An outer covering (17) over the sleeve (16) can control the drug release rate and impart greater strength to the fillerless silicone rubber of the attachment (15). The outer covering (17) can be a tube likewise swollen and slipped onto the sleeve (16) to tightly shrink thereon.
DE8181201409T 1981-12-30 1981-12-30 Method of making intrauterine devices Expired DE3175137D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP81201409A EP0082894B1 (en) 1981-12-30 1981-12-30 Method of making intrauterine devices

Publications (1)

Publication Number Publication Date
DE3175137D1 true DE3175137D1 (en) 1986-09-18

Family

ID=8188181

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8181201409T Expired DE3175137D1 (en) 1981-12-30 1981-12-30 Method of making intrauterine devices

Country Status (3)

Country Link
EP (1) EP0082894B1 (en)
AT (1) ATE21331T1 (en)
DE (1) DE3175137D1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI913025A0 (en) * 1991-06-20 1991-06-20 Huhtamaeki Oy ANORDNING FOER INTRA-UTERINT BRUK.
DE4125575C2 (en) * 1991-08-02 1997-10-02 Piening Wolf Dietrich Dr Med Intrauterine device
FI95768C (en) * 1993-06-17 1996-03-25 Leiras Oy Intravaginal dosing system
DE19846129C1 (en) * 1998-10-07 1999-12-02 Brouwers Michel Reproducing scaled copies of original objects
WO2015189853A1 (en) 2014-06-13 2015-12-17 Meril Endo Surgery Private Limited An intrauterine device

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3807395A (en) * 1965-12-06 1974-04-30 M Chaft Intra-uterine contraceptive devices
US4188951A (en) * 1972-08-17 1980-02-19 Alza Corporation Intrauterine system embracing selected copolymeric membranes for administering beneficial agent
US3913573A (en) * 1972-10-02 1975-10-21 Morton Gutnick Intrauterine contraceptive devices with plural parallel leg segments
US3898986A (en) * 1972-12-27 1975-08-12 Alza Corp Biotransformable intrauterine device
US3993058A (en) * 1974-08-21 1976-11-23 Alza Corporation Intrauterine device with seeker for finding the cervical os and housing member for fitting device in an inserter
NZ194468A (en) * 1979-08-13 1982-11-23 R Strickman Medicated foam apllicator

Also Published As

Publication number Publication date
EP0082894A1 (en) 1983-07-06
EP0082894B1 (en) 1986-08-13
ATE21331T1 (en) 1986-08-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition