KR950703938A - 하부소화관 방출성의 경구의약제제(oral pharmaceutlcal preparation releasable in the lower digestive tract) - Google Patents
하부소화관 방출성의 경구의약제제(oral pharmaceutlcal preparation releasable in the lower digestive tract) Download PDFInfo
- Publication number
- KR950703938A KR950703938A KR1019950701773A KR19950701773A KR950703938A KR 950703938 A KR950703938 A KR 950703938A KR 1019950701773 A KR1019950701773 A KR 1019950701773A KR 19950701773 A KR19950701773 A KR 19950701773A KR 950703938 A KR950703938 A KR 950703938A
- Authority
- KR
- South Korea
- Prior art keywords
- digestive tract
- acid
- oral pharmaceutical
- lower digestive
- pharmaceutical preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
Abstract
본 발명은 활성성분을 함유하는 핵으로 이루어진 고형약제를 양이온성폴리머로 이루어진 내부층, 음이온성 폴리머로 이루어진 외부층을 각각 피복해서 이루어진 2중피복구조를 가진 것을 특징으로 하는 하부소화관방출성의 경구의약제제.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 인비트로에 의한 약물의 방출성 시험을 표시한 그래프,
제2도는 인비보에 의한 약물의 혈중농도시험을 표시한 그래프,
제3도는 인비트로에 의한 코팅중량변화에 대한 방출성시험을 표시한 그래프,
제4도는 pH변화에 대한 케트프로펜의 방출성 시험을 표시한 그래프,
제5도는 pH변화에 대한 FITC덱스트란의 방출성시험을 표시한 그래프.
Claims (7)
- 활성성분을 하유하는 핵으로 이루어진 고형약제를, 양이온성폴리머로 이루어진 내부층, 음이온성 폴리머로 이루어진 외부층을 각각 피복해서 이루어진 2중피복구조를 가진 것을 특징으로 하는 하부소화관방출성의 경구의약제제.
- 제1항에 있어서, 상기 핵이 흡수촉진제를 함유하는 것을 특징으로 하는 하부소화관 방출성의 경구의약제제.
- 제2항에 있어서, 상기 흡수촉진제가 슈거에스테르, 자당지방산에스테르, 글리실리진산염, 글리틸레틴산, 글리틸리틴산디칼륨, 담즙산, 글리세린지방산에스테르, 1-〔2-(데실티오)에틸〕아자시클로 펜탄2-온, 아디핀산, 염기성아미노산, 폴리에틸렌글리콜, 카프린산나트륨로부터 선택되는 것을 특징으로 하는 하부소화관방출성의 경구의약제제.
- 제1항에 있어서, 상기 양이온성폴리머가, pH6.0이하에서 가용성 또는 팽윤성을 표시하는 아미노알킬메타아크릴레이트코폴리머 또는 폴리비닐아세탈디에틸아미노아세테이트인 것을 특징으로 하는 하부소화관방출성의 경구의약제제.
- 제1항에 있어서, 상기 음이온성폴리머가, pH5.5이하에서 용해하는 메타아크릴산코폴리머L, 메타아크릴산코폴리머S, 히드록시프로필메틸셀룰로스, 히드록시에틸셀룰로스프달레이트, 폴리비닐아세테이트프탈레에트, 셀룰로스아세테이트 및 셀룰로스아세테이트테트라히드로프탈레이트로 이루어진 군으로부터 선택되는 것을 특징으로 하는 하부소화관방출성의 경구의약제제.
- 제1항에 있어서, 상기 소화관내의 pH7.0∼5.5범위이하로 변화하는 하부소화관내에 있어서 붕괴흡수하는 것을 특징으로 하는 하부소화관방출성의 경구의약제제.
- 제1항에 있어서, 상기 활성성분이 펩타이드, 담백질, 항염증제, 항종양제, 항생물질 및 화학료법제로 이루어진 군으로부터 선택되는 것을 특징으로 하는 하부소화관방출성의 경구의약제제.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP92-322478 | 1992-11-06 | ||
JP32247892 | 1992-11-06 | ||
PCT/JP1993/001608 WO1994010983A1 (en) | 1992-11-06 | 1993-11-05 | Peroral pharmaceutical preparation releasable in lower digestive tract |
Publications (2)
Publication Number | Publication Date |
---|---|
KR950703938A true KR950703938A (ko) | 1995-11-17 |
KR0157280B1 KR0157280B1 (ko) | 1998-11-16 |
Family
ID=18144084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019950701773A KR0157280B1 (ko) | 1992-11-06 | 1993-11-05 | 하부소화관 방출성의 경구의약제제 |
Country Status (9)
Country | Link |
---|---|
US (1) | US5654004A (ko) |
EP (1) | EP0667148B1 (ko) |
KR (1) | KR0157280B1 (ko) |
AU (1) | AU5376894A (ko) |
CA (1) | CA2148465C (ko) |
DE (1) | DE69332082T2 (ko) |
DK (1) | DK0667148T3 (ko) |
ES (1) | ES2176209T3 (ko) |
WO (1) | WO1994010983A1 (ko) |
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JPH11246439A (ja) * | 1998-03-02 | 1999-09-14 | Hisamitsu Pharmaceut Co Inc | 経粘膜用吸収促進剤 |
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-
1993
- 1993-11-05 AU AU53768/94A patent/AU5376894A/en not_active Abandoned
- 1993-11-05 CA CA002148465A patent/CA2148465C/en not_active Expired - Fee Related
- 1993-11-05 EP EP93924185A patent/EP0667148B1/en not_active Expired - Lifetime
- 1993-11-05 KR KR1019950701773A patent/KR0157280B1/ko not_active IP Right Cessation
- 1993-11-05 ES ES93924185T patent/ES2176209T3/es not_active Expired - Lifetime
- 1993-11-05 WO PCT/JP1993/001608 patent/WO1994010983A1/ja active IP Right Grant
- 1993-11-05 DE DE69332082T patent/DE69332082T2/de not_active Expired - Fee Related
- 1993-11-05 US US08/432,202 patent/US5654004A/en not_active Expired - Fee Related
- 1993-11-05 DK DK93924185T patent/DK0667148T3/da active
Also Published As
Publication number | Publication date |
---|---|
EP0667148A1 (en) | 1995-08-16 |
EP0667148B1 (en) | 2002-07-03 |
KR0157280B1 (ko) | 1998-11-16 |
WO1994010983A1 (en) | 1994-05-26 |
ES2176209T3 (es) | 2002-12-01 |
CA2148465A1 (en) | 1994-05-26 |
EP0667148A4 (en) | 1997-02-26 |
CA2148465C (en) | 1999-11-02 |
AU5376894A (en) | 1994-06-08 |
US5654004A (en) | 1997-08-05 |
DE69332082T2 (de) | 2003-02-06 |
DE69332082D1 (de) | 2002-08-08 |
DK0667148T3 (da) | 2002-07-22 |
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