WO2008117814A1 - 大腸送達用経口製剤 - Google Patents

大腸送達用経口製剤 Download PDF

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Publication number
WO2008117814A1
WO2008117814A1 PCT/JP2008/055652 JP2008055652W WO2008117814A1 WO 2008117814 A1 WO2008117814 A1 WO 2008117814A1 JP 2008055652 W JP2008055652 W JP 2008055652W WO 2008117814 A1 WO2008117814 A1 WO 2008117814A1
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WIPO (PCT)
Prior art keywords
pharmaceutical preparation
oral pharmaceutical
colon
drug
specific delivery
Prior art date
Application number
PCT/JP2008/055652
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English (en)
French (fr)
Inventor
Hiroyuki Kubo
Original Assignee
Teikoku Seiyaku Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Seiyaku Co., Ltd. filed Critical Teikoku Seiyaku Co., Ltd.
Priority to JP2009506354A priority Critical patent/JPWO2008117814A1/ja
Priority to CN200880017544A priority patent/CN101677958A/zh
Priority to US12/450,438 priority patent/US20100209520A1/en
Priority to CA002684655A priority patent/CA2684655A1/en
Priority to EP08738876.5A priority patent/EP2143424A4/en
Priority to AU2008230364A priority patent/AU2008230364A1/en
Publication of WO2008117814A1 publication Critical patent/WO2008117814A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

　本発明は、優れた大腸への薬物送達能を有する経口製剤に関し、より詳しくは、本発明は、薬物を大腸に送達するための経口製剤であって、薬学的に許容可能な賦形剤から少なくともなる核と、該核を被覆する、薬物を含む内層と、該内層を被覆する、ｐＨ６．６以下で溶解または膨潤しうる陽イオン性ポリマーを含む中間層と、該中間層を被覆する、ｐＨ７．０以上で溶解しうる陰イオン性ポリマーを含む外層とを含んでなる、経口製剤に関する。
PCT/JP2008/055652 2007-03-26 2008-03-26 大腸送達用経口製剤 WO2008117814A1 (ja)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2009506354A JPWO2008117814A1 (ja) 2007-03-26 2008-03-26 大腸送達用経口製剤
CN200880017544A CN101677958A (zh) 2007-03-26 2008-03-26 用于结肠-特异性递送的口服药物制剂
US12/450,438 US20100209520A1 (en) 2007-03-26 2008-03-26 Oral pharmaceutical preparation for colon-specific delivery
CA002684655A CA2684655A1 (en) 2007-03-26 2008-03-26 Oral pharmaceutical preparation for colon-specific delivery
EP08738876.5A EP2143424A4 (en) 2007-03-26 2008-03-26 ORAL PHARMACEUTICAL PREPARATION FOR SPECIFIC DELIVERY TO THE COLON
AU2008230364A AU2008230364A1 (en) 2007-03-26 2008-03-26 Oral pharmaceutical preparation for colon-specific delivery

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90723007P 2007-03-26 2007-03-26
US60/907,230 2007-03-26

Publications (1)

Publication Number Publication Date
WO2008117814A1 true WO2008117814A1 (ja) 2008-10-02

Family

ID=39788547

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/055652 WO2008117814A1 (ja) 2007-03-26 2008-03-26 大腸送達用経口製剤

Country Status (8)

Country Link
US (1) US20100209520A1 (ja)
EP (1) EP2143424A4 (ja)
JP (1) JPWO2008117814A1 (ja)
KR (1) KR20090122489A (ja)
CN (1) CN101677958A (ja)
AU (1) AU2008230364A1 (ja)
CA (1) CA2684655A1 (ja)
WO (1) WO2008117814A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014529630A (ja) * 2011-09-07 2014-11-13 ザウラー−ブロシュ、ローラント 哺乳類の消化管における一つあるいは複数の物質の放出制御製剤
JP2016517425A (ja) * 2013-03-14 2016-06-16 セラバイオーム，エルエルシー プロバイオティクス生物及び／又は治療剤の標的化胃腸管デリバリー
JP2020534290A (ja) * 2017-09-20 2020-11-26 ティロッツ ファーマ アーゲーＴｉｌｌｏｔｔｓ Ｐｈａｒｍａ Ａｇ 溶液／懸濁液層状化による抗体を含む固形剤形の調製
JP2022503581A (ja) * 2018-08-24 2022-01-12 ドクトル ファルク ファルマ ゲーエムベーハー 有効成分を遠位結腸で遅延放出する多層構造ペレット剤

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US10653631B2 (en) 2011-09-07 2020-05-19 Roland SAUR-BROSCH Optimal colon targeting technology
GB201202433D0 (en) 2012-02-13 2012-03-28 Diurnal Ltd Controlled drug release
BR112014024159A2 (pt) * 2012-03-29 2017-06-20 Therabiome Llc Formulações de vacina oral específicas do local gastrintestinal , ativas no íleo e apêndice.
RS56839B1 (sr) * 2012-04-30 2018-04-30 Tillotts Pharma Ag Formulacija leka sa odloženim otpuštanjem
US10799515B2 (en) 2013-10-29 2020-10-13 Tillotts Pharma Ag Delayed release drug formulation
US10182993B2 (en) 2015-04-06 2019-01-22 Patheon Softgels Inc. Compositions for colonic delivery of drugs
RU2018111690A (ru) 2015-09-11 2019-10-11 Сан Фармасьютикл Индастриз Лтд. Пероральная лекарственная форма будесонида
US20190111001A1 (en) * 2016-03-30 2019-04-18 University Of Maryland, Baltimore Microparticulate system for colonic drug delivery
US20180272042A1 (en) * 2017-03-22 2018-09-27 Brown University Drug-polymer film for controlled local delivery at tissue-device interface
KR102336720B1 (ko) * 2017-08-03 2021-12-08 주식회사 씨티씨바이오 유산균을 함유하는 장용성 과립 및 이의 제조방법
WO2019086427A1 (en) 2017-11-03 2019-05-09 Dsm Ip Assets B.V. New delivery system
IL303390A (en) 2020-12-03 2023-08-01 Battelle Memorial Institute Compositions of polymer nanoparticles and DNA nanostructures and methods for non-viral transport
AU2022253899A1 (en) 2021-04-07 2023-10-26 Battelle Memorial Institute Rapid design, build, test, and learn technologies for identifying and using non-viral carriers

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JPS6327424A (ja) * 1986-07-17 1988-02-05 Shionogi & Co Ltd 徐放性製剤およびその製造法
JPS63301816A (ja) * 1987-01-29 1988-12-08 Takeda Chem Ind Ltd 有核顆粒およびその製造法
JP2967492B2 (ja) 1989-05-11 1999-10-25 中外製薬株式会社 腸内適所放出経口製剤
WO1994010983A1 (en) * 1992-11-06 1994-05-26 Hisamitsu Pharmaceutical Co., Inc. Peroral pharmaceutical preparation releasable in lower digestive tract
JP2821952B2 (ja) 1992-11-06 1998-11-05 久光製薬株式会社 下部消化管放出性の経口医薬製剤
JPH0710745A (ja) * 1993-06-22 1995-01-13 Tanabe Seiyaku Co Ltd 放出開始時間制御型腸デリバリー経口製剤
JP3185206B2 (ja) 1995-07-20 2001-07-09 田辺製薬株式会社 消化管下部放出型被覆カプセル製剤
JP2002080398A (ja) * 2000-07-14 2002-03-19 Roberto Valducci ｐＨに依存する多相的な放出を伴う経口用の固体の薬学的組成物

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* Cited by examiner, † Cited by third party
Title
See also references of EP2143424A4

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014529630A (ja) * 2011-09-07 2014-11-13 ザウラー−ブロシュ、ローラント 哺乳類の消化管における一つあるいは複数の物質の放出制御製剤
JP2018065846A (ja) * 2011-09-07 2018-04-26 ザウラー−ブロシュ、ローラント 哺乳類の消化管における一つあるいは複数の物質の放出制御製剤
JP2016517425A (ja) * 2013-03-14 2016-06-16 セラバイオーム，エルエルシー プロバイオティクス生物及び／又は治療剤の標的化胃腸管デリバリー
JP2019077705A (ja) * 2013-03-14 2019-05-23 セラバイオーム，エルエルシー プロバイオティクス生物及び／又は治療剤の標的化胃腸管デリバリー
JP2020534290A (ja) * 2017-09-20 2020-11-26 ティロッツ ファーマ アーゲーＴｉｌｌｏｔｔｓ Ｐｈａｒｍａ Ａｇ 溶液／懸濁液層状化による抗体を含む固形剤形の調製
JP7204743B2 (ja) 2017-09-20 2023-01-16 ティロッツ ファーマ アーゲー 溶液／懸濁液層状化による抗体を含む固形剤形の調製
JP2023036901A (ja) * 2017-09-20 2023-03-14 ティロッツ ファーマ アーゲー 溶液／懸濁液層状化による抗体を含む固形剤形の調製
JP2022503581A (ja) * 2018-08-24 2022-01-12 ドクトル ファルク ファルマ ゲーエムベーハー 有効成分を遠位結腸で遅延放出する多層構造ペレット剤
JP7374992B2 (ja) 2018-08-24 2023-11-07 ドクトル ファルク ファルマ ゲーエムベーハー 有効成分を遠位結腸で遅延放出する多層構造ペレット剤

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EP2143424A4 (en) 2013-07-31
EP2143424A1 (en) 2010-01-13
JPWO2008117814A1 (ja) 2010-07-15
AU2008230364A1 (en) 2008-10-02
CN101677958A (zh) 2010-03-24
US20100209520A1 (en) 2010-08-19
KR20090122489A (ko) 2009-11-30
CA2684655A1 (en) 2008-10-02

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