KR950014745B1 - 자동 면역 측정장치 및 그 측정방법 - Google Patents
자동 면역 측정장치 및 그 측정방법 Download PDFInfo
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- KR950014745B1 KR950014745B1 KR1019910005148A KR910005148A KR950014745B1 KR 950014745 B1 KR950014745 B1 KR 950014745B1 KR 1019910005148 A KR1019910005148 A KR 1019910005148A KR 910005148 A KR910005148 A KR 910005148A KR 950014745 B1 KR950014745 B1 KR 950014745B1
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- Y10T436/114998—Automated chemical analysis with conveyance of sample along a test line in a container or rack with treatment or replacement of aspirator element [e.g., cleaning, etc.]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/11—Automated chemical analysis
- Y10T436/119163—Automated chemical analysis with aspirator of claimed structure
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP80993/90 | 1990-03-30 | ||
| JP8099390 | 1990-03-30 | ||
| JP11901090 | 1990-05-09 | ||
| JP119010/90 | 1990-05-09 | ||
| JP166756/90 | 1990-06-27 | ||
| JP16675690 | 1990-06-27 | ||
| JP91567/90 | 1990-09-03 | ||
| JP9156790U JP2507121Y2 (ja) | 1990-09-03 | 1990-09-03 | 自動酵素免疫測定装置の光学測定装置 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR950014745B1 true KR950014745B1 (ko) | 1995-12-14 |
Family
ID=27466507
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019910005148A Expired - Lifetime KR950014745B1 (ko) | 1990-03-30 | 1991-03-30 | 자동 면역 측정장치 및 그 측정방법 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US5158895A (enExample) |
| EP (1) | EP0449321B1 (enExample) |
| KR (1) | KR950014745B1 (enExample) |
| AU (2) | AU640762B2 (enExample) |
| CA (1) | CA2039322C (enExample) |
| DE (1) | DE69130303T2 (enExample) |
| ES (1) | ES2124691T3 (enExample) |
| TW (1) | TW199858B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180087667A (ko) * | 2017-01-25 | 2018-08-02 | 메디엇 주식회사 | 화합물 분리장치 및 이를 이용한 화학발광 면역검정장치 |
Families Citing this family (162)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9020352D0 (en) * | 1990-09-18 | 1990-10-31 | Anagen Ltd | Assay or reaction apparatus |
| US6436349B1 (en) | 1991-03-04 | 2002-08-20 | Bayer Corporation | Fluid handling apparatus for an automated analyzer |
| CA2050121C (en) | 1991-03-04 | 2005-04-19 | Glen A. Carey | Automated analyzer |
| US6498037B1 (en) | 1991-03-04 | 2002-12-24 | Bayer Corporation | Method of handling reagents in a random access protocol |
| US5877028A (en) | 1991-05-29 | 1999-03-02 | Smithkline Diagnostics, Inc. | Immunochromatographic assay device |
| US5998220A (en) | 1991-05-29 | 1999-12-07 | Beckman Coulter, Inc. | Opposable-element assay devices, kits, and methods employing them |
| US6168956B1 (en) | 1991-05-29 | 2001-01-02 | Beckman Coulter, Inc. | Multiple component chromatographic assay device |
| US5282149A (en) * | 1991-06-03 | 1994-01-25 | Abbott Laboratories | Adaptive scheduling system and method for a biological analyzer with reproducible operation time periods |
| US5289385A (en) * | 1991-06-03 | 1994-02-22 | Abbott Laboratories | Adaptive scheduling system and method for operating a biological sample analyzer with variable rinsing |
| US5366896A (en) * | 1991-07-30 | 1994-11-22 | University Of Virginia Alumni Patents Foundation | Robotically operated laboratory system |
| US6190617B1 (en) | 1992-03-27 | 2001-02-20 | Abbott Laboratories | Sample container segment assembly |
| US5507410A (en) | 1992-03-27 | 1996-04-16 | Abbott Laboratories | Meia cartridge feeder |
| US5610069A (en) | 1992-03-27 | 1997-03-11 | Abbott Laboratories | Apparatus and method for washing clinical apparatus |
| US5376313A (en) | 1992-03-27 | 1994-12-27 | Abbott Laboratories | Injection molding a plastic assay cuvette having low birefringence |
| US5646049A (en) | 1992-03-27 | 1997-07-08 | Abbott Laboratories | Scheduling operation of an automated analytical system |
| US5635364A (en) | 1992-03-27 | 1997-06-03 | Abbott Laboratories | Assay verification control for an automated analytical system |
| US5536471A (en) | 1992-03-27 | 1996-07-16 | Abbott Laboratories | Syringe with bubble flushing |
| US5575978A (en) | 1992-03-27 | 1996-11-19 | Abbott Laboratories | Sample container segment assembly |
| US5578494A (en) | 1992-03-27 | 1996-11-26 | Abbott Laboratories | Cap actuator for opening and closing a container |
| US5627522A (en) | 1992-03-27 | 1997-05-06 | Abbott Laboratories | Automated liquid level sensing system |
| AU3929093A (en) * | 1992-03-27 | 1993-11-08 | Abbott Laboratories | Automated continuous and random access analytical system and components thereof |
| US5960160A (en) | 1992-03-27 | 1999-09-28 | Abbott Laboratories | Liquid heater assembly with a pair temperature controlled electric heating elements and a coiled tube therebetween |
| WO1993020449A1 (en) * | 1992-03-27 | 1993-10-14 | Perseptive Biosystems, Inc. | Rapid hypersensitive flowthrough immunodetection system |
| US5605665A (en) | 1992-03-27 | 1997-02-25 | Abbott Laboratories | Reaction vessel |
| US5540890A (en) | 1992-03-27 | 1996-07-30 | Abbott Laboratories | Capped-closure for a container |
| EP1537915A3 (en) * | 1992-03-27 | 2006-05-24 | Abbott Laboratories | Reaction vessel |
| JP2561367Y2 (ja) * | 1992-04-03 | 1998-01-28 | 東亞医用電子株式会社 | 試料吸排装置 |
| JP2745091B2 (ja) * | 1992-04-03 | 1998-04-28 | 東亞医用電子株式会社 | 免疫凝集測定装置 |
| US5397539A (en) * | 1992-04-23 | 1995-03-14 | Toray Industries, Inc. | Automatic analyzing apparatus |
| DE4313807C2 (de) * | 1992-04-28 | 1995-03-09 | Olympus Optical Co | Reagenz-Container-System für die immunologische Analyse einer Probe in einem automatischen Analysiergerät |
| FI922004A7 (fi) * | 1992-05-04 | 1993-11-05 | Wallac Oy | Mittausmenetelmä ja mittauslaite |
| JP2844264B2 (ja) * | 1992-07-01 | 1999-01-06 | ベーリング ダイアグノスティックス,インコーポレーテッド | 流体試料保持トレー移送アセンブリを備えた自動化分析器械 |
| FR2695729B1 (fr) * | 1992-09-11 | 1994-11-04 | Biotrol Sa Lab | Appareil automatique de dosage immunologique. |
| US5681530A (en) * | 1993-06-11 | 1997-10-28 | Ortho Diagnostic Systems Inc. | Transport system for fluid analysis instrument |
| US5578269A (en) * | 1993-06-11 | 1996-11-26 | Ortho Diagnostic Systems Inc. | Automated blood analysis system with an integral centrifuge |
| JP3347407B2 (ja) * | 1993-08-17 | 2002-11-20 | シスメックス株式会社 | 試料容器回転装置 |
| US5374395A (en) * | 1993-10-14 | 1994-12-20 | Amoco Corporation | Diagnostics instrument |
| US5948360A (en) | 1994-07-11 | 1999-09-07 | Tekmar Company | Autosampler with robot arm |
| EP0770212A1 (en) * | 1994-07-11 | 1997-05-02 | Tekmar Company | Modular vial autosampler |
| US5589137A (en) * | 1995-04-07 | 1996-12-31 | Lab-Interlink, Inc. | Specimen carrier |
| US5567386A (en) * | 1995-04-07 | 1996-10-22 | Board Of Regents- Univ. Of Ne | Elevator and speciman carrier for automated conveyor system |
| US5772962A (en) * | 1995-05-29 | 1998-06-30 | Hitachi, Ltd. | Analyzing apparatus using disposable reaction vessels |
| US6025149A (en) * | 1995-07-07 | 2000-02-15 | Yale University | Urinary screening for down syndrome and other aneuploidies |
| EP2259070A3 (en) * | 1995-07-31 | 2011-03-30 | Precision System Science Co., Ltd. | Container |
| DE69638151D1 (de) * | 1996-05-20 | 2010-04-29 | Prec System Science Co Ltd | Prozess und apparat zur kontrolle magnetischer teilchen mit hilfe einer pipettier-maschine |
| WO1997047388A1 (en) * | 1996-06-11 | 1997-12-18 | Dilux, Inc. | Multichannel dilution reservoir |
| US5885529A (en) * | 1996-06-28 | 1999-03-23 | Dpc Cirrus, Inc. | Automated immunoassay analyzer |
| US5798263A (en) * | 1996-09-05 | 1998-08-25 | Promega Corporation | Apparatus for quantifying dual-luminescent reporter assays |
| US5856194A (en) | 1996-09-19 | 1999-01-05 | Abbott Laboratories | Method for determination of item of interest in a sample |
| US5795784A (en) | 1996-09-19 | 1998-08-18 | Abbott Laboratories | Method of performing a process for determining an item of interest in a sample |
| US5798218A (en) * | 1996-09-24 | 1998-08-25 | University Of British Columbia Innovation And Development Corporation | Compositions and methods for the specific detection of thy-1 antigen |
| US6495195B2 (en) | 1997-02-14 | 2002-12-17 | Arcturus Engineering, Inc. | Broadband absorbing film for laser capture microdissection |
| JP3736007B2 (ja) * | 1997-03-03 | 2006-01-18 | 株式会社島津製作所 | マイクロチップ電気泳動装置 |
| FR2763396A1 (fr) * | 1997-05-15 | 1998-11-20 | Tosoh Corp | Appareil de dosage, et dispositif de support de recipients utilise avec ledit appareil |
| US5985214A (en) * | 1997-05-16 | 1999-11-16 | Aurora Biosciences Corporation | Systems and methods for rapidly identifying useful chemicals in liquid samples |
| ES2150339B1 (es) * | 1997-07-30 | 2001-06-01 | Grifols Grupo Sa | "maquina universal para analisis clinicos". |
| US7075640B2 (en) | 1997-10-01 | 2006-07-11 | Arcturus Bioscience, Inc. | Consumable for laser capture microdissection |
| ES2133129B1 (es) * | 1997-11-19 | 2000-05-01 | Grifols Grupo Sa | Aparato para la realizacion automatica de pruebas de laboratorio. |
| AR017411A1 (es) | 1997-11-19 | 2001-09-05 | Grifols Sa | Aparato para la realizacion automatica de pruebas de laboratorio |
| US6046585A (en) * | 1997-11-21 | 2000-04-04 | Quantum Design, Inc. | Method and apparatus for making quantitative measurements of localized accumulations of target particles having magnetic particles bound thereto |
| US7473401B1 (en) | 1997-12-04 | 2009-01-06 | Mds Analytical Technologies (Us) Inc. | Fluidic extraction of microdissected samples |
| JPH11183484A (ja) * | 1997-12-17 | 1999-07-09 | Olympus Optical Co Ltd | 自動分析装置 |
| US6184040B1 (en) | 1998-02-12 | 2001-02-06 | Polaroid Corporation | Diagnostic assay system and method |
| ID23862A (id) * | 1998-02-20 | 2000-05-25 | Scil Diagnotics Gmbh | Sistem analisis |
| US6146591A (en) * | 1998-05-01 | 2000-11-14 | Miller; C David | Biochemical detection system for rapid determination of the presence of toxins, bacteria, and other substances |
| EP2082806A3 (en) | 1998-05-01 | 2010-04-28 | Gen-Probe Incorporated | Automated diagnostic analyzer and method |
| US8337753B2 (en) | 1998-05-01 | 2012-12-25 | Gen-Probe Incorporated | Temperature-controlled incubator having a receptacle mixing mechanism |
| US6331437B1 (en) * | 1998-07-14 | 2001-12-18 | Bayer Corporation | Automatic handler for feeding containers into and out of an analytical instrument |
| CA2273729A1 (en) | 1998-07-14 | 2000-01-14 | Bayer Corporation | Robotics for transporting containers and objects within an automated analytical instrument and service tool for servicing robotics |
| FR2783321B1 (fr) * | 1998-09-11 | 2000-11-24 | Biotrol Diagnostic | Cuvettes de reaction, ensemble de telles cuvettes, appareil de dosage immunologique et procede mettant en oeuvre de tels ensembles de cuvettes |
| US6331715B1 (en) | 1998-10-14 | 2001-12-18 | Polaroid Corporation | Diagnostic assay system and method having a luminescent readout signal |
| US6555060B1 (en) | 1998-10-14 | 2003-04-29 | Polaroid Corporation | Apparatus for performing diagnostic testing |
| US6495373B1 (en) | 1998-10-14 | 2002-12-17 | Polaroid Corporation | Method and apparatus for performing diagnostic tests |
| US6328930B1 (en) | 1999-02-11 | 2001-12-11 | Polaroid Corporation | Apparatus for performing diagnostic testing |
| GB9922971D0 (en) * | 1999-09-29 | 1999-12-01 | Secr Defence | Reaction system |
| US6468809B1 (en) * | 2000-02-04 | 2002-10-22 | The United States Of America As Represented By The Secretary Of The Navy | High efficiency magnetic sensor for magnetic particles |
| AU2001259241A1 (en) * | 2000-04-26 | 2001-11-07 | Arcturus Engineering, Inc. | Laser capture microdissection (lcm) extraction device and device carrier and method for post-lcm fluid processing |
| ES2491192T3 (es) | 2000-04-28 | 2014-09-05 | Mitsubishi Chemical Medience Corporation | Método e instrumento de medida que usan un cartucho |
| US6746648B1 (en) * | 2000-06-15 | 2004-06-08 | Beckman Coulter, Inc. | Method and system for transporting and storing multiple reagent packs and reagent packs used therein |
| US6641782B1 (en) | 2000-11-15 | 2003-11-04 | Polaroid Corporation | Apparatus for performing diagnostic testing |
| US6518747B2 (en) | 2001-02-16 | 2003-02-11 | Quantum Design, Inc. | Method and apparatus for quantitative determination of accumulations of magnetic particles |
| US6825041B2 (en) | 2001-03-16 | 2004-11-30 | Beckman Coulter, Inc. | Method and system for automated immunochemistry analysis |
| GB0110476D0 (en) * | 2001-04-30 | 2001-06-20 | Secr Defence | Reagent delivery system |
| EP1390147A4 (en) * | 2001-05-03 | 2006-06-07 | Affymetrix Inc | SYSTEM AND METHOD FOR DEPOSITING HIGH-SPEED MICROARRAYSES |
| EP1440320B1 (en) * | 2001-10-01 | 2012-03-28 | Leica Biosystems Melbourne Pty Ltd | Processor for histological tissue specimen treatment |
| US6998270B2 (en) * | 2001-11-26 | 2006-02-14 | Lab Vision Corporation | Automated tissue staining system and reagent container |
| US20040033163A1 (en) * | 2001-11-26 | 2004-02-19 | Lab Vision Corporation | Automated tissue staining system and reagent container |
| ATE309544T1 (de) * | 2002-04-09 | 2005-11-15 | Cholestech Corp | Verfahren und vorrichtung zur quantifizierung von lipoprotein-cholesterol hoher dichte |
| US7238519B2 (en) * | 2002-06-07 | 2007-07-03 | Cholestech Corporation | Automated immunoassay cassette, apparatus and method |
| JP3765788B2 (ja) * | 2002-11-29 | 2006-04-12 | 照明 伊藤 | 検体分注システム |
| US8554372B2 (en) * | 2003-09-29 | 2013-10-08 | Leica Biosystems Melbourne Pty Ltd | System and method for histological tissue specimen processing |
| US7307718B2 (en) * | 2004-02-23 | 2007-12-11 | Ortho-Clinical Diagnostics, Inc. | Determining an analyte by multiple measurements through a cuvette |
| US20050185176A1 (en) * | 2004-02-23 | 2005-08-25 | Moran Donald J.Jr. | Determining an analyte by multiple measurements through a cuvette |
| EP1582875A1 (en) * | 2004-03-31 | 2005-10-05 | Boehringer Mannheim Gmbh | Analyser with a lift system |
| US8211386B2 (en) | 2004-06-08 | 2012-07-03 | Biokit, S.A. | Tapered cuvette and method of collecting magnetic particles |
| US7206667B2 (en) * | 2004-06-18 | 2007-04-17 | Siemens Medical Solutions Diagnostics | Robot alignment system and method |
| EP1759170B2 (en) * | 2004-06-23 | 2019-11-06 | Ecolab Inc. | Method for multiple dosage of liquid products, dosing appartus and dosing system |
| US7914737B2 (en) | 2004-07-01 | 2011-03-29 | Roche Molecular Systems, Inc. | Multi-level diagnostic apparatus with a lift system |
| US7473678B2 (en) | 2004-10-14 | 2009-01-06 | Biomimetic Therapeutics, Inc. | Platelet-derived growth factor compositions and methods of use thereof |
| EP2322940B1 (en) * | 2005-03-10 | 2014-10-29 | Gen-Probe Incorporated | Systems amd methods to perform assays for detecting or quantifing analytes within samples |
| JP5368102B2 (ja) | 2005-11-17 | 2013-12-18 | バイオミメティック セラピューティクス, インコーポレイテッド | rhPDGF−BB及び生体適合性マトリックスを用いた顎顔面骨強化 |
| AU2007212273B2 (en) | 2006-02-09 | 2013-10-10 | Stryker Corporation | Compositions and methods for treating bone |
| US9161967B2 (en) * | 2006-06-30 | 2015-10-20 | Biomimetic Therapeutics, Llc | Compositions and methods for treating the vertebral column |
| US9642891B2 (en) * | 2006-06-30 | 2017-05-09 | Biomimetic Therapeutics, Llc | Compositions and methods for treating rotator cuff injuries |
| FR2907905B1 (fr) * | 2006-10-30 | 2009-04-03 | C2 Diagnostics Sa | "appareil et procede pour manipuler des tubes,notamment appareil automate d'analyse sanguine" |
| AU2007333425B2 (en) | 2006-11-03 | 2014-03-27 | Stryker Corporation | Compositions and methods for arthrodetic procedures |
| DE602008002825D1 (de) * | 2007-01-09 | 2010-11-11 | Cholestech Corp | Vorrichtung und verfahren zur messung des ldl-assoziierten cholesterols |
| US20080195476A1 (en) * | 2007-02-09 | 2008-08-14 | Marchese Michael A | Abandonment remarketing system |
| KR101670621B1 (ko) | 2007-10-02 | 2016-10-28 | 테라노스, 인코포레이티드 | 모듈러 현장 진료 장치 및 이의 용도 |
| JP5864106B2 (ja) * | 2008-02-07 | 2016-02-17 | バイオミメティック セラピューティクス, エルエルシー | 仮骨延長のための組成物および方法 |
| NZ602861A (en) | 2008-09-09 | 2014-03-28 | Biomimetic Therapeutics Llc | Platelet-derived growth factor compositions and methods for the treatment of tendon and ligament injuries |
| CN102405408A (zh) * | 2009-01-29 | 2012-04-04 | 切克莱特有限公司 | 用于自动和连续水质监测的一次性套件 |
| KR20110135949A (ko) * | 2009-03-05 | 2011-12-20 | 바이오미메틱 세라퓨틱스, 인크. | 혈소판-유래 성장 인자 조성물 및 골연골성 결함의 치료 방법 |
| US20100248981A1 (en) * | 2009-03-27 | 2010-09-30 | Affymetrix, Inc. | System and methods for processing microarrays |
| EP3663004B1 (en) | 2009-05-15 | 2022-01-26 | Gen-Probe Incorporated | Method and apparatus for performing a magnetic separation procedure |
| USRE48951E1 (en) | 2015-08-05 | 2022-03-01 | Ecolab Usa Inc. | Hand hygiene compliance monitoring |
| WO2011008972A1 (en) * | 2009-07-17 | 2011-01-20 | Ibis Biosciences, Inc. | Systems for bioagent identification |
| US9102509B2 (en) | 2009-09-25 | 2015-08-11 | Ecolab Inc. | Make-up dispense in a mass based dispensing system |
| US9051163B2 (en) | 2009-10-06 | 2015-06-09 | Ecolab Inc. | Automatic calibration of chemical product dispense systems |
| US8511512B2 (en) * | 2010-01-07 | 2013-08-20 | Ecolab Usa Inc. | Impact load protection for mass-based product dispensers |
| US8492335B2 (en) | 2010-02-22 | 2013-07-23 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor compositions and methods for the treatment of tendinopathies |
| CN103543282A (zh) | 2010-07-23 | 2014-01-29 | 贝克曼考尔特公司 | 用于处理化验盒的系统 |
| US9046507B2 (en) | 2010-07-29 | 2015-06-02 | Gen-Probe Incorporated | Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure |
| CN103403533B (zh) | 2011-02-24 | 2017-02-15 | 简.探针公司 | 用于分辨光信号检测器中不同调制频率的光信号的系统和方法 |
| US9164114B2 (en) | 2011-04-19 | 2015-10-20 | Roche Molecular Systems, Inc. | Supply unit for continuous loading |
| DE102011113358A1 (de) | 2011-09-15 | 2013-03-21 | Groninger & Co. Gmbh | Verfahren und Vorrichtung zum Füllen und Verschließen von pharmazeutischen Objekten |
| USD692162S1 (en) * | 2011-09-30 | 2013-10-22 | Becton, Dickinson And Company | Single piece reagent holder |
| WO2013062995A1 (en) | 2011-10-25 | 2013-05-02 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating deep partial and full thickness wounds and injuries |
| WO2013062994A1 (en) | 2011-10-25 | 2013-05-02 | Biomimetic Therapeutics, Inc. | Compositions and methods for treating full thickness burn injuries |
| BR112014011035A2 (pt) | 2011-11-07 | 2017-06-13 | Beckman Coulter, Inc. | sistema de aliquotagem e fluxo de trabalho |
| WO2013070754A1 (en) | 2011-11-07 | 2013-05-16 | Beckman Coulter, Inc. | Robotic arm |
| KR20140091032A (ko) | 2011-11-07 | 2014-07-18 | 베크만 컬터, 인코포레이티드 | 검체 수송 시스템의 자기 감쇠 |
| WO2013070744A2 (en) | 2011-11-07 | 2013-05-16 | Beckman Coulter, Inc. | Specimen container detection |
| CN104105969B (zh) | 2011-11-07 | 2016-10-12 | 贝克曼考尔特公司 | 离心机系统和工作流程 |
| ES2778054T3 (es) | 2011-11-07 | 2020-08-07 | Beckman Coulter Inc | Sistema y método para transportar recipientes de muestras |
| FR2986617B1 (fr) * | 2012-02-02 | 2015-03-27 | Horiba Abx Sas | Dispositif et procede pour effectuer des mesures hematologiques et biochimiques a partir d'un echantillon biologique |
| WO2014144870A2 (en) | 2013-03-15 | 2014-09-18 | Abbott Laboratories | Light-blocking system for a diagnostic analyzer |
| ES2970108T3 (es) | 2013-03-15 | 2024-05-27 | Abbott Lab | Analizadores de diagnóstico con carruseles de pretratamiento y métodos relacionados |
| CN107966576B (zh) | 2013-03-15 | 2021-08-03 | 雅培制药有限公司 | 具有后面可进入轨道系统的自动化诊断分析仪及相关方法 |
| US9632103B2 (en) | 2013-03-15 | 2017-04-25 | Abbott Laboraties | Linear track diagnostic analyzer |
| EP4571318A3 (en) | 2013-03-15 | 2025-09-17 | Abbott Laboratories | Automated diagnostic analyzers having vertically arranged carousels and related methods |
| CN105164511B (zh) | 2013-03-15 | 2019-03-22 | 雅培实验室 | 诊断分析器系统的自动试剂管理器 |
| WO2015007188A1 (zh) * | 2013-07-16 | 2015-01-22 | 北京金麦格生物技术有限公司 | 用于磁珠法提取生物活性物质的装置和方法 |
| ES2724537T3 (es) * | 2013-12-03 | 2019-09-11 | Immunodiagnostic Systems Ltd | Procedimiento para cuantificar un analito, y un dispositivo analítico automático configurado para poner en práctica dicho procedimiento |
| EP2884285B1 (en) * | 2013-12-13 | 2024-07-24 | F. Hoffmann-La Roche AG | Supply module for an automated analyzer |
| AU2015332556B2 (en) | 2014-10-14 | 2021-04-29 | Samuel Lynch | Compositions for treating wounds |
| ES3038129T3 (en) | 2015-06-26 | 2025-10-09 | Abbott Lab | Rotating device in a diagnostic analyzer |
| WO2016210420A1 (en) | 2015-06-26 | 2016-12-29 | Abbott Laboratories | Reaction vessel exchanger device for a diagnostic analyzer |
| USD821607S1 (en) * | 2016-07-27 | 2018-06-26 | Beckman Coulter, Inc. | Hood for a laboratory instrument |
| US10427162B2 (en) | 2016-12-21 | 2019-10-01 | Quandx Inc. | Systems and methods for molecular diagnostics |
| WO2018165107A1 (en) | 2017-03-07 | 2018-09-13 | Ecolab Usa Inc. | Monitoring modules for hand hygiene dispensers |
| GB201712915D0 (en) * | 2017-07-11 | 2017-09-27 | Microgen Bioproducts Ltd | System for automated sample preparation |
| US10529219B2 (en) | 2017-11-10 | 2020-01-07 | Ecolab Usa Inc. | Hand hygiene compliance monitoring |
| WO2020037670A1 (zh) * | 2018-08-24 | 2020-02-27 | 深圳迈瑞生物医疗电子股份有限公司 | 血样分析仪及血样混匀方法 |
| EP3900307A1 (en) | 2018-12-20 | 2021-10-27 | Ecolab USA, Inc. | Adaptive route, bi-directional network communication |
| CN111521476B (zh) * | 2019-02-02 | 2021-06-15 | 深圳迎凯生物科技有限公司 | 样本稀释方法和免疫分析方法 |
| KR102102988B1 (ko) | 2019-03-28 | 2020-04-22 | 주식회사 엘지화학 | 면역 검사 장치 및 면역 검사 방법 |
| TWI714353B (zh) * | 2019-11-18 | 2020-12-21 | 瑞基海洋生物科技股份有限公司 | 便攜式生化反應器 |
| CN111077144B (zh) * | 2020-02-27 | 2025-02-28 | 重庆恭逸科技有限公司 | 一种试纸自动进纸装置及方法 |
| US20230280361A1 (en) * | 2020-07-15 | 2023-09-07 | Mgi Tech Co., Ltd. | Automated library preparation system |
| AU2024311668A1 (en) | 2023-06-23 | 2025-10-23 | Samuel E. Lynch | Methods and compositions for skin repair, rejuvenation and comfort |
| WO2025042830A1 (en) | 2023-08-18 | 2025-02-27 | Biomimetic Therapeutics, Llc | Platelet-derived growth factor bone graft putty formulation |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5774662A (en) * | 1980-10-28 | 1982-05-10 | Fujirebio Inc | Automatic measuring apparatus for enzyme immunity |
| JPS5836631A (ja) * | 1981-08-27 | 1983-03-03 | Mochida Pharmaceut Co Ltd | 固相と液相との反応方法及び装置 |
| US4477578A (en) * | 1982-03-04 | 1984-10-16 | Medical & Scientific, Inc. | Method and apparatus for performing assays |
| US5175086A (en) * | 1983-01-24 | 1992-12-29 | Olympus Optical Co., Ltd. | Method for effecting heterogeneous immunological analysis |
| US4937048A (en) * | 1983-01-31 | 1990-06-26 | Olympus Optical Company Limited | Carrier transporting apparatus and carrier container for use in an immunological analysis |
| FI842992A0 (fi) * | 1984-07-26 | 1984-07-26 | Labsystems Oy | Immunologiskt definitionsfoerfarande. |
| JPH0690211B2 (ja) * | 1984-09-21 | 1994-11-14 | オリンパス光学工業株式会社 | 免疫学的分析装置およびその方法 |
| US4952518A (en) * | 1984-10-01 | 1990-08-28 | Cetus Corporation | Automated assay machine and assay tray |
| CH663476A5 (fr) * | 1985-07-08 | 1987-12-15 | Serono Diagnostics Ltd | Enceinte pour le dosage d'anticorps ou d'antigenes dans un liquide biologique. |
| US4933147A (en) * | 1985-07-15 | 1990-06-12 | Abbott Laboratories | Unitized reagent containment system for clinical analyzer |
| US4803050A (en) * | 1985-07-22 | 1989-02-07 | Sequoia-Turner Corporation | Method and apparatus for liquid addition and aspiration in automated immunoassay techniques |
| US4678752A (en) * | 1985-11-18 | 1987-07-07 | Becton, Dickinson And Company | Automatic random access analyzer |
| JP2510152B2 (ja) * | 1985-11-19 | 1996-06-26 | オリンパス光学工業株式会社 | 自動分析装置 |
| EP0231430B1 (en) * | 1986-01-31 | 1991-07-17 | Kabushiki Kaisha Nittec | Automatic analysis apparatus |
| US4970053A (en) * | 1986-07-11 | 1990-11-13 | Beckman Instruments, Inc. | Reagent cartridge |
| EP0288793A3 (en) * | 1987-04-22 | 1990-04-25 | Abbott Laboratories | Cartridge and methods for performing a solid-phase immunoassay |
| US4956148A (en) * | 1987-04-22 | 1990-09-11 | Abbott Laboratories | Locking rack and disposable sample cartridge |
| US5035861A (en) * | 1987-04-22 | 1991-07-30 | Abbott Laboratories | Locking rack and disposable sample cartridge |
| US4849177A (en) * | 1987-05-08 | 1989-07-18 | Abbott Laboratories | Reagent pack and carousel |
| US5009998A (en) * | 1987-06-26 | 1991-04-23 | E. I. Du Pont De Nemours And Company | Method for performing heterogeneous immunoassay |
| US4988618A (en) * | 1987-11-16 | 1991-01-29 | Gene-Trak Systems | Magnetic separation device and methods for use in heterogeneous assays |
| US5147529A (en) * | 1988-08-10 | 1992-09-15 | E. I. Du Pont De Nemours And Company | Method for automatically processing magnetic solid phase reagents |
| US5104808A (en) * | 1988-08-26 | 1992-04-14 | Laska Paul F | Method and apparatus for effecting a plurality of assays on a plurality of samples in an automatic analytical device |
| US5167922A (en) * | 1990-04-27 | 1992-12-01 | Pb Diagnostic Systems Inc. | Assay cartridge |
-
1991
- 1991-03-21 TW TW080102229A patent/TW199858B/zh not_active IP Right Cessation
- 1991-03-28 EP EP91105095A patent/EP0449321B1/en not_active Expired - Lifetime
- 1991-03-28 ES ES91105095T patent/ES2124691T3/es not_active Expired - Lifetime
- 1991-03-28 AU AU73977/91A patent/AU640762B2/en not_active Ceased
- 1991-03-28 DE DE69130303T patent/DE69130303T2/de not_active Expired - Lifetime
- 1991-03-28 CA CA002039322A patent/CA2039322C/en not_active Expired - Lifetime
- 1991-03-29 US US07/677,686 patent/US5158895A/en not_active Expired - Fee Related
- 1991-03-30 KR KR1019910005148A patent/KR950014745B1/ko not_active Expired - Lifetime
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1992
- 1992-07-17 US US07/915,124 patent/US5290708A/en not_active Expired - Lifetime
-
1993
- 1993-05-04 US US08/057,503 patent/US5482839A/en not_active Expired - Lifetime
- 1993-07-01 AU AU41697/93A patent/AU660814B2/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180087667A (ko) * | 2017-01-25 | 2018-08-02 | 메디엇 주식회사 | 화합물 분리장치 및 이를 이용한 화학발광 면역검정장치 |
Also Published As
| Publication number | Publication date |
|---|---|
| US5482839A (en) | 1996-01-09 |
| DE69130303D1 (de) | 1998-11-12 |
| AU4169793A (en) | 1993-10-14 |
| DE69130303T2 (de) | 1999-05-20 |
| US5290708A (en) | 1994-03-01 |
| US5158895A (en) | 1992-10-27 |
| AU640762B2 (en) | 1993-09-02 |
| CA2039322C (en) | 2002-02-05 |
| CA2039322A1 (en) | 1991-10-01 |
| AU7397791A (en) | 1991-10-03 |
| ES2124691T3 (es) | 1999-02-16 |
| EP0449321A3 (en) | 1992-09-09 |
| EP0449321A2 (en) | 1991-10-02 |
| TW199858B (enExample) | 1993-02-11 |
| EP0449321B1 (en) | 1998-10-07 |
| AU660814B2 (en) | 1995-07-06 |
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