KR950002161B1 - 5-플루오로우라실 유도체의 제조방법 - Google Patents

5-플루오로우라실 유도체의 제조방법 Download PDF

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Publication number
KR950002161B1
KR950002161B1 KR1019870701257A KR870701257A KR950002161B1 KR 950002161 B1 KR950002161 B1 KR 950002161B1 KR 1019870701257 A KR1019870701257 A KR 1019870701257A KR 870701257 A KR870701257 A KR 870701257A KR 950002161 B1 KR950002161 B1 KR 950002161B1
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KR
South Korea
Prior art keywords
group
lower alkyl
phenyl
halogen atom
ring
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Expired - Fee Related
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KR1019870701257A
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English (en)
Korean (ko)
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KR880701232A (ko
Inventor
세쓰로 후지이
미쓰루 히로하시
요시히또 야마모또
유따까 고지마
Original Assignee
오오쓰까 세이야꾸 가부시끼가이샤
오오쓰까 아끼히꼬
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Publication of KR880701232A publication Critical patent/KR880701232A/ko
Application granted granted Critical
Publication of KR950002161B1 publication Critical patent/KR950002161B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/553—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with halogen atoms or nitro radicals directly attached to ring carbon atoms, e.g. fluorouracil
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1019870701257A 1986-04-30 1987-04-30 5-플루오로우라실 유도체의 제조방법 Expired - Fee Related KR950002161B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP10128586 1986-04-30
JP61-101285 1986-04-30
JP62-45754 1987-02-27
JP4575487 1987-02-27
PCT/JP1987/000275 WO1987006582A1 (fr) 1986-04-30 1987-04-30 Derives de 5-fluorouracyle

Publications (2)

Publication Number Publication Date
KR880701232A KR880701232A (ko) 1988-07-26
KR950002161B1 true KR950002161B1 (ko) 1995-03-14

Family

ID=26385819

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870701257A Expired - Fee Related KR950002161B1 (ko) 1986-04-30 1987-04-30 5-플루오로우라실 유도체의 제조방법

Country Status (9)

Country Link
US (1) US5047521A (https=)
EP (1) EP0247381B1 (https=)
JP (1) JPH07103112B2 (https=)
KR (1) KR950002161B1 (https=)
DE (1) DE3786834T2 (https=)
DK (1) DK166088C (https=)
ES (1) ES2058073T3 (https=)
GB (1) GB2200352B (https=)
WO (1) WO1987006582A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101441770B1 (ko) * 2009-10-27 2014-09-17 데루타-후라이 화마 가부시키가이샤 신규 5-플루오로우라실 유도체

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4864021A (en) * 1984-10-30 1989-09-05 Otsuka Pharmaceutical Co., Ltd. 5-fluorouracil derivatives
AU610913B2 (en) * 1987-07-31 1991-05-30 Taiho Pharmaceutical Co., Ltd. 2'-deoxy-5-fluorouridine derivatives
US4992534A (en) * 1987-08-12 1991-02-12 Otsuka Pharmaceutical Co., Ltd. 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine
EP1594842A1 (en) * 2003-02-22 2005-11-16 MERCK PATENT GmbH Cyanopyridone derivatives as liquid crystals
CA2526289A1 (en) * 2003-05-20 2004-12-02 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising 5-fluorouracil or a derivative thereof and a liposomal platinum complex
JP2007077109A (ja) * 2005-09-16 2007-03-29 Tokyo Institute Of Technology ヌクレオシド誘導体及びその製造方法
US7561776B2 (en) * 2005-11-29 2009-07-14 Petrospec Engineering Ltd. Method of preventing hydrogen darkening of optic fibre
AU2013203591B2 (en) * 2009-05-01 2017-01-19 University Court Of The University Of Dundee Treatment or prophylaxis of proliferative conditions
GB0907551D0 (en) * 2009-05-01 2009-06-10 Univ Dundee Treatment or prophylaxis of proliferative conditions
AU2019216531A1 (en) 2018-02-02 2020-09-24 Maverix Oncology, Inc. Small molecule drug conjugates of gemcitabine monophosphate

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4124765A (en) * 1975-05-13 1978-11-07 Ono Pharmaceutical Co., Ltd. 5-Fluorouracil derivatives
JPS6011704B2 (ja) * 1976-07-30 1985-03-27 大鵬薬品工業株式会社 ５−フルオルウラシル誘導体の製造法
DE2658672A1 (de) * 1976-12-23 1978-06-29 Robugen Gmbh Neue nucleosid-verbindungen und verfahren zu ihrer herstellung
JPS5379879A (en) * 1976-12-23 1978-07-14 Mitsui Toatsu Chem Inc 1,3-substituted-5-fluorouracils and process for their preparation
JPS5924999B2 (ja) * 1978-06-10 1984-06-13 富山化学工業株式会社 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体の製造法
JPS5535057A (en) * 1978-09-05 1980-03-11 Funai Corp 2'-deoxy-5-fluorouridine derivative, its preparation, and antitumor agent comprising it
US4340728A (en) * 1979-11-28 1982-07-20 Fuji Kagaku Kogyo Kabushiki Kaisha Nucleoside derivatives and process for preparing same
GB2072164B (en) * 1980-02-15 1983-12-21 Funai Pharmaceutical Ind Ltd 2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine derivatives a process for the preparation of the derivatives and antitumor agents containing the derivatives
JPS5929699A (ja) * 1982-08-11 1984-02-16 Funai Corp ２′−デオキシ−５−フルオロウリジンのエ−テル誘導体およびその製造方法並びにこれを含有する抗腫瘍剤
JPS58185522A (ja) * 1983-02-28 1983-10-29 Toyama Chem Co Ltd 新規な５−フルオロ−２′−デオキシ−β−ウリジン誘導体
DE3469533D1 (en) * 1983-05-23 1988-04-07 Taiho Pharmaceutical Co Ltd Novel 2'-deoxy-5-substituted uridine derivatives, processes for preparing the same and antitumor agent containing the same
JPS6061593A (ja) * 1983-09-14 1985-04-09 Taiho Yakuhin Kogyo Kk ２’−デオキシ−５−トリフルオロメチルウリジン誘導体及びそれを含む抗腫瘍剤
DE3481191D1 (de) * 1983-07-20 1990-03-08 Teijin Ltd Antineoplastisches mittel.
US4515618A (en) * 1983-12-07 1985-05-07 Chevron Research Company 5-Deoxy-3-O-thienylmethyl or furylmethyl-1,2-O-alkylidene-alpha-D-xylofuranose herbicide derivatives
DK175432B1 (da) * 1984-10-30 2004-10-18 Otsuka Pharma Co Ltd Middel til forögelse af anticancervirkningen af anticancerforbindelser
AU610913B2 (en) * 1987-07-31 1991-05-30 Taiho Pharmaceutical Co., Ltd. 2'-deoxy-5-fluorouridine derivatives
US4992534A (en) * 1987-08-12 1991-02-12 Otsuka Pharmaceutical Co., Ltd. 3'-O-,5'-O-derivatives of 2'-deoxy-5-fluorouridine
JPH02187484A (ja) * 1989-01-13 1990-07-23 Okitsumo Kk 紙用瞬間接着剤

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101441770B1 (ko) * 2009-10-27 2014-09-17 데루타-후라이 화마 가부시키가이샤 신규 5-플루오로우라실 유도체

Also Published As

Publication number Publication date
EP0247381A3 (en) 1988-11-23
DK166088B (da) 1993-03-08
DE3786834D1 (de) 1993-09-09
JPH07103112B2 (ja) 1995-11-08
DK691287D0 (da) 1987-12-29
WO1987006582A1 (fr) 1987-11-05
EP0247381B1 (en) 1993-08-04
JPH07103112B1 (https=) 1995-11-08
KR880701232A (ko) 1988-07-26
DK166088C (da) 1993-08-23
ES2058073T3 (es) 1994-11-01
US5047521A (en) 1991-09-10
DK691287A (da) 1988-02-19
GB2200352A (en) 1988-08-03
DE3786834T2 (de) 1994-03-03
GB8730031D0 (en) 1988-02-03
EP0247381A2 (en) 1987-12-02
GB2200352B (en) 1990-07-25

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