KR940005584A - 벤즈이미다졸, 이를 함유하는 약제학적 조성물 및 이의 제조방법 - Google Patents

벤즈이미다졸, 이를 함유하는 약제학적 조성물 및 이의 제조방법 Download PDF

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Publication number
KR940005584A
KR940005584A KR1019930013764A KR930013764A KR940005584A KR 940005584 A KR940005584 A KR 940005584A KR 1019930013764 A KR1019930013764 A KR 1019930013764A KR 930013764 A KR930013764 A KR 930013764A KR 940005584 A KR940005584 A KR 940005584A
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KR
South Korea
Prior art keywords
group
methyl
imidazo
benzimidazol
pyridin
Prior art date
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Ceased
Application number
KR1019930013764A
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English (en)
Korean (ko)
Inventor
하우엘 노르베르트
리즈 우베
잔 밀 자크
비넨 볼프강
엔트쩨로트 미카엘
Original Assignee
디터 라우딘, 게르하르트 후버
닥터 칼 토매 게엠베하
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Publication of KR940005584A publication Critical patent/KR940005584A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1019930013764A 1992-07-22 1993-07-21 벤즈이미다졸, 이를 함유하는 약제학적 조성물 및 이의 제조방법 Ceased KR940005584A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4224133A DE4224133A1 (de) 1992-07-22 1992-07-22 Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DEP4224133.2 1992-07-22

Publications (1)

Publication Number Publication Date
KR940005584A true KR940005584A (ko) 1994-03-21

Family

ID=6463804

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930013764A Ceased KR940005584A (ko) 1992-07-22 1993-07-21 벤즈이미다졸, 이를 함유하는 약제학적 조성물 및 이의 제조방법

Country Status (20)

Country Link
EP (1) EP0581166A1 (enExample)
JP (1) JPH06179659A (enExample)
KR (1) KR940005584A (enExample)
CN (1) CN1050122C (enExample)
AU (1) AU675433B2 (enExample)
CA (1) CA2100927A1 (enExample)
CZ (1) CZ144993A3 (enExample)
DE (1) DE4224133A1 (enExample)
FI (1) FI933284A7 (enExample)
HU (1) HUT64955A (enExample)
IL (1) IL106408A (enExample)
MX (1) MX9304424A (enExample)
NO (1) NO300772B1 (enExample)
NZ (1) NZ248217A (enExample)
PL (1) PL172929B1 (enExample)
RU (1) RU2126401C1 (enExample)
SG (1) SG43083A1 (enExample)
SK (1) SK73293A3 (enExample)
TW (1) TW229207B (enExample)
ZA (1) ZA93529B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4233590A1 (de) * 1992-10-06 1994-04-07 Thomae Gmbh Dr K Benzimidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4304455A1 (de) * 1993-02-15 1994-08-18 Bayer Ag Heterocyclisch substituierte Phenyl-cyclohexan-carbonsäurederivate
DE4324580A1 (de) * 1993-07-22 1995-01-26 Thomae Gmbh Dr K Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE19503160A1 (de) * 1995-02-01 1996-08-08 Bayer Ag Verwendung von Phenylcyclohexylcarbonsäureamiden
EP0882718B1 (en) * 1995-12-28 2005-08-31 Fujisawa Pharmaceutical Co., Ltd. Benzimidazole derivatives
TW453999B (en) * 1997-06-27 2001-09-11 Fujisawa Pharmaceutical Co Benzimidazole derivatives
RU2185171C2 (ru) * 1999-06-25 2002-07-20 Институт нефтехимии и катализа АН РБ и УНЦ РАН Способ профилактики реокклюзий при операциях на магистральных сосудах
HU222773B1 (hu) * 2000-04-21 2003-10-28 Richter Gedeon Vegyészeti Gyár Rt. Eljárás egy ismert tetrazolszármazék előállítására
WO2005011736A1 (ja) * 2003-07-30 2005-02-10 Tohoku Techno Arch Co., Ltd. アルツハイマー病の予防および／または治療剤
DE102004060699A1 (de) * 2004-12-16 2006-06-22 Ratiopharm Gmbh Verfahren zur Herstellung von Candesartan
RU2427574C2 (ru) * 2009-07-16 2011-08-27 Государственное образовательное учреждение высшего профессионального образования "Астраханский государственный университет" (АГУ) Моногидрохлориды и натриевые соли таутомерных 5(6)-алкоксикарбониламинопроизводных 2-арил-1-гидроксибензимидазол-3-оксида с высокой противогрибковой активностью и способ их получения
CN101891735B (zh) * 2009-11-25 2012-07-18 北京理工大学 联苯磺胺异噁唑类化合物、合成方法及用途
CN101921265B (zh) * 2009-11-25 2012-07-04 北京理工大学 联苯酰胺四唑类化合物、合成方法及用途
CA2852964A1 (en) * 2011-11-03 2013-05-10 F. Hoffmann-La Roche Ag Bicyclic piperazine compounds
CN105820125B (zh) * 2015-01-09 2018-12-07 北京中医药大学 一种用于治疗高血压的化合物及其制备方法和用途
CN105384729B (zh) * 2015-07-09 2019-02-19 天津青松华药医药有限公司 替米沙坦酯类衍生物及其制备方法与应用
CN106749220B (zh) * 2017-01-18 2019-08-06 东华大学 一种6’-取代苯并咪唑-4-取代甲基吲哚衍生物及其制备和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3928177A1 (de) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
WO1991012001A1 (en) * 1990-02-13 1991-08-22 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted benzyl element
RU1836357C (ru) * 1990-07-23 1993-08-23 Др.Карл Томэ ГмбХ Производные бензимидазола, их изомеры, смеси изомеров, гидраты или их физиологически переносимые соли, обладающие антагонистическими в отношении ангиотензина свойствами
SI9210098B (sl) * 1991-02-06 2000-06-30 Dr. Karl Thomae Benzimidazoli, zdravila, ki te spojine vsebujejo, in postopek za njihovo pripravo
DE4237656A1 (de) * 1992-06-13 1993-12-16 Merck Patent Gmbh Benzimidazolderivate

Also Published As

Publication number Publication date
PL172929B1 (pl) 1997-12-31
JPH06179659A (ja) 1994-06-28
HU9302115D0 (en) 1993-10-28
NO932636L (no) 1994-01-24
IL106408A (en) 1998-08-16
NZ248217A (en) 1996-06-25
CN1083812A (zh) 1994-03-16
AU4209493A (en) 1994-01-27
MX9304424A (es) 1994-01-31
FI933284A0 (fi) 1993-07-21
CZ144993A3 (en) 1994-03-16
CN1050122C (zh) 2000-03-08
FI933284A7 (fi) 1994-01-23
IL106408A0 (en) 1993-11-15
CA2100927A1 (en) 1994-01-23
NO932636D0 (no) 1993-07-21
EP0581166A1 (de) 1994-02-02
RU2126401C1 (ru) 1999-02-20
HUT64955A (en) 1994-03-28
SG43083A1 (en) 1997-10-17
NO300772B1 (no) 1997-07-21
AU675433B2 (en) 1997-02-06
TW229207B (enExample) 1994-09-01
SK73293A3 (en) 1994-04-06
PL299754A1 (en) 1994-03-21
DE4224133A1 (de) 1994-01-27
ZA93529B (en) 1995-01-23

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