KR930009591A - 트리-아르기닌 인슐린 - Google Patents

트리-아르기닌 인슐린 Download PDF

Info

Publication number
KR930009591A
KR930009591A KR1019920022175A KR920022175A KR930009591A KR 930009591 A KR930009591 A KR 930009591A KR 1019920022175 A KR1019920022175 A KR 1019920022175A KR 920022175 A KR920022175 A KR 920022175A KR 930009591 A KR930009591 A KR 930009591A
Authority
KR
South Korea
Prior art keywords
insulin
arginine
tri
chain
additional
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1019920022175A
Other languages
English (en)
Korean (ko)
Inventor
아서 호프만 제임스
칼 램부이 피터
Original Assignee
리로이 휘테커
일라이 릴리 앤드 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 리로이 휘테커, 일라이 릴리 앤드 캄파니 filed Critical 리로이 휘테커
Publication of KR930009591A publication Critical patent/KR930009591A/ko
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Emergency Medicine (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1019920022175A 1991-11-26 1992-11-24 트리-아르기닌 인슐린 Withdrawn KR930009591A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80116391A 1991-11-26 1991-11-26
US801,163 1991-11-26

Publications (1)

Publication Number Publication Date
KR930009591A true KR930009591A (ko) 1993-06-21

Family

ID=25180362

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920022175A Withdrawn KR930009591A (ko) 1991-11-26 1992-11-24 트리-아르기닌 인슐린

Country Status (17)

Country Link
US (2) US5491216A (https=)
EP (1) EP0544466A1 (https=)
JP (1) JP3304442B2 (https=)
KR (1) KR930009591A (https=)
CN (1) CN1072723A (https=)
AU (1) AU2857692A (https=)
BR (1) BR9204542A (https=)
CA (1) CA2083360A1 (https=)
CZ (1) CZ342492A3 (https=)
FI (1) FI925343A7 (https=)
HU (2) HU9203688D0 (https=)
IL (1) IL103849A0 (https=)
MX (1) MX9206724A (https=)
NO (1) NO924525L (https=)
NZ (1) NZ245170A (https=)
TW (1) TW224471B (https=)
ZA (1) ZA928916B (https=)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2213301C (en) * 1995-02-20 2010-01-26 Amrad Operations Pty. Ltd. Immunoreactive and immunotherapeutic molecules which interact in subjects with insulin-dependent diabetes mellitus (iddm)
DK0821006T3 (da) * 1996-07-26 2004-08-16 Aventis Pharma Gmbh Insulinderivater med öget zinkbinding
US6444641B1 (en) 1997-10-24 2002-09-03 Eli Lilly Company Fatty acid-acylated insulin analogs
US6933272B1 (en) 1998-09-22 2005-08-23 Erik Helmerhorst Use of non-peptidyl compounds for the treatment of insulin related ailments
CA2402191C (en) 2000-03-24 2012-03-13 Genentech, Inc. Use of insulin for the treatment of cartilagenous disorders
PL374949A1 (en) * 2001-12-20 2005-11-14 Eli Lilly And Company Insulin molecule having protracted time action
US20060217290A1 (en) * 2003-04-29 2006-09-28 Kohn Wayne D Insulin analogs having protracted time action
WO2007081824A2 (en) * 2006-01-06 2007-07-19 Case Western Reserve University Fibrillation resistant proteins
ES2542146T3 (es) 2006-07-31 2015-07-31 Novo Nordisk A/S Insulinas extendidas PEGiladas.
DK2074141T3 (en) 2006-09-22 2016-11-28 Novo Nordisk As The protease resistant insulin analogues.
EP2074140B8 (en) * 2006-10-04 2015-10-28 Case Western Reserve University Fibrillation-resistant insulin and insulin analogues
US9387176B2 (en) 2007-04-30 2016-07-12 Novo Nordisk A/S Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
CN102037008B (zh) 2008-03-18 2016-08-31 诺沃-诺迪斯克有限公司 蛋白酶稳定化的、酰化胰岛素类似物
US8993516B2 (en) * 2008-04-14 2015-03-31 Case Western Reserve University Meal-time insulin analogues of enhanced stability
RU2010147076A (ru) * 2008-04-22 2012-05-27 Кейз Вестерн Ризев Юнивесити (Us) Аналоги инсулина специфичные к изоформам
US9200053B2 (en) 2008-07-31 2015-12-01 Case Western Reserve University Insulin analogues containing penta-fluoro-Phenylalanine at position B24
KR20120129875A (ko) 2008-07-31 2012-11-28 케이스 웨스턴 리저브 유니버시티 염소화 아미노산을 갖는 인슐린 유사체
US8399407B2 (en) * 2009-09-17 2013-03-19 Case Western Reserve University Non-standard insulin analogues
EA201200717A1 (ru) 2009-12-11 2013-03-29 Кейз Вестерн Ризев Юнивесити Аналоги инсулина, содержащие хлорированные аминокислоты
EP2686003A2 (en) * 2011-03-15 2014-01-22 Novo Nordisk A/S Human insulin analogues and derivatives comprising cysteine substitutions
US9481721B2 (en) 2012-04-11 2016-11-01 Novo Nordisk A/S Insulin formulations
AU2014333979B2 (en) 2013-10-07 2018-02-15 Novo Nordisk A/S Novel derivative of an insulin analogue
CN104017809A (zh) * 2014-06-05 2014-09-03 山东省农业科学院生物技术研究中心 改造的人Insulin蛋白表达基因及表达方法
AU2015328222B9 (en) 2014-10-06 2020-12-24 Case Western Reserve University Biphasic single-chain insulin analogues
CA2979397A1 (en) * 2015-03-12 2016-09-15 Board Of Trustees Of Michigan State University Compositions and methods for measuring c-peptide binding and diagnosing immune-mediated diseases
WO2017052305A1 (en) * 2015-09-24 2017-03-30 Hanmi Pharm. Co., Ltd. Method of insulin production
TWI700091B (zh) 2016-12-16 2020-08-01 丹麥商諾佛 儂迪克股份有限公司 含胰島素醫藥組成物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3326473A1 (de) * 1983-07-22 1985-01-31 Hoechst Ag, 6230 Frankfurt Pharmazeutisches mittel zur behandlung des diabetes mellitus
DE3326472A1 (de) * 1983-07-22 1985-02-14 Hoechst Ag, 6230 Frankfurt Neue insulin-derivate, verfahren zu deren herstellung und deren verwendung sowie pharmazeutische mittel zur behandlung des diabetes mellitus
US4581165A (en) * 1984-06-14 1986-04-08 Eli Lilly And Company Anti-diabetic compounds
US4569792A (en) * 1984-06-14 1986-02-11 Eli Lilly And Company Anti-diabetic compounds
US4569791A (en) * 1984-06-14 1986-02-11 Eli Lilly And Company Anti-diabetic compounds
US5008241A (en) * 1985-03-12 1991-04-16 Novo Nordisk A/S Novel insulin peptides
DK129385A (da) * 1985-03-22 1986-09-23 Novo Industri As Peptider og fremstilling deraf
IL84110A (en) * 1986-10-14 1992-11-15 Lilly Co Eli Process for transforming a human insulin precursor to a human insulin
US4992418A (en) * 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogue-[10-Aspartic Acid-B]Human Insulin
ATE101620T1 (de) * 1988-06-23 1994-03-15 Hoechst Ag Mini-proinsulin, seine herstellung und verwendung.
DE3844211A1 (de) * 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DK134189D0 (da) * 1989-03-20 1989-03-20 Nordisk Gentofte Insulinforbindelser
DE3936876A1 (de) * 1989-11-06 1991-05-23 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
US5130236A (en) * 1989-12-07 1992-07-14 Eli Lilly And Company Process for producing des(64,65)-proinsulin
US5139716A (en) * 1990-02-20 1992-08-18 Loral Aerospace Corp. Method of fabricating coolable ceramic structures

Also Published As

Publication number Publication date
CN1072723A (zh) 1993-06-02
HU9203688D0 (en) 1993-03-29
BR9204542A (pt) 1993-06-01
IL103849A0 (en) 1993-04-04
JP3304442B2 (ja) 2002-07-22
HUT63457A (en) 1993-08-30
CZ342492A3 (en) 1993-06-16
NO924525L (no) 1993-05-27
EP0544466A1 (en) 1993-06-02
FI925343L (fi) 1993-05-27
US5491216A (en) 1996-02-13
NZ245170A (en) 1994-07-26
NO924525D0 (no) 1992-11-24
CA2083360A1 (en) 1993-05-27
FI925343A7 (fi) 1993-05-27
ZA928916B (en) 1994-05-18
JPH05286998A (ja) 1993-11-02
AU2857692A (en) 1993-05-27
TW224471B (https=) 1994-06-01
MX9206724A (es) 1993-05-01
FI925343A0 (fi) 1992-11-25
US5698669A (en) 1997-12-16

Similar Documents

Publication Publication Date Title
KR930009591A (ko) 트리-아르기닌 인슐린
DE68928810D1 (de) Analoge vom menschlichen Insulin
KR900701840A (ko) 인슐린 유사체
NO167187B (no) Fremgangsmaate til fremstilling av et legemiddel.
KR970706842A (ko) 아실화된 인슐린 동족체(Acylated Insulin Analogs)
RU98112109A (ru) Производное инсулина или его физиологически приемлемая соль, предшественник производного инсулина, днк-последовательность, кодирующая предшественник, вектор экспрессии, содержащий упомянутую днк-последовательность, субстрат, трансформированный упомянутым вектором экспрессии, и фармацевтическая композиция с понижающей, соответственно регулирующей уровень глюкозы в крови эффективностью
DE60045524D1 (de) Ein Huhn GnRH-II Analog zur Verwendung in der Reduktion des Tumorzellwachstums
AU6183886A (en) GRF analogs
YU46023B (sh) Postupak za dobijanje novih analoga insulina
NO178914B (no) Fremgangsmåte for fremstilling av et farmasöytisk preparat for behandling av Diabetes mellitus
WO2020236762A3 (en) Variant single-chain insulin analogues
ATE162201T1 (de) Cnp-gen und vorläuferprotein aus schwein
JP2022507627A (ja) ポリ－アラニンｃ－ドメインのサブセグメントを有する単鎖インスリンアナログ
CA2002924A1 (en) Anti-Thrombins
KR927002373A (ko) 성장 호르몬 분비 활성을 갖는 폴리펩타이드 화합물
AU682638B2 (en) Peptide, bronchodilator and blood flow ameliorant
FR2266516A1 (en) Somatostatin peptide analogues having prolonged activity - inhibit secretion of pituitary growth hormone and glucagon and are used to treat diabetes
KR890005149A (ko) 합성 펩타이드 및 이를 포함한 제약학적 조성물
Chu et al. High-potency hybrid compounds related to insulin and amphioxus insulin-like peptide
YU64192A (sh) Analozi insulina
SE8006333L (sv) Polypeptid psp och salter derav
KR880006262A (ko) 펩티드
CA3149925A1 (en) Premixed ultra-stable single-chain insulin analogue formulations
Pan et al. Design and synthesis of salmon calcitonin and its analogues
RU97107460A (ru) Новые пептиды с иммуномодуляторным действием

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19921124

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid